Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 17, Issue 5, Pages 532-540Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2015.1046449
Keywords
sesquiterpenes; Curcuma phaeocaulis; germacrane; guaiane; nitric oxide
Funding
- National Natural Science Foundation of China (NSFC) [30973630, 81430095]
- Medicinal Chemistry Subject Construction Project of Shenyang Pharmaceutical University [20130017]
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Three new guaiane-type sesquiterpenes named phaeocaulisins K-M (1-3), and one germacrane-type sesquiterpenoid with new ring system of 1,5- and 1,8-ether groups named phagermadiol (4), were isolated from rhizomes of Curcuma phaeocaulis. Their structures were established based on extensive spectroscopic analysis. Compound 1, the first example of norsesquiterpene with tropone backbone, and compound 3 with a novel 1,2-dioxolane sesquiterpene alcohol were isolated from the genus Curcuma. All of the isolated compounds were tested for inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compound 3 inhibited NO production with IC50 value of 6.05 +/- 0.43 mu M. The plausible biosynthetic pathway for compounds 3 and 4 in C. phaeocaulis was also discussed.
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