Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 17, Issue 5, Pages 430-438Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2015.1039524
Keywords
sesquiterpene; coxsackie virus; Illiciaceae; Illiciumoligandrum; antiviral activity
Funding
- National Natural Science Foundation of China [21132009]
- National Science and Technology Project of China [2012ZX09301002-002, 2014ZX09507003-006]
- CICSEM [2013-B1]
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Two new sesquiterpenes, oligandrin (1) and oligandric acid (2), together with three analogues, tashironin A (3), tashironin (4), and oplodiol (5), were isolated from the roots of Illicium oligandrum. The structures of new compounds were determined based on 1D and 2D NMR experiments and X-ray diffraction. Compound 1 represents a presumed biosynthetic precursor of seco-prezizaane sesquiterpenes which consists of a novel 6/6/5 tricarbocyclic skeleton. Compound 2 is the first example of chamipinene-type sesquiterpene possessing a 6/4/6 tricyclic system from the genus Illicium. Compounds 1-5 were evaluated in vitro for their activity against coxsackie virus B3 (CVB3), influenza virus A/Hanfang/359/95 (H3N2), and influenza virus A/FM/1/47 (H1N1). Compound 1 showed selective antiviral activity against CVB3 with IC50 value of 11.11 mu M.
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