Article
Medicine, General & Internal
Soshi Samejima, Claire Shackleton, Raza N. Malik, Kawami Cao, Anibal Bohorquez, Tom E. Nightingale, Rahul Sachdeva, Andrei V. Krassioukov
Summary: Spinal cord injury (SCI) leads to severe cardiovascular dysfunction, and autonomic dysreflexia (AD) is one of the causes of high blood pressure in SCI patients. Recently, spinal cord stimulation (SCS) has been considered as a potential intervention to alleviate unstable blood pressure after SCI. This case series demonstrates the real-time effect of epidural SCS (eSCS) at the lumbosacral spinal cord in mitigating AD in individuals with SCI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Ashraf S. Gorgey, Jacob Goldsmith, Ahmad Alazzam, Robert Trainer
Summary: This case report highlights the potential of spinal cord epidural stimulation (SCES) to improve physical function and cardiovascular autonomic regulation in individuals with spinal cord injury (SCI). The results demonstrate that SCES intended for walking can also benefit cardiovascular autonomic control and attenuate spasticity. Using a single SCES configuration that targets multiple functions may accelerate clinical translation.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Mariah J. Wulf, Veronica J. Tom
Summary: Spinal cord injury damages multiple structures in the lesion site, interrupting the conduction of information in the spinal cord. It also affects the autonomic nervous system and can lead to dysfunction of various organs. Understanding how SCI impacts the sympathetic nervous system and its effects on target organs may provide insights for improving health and quality of life for SCI individuals.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Maria K. Jantz, Chaitanya Gopinath, Ritesh Kumar, Celine Chin, Liane Wong, John Ogren, Lee E. Fisher, Bryan L. McLaughlin, Robert A. Gaunt
Summary: By studying sacral spinal cord stimulation, it has been found that nerves can be selectively activated to improve bladder and urethral function, providing a direct modulation mechanism for the restoration of bladder and urethral function after injury or disease.
JOURNAL OF NEURAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Mostafa Seblani, Patrick Decherchi, Jean-Michel Brezun
Summary: Edema after spinal cord injury is a significant concern and can worsen the condition. The mechanisms behind the increase in water content after SCI are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Oscar Alcantar-Garibay, Diego Incontri-Abraham, Antonio Ibarra
Summary: Spinal cord injury is a serious condition that can lead to lifelong disability. It can be classified into traumatic and non-traumatic types, and has primary and secondary injury phases. The secondary phase, which lasts for weeks or months, is characterized by pro-inflammatory processes and can result in cognitive impairment.
NEURAL REGENERATION RESEARCH
(2022)
Article
Health Care Sciences & Services
James Guest, Nilanjana Datta, George Jimsheleishvili, David R. Gater
Summary: The spinal cord serves as a communication conduit between the brain and the body, responsible for transmitting information and controlling various functions. Following a spinal cord injury, various complications can arise, including paralysis, pain, and autonomic dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Austin M. Henke, Zackery J. Billington, David R. Gater
Summary: Spinal cord injury can lead to autonomic dysfunction, causing cardiovascular, respiratory, and excretory problems.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Neurosciences
Pei Li, Yuanyuan Jia, Wenbo Tang, Qingjun Cui, Ming Liu, Jingjing Jiang
Summary: This review summarizes the important roles of non-coding RNAs in axon regeneration after central nervous system injuries, especially lncRNA, miRNA, and circRNA. It also reveals the interactive networks among them.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Siamak Salavatian, Yuki Kuwabara, Benjamin Wong, Jonathan R. R. Fritz, Kimberly Howard-Quijano, Robert D. D. Foreman, J. Andrew Armour, Jeffrey L. L. Ardell, Aman Mahajan
Summary: Myocardial ischemia disrupts the neural network controlling cardiac sympathetic preganglionic neurons, leading to sympathetic overexcitation and ventricular tachyarrhythmias. Spinal cord stimulation can suppress the sympathoexcitation caused by myocardial ischemia, but how it modulates the spinal neural network is not fully understood.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Chi Feng, Lan Deng, Yuan-Yuan Yong, Jian-Ming Wu, Da-Lian Qin, Lu Yu, Xiao-Gang Zhou, An-Guo Wu
Summary: The spinal cord and brain are vital to the central nervous system (CNS), but spinal cord injury (SCI) caused by external forces is challenging to treat and results in loss of motor, sensory, and autonomic functions. The incidence of SCI is increasing globally, emphasizing the urgent need for treatments. Various approaches, such as surgery, drug therapy, stem cell transplantation, regenerative medicine, and rehabilitation therapy, have been developed. Among them, biomaterials using tissue engineering and bioscaffolds show promise for transporting cells or drugs to injured sites. However, clinical evidence for the treatment of SCI with biomaterials remains limited. This review provides inspiration and guidance for future studies and applications of biomaterials in SCI treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Joslyn Gober, Sruthi P. Thomas, David R. Gater
Summary: This manuscript discusses the epidemiology, pathophysiology, prevention, and management strategies for pediatric spina bifida and spinal cord injury. Growing and developing children are at high risk for spinal cord tethering, syringomyelia, and other complications that must be addressed carefully. Proper management of neurogenic bladder and neurogenic bowel is crucial for both medical safety and psychosocial integration into the child's expanding social circle.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Neurosciences
Ana Karina Kirby, Sidharth Pancholi, Zada Anderson, Caroline Chesler, Thomas H. Everett, Bradley S. Duerstock
Summary: Autonomic dysreflexia (AD) is a condition that affects around 70% of individuals with spinal cord injury (SCI) and can have serious consequences if not detected and managed promptly. Currently, continuous blood pressure monitoring is used as the gold standard for AD detection, but it can be inconvenient. Therefore, a non-invasive detection device would be valuable for rapid and continuous AD detection.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Chang Sun, Junhao Deng, Yifei Ma, Fanqi Meng, Xiang Cui, Ming Li, Jiantao Li, Jia Li, Pengbin Yin, Lingjie Kong, Licheng Zhang, Peifu Tang
Summary: This article presents a comprehensive overview of recent advances in understanding the role of microglia in the development of neuropathic pain following spinal cord injury (SCI). It delves into the detrimental and protective effects of microglia on neuropathic pain following SCI, as well as the mechanisms underlying their interconversion. The article also provides a thorough overview of potential avenues for future research in this area.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Biology
Marisa A. Jeffries, Veronica J. Tom
Summary: Individuals with spinal cord injuries (SCI) exhibit increased susceptibility to infection due to immune dysfunction, which is characterized by immunosuppression and chronic inflammation. Recent research has identified altered sympathetic input to lymphoid organs post-SCI as a key instigator of immune dysfunction, resulting in secondary effects that exacerbate immune pathology. Promising therapies, such as modulation of neuroimmune activity, have shown potential to improve regulation of peripheral immune function in SCI individuals to enhance resistance to deadly infections.
Article
Sport Sciences
Michael John Hutchinson, Maureen Jane MacDonald, Roger Eston, Victoria Louise Goosey-Tolfrey
JOURNAL OF SPORTS SCIENCES
(2019)
Article
Physiology
Jem L. Cheng, Jason S. Au, Maureen J. MacDonald
EXPERIMENTAL PHYSIOLOGY
(2019)
Article
Nutrition & Dietetics
Michael John Hutchinson, Sydney Ella Valentino, Julia Totosy de Zepetnek, Maureen Jane MacDonald, Victoria Louise Goosey-Tolfrey
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2020)
Article
Environmental Sciences
Hilary A. T. Caldwell, Natascja A. Di Cristofaro, John Cairney, Steven R. Bray, Maureen J. MacDonald, Brian W. Timmons
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Review
Cardiac & Cardiovascular Systems
Jennifer S. Williams, Emily C. Dunford, Maureen J. MacDonald
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Joshua M. Cherubini, Jem L. Cheng, Jennifer S. Williams, Maureen J. MacDonald
Summary: Sleep is crucial for maintaining physiological homeostasis, and inadequate sleep can lead to various pathologies, especially increasing the risk of cardiovascular diseases and atherosclerosis. Short sleep durations are found to decrease endothelial function, possibly disrupting autonomic balance and circadian rhythmicity of vascular clock components.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Kenneth Shinkichi Noguchi, Mike Pryzbek, Kevin Moncion, Angelica McQuarrie, Maureen Jane MacDonald, Ada Tang
Summary: Long-term exercise-based cardiac rehabilitation has similar benefits on cardiorespiratory fitness for both smokers and non-smokers. Neither the number of pack-years nor the length of time spent smoke-free influence cardiorespiratory fitness trajectories following long-term cardiac rehabilitation.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Review
Cardiac & Cardiovascular Systems
Jennifer S. Williams, Maureen J. MacDonald
Summary: Hormonal contraceptives have been found to impact vascular function and structure, with differences in endothelial function in different types of contraceptives. However, they do not seem to affect smooth muscle function, arterial stiffness, or vascular structure. Phasic differences exist in the effects of hormonal contraceptives based on progestin type, ethinyl estradiol-to-progestin ratio, and route of administration.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
William Bostad, Sydney E. Valentino, Devin G. McCarthy, Douglas L. Richards, Martin J. MacInnis, Maureen J. MacDonald, Martin J. Gibala
Summary: The study found that 12 weeks of Sprint Interval Training (SIT) increased peak cardiac output ((Q)dot(peak)) by 6% in previously untrained participants, and the change was correlated with a 21% increase in peak oxygen uptake ((V)dotO(2peak)). Additionally, there was a significant increase in peak arterio-venous oxygen difference (a-vO2diff) after the training period.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Jem L. Cheng, Jennifer S. Williams, Sven P. Hoekstra, Maureen J. MacDonald
Summary: Lower limb heating, especially at the knee level, acutely improves vascular function in young, healthy individuals.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Lauren V. Turner, Maureen J. MacDonald, Michael C. Riddell, Jennifer Voth, Thomas J. Hawke
Summary: This study found that aging individuals with type 1 diabetes may have differences in cardiovascular health and skeletal muscle function, including lower grip strength and significantly reduced diastolic blood pressure, which may put them at risk of premature morbidity and mortality.
CANADIAN JOURNAL OF DIABETES
(2022)
Review
Physiology
Kevin Moncion, Elric Y. Allison, Baraa K. Al-Khazraji, Maureen J. MacDonald, Marc Roig, Ada Tang
Summary: Exercise training may increase cerebral blood flow and cerebrovascular reactivity to carbon dioxide in individuals after stroke. However, meta-analysis of acute exercise studies revealed no significant changes in MCAv during acute moderate-intensity exercise in individuals after stroke.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Sydney E. Valentino, Emily C. Dunford, Jonathan Dubberley, Eva M. Lonn, Martin J. Gibala, Stuart M. Phillips, Maureen J. MacDonald
Summary: Exercise-based cardiac rehabilitation can improve cardiovascular function in individuals with coronary artery disease. Clinical and additional measures of cardiovascular function can be used to assess changes after rehabilitation, but only a small increase in cardiac apical rotation was observed after 4 weeks of training in this study, suggesting a need for a larger training stimulus to elicit other cardiovascular function changes.
PHYSIOLOGICAL REPORTS
(2022)
Article
Physiology
Howard H. Carter, Jem L. Cheng, Maureen J. MacDonald, Oliver Pienaar, Alexander Coleman, Louise H. Naylor, Daniel J. Green
Summary: This study investigated the effects of exercise in 32 °C and 38 °C water on flow-mediated dilation (FMD). The results showed that exercise in water can decrease brachial artery shear and FMD compared to land-based exercise, and exercise in 38 °C water can increase brachial shear and FMD.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Letter
Computer Science, Interdisciplinary Applications
Jennifer S. S. Williams, Jenna C. C. Stone, Stacey A. A. Ritz, Maureen J. J. MacDonald