Journal
AUTOIMMUNITY REVIEWS
Volume 12, Issue 8, Pages 796-801Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2012.11.003
Keywords
Common variable immunodeficiency; CVID; Autoimmune diseases; Granulomatous diseases
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Common variable immunodeficiency is a collection of diseases characterized by primary hypogammaglobulinemia. The causes of CVID are extremely heterogeneous and may affect virtually every pathway linked to B cell development and function. Clinical manifestations of CVID mainly include recurrent bacterial infections, but autoimmune, gastrointestinal, lymphoproliferative, granulomatous, and malignant disorders have also been frequently reported as associated conditions. We aimed to focus on the state of the art of the relationship between infections, inflammation and autoimmunity in CVID. (C) 2012 Elsevier B.V. All rights reserved.
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