Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Julia Elmgren, Filippa Nyberg
Summary: Lupus erythematosus is an autoimmune inflammatory disease with a wide spectrum of clinical manifestations. The etiology of cutaneous lupus erythematosus is multifactorial, involving genetic predisposition and environmental triggers. UV-irradiation and smoking can induce and aggravate skin lesions. Subacute cutaneous lupus erythematosus can be drug-induced. Cutaneous lupus erythematosus is currently classified into acute, subacute, and chronic forms based on clinical presentation and duration.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Cristina Drenkard, Kamil E. E. Barbour, Kurt J. J. Greenlund, S. Sam Lim
Summary: This review examines the psychosocial burden faced by patients with Cutaneous lupus erythematosus (CLE), and explores the relationships between disease characteristics, patient factors, and social determinants of health. Additionally, it highlights the need for patient care and research to improve quality of life.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Alice Verdelli, Alberto Corra, Elena Biancamaria Mariotti, Cristina Aimo, Valentina Ruffo di Calabria, Walter Volpi, Lavinia Quintarelli, Marzia Caproni
Summary: Management of cutaneous lupus erythematosus (CLE) involves a combination of preventive measures, topical and systemic drugs, with antimalarials as the first-line systemic treatment. However, many patients do not respond to antimalarials, making refractory lupus a challenge for clinicians. Most available drugs for CLE have been adapted from systemic lupus erythematosus (SLE) treatment, with limited evidence from small studies. Promising new therapies are emerging as understanding of pathogenesis of both CLE and SLE improves.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Magdalena Zychowska, Adam Reich
Summary: Different clinical variants of CLE exhibit distinct dermoscopic patterns and vessel morphologies. Certain features show significant differences between different subtypes and can be used as auxiliary tools for differential diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu, Yong Miao
Summary: A large number of pelage HF-MSCs can be quickly and conveniently isolated from adult mice using a two-step Ficoll density gradient sedimentation method. These cells possess similar characteristics and functions as whisker HF-MSCs and can promote hair growth by secreting exosomes.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Veterinary Sciences
Wei Yan, Fei Hao, Xiaoshu Zhe, Yingmin Wang, Dongjun Liu
Summary: This study confirmed the biological characteristics and differentiation potential of PHFSCs and SHFSCs from Arbas Cashmere goats, expanding and refining our knowledge of adult stem cell types and characteristics.
BMC VETERINARY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jorge A. Soto, Felipe Melo-Gonzalez, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis
Summary: CLE is an autoimmune disorder characterized by autoantibody secretion and immune cell recruitment, similar to SLE. It can be divided into different types with varying severity of skin lesions. Type I IFN plays a significant role in the development of CLE. Research aims to develop effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Jane L. Zhu, Samantha M. Black, Benjamin F. Chong
Summary: Cutaneous lupus erythematosus (CLE) is a connective tissue disease with diverse clinical presentations, which can occur independently or in conjunction with systemic lupus erythematosus (SLE). Despite extensive studies on potential biomarkers in SLE, few biomarkers for CLE have been identified. Established biomarkers such as anti-SS-A antibody and emerging biomarkers like type I interferon-related proteins and chemokines may aid in diagnosis and tracking disease activity in CLE patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Hui Cheng, Fei Liu, Manqian Zhou, Shang Chen, Haoyan Huang, Yue Liu, Xiaotong Zhao, Qiaonan Zhang, Xinrun Zhou, Zongjin Li, Hong Cai
Summary: The study found that the PGE2 matrix can promote early stage hair follicle development and improve the condition of hair follicle stem cells. In addition, the PGE2 delivery system may be a new strategy for treating hair disorders.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Veterinary Sciences
Alice A. Amudzi, Cesar Piedra-Mora, Diana Junyue Ma, Neil B. Wong, Clement N. David, Nicholas A. Robinson, Ramon M. Almela, Jillian M. Richmond
Summary: Cutaneous Lupus Erythematosus (CLE) is an autoimmune skin disease that can occur in dogs as well as humans. Transcriptomic analysis of skin biopsies in dogs with CLE can help understand the pathogenesis of this disease and provide insights for human treatment.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Dermatology
Wen-Yen Huang, Jin-Bon Hong, Michael Chang, Shih-Yi Wang, Shih-Fan Lai, Hsiung-Fei Chien, Sung-Jan Lin
Summary: The effects of cyclophosphamide on anagen hair follicles depend on dosage, with low dosages leading to dystrophy that can be self-repaired, while high dosages prematurely induce other growth stages. Analysis of cell dynamics revealed that apoptosis of central cells in hair bulbs is repairable, bulge stem cells remain unaffected, and basal cup cells can quickly replenish damaged cells and reconstruct structures.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Jingjing Wang, Yuheng Fu, Wenmao Huang, Ritusree Biswas, Avinanda Banerjee, Joshua A. Broussard, Zhihai Zhao, Dongmei Wang, Glen Bjerke, Srikala Raghavan, Jie Yan, Kathleen J. Green, Rui Yi
Summary: This study reveals that hair follicle stem cells (SCs) and hair germ (HG) progenitors have different mechanical properties, with SCs being stiff and resistant to size change, while HG progenitors are soft and periodically enlarge and contract. During hair follicle growth, HGs reduce contraction and more frequently enlarge, which is associated with weakening of the actomyosin network and nuclear YAP accumulation. miR-205 can reduce actomyosin contractility and activate hair regeneration in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Michiko Yamane, Nanako Takaoka, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M. Hoffman, Yasuyuki Amoh
Summary: Hair-follicle-associated pluripotent (HAP) stem cells, located in hair follicles, can differentiate into multiple cell types, including neurons and cardiomyocytes. Studies have shown that HAP stem cells treated with neural-induction medium can differentiate into dopaminergic neurons, which may potentially help improve symptoms of Parkinson's disease in the future.
Article
Integrative & Complementary Medicine
Xiaojiao Fan, Jing Chen, Yajun Zhang, Siyi Wang, Wenqian Zhong, Huipu Yuan, Xia Wu, Chaochen Wang, Yixin Zheng, Yuan Wei, Ying Xiao
Summary: This study clarified the mechanism by which Alpinetin (AP) promotes hair regeneration by activating HFSCs via Wnt signaling. These findings may contribute to the development of a new generation of pilatory that is more efficient and less cytotoxic for treating alopecia.