Journal
AUTOIMMUNITY
Volume 47, Issue 1, Pages 57-66Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08916934.2013.832220
Keywords
Demyelination; endocrine disruptor; gene expression; immune response; inflammation
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Funding
- Texas A&M College of Veterinary Medicine and Biomedical Sciences
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Multiple sclerosis (MS) is a complex disease influenced by genetic and environmental contributing factors. Endocrine disrupting compounds (EDCs) such as bisphenol A (BPA) affect gene expression and hormone-regulated systems throughout the body. We investigated the effects of BPA on Theiler's-virus induced demyelination (TVID), a mouse model of MS. Perinatal BPA exposure, combined with viral infection, resulted in a decreased level of viral antibodies, accelerated the onset of TVID symptoms, increased inflammation in both the spinal cord and digestive tract, and amplified immune-related gene expression changes induced by viral infection. These results demonstrate the effect of BPA on the trajectory of TVID, and illustrate how multiple factors collectively influence autoimmune disease.
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