Review
Endocrinology & Metabolism
Morgan Terrell, Laurence Morel
Summary: There is a high prevalence of metabolic syndrome (MetS) in systemic lupus erythematosus (SLE) patients, which is likely caused by autoimmune pathogenesis. The impact of MetS on the immune system and disease manifestations in SLE patients is not well understood. Immune cell metabolism is altered and overactivated in SLE patients.
Article
Rheumatology
Gaelle Tilman, Emilie Dupre, Laura Watteyne, Charlotte Anne Baert, Delphine Nolf, Fatima Benhaddi, Fanny Lambert, Aurelie Daumerie, Caroline Bouzin, Sophie Lucas, Nisha Limaye
Summary: The presence of p16(INK4a)-positive cells, a marker of cellular senescence, is associated with renal disease severity in both human and mouse models of lupus nephritis.
LUPUS SCIENCE & MEDICINE
(2023)
Review
Rheumatology
Myrto Kostopoulou, Antonis Fanouriakis, George Bertsias, Dimitrios T. Boumpas
Summary: The kidneys have been the focus of attention in systemic lupus erythematosus (SLE). From 2019 to 2022, the Annals of the Rheumatic Diseases published various papers that contributed to the understanding and management of lupus nephritis (LN). This review highlights a selection of representative original papers.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Haeun Ko, Chan Johng Kim, Sin-Hyeog Im
Summary: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that mainly affects women in their reproductive years. Type 2 immune responses are involved during the pathology of SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jeremy S. Tilstra, Minjung Kim, Rachael A. Gordon, Claire Leibler, Haylee A. Cosgrove, Sheldon Bastacky, Kevin M. Nickerson, Mark J. Shlomchik
Summary: Studies have shown that MyD88 in B cells plays a crucial role in the onset and progression of lupus in mice, and its deficiency can improve disease symptoms and reduce autoantibody production. Therefore, targeting MyD88 or its upstream activators may be an effective option for treating lupus.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Immunology
Maria A. Bacalao, Anne B. Satterthwaite
Summary: In patients with SLE, B cells play a key role in inflammation and tissue damage, with the PI3K and IFN-γ signaling pathways being crucial in the pathogenesis of SLE. Changes in chromatin accessibility and epigenetic modifications in SLE B cells are also important areas of research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Najla Aljaberi, Scott E. Wenderfer, Arjun Mathur, Tingting Qiu, Steffy Jose, Angela Merritt, James Rose, Prasad Devarajan, Bin Huang, Hermine Brunner
Summary: This study compares the accuracy of RAIL and rSLEDAI in detecting LN activity. The results show that RAIL has a higher AUC than rSLEDAI, suggesting that RAIL can serve as an important auxiliary tool for monitoring LN activity.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Rheumatology
Eleni Frangou, Panagiotis Garantziotis, Maria Grigoriou, Aggelos Banos, Dionysis Nikolopoulos, Antigone Pieta, Stavros A. Doumas, Antonis Fanouriakis, Aikaterini Hatzioannou, Theodora Manolakou, Themis Alissafi, Panayotis Verginis, Emmanouil Athanasiadis, Emmanouil Dermitzakis, George Bertsias, Anastasia Filia, Dimitrios T. Boumpas
Summary: By using RNA sequencing in mouse models and human datasets, we identified kidney-specific molecular features of lupus nephritis and developed a blood-based algorithm for early diagnosis and therapeutic intervention. This may facilitate prevention and early intervention trials for LN.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
John Tchen, Quentin Simon, Lea Chapart, Christophe Pellefigues, Hajime Karasuyama, Kensuke Miyake, Ulrich Blank, Marc Benhamou, Eric Daugas, Nicolas Charles
Summary: Tissue-specific mouse models are important tools for studying the role of different cell compartments and genes in diseases. A new knock-in mouse model is described here, allowing selective expression of fluorescent protein tdTomato and CRE recombinase in the basophil compartment. This model enabled the identification and study of basophils, and breeding with another mouse model resulted in basophil-deficient mice with no abnormalities in other cell compartments. The study showed that basophils play a nonredundant role in pristane-induced lupus-like disease, both in its induction and amplification.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tom Aschman, Sandra Schaffer, Stylianos Iason Biniaris Georgallis, Antigoni Triantafyllopoulou, Peter Staeheli, Reinhard E. Voll
Summary: The role of type III interferons in systemic lupus erythematosus has been increasingly studied, with evidence suggesting their involvement in regulating immune responses and promoting inflammation. In a lupus disease model, mice lacking type III interferon receptors showed improved survival rates, reduced autoantibody production, and decreased inflammatory cell infiltration in the kidneys, indicating a potential protective effect of inhibiting type III interferon signaling in autoimmunity development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Emma Weeding, Andrea Fava, Chandra Mohan, Laurence Magder, Daniel Goldman, Michelle Petri
Summary: Objective urine proteomic approaches can identify biological pathways in lupus nephritis, and changes in the urine proteome are associated with treatment response and belimumab therapy.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Immunology
Jasmin Felux, Annika Erbacher, Magali Breckler, Roxane Herve, Delphine Lemeiter, Hans Georg Mannherz, Markus Napirei, Hans-Georg Rammensee, Patrice Decker
Summary: Increased concentrations of circulating chromatin are associated with diseases like sepsis, cancer, and systemic lupus erythematosus, leading to immune cell activation. Low activities of DNase1 and Trap1 contribute to impaired chromatin degradation and delayed chromatin clearance, resulting in enhanced immune cell activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Patricia Costa-Reis, Kelly Maurer, Michelle A. Petri, Daniella Levy Erez, Xue Zhao, Walter Faig, Jon Burnham, Kathleen O'Neil, Marisa S. Klein-Gitelman, Emily von Scheven, Laura Eve Schanberg, Kathleen E. Sullivan
Summary: Lupus nephritis is a major cause of morbidity and mortality in SLE patients. There is a need for a biomarker that can distinguish active lupus nephritis, especially for pediatric patients where minimizing invasive procedures is desirable.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Medicine, General & Internal
Roberta Bertelli, Francesca Schena, Francesca Antonini, Daniele Reverberi, Sara Signa, Nicoletta Pedemonte, Alessandro Consolaro, Marco Gattorno, Simone Negrini, Francesca Pupo, Stefano Volpi, Gian Marco Ghiggeri
Summary: IgG2 isotype autoantibodies predominate in Systemic Lupus Erythematosus (SLE) and contribute to Lupus Nephritis (LN) development. Neutrophil Extracellular Traps (NETs) play a key role in externalizing autoantigens and regulating IgG2 isotype switching, potentially through the induction of T-bet.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Wei Sun, Pengchong Li, Jianping Cai, Jie Ma, Xuan Zhang, Yong Song, Yudong Liu
Summary: This article summarizes the altered lipid metabolism and its role in the pathogenesis and progression of SLE. Dysregulated lipid metabolism has complex effects on specific cell types, and may serve as a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)