Pathogenic mechanisms in systemic lupus erythematosus

Lupus-prone MRL/faslpr/lprmice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination

(2009) Hong Zan et al.   AUTOIMMUNITY

Long interspersed nuclear elements (LINE-1): Potential triggers of systemic autoimmune disease

(2009) Mary K. Crow   AUTOIMMUNITY

Systems biology of lupus: Mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment

(2009) Andras Perl   AUTOIMMUNITY

Selective Up-Regulation of Intact, but Not Defective env RNAs of Endogenous Modified Polytropic Retrovirus by the Sgp3 Locus of Lupus-Prone Mice

(2009) K. Yoshinobu et al.   JOURNAL OF IMMUNOLOGY

Activation of Mammalian Target of Rapamycin Controls the Loss of TCR  in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation

(2009) D. R. Fernandez et al.   JOURNAL OF IMMUNOLOGY

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk

(2008) A-K Abelson et al.   ANNALS OF THE RHEUMATIC DISEASES

Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus

(2008) Rudolf Pullmann et al.   ARTHRITIS AND RHEUMATISM

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

(2008) Frances Rena Bahjat et al.   ARTHRITIS AND RHEUMATISM

Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE

(2008) Andras Perl et al.   AUTOIMMUNITY

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus

(2008) Tamara Vyshkina et al.   CLINICAL IMMUNOLOGY

The Lupus-Related Lmb3 Locus Contains a Disease-Suppressing Coronin-1A Gene Mutation

(2008) M. Katarina Haraldsson et al.   IMMUNITY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA