Journal
AUTOIMMUNITY
Volume 42, Issue 4, Pages 359-361Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930902832009
Keywords
DNA-hydrolyzing Ab; abzymes; Ab penetration; Ab internalization; cytotoxicity
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Funding
- RFFI [07-04-92168-NICI]
- NATO SfP [982833]
- Russian Academy of Sciences Fundamental medicine and Cellular and Molecular Biology
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Ab with DNA-hydrolyzing properties were described in autoimmune pathologies, such as SLE and RA, and in other autoimmune diseases, including chronic lymphocytic leukemia, AIDS, and others. The disease-associated DNA-binding AAb penetrate cell membrane and enter the nucleus. Intracellular entry of anti-DNA was linked to cellular damage and apo. Here we discuss the possible pathological process induced by DNA-cleaving Ab in the nucleus, where these Ab may induce apo. Apo processes, e.g., induced by DNA-hydrolyzing Ab, may underlie a number of syndromes observed in autoimmunity thus providing the grounds for the pathological role of DNA-hydrolyzing Ab in these diseases.
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