☆ 4.5 Article

Lack of Association Between Markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and Autism in an Irish Sample

AUTISM RESEARCH (2010)

Journal

AUTISM RESEARCH

Volume 3, Issue 6, Pages 342-344

Publisher

WILEY

DOI: 10.1002/aur.157

Keywords

genetics; allelic association < statistical genetics

Categories

Behavioral Sciences Psychology, Developmental

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Abstract

Autism is a neurodeveloprnental disorder characterized by impairments in three core areas-language, social interaction and restricted/repetitive behaviours. It is generally accepted that genetics plays a large role in the aetiology of autism, but the exact mechanism is still unknown. We recently published evidence of an association between autism and the ITGA4 gene [Conroy et al., 2008]. Two genomic regions have shown evidence of linkage to autism in multiple studies 2q31-q33 and 17q21-q22. Both of these regions harbour multiple integrin subunit genes. We tested markers in ITGA3, ITGA6, ITGAV and ITGB3 for association with autism in the Irish autism sample. No markers in ITGA3, ITGA6, ITGAV and ITGB3 were found to be associated with autism. Three 3-marker haplotypes in ITGAV, ITGA3 and ITGA6 were found to be nominally associated (0.01 <0.05) and to have unremarkable findings. Our data indicates that in the Irish autism sample the integrin genes tested here do not play an important role in the aetiology of autism.

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