Synthesis of Chiral 1,2-Dihydronaphtho[2,1-b]furans by Organocatalytic Domino Reactions Catalyzed with Multiple Catalysis

A chiral multiple catalysis with two chiral units has been proved effective in the domino Friedel-Crafts alkylation of -naphthols with -bromonitroalkenes. This novel and efficient domino reaction affords chiral 1,2-dihydronaphtho[2,1-b]furans in good to high yields and enantioselectivities (up to 93% yield, 91% enantiomeric excess).