Article
Biochemistry & Molecular Biology
Bingbing Cai, Ting Wang, Hong Sun, Cuimei Liu, Jinfang Chu, Zhonghai Ren, Qiang Li
Summary: Cucumber LR development is regulated by GAs in a concentration-dependent manner, with 50 muM GA3 showing strong effects on root dry weight and root/shoot dry weight ratio. GA3 treatment up-regulates genes involved in auxin and cell wall metabolisms in roots.
Article
Plant Sciences
Wenjiao Zou, Kui Liu, Xueping Gao, Changjiang Yu, Xiaofei Wang, Junjie Shi, Yanru Chao, Qian Yu, Gongke Zhou, Lei Ge
Summary: This study reveals altered metabolism of transitory starch in the wxr1/wxr3 mutants of Arabidopsis, shedding light on the important roles of WXR1/WXR3 in plant growth, possibly through regulating ionic equilibrium in the root to promote transitory starch degradation.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biotechnology & Applied Microbiology
Yi Hao, Wenshuai Liu, Xingwang Li, Ying Wen
Summary: This study investigates the regulatory mechanism of AfsR and AfsS in Streptomyces species and their roles in antibiotic production and development. The results demonstrate that AfsR and AfsS negatively regulate avermectin production and morphological development and their interaction enhances the binding affinity of AfsR to target promoters.
MICROBIAL BIOTECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Liu Yang, Li Yu-xiang, Li Yi-xiang, Tian Zhong-wei, Hu Jin-ling, Steve Adkins, Dai Ting-bo
Summary: The study revealed that high ammonium concentrations negatively affected root growth of wheat seedlings, especially in the NH4+-sensitive cultivar. EAC treatment resulted in decreased ASA synthesis and accumulation of ROS, causing severe disruption of oxidative metabolism and inhibition of root growth.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Forestry
Rafael Caetano da Silva, Artur Berbel Lirio Rondina, Waldemar Zangaro, Halley Caixeta Oliveira
Summary: The root morphological responses of neotropical tree seedlings to nitrate and ammonium nutrition varied depending on the successional group and the species. Nitrate treatment led to longer main and lateral roots in most species, while the effects of nitrate and ammonium on specific root traits were associated with successional groups and nitrogen source preference. Specific root hair responses varied according to each species, suggesting that the effects of nitrogen source on growth and root morphology may be linked to the successional group of the tree seedlings.
TREES-STRUCTURE AND FUNCTION
(2021)
Article
Biochemistry & Molecular Biology
Lijia Gao, Wanxin Wang, Chuanqiang Xu, Xintong Han, Yanan Li, Yiling Liu, Hongyan Qi
Summary: Elevated root-zone CO2 concentration affects the microstructure, sugar and starch content, enzymatic activities, and gene expression in the roots of oriental melon seedlings. It alters the cellular microstructure, accelerates starch grain accumulation and release, disrupts organelle formation, and accelerates root senescence. The sugar and starch contents and metabolic activity in the roots increase following treatment. Gene expression analysis reveals differentially expressed genes related to metabolic pathways. The study provides insights into the molecular mechanism underlying oriental melon seedlings' response to elevated root-zone CO2 stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Forestry
Andrei Toca, Ehren Moler, Andrew Nelson, Douglass F. Jacobs
Summary: The growth dynamics and architecture of the root system have a significant impact on the establishment and performance of planted forest tree seedlings. Factors such as nutrients, light, soil temperature, and water availability play important roles in the development and structure of seedling root systems. Nutrient and water availability have the greatest potential for regulating root system development and architecture. Other environmental factors, such as drought preconditioning, soil temperature, and light availability, also influence seedling growth and stress resistance. The interactions between nutrient availability and other environmental factors have the greatest potential to improve seedling root development and field performance.
Article
Biochemistry & Molecular Biology
Maofei Ren, Shanzhen Liu, Guiling Mao, Chengzhu Tang, Panpan Gai, Xiaoli Guo, Huabin Zheng, Weiqin Wang, Qiyuan Tang
Summary: The purpose of this study was to investigate the impact of light quality on the growth and metabolism of rice seedlings. The combination of red and blue light was found to promote growth under low light stress and increase both carbon and nitrogen metabolites in rice seedling leaves. It was also discovered that red and blue light could enhance the antioxidant enzyme activity of rice seedlings. This new discovery provides insights into the application of light quality in crop production and offers potential strategies to enhance crop stress resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Vivian Ebeling Viana, Bianca Camargo Aranha, Carlos Busanello, Latoia Eduarda Maltzahn, Luis Eduardo Panozzo, Antonio Costa de Oliveira, Cesar Valmor Rombaldi, Camila Pegoraro
Summary: The accumulation of metabolites in canola seedlings under different abiotic stresses was analyzed. Heat stress mainly affected the shoots, increasing some amino acids and sucrose while decreasing glucose and fructose contents. Waterlogging stress also mainly affected the shoots, decreasing the contents of citric acid, malic acid, some amino acids, and xylose. Salt stress led to a reduction of most metabolites in shoots and roots. Conversely, drought stress resulted in an increase of metabolite groups in both shoots and roots.
Article
Pharmacology & Pharmacy
Aline Zaparte, Angelica R. Cappellari, Caroline A. Brandao, Julia B. de Souza, Thiago J. Borges, Luiza W. Kist, Mauricio R. Bogo, Luiz F. Zerbini, Luis Felipe Ribeiro Pinto, Talita Glaser, Maria Carolina B. Goncalves, Yahaira Naaldijk, Henning Ulrich, Fernanda B. Morrone
Summary: Esophageal cancer is a global disease with two main subtypes, esophageal squamous cell carcinoma and esophageal adenocarcinoma. Research shows that P2Y(2) receptor activation in esophageal cancer cells promotes cell proliferation and colony formation, while its blockade reduces these effects. Targeting P2Y(2) receptors may have therapeutic potential for esophageal cancer treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Correction
Environmental Sciences
Talita Carneiro Brandao Pereira, Karine Batista dos Santos, William Lautert-Dutra, Lilian de Souza Teodoro, Vitor Otacilio de Almeida, Jessica Weiler, Ivo Andre Homrich Schneider, Mauricio Reis Bogo
Article
Environmental Sciences
Vitor Otacilio de Almeida, Talita Carneiro Brandao Pereira, Lilian de Souza Teodoro, Manuella Escobar, Carolina Junqueira Ordovas, Karine Batista dos Santos, Jessica Weiler, Mauricio Reis Bogo, Ivo Andre Homrich Schneider
Summary: The study found that iron ore tailings particles did not have significant harmful effects on the development and behavior of zebrafish embryos and larvae, although particle adhesion on the chorion was observed. Therefore, the particle size range and potential interactions with SiO2 content may contribute to explaining this effect.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Barbara Dutra Petersen, Talita Carneiro Brandao Pereira, Stefani Altenhofen, Debora Dreher Nabinger, Pedro Maria de Abreu Ferreira, Mauricio Reis Bogo, Carla Denise Bonan
Summary: Antibiotics are widely used in human and veterinary health along with the food industry, resulting in their presence as contaminants in water bodies. This study reveals that exposure to certain antibiotics led to hyperlocomotion, cognitive decline, and exacerbated aggressive behavior in adult zebrafish, indicating a short-term impact on their behavior.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thamiris Becker Scheffel, Liliana Rockenbach, Fernanda Fernandes Cruz, Luiza Wilges Kist, Mauricio Reis Bogo, Juliete Nathali Scholl, Fabricio Figueiro, Guido Lenz, Fernanda Bueno Morrone
Summary: This study reveals the regulatory role of extracellular ATPase activity in the cytotoxicity and migration process of malignant gliomas.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Adriana Fernanda Kuckartz Vizuete, Ben Hur Mussulini, Kamila Cagliari Zenki, Suelen Baggio, Amanda Pasqualotto, Denis Broock Rosemberg, Mauricio Reis Bogo, Diogo Losch de Oliveira, Eduardo Pacheco Rico
Summary: Prolonged ethanol exposure can lead to impairment of the glutamatergic uptake system, changes in astroglial markers, increased neuroinflammation, and elevated levels of brain-derived neurotrophic factor. After 28 days of exposure, ethanol may play a modulatory role in glutamate uptake.
Article
Neurosciences
Camilo Alexandre Jablonski, Talita Carneiro Brandao Pereira, Lilian De Souza Teodoro, Stefani Altenhofen, Gabriel Rubensam, Carla Denise Bonan, Mauricio Reis Bogo
Summary: The use of pesticides has increased in recent years, leading to concerns regarding the environment and human health. This study investigated the effects of acute exposure to the insecticide methomyl on zebrafish embryos and larvae. The results showed that methomyl had lethal and sublethal effects on zebrafish, affecting their development, morphology, behavior, and enzyme activity.
NEUROTOXICOLOGY AND TERATOLOGY
(2022)
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Article
Biochemistry & Molecular Biology
Pedro Vargas, Thamiris Becker Scheffel, Fernando Mendonca Diz, Liliana Rockenbach, Nathalia Grave, Angelica Regina Cappellari, Luiza Wilges Kist, Mauricio Reis Bogo, Marcos Paulo Thome, Gabriel Fernandes Leal, Amanda de Fraga Dias, Fabricio Figueiro, Eduardo Cremonese Filippi-Chiela, Guido Lenz, Fernanda Bueno Morrone
Summary: This study investigated the role of the P2Y(12) receptor in the proliferation and migration of GBM cells and evaluated its expression in patients' data. The results showed that the P2Y(12) antagonist, ticagrelor, decreased the viability and proliferation of GBM cells and reduced colony formation and migration potentials. The expression of P2Y(12)R was found to be higher in glioma samples, suggesting its importance in glioma development.
PURINERGIC SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Luiza Reali Nazario, Jessica Streb de Sousa, Francielle Schroeder de Moraes Silveira, Kesiane Mayra Costa, Giovanna Medeiros Tavares de Oliveira, Mauricio Reis Bogo, Rosane Souza da Silva
Summary: This study evaluated the effects of LPS on white blood cells, inflammatory markers, and ecto-5'-nucleotidase activity and expression in zebrafish. The results showed that inflammation did not affect ecto-5'-nucleotidase activity in most tissues, but there was a delayed increase in activity in the heart, possibly related to tissue repair.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Clinical Neurology
Melissa Talita Wiprich, Stefani Altenhofen, Darlan Gusso, Rafaela da Rosa Vasques, Rodrigo Zanandrea, Luiza Wilges Kist, Mauricio Reis Bogo, Carla Denise Bonan
Summary: This study investigated the effects of acute exposure to different substances in an HD pharmacological model induced by 3-NPA in adult zebrafish. The results showed that some substances could reverse or exacerbate the bradykinesia symptoms of HD, and also reverse memory impairment. The study suggests that these substances play an important role in modulating locomotor function and memory, and may be a potential pharmacological strategy against late-stage symptoms of HD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Environmental Sciences
Kaue Pelegrini, Talita Carneiro Brandao Pereira, Thuany Garcia Maraschin, Lilian De Souza Teodoro, Nara Regina De Souza Basso, Griselda Ligia Barrera De Galland, Rosane Angelica Ligabue, Mauricio Reis Bogo
Summary: Polymeric wastes, especially microplastics (MPs) and nanoplastics (NPs), contribute to significant environmental problems and can induce toxic effects on various organisms. This review aims to summarize the current knowledge and identify literature gaps regarding the generation and toxicological effects of MPs and NPs, considering factors such as polymer type, size, source, and test organisms. The analysis of 615 publications revealed that PS was the most commonly studied polymer, and toxicity testing primarily focused on arthropods and fish. NPs were found to exhibit greater toxicity than MPs, particularly in terms of oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Neurosciences
Melissa Talita Wiprich, Rafaela da Rosa Vasques, Darlan Gusso, Gabriel Ruebensam, Luiza Wilges Kist, Mauricio Reis Bogo, Carla Denise Bonan
Summary: Huntington's disease is a progressive neurodegenerative disease characterized by neuropsychiatric disturbance, cognitive impairment, and locomotor dysfunction. The levels of dopamine and the expression of dopamine receptors are altered in different stages of the disease.
MOLECULAR NEUROBIOLOGY
(2023)
