Article
Psychiatry
Juan Wang, Feng Jiang, Yulong Zhang, Robert O. Cotes, Yating Yang, Zhiwei Liu, Xiaoshuai Ning, Tingfang Liu, Yuanli Liu, Yi-lang Tang, Huanzhong Liu
Summary: Antipsychotic polypharmacy is common among recently discharged schizophrenia inpatients in China, with a higher utilization rate of second-generation antipsychotics compared to first-generation ones. Risperidone, olanzapine, and clozapine are the most commonly used antipsychotic medications. Predictors of polypharmacy include age, geographic location, duration of illness, history of hospitalizations, and behavioral symptoms during hospitalization.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Fei Wang, Zhuo-hui Huang, Christine Migliorini, Shi-Bin Wang, Zi-Lang Chen, Qian-Wen Wang, Xiao-Yan He, Carol Harvey, Cai-Lan Hou
Summary: This study examined the usage of clozapine and its influencing factors in Chinese patients with schizophrenia in rural primary care. It found that marital status, years of education, waist circumference, use of mood stabilizers, anticholinergics, and higher ITAQ scores were significantly associated with clozapine use. Older age of onset and use of other second-generation antipsychotics (SGAs) except clozapine predicted lower prevalence of clozapine use. The study also highlighted the impact of drug price, clinical factors, health regulations, and treatment environment characteristics on clozapine usage.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Raffael Massuda, Clarissa S. Gama, Paulo Belmonte-de-Abreu, Helio Elkis, David Freitas de Lucena, Rodrigo Bressan, Cristiano Noto, Ary Gadelha
Summary: Despite a slight increase in prescriptions in the last decade, clozapine is still underutilized in Brazil.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Ming-Huan Zhu, Zhen-Jing Liu, Qiong-Yue Hu, Jia-Yu Yang, Ying Jin, Na Zhu, Ying Huang, Dian-Hong Shi, Min-Jia Liu, Hong-Yang Tan, Lei Zhao, Qin-Yu Lv, Zheng-Hui Yi, Feng-Chun Wu, Ze-Zhi Li
Summary: This study aimed to investigate the efficacy of amisulpride augmentation therapy in treating patients with treatment-resistant schizophrenia. The results showed that amisulpride augmentation therapy improved psychiatric symptoms and cognitive function with tolerability and safety.
MILITARY MEDICAL RESEARCH
(2022)
Article
Clinical Neurology
Sherry Kit Wa Chan, Yi Nam Suen, Wai Ching Yan, Chun Lam, Eileena Chui, Christy Lai Ming Hui, Wing Chung Chang, Edwin Ho Ming Lee, Eric Yu Hai Chen, William G. Honer, Hiroyoshi Takeuchi
Summary: The study aims to explore the impact of clozapine dosing frequency, dose level, and pharmacological augmentation on the clinical, social, and cognitive outcomes in patients with treatment-resistant schizophrenia spectrum disorders (TRS). The results showed that among patients receiving low-dose clozapine, multiple daily doses were associated with better processing speed, short-term, and visual memory. Additionally, clozapine monotherapy was related to better motivation in TRS patients. These findings provide guidance for optimizing outcomes in TRS patients and further research is needed to confirm the results.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Laura Orsolini, Silvia Bellagamba, Virginio Salvi, Umberto Volpe
Summary: This article describes a 20-year-old patient with clozapine-resistant schizophrenia and comorbid cannabinoid use disorder, who was successfully treated with a combination of clozapine and brexpiprazole, and later switched to clozapine with long-acting injectable aripiprazole.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Hikaru Hori, Norio Yasui-Furukori, Naomi Hasegawa, Jun-ichi Iga, Shinichiro Ochi, Kayo Ichihashi, Ryuji Furihata, Yoshitaka Kyo, Yoshikazu Takaesu, Takashi Tsuboi, Fumitoshi Kodaka, Toshiaki Onitsuka, Tsuyoshi Okada, Atsunobu Murata, Hiroko Kashiwagi, Hitoshi Iida, Naoki Hashimoto, Kazutaka Ohi, Hisashi Yamada, Kazuyoshi Ogasawara, Yuka Yasuda, Hiroyuki Muraoka, Masahide Usami, Shusuke Numata, Masahiro Takeshima, Hirotaka Yamagata, Tatsuya Nagasawa, Hiromi Tagata, Manabu Makinodan, Mikio Kido, Eiichi Katsumoto, Hiroshi Komatsu, Junya Matsumoto, Chika Kubota, Kenichiro Miura, Akitoyo Hishimoto, Koichiro Watanabe, Ken Inada, Hiroaki Kawasaki, Ryota Hashimoto
Summary: This study investigated the characteristics of anticholinergic drug use in patients with schizophrenia and found that psychotropic prescription patterns and hospital characteristics influence the prescribing of anticholinergic drugs.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Shushan Zheng, Sherry Kit Wa Chan, Jimmy Lee
Summary: This study surveyed psychiatrists in Hong Kong and Singapore to understand their familiarity and prescribing practices in treatment-resistant schizophrenia and clozapine-resistant schizophrenia. The results showed that, despite the familiarity with treatment guidelines, delays in prescribing clozapine still occur. The study also found regional differences in alternative treatment methods to clozapine.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Public, Environmental & Occupational Health
Grace N. Okoli, Puja Myles, Tarita Murray-Thomas, Hilary Shepherd, Ian C. K. Wong, Duncan Edwards
Summary: The use of primary care databases is important in pharmacoepidemiological studies and pharmacovigilance, providing comprehensive patient data but with limitations due to missing prescribing data in certain scenarios. Awareness of potential missing data and collaboration with primary care clinicians in the UK are crucial for researchers using these databases.
Article
Psychiatry
Elias Wagner, Dan Siskind, Peter Falkai, Oliver Howes, Christoph Correll, Jimmy Lee, William G. Honer, John M. Kane, Emilio Fernandez-Egea, Thomas R. E. Barnes, Alkomiet Hasan
Summary: This study conducted an online Delphi survey to develop consensus recommendations for the optimization of clozapine monotherapy. The recommendations include specific treatment options for certain symptoms and management of side effects. The study results provide guidance for clinical decision-making and future research in treatment-resistant schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Chuanjun Zhuo, Yong Xu, Haibo Wang, Chunhua Zhou, Jian Liu, Xiaocui Yu, Hailin Shao, Hongjun Tian, Tao Fang, Qianchen Li, Jiayue Chen, Shuli Xu, Xiaoyan Ma, Weiliang Yang, Cong Yao, Bo Li, Anqu Yang, Yuhui Chen, Guoyong Huang, Chongguang Lin
Summary: Clozapine-induced metformin-resistant prediabetes/diabetes is common in the early-treatment resistance subtype of treatment-resistant schizophrenia and is associated with poor clinical efficacy of clozapine.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Christine Sahyouni, Elika Hefazi
Summary: Clozapine, a second-generation antipsychotic used for treatment-refractory schizophrenia, can lead to cardiac adverse events such as myocarditis and pericarditis. This case report highlights the rare occurrence of clozapine-induced pericarditis and emphasizes the importance of cardiac monitoring for patients on clozapine therapy.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Ira R. Katz, Benjamin R. Szymanski, Stephen R. Marder, Abigail Shotwell, Tyler C. Hein, John F. McCarthy, Nicholas W. Bowersox
Summary: This study aimed to evaluate the associations between the use of clozapine and other antipsychotic medications with all-cause mortality in patients with schizophrenia. The results showed that partial and decreasing clozapine coverage were associated with higher mortality rates, similar to the effects of other medications considered. Further research is needed to explore the relationship between the use of olanzapine and mortality rates, particularly in patients with diabetes.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Yuta Kawakita, Masahiro Takeshima, Tomonari Komatsu, Aya Imanishi, Dai Fujiwara, Yu Itoh, Kazuo Mishima
Summary: This study retrospectively compared the incidence of appendicitis in patients with schizophrenia with and without a history of clozapine exposure, finding a relationship between clozapine exposure and appendicitis onset.
Article
Neurosciences
Hana Hribkova, Ondrej Svoboda, Elis Bartecku, Jana Zelinkova, Jana Horinkova, Lubica Lacinova, Martin Piskacek, Bretislav Lipovy, Ivo Provaznik, Joel C. Glover, Tomas Kasparek, Yuh-Man Sun
Summary: This study investigated the cellular pathology and potential of antipsychotics in treating schizophrenia at the neuronal level. The findings suggest that neurons derived from schizophrenia patients show deficits in electrophysiological properties, synaptic function, and network activity, which can be restored by clozapine treatment in patients who respond to the drug. Additionally, clozapine treatment reverses gene expression dysregulation in neurons from clozapine-responsive patients. This study highlights the importance of K+ and Na+ channels and glutamatergic synaptic signaling in schizophrenia, and suggests that clozapine may act by normalizing perturbances in this signaling pathway.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yiguo Tang, Yulu Wu, Xiaojing Li, QinJian Hao, Wei Deng, Weihua Yue, Hao Yan, Yamin Zhang, Liwen Tan, Qi Chen, Guigang Yang, Tianlan Lu, Lifang Wang, Fude Yang, Fuquan Zhang, Jianli Yang, Keqing Li, Luxian Lv, Qingrong Tan, Hongyan Zhang, Xin Ma, Lingjiang Li, Chuanyue Wang, Xiaohong Ma, Dai Zhang, Hao Yu, Liansheng Zhao, Hongyan Ren, Yingcheng Wang, Guangya Zhang, Chuanwei Li, Xiangdong Du, Xun Hu, Tao Li, Qiang Wang
Summary: This study found that the efficacy of antipsychotics at week 2 can predict subsequent responses at week 6, and this predictive capacity varies among different antipsychotics and psychotic symptoms. The reduction rate of PANSS total score and improvement of psychotic symptoms at week 2 can be used to clinically predict treatment responses to antipsychotics at week 6.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Chika Kubota, Toshiya Inada, Shih-Ku Lin, Ajit Avasthi, Kok Yoon Chee, Andi Jayalangkara Tanra, Shu-Yu Yang, Lian-Yu Chen, Mian-Yoon Chong, Adarsh Tripathi, Roy Abraham Kallivayalil, Sandeep Grover, Seon-Cheol Park, Takahiro A. Kato, Yu-Tao Xiang, Kang Sim, Margarita M. Maramis, Isa Multazam Noor, Chay-Hoon Tan, Norman Sartorius, Naotaka Shinfuku
Summary: This study aimed to examine the factor structure of drug-induced extrapyramidal symptoms in patients with schizophrenia using the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). The results identified three factors: F1 (gait and bradykinesia), F2 (muscle rigidity and tremor), and F3 (sialorrhea, akathisia, dystonia, and dyskinesia). These findings suggest that the DIEPSS items could be composed of three different mechanisms.
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
(2023)
Article
Public, Environmental & Occupational Health
Zhaohui Su, Barry L. Bentley, Ali Cheshmehzangi, Dean Mcdonnell, Junaid Ahmad, Sabina Segalo, Hengcai Chen, Claudimar Pereira da Veiga, Yu-Tao Xiang
Summary: Violence against women is a serious problem in China, with men frequently verbally or physically assaulting women, whether or not they are their partners, in broad daylight. COVID-19 and its restrictions have exacerbated the issue by limiting women's ability to escape abuse and society's ability to provide timely help. This paper discusses the policy imperatives for countries like China to establish effective guardrails and support systems to protect women from the dehumanizing and destabilizing crime that is violence against women.
PREVENTIVE MEDICINE
(2023)
Article
Clinical Neurology
Ting Liu, Lu Wang, Jimin Guo, Tingyu Zhao, Hui Tang, Fang Dong, Chuanyue Wang, Jindong Chen, Mimi Tang
Summary: The levels of erythrocyte membrane fatty acids were found to be elevated in patients with severe depression and anxiety. These findings suggest that erythrocyte membrane fatty acid levels could serve as biological indicators for the severity of depressive symptoms and anxiety.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Hong Cai, Ines H. I. Chow, Si-Man Lei, Grace K. I. Lok, Zhaohui Su, Teris Cheung, Anastasia Peshkovskaya, Yi-Lang Tang, Todd Jackson, Gabor S. Ungvari, Ling Zhang, Yu-Tao Xiang
Summary: This study examined the relationships between depressive and anxiety symptoms with suicidality among adolescents during the COVID-19 pandemic using network analysis. The findings suggest that reducing specific depressive and anxiety symptoms, such as excessive worry, may help reduce suicidality among adolescents.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Correction
Clinical Neurology
Wei Bai, Hai-Tao Xi, Qianqian Zhu, Mengmeng Ji, Hongyan Zhang, Bing Xiang, Hong Cai, Rui Liu, Yan-Jie Zhao, Li Chen, Zong-Mei Ge, Zhiwen Wang, Lin Han, Pan Chen, Shuo Liu, Teris Cheung, Yi-Lang Tang, Todd Jackson, Fengrong An, Yu-Tao Xiang
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Lek Wei Javier Loo, Qian Hui Chew, Shih-Ku Lin, Su-Yu Yang, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Jun Hyuk Park, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy A. Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M. Maramis, Paing Phyo Aung, Norman Sartorius, Yu-Tao Xiang, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Takahiro A. Kato, Naotaka Shinfuku, Ross J. Baldessarini, Kang Sim
Summary: This study is the first pharmacoepidemiological research on the use of clozapine to treat bipolar disorder in Asia. It found that approximately 2.13% of bipolar disorder patients received clozapine treatment, with an average daily dose of 275mg/day. Patients receiving clozapine were generally older, more likely to be male, hospitalized, currently manic, and were taking more mood-stabilizing and antipsychotic drugs in addition to clozapine. Logistic regression analysis identified that older age, male sex, current mania, and greater number of other antipsychotics were significantly associated with clozapine treatment.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Letter
Psychiatry
Zhaohui Su, Barry L. Bentley, Ali Cheshmehzangi, Dean McDonnell, Sabina Segalo, Claudimar Pereira da Veiga, Yu-Tao Xiang
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Elias Wagner, Dan Siskind, Peter Falkai, Oliver Howes, Christoph Correll, Jimmy Lee, William G. Honer, John M. Kane, Emilio Fernandez-Egea, Thomas R. E. Barnes, Alkomiet Hasan
Summary: This study conducted an online Delphi survey to develop consensus recommendations for the optimization of clozapine monotherapy. The recommendations include specific treatment options for certain symptoms and management of side effects. The study results provide guidance for clinical decision-making and future research in treatment-resistant schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Jie Zhao, Dong-Yang Chen, Xian-Bin Li, Ying-Jun Xi, Swapna Verma, Fu -Chun Zhou, Chuan-Yue Wang
Summary: The aim of this study was to examine the efficacy and safety of Eye Movement Desensitization and Reprocessing (EMDR) in individuals at clinical-high risk for psychosis (CHR) with comorbid or subthreshold PTSD. The results showed that the EMDR group had significantly lower scores on CAPS, SIPS and self-rating inventories compared to the waiting list group, and the remission rate of CHR was higher in the EMDR group. Therefore, this study highlighted the necessity of adding a trauma-focused component to the present approach of early intervention in psychosis.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Meng-Yi Chen, Qinge Zhang, Yu-Fei Liu, Wan-Ying Zheng, Tong Leong Si, Zhaohui Su, Teris Cheung, Todd Jackson, Xiao-Hong Li, Yu-Tao Xiang
Summary: This study explored the research on the association between schizophrenia and oxidative stress from a bibliometric perspective. The findings revealed an increasing focus on this topic in the academic literature in recent years. The main areas of interest include the prefrontal cortex, brain, and nitric oxide.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Pan Chen, Yuan Feng, Xiao-Hong Li, Jia-Xin Li, Yue-Ying Wang, Wan-Ying Zheng, Zhaohui Su, Teris Cheung, Gabor S. Ungvari, Chee H. Ng, Sha Sha, Yu-Tao Xiang
Summary: This study explored and mapped the research outputs of major depressive disorder (MDD)-related systematic reviews and meta-analyses (SR/MA) using a bibliometric approach. The results showed a rapid increase in the number of SR/MA in recent years, highlighting the importance of this research field. Psychiatric comorbidities, clinical interventions, and treatment of MDD were identified as hot topics, while biological mechanisms in MDD are likely to be an emerging research priority.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Mei Ieng Lam, Pan Chen, Xiao-Meng Xie, Grace K. I. Lok, Yu-Fei Liu, Tong Leong Si, Gabor S. S. Ungvari, Chee H. H. Ng, Yu-Tao Xiang
Summary: This bibliometric analysis explored the trends and keywords in heart failure and depression related research. The study found that research in this field was mainly led by the United States and Europe, with keywords including quality of life, mortality, and myocardial infarction. Future research should focus on self-care and anxiety in heart failure, and examine publications in languages other than English.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Yan-Jie Zhao, Ling Zhang, Yuan Feng, Sha Sha, Mei Ieng Lam, Yue-Ying Wang, Jia-Xin Li, Zhaohui Su, Teris Cheung, Gabor S. Ungvari, Todd Jackson, Feng-Rong An, Yu-Tao Xiang
Summary: This study investigated the prevalence of depression and its impact on quality of life among guardians of hospitalized psychiatric patients during the COVID-19 pandemic. The findings revealed that approximately one third of guardians reported symptoms of depression, and depressed guardians had lower quality of life. Loss of energy, concentration difficulties, and sad mood were identified as central symptoms in the network model for depression among guardians.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Zhenzhu Chen, Qijing Bo, Lei Zhao, Yimeng Wang, Zhifang Zhang, Yuan Zhou, Chuanyue Wang
Summary: This study investigated the microstructure of white matter (WM) in individuals with attenuated positive symptom syndrome (APSS) using diffusion tensor and T1-weighted imaging. Compared with healthy controls, individuals with APSS showed differences in diffusion index values in certain segments of WM tracts involved in frontal and limbic-cortical connections. Abnormal WM tracts were also associated with impaired general and neurocognitive function.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)