Article
Psychiatry
Mabel Rodriguez, Karolina Knizkova, Barbora Kerkova, Aneta Sironova, Petra Sustova, Juraj Jonas, Filip Spaniel
Summary: Cognitive reserve (CR) is related to cognitive performance and quality of life in first-episode schizophrenia patients. It was found that CR has a positive relationship with cognitive performance in all domains in patients, and it contributes to cognitive variations present in these patients. Additionally, CR is negatively related to patients' quality of life.
PSYCHIATRY RESEARCH
(2022)
Article
Medicine, General & Internal
David Batalla-Martin, Maria-Antonia Martorell-Poveda, Angel Belzunegui-Eraso, Alejandro Marieges Gordo, Helena Batlle Lleal, Raquel Pasqual Melendez, Raquel Querol Girona, Marina Lopez-Ruiz
Summary: Cognitive behavioural therapies (CBT) have been shown to be effective in treating insomnia in patients with schizophrenia. A group intervention led by nurses, combining cognitive behavioural and psychoeducational interventions, can improve insomnia symptoms and health-related quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Gurpreet Rekhi, Young Ern Saw, Keane Lim, Richard S. E. Keefe, Jimmy Lee
Summary: The aim of this study was to examine the association between cognitive impairments and health-related quality of life (HRQoL) in individuals with schizophrenia. The study found that cognitive factor g was significantly associated with EQ-5D-5L scores. Age, sex, and employment status were also significant predictors of EQ-5D-5L. These results are important for understanding the burden of cognitive impairments in individuals with schizophrenia.
Article
Clinical Neurology
Phern Chern Tor, Xiao Wei Tan, Donel Martin, Colleen Loo
Summary: Electroconvulsive Therapy (ECT) varies in use and effectiveness for different indications worldwide, but can significantly improve clinical global impression, quality of life, and global functioning for patients with acute psychosis, mania, depression, psychotic depression, and catatonia.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Xiao Wei Tan, Kenny Wai Kwong Lim, Donel Martin, Phern Chern Tor
Summary: This study demonstrates that ECT treatment improves the quality of life among patients with schizophrenia. Improvement in psychiatric symptoms is associated with better mental health, while improvement in cognitive function is associated with better physical health.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Article
Psychiatry
Marion Freidl, Melanie Wegerer, Zsuzsa Litvan, Daniel Koenig, Rainer W. Alexandrowicz, Filipe Portela-Millinger, Maria Gruber
Summary: This study investigated the impact of inpatient cognitive behavior therapy (CBT) on quality of life (QoL) in patients with anxiety disorders and depressive disorders. The results showed that improvements in psychological and physical QoL were strongly correlated with reductions in anxious and depressive symptoms. Poor QoL before treatment and low levels of specific anxiety sensitivity symptoms significantly predicted improvements in QoL.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Jeffrey R. Vittengl, Manish K. Jha, Abu Minhajuddin, Michael E. Thase, Robin B. Jarrett
Summary: The study found that improvements in quality of life achieved during response to cognitive therapy are relatively stable in the long term and may help prevent depressive relapse. However, continuation cognitive therapy or fluoxetine may not further enhance quality of life. Additionally, higher quality of life predicted reductions in depressive symptoms severity, but severity of depressive symptoms did not predict changes in quality of life.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Ye Zhang, Rong Ren, Linghui Yang, Haipeng Zhang, Yuan Shi, Jie Shi, Larry D. Sanford, Lin Lu, Michael V. Vitiello, Xiangdong Tang
Summary: This study compares the efficacy and acceptability of psychotherapies, pharmaco-therapies, and their combinations for treating insomnia. The results suggest that cognitive behavior therapy for insomnia (CBT-I) is more beneficial in improving subjective sleep efficiency compared to pharmacotherapy. However, pharmacotherapy may be more effective in improving certain sleep parameters. Combining CBT-I with pharmacotherapy appears to be more effective in improving sleep parameters compared to pharmacotherapy alone.
SLEEP MEDICINE REVIEWS
(2022)
Article
Psychiatry
Jose Heliodoro Marco, Pilar Llombart, Veronica Guillen, Rosa M. Banos, Rocio Romero, Ana Garcia-Conde, Sandra Perez Rodriguez
Summary: The present study aims to verify the efficacy of Meaning-Centered Psychotherapy (MCP) in Spanish participants with cancer by comparing it to Cognitive Behavioral Therapy (CBT), and analyze the feasibility and acceptance of MCP in this population. Furthermore, the study aims to examine whether changes in meaning in life dimensions can predict changes in anxiety, depression, and quality of life. The study design consists of a randomized control trial (RCT) with participants randomized to either the MCP or CBT group.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Oncology
Mahsa Raji Lahiji, Akram Sajadian, Shahpar Haghighat, Mitra Zarrati, Homa Dareini, Mahtab Raji Lahiji, Elham Razmpoosh
Summary: This study aimed to investigate the effects of nutrition counseling and logotherapy on the psychological status, quality of life, and dietary intake of breast cancer survivors. The results indicated that the combination of nutrition counseling and logotherapy significantly improved anxiety and depression, as well as reduced energy, carbohydrate, and fat intake.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Psychiatry
Erik Hedman-Lagerlof, Per Carlbring, Frank Svardman, Heleen Riper, Pim Cuijpers, Gerhard Andersson
Summary: The question examined in this study is whether therapist-supported internet cognitive behavior therapy (ICBT) can achieve similar clinical effects as face-to-face cognitive behavior therapy (CBT). The updated meta-analysis found evidence that therapist-supported ICBT produces similar outcomes to face-to-face CBT in the treatment of psychiatric and somatic disorders.
Article
Medicine, General & Internal
Alba Villasan Rueda, Antonio Sanchez Cabaco, Manuel Mejia-Ramirez, Susana Justo-Henriques, Janessa O. Carvalho
Summary: The study demonstrated the effectiveness of REMPOS and reminiscence therapy in cognitively impaired older adults, showing improvements in cognitive functioning, reduced depressive symptoms, and increased recall of positive memories.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Psychiatry
Rafael Penades, Til Wykes
Summary: Cognitive remediation is recommended for treating cognitive and functional impairments in patients with schizophrenia. Recent research suggests that it could also help reduce negative symptoms, but more studies focusing on individuals with primary negative symptoms are needed. Furthermore, the role of moderators and mediators and the use of more specific assessments should be investigated. Despite these challenges, cognitive remediation shows promise as a treatment option for primary negative symptoms.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Marlene V. Strege, John A. Richey, Greg J. Siegle
Summary: This study evaluated the course of MDD with consideration of low grade depressive symptoms and quality of life, finding that chronic depression symptoms and decreased quality of life are common, suggesting poorer sustained remission rates than previously observed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Nuria Javaloyes, Aurora Crespo, M. Carmen Redal, Antonio Brugarolas, Lara Botella, Vanesa Escudero-Ortiz, Manuel Sureda
Summary: This study demonstrates significant benefits of psycho-oncological intervention based on counseling in anxiety, depression, quality of life, and well-being of patients with differentiated thyroid carcinomas.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
M. J. C. Formica, L. J. Phillips, J. A. Hartmann, A. R. Yung, S. J. Wood, A. Lin, G. P. Amminger, P. D. McGorry, B. Nelson
Summary: The study found that changes in standard treatment, particularly increases in cognitive behavioral therapy (CBT), may have contributed to the decline in psychosis risk observed in recent ultra-high-risk cohorts. However, these variables do not fully explain this trend.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Immunology
Subash Raj Susai, David Mongan, Colm Healy, Mary Cannon, Barnaby Nelson, Connie Markulev, Miriam R. Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schloegelhofer, Stefan Smesny, Ian B. Hickie, Gregor E. Berger, Eric Y. H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Roessler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, Patrick D. McGorry, Melanie Focking, David Cotter, G. Paul Amminger
Summary: This study investigated the relationship of erythrocyte omega-3 FAs with plasma immune markers and examined whether the associations between omega-3 FAs and clinical outcomes were mediated via plasma immune markers in CHR individuals. The results indicate a predominantly anti-inflammatory relationship of omega-3 FAs on plasma inflammatory status in CHR individuals, but this did not appear to convey clinical benefits at 6 month and 12 month follow-up. Both immune and non-immune biological effects of omega-3 FAs would be resourceful in understanding the clinical benefits of omega-3 FAs in CHR population.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Psychiatry
Jessica A. Hartmann, Barnaby Nelson, Gunther Paul Amminger, Jessica Spark, Hok Pan Yuen, Melissa J. Kerr, Andrea Polari, Nicky Wallis, Julie Blasioli, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A. Niendam, Martha Shumway, Patrick D. McGorry
Summary: The aim of this study is to determine the most effective type, timing, and sequence of interventions in individuals at ultra-high risk of psychosis, and evaluate the acceptability and feasibility of the treatment approach through the recruitment flow and baseline clinical characteristics.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Tor Gunnar Vaernes, Jan Ivar Rossberg, Ingrid Melle, Barnaby Nelson, Kristin Lie Romm, Paul Moller
Summary: The study found that levels of basic self-disturbance in patients with schizophrenia spectrum disorders are influenced by negative symptoms, and higher levels of BSD are associated with more severe symptoms and lower levels of functioning. Higher BSD levels related to schizophrenia spectrum disorders were also found at follow-up.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Renata Pionke-Ubych, Dorota Frydecka, Andrzej Cechnicki, Martyna Krezolek, Barnaby Nelson, Lukasz Gaweda
Summary: The study aimed to investigate self-disturbances (SD) as a risk factor that has attracted attention over the last two decades, in combination with trauma, cognitive biases, and personality traits. Results indicated a significant reduction in SD and subclinical positive symptoms (PS) over a 12-month follow-up period, suggesting that a model integrating trauma, cognitive biases, SD, and personality traits can enhance understanding of subclinical PS.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Review
Psychiatry
Holly Sizer, Ellie Brown, Hellen Geros, Alison Yung, Barnaby Nelson, Patrick McGorry, Brian O'Donoghue
Summary: Limited research suggests similar or superior outcomes for individuals with a first episode of psychosis who present initially via an ARMS clinic. The reduced psychiatric admission rate is an important potential benefit of ARMS clinics that requires further validation.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Tara Burke, Andrew Thompson, Nathan Mifsud, Alison R. Yung, Barnaby Nelson, Patrick McGorry, Brian O'Donoghue
Summary: This study found that a significant proportion of young people initially attended other specialist youth mental health services, and these individuals had lower rates of hospital admission at the time of transition to first-episode psychosis.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Brian O'Donoghue, Andrea Polari, Patrick McGorry, Barnaby Nelson
Summary: This study aimed to investigate the under-representation of migrants in cohorts of young people at ultra-high risk for psychosis. The study found that migrants were more commonly referred by community health services, while non-migrants were more likely to be referred through other mental health services. The severity of attenuated psychotic symptoms and depressive symptoms did not differ based on migrant status.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
Tracey Dryden-Mead, Barnaby Nelson, Sarah Bendall
Summary: This study explored the experiences of young people completing a trauma and PTSD screening tool in an Early Psychosis Program. The results showed that young people expected to be asked about their trauma experiences and accepted the need for screening. The trust and relationship with the clinician, timing of the screening, and format of the questionnaires were important factors in facilitating their willingness to complete the screening.
PSYCHOLOGY AND PSYCHOTHERAPY-THEORY RESEARCH AND PRACTICE
(2022)
Article
Psychiatry
Nicholas Cheng, Alison McLaverty, Barnaby Nelson, Connie Markulev, Miriam R. Schafer, Maximus Berger, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B. Hicikie, Gregor E. Berger, Eric Y. H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Rossler, Swapna Verma, Rebekah Street, Andrew Thompson, Hok Pan Yuen, Robert Hester, Alison Ruth Yung, Patrick D. McGorry, Kelly Allott, G. Paul Amminger
Summary: This study investigated whether omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation improves cognitive functioning in individuals at ultra-high risk for psychosis. Results showed that there was no evidence to support the use of omega-3 supplementation to improve cognitive functioning in this population. Biomarker analysis suggested that poor adherence or consumption of non-trial n-3 PUFAs was unlikely to be the cause of the findings.
Article
Psychiatry
Stefania Tognin, Ana Catalan, Matthew J. Kempton, Barnaby Nelson, Patrick McGorry, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Philip R. McGuire, Lucia Valmaggia
Summary: Research shows that adverse childhood experiences (ACE) can impact educational achievements in individuals at clinical high risk of psychosis (CHR). Specifically, CHR individuals with ACE had lower education levels, employment rates, and estimated IQ compared to healthy controls. Early intervention programs for psychosis should integrate interventions to support the educational and vocational recovery of young CHR individuals, and public health and social interventions to prevent or reduce the impact of ACE are recommended.
EUROPEAN PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Alison R. Yung, Marko Milicevic, Michael Berk
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Shaunagh O'Sullivan, Niels van Berkel, Vassilis Kostakos, Lianne Schmaal, Simon D'Alfonso, Lee Valentine, Sarah Bendall, Barnaby Nelson, John F. Gleeson, Mario Alvarez-Jimenez
Summary: This study aimed to determine the causal relationship between the social networking and therapeutic components of the Horyzons intervention. The results showed that the social network component of Horyzons was the most engaging, driving engagement with the therapeutic components. Therefore, online social networks can be further leveraged to maintain treatment effects and create virtuous cycles between intervention components to sustain user engagement.
JMIR MENTAL HEALTH
(2023)
Review
Psychiatry
Michael Berk, Ole Kohler-Forsberg, Megan Turner, Brenda W. J. H. Penninx, Anna Wrobel, Joseph Firth, Amy Loughman, Nicola J. Reavley, John J. Mcgrath, Natalie C. Momen, Oleguer Plana-Ripoll, Adrienne O'Neil, Dan Siskind, Lana J. Williams, Andre F. Carvalho, Lianne Schmaal, Adam J. Walker, Olivia Dean, Ken Walder, Lesley Berk, Seetal Dodd, Alison R. Yung, Wolfgang Marx
Summary: Populations with common physical diseases are more likely to have major depressive disorder (MDD), and people with MDD are at a greater risk for physical diseases. This comorbidity is associated with worse outcomes, reduced treatment adherence, increased mortality, and higher healthcare utilization and costs. Shared genetic and biological pathways, as well as social and lifestyle factors, contribute to the high prevalence of comorbidity. Pharmacotherapies and psychotherapies are effective treatments, and lifestyle interventions and collaborative care models show promise for improving management.
Article
Psychiatry
Andrew Gumley, Simon Bradstreet, John Ainsworth, Stephanie Allan, Mario Alvarez-Jimenez, Lorna Aucott, Maximillian Birchwood, Andrew Briggs, Sandra Bucci, Sue M. Cotton, Lidia Engel, Paul French, Reeva Lederman, Shon Lewis, Matthew Machin, Graeme MacLennan, Hamish McLeod, Nicola McMeekin, Cathy Mihalopoulos, Emma Morton, John Norrie, Matthias Schwannauer, Swaran P. Singh, Suresh Sundram, Andrew Thompson, Chris Williams, Alison R. Yung, John Farhall, John Gleeson
Summary: This study aimed to assess the feasibility of a blended digital intervention for relapse prevention in schizophrenia. The results showed that this intervention was safe, acceptable, and feasible, indicating the need for further main trials.
