Article
Psychiatry
Xi Hu, Yifan Li, Jing Wu, Hanping Zhang, Yu Huang, Xunmin Tan, Lu Wen, Xingyu Zhou, Peijun Xie, Oluwatayo Israel Olasunkanmi, Jingjing Zhou, Zuoli Sun, Min Liu, Guofu Zhang, Jian Yang, Peng Zheng, Peng Xie
Summary: Disturbed gut microbiota is closely associated with the severity of major depressive disorder (MDD). The abundance of Bacteroides is increased in moderate and severe MDD, while Ruminococcus and Eubacterium are depleted mainly in severe MDD. Additionally, 99 bacteria species specific to severity of depression were identified, and a panel of 37 bacteria species can effectively distinguish MDD patients with different severity.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Timothy A. Matthews, Natalie Porter, Johannes Siegrist, Jian Li
Summary: This study found an association between work stress, specifically in terms of unrewarding work, and major depressive episodes. The findings suggest that individuals with higher levels of effort-reward imbalance at work have an increased risk of experiencing depression. These results support previous research and indicate that reducing work stress may be an important intervention for preventing depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Shuang Liu, Xiaoya Liu, Sitong Chen, Fangyue Su, Bo Zhang, Yufeng Ke, Jie Li, Dong Ming
Summary: This study aimed to examine the impairment of gamma auditory steady-state responses (gamma-ASSRs) in drug-naive first-episode major depressive disorder (FEMD) patients and their predictive value for depression severity. The results showed that FEMD patients exhibited significant deficits in 40 Hz-ASSR-ITC and attenuated theta-ITC during 60 Hz clicks. The combination of 40 Hz-ASSR-ITC and theta-ITC in the right hemisphere can be used as a marker for detecting FEMD patients with high sensitivity and specificity (area under the curve was 0.868).
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Giulia Serra, Maria Elena Iannoni, Monia Trasolini, Gino Maglio, Camilla Frattini, Maria Pia Casini, Ross J. Baldessarini, Stefano Vicari
Summary: This study analyzed factors associated with depression severity in 270 juveniles aged 6-18 who were diagnosed with major depressive episode. It was found that greater depression severity was associated with female sex, diagnosis of major depressive disorder (MDD), and some manic symptoms. Careful assessment of manic/psychotic symptoms is crucial in evaluating juvenile depression and should be considered in treatment planning.
Article
Multidisciplinary Sciences
Betina Daniele Flesch, Ana Laura Sica Cruzeiro Szortyka, Gbenankpon Mathias Houvessou, Fabiane Neitzke Hoefs, Anaclaudia Gastal Fassa
Summary: MDE externalizing symptoms were present in 20% of university students, with females, individuals with a family history of depression, minority sexual orientation, and those experiencing conflicts with teachers or colleagues being more likely to exhibit these symptoms. It is important for educational institutions to train teachers to identify and handle students with externalizing symptoms of MDE, as well as to address conflicts between students and teachers.
Article
Clinical Neurology
Jingyu Lin, Yunai Su, Chuan Shi, Qi Liu, Gang Wang, Jing Wei, Gang Zhu, Qiaoling Chen, Hongjun Tian, Kerang Zhang, Xueyi Wang, Nan Zhang, Ying Wang, Xin Yu, Tianmei Si
Summary: Cognitive deficits are prevalent among patients with first-episode and recurrent depression, with differences in verbal and visual learning between these two groups. Future interventions should focus on addressing deficits in these specific cognitive domains.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Jamie Bryant, Elise Mansfield, Emilie Cameron, Rob Sanson-Fisher
Summary: Future medical and financial planning is crucial for persons with dementia, but more than half of them do not have an advance care directive. There is variation in preferences for timing of discussions about advance care planning following diagnosis.
Article
Clinical Neurology
Kazuhisa Yoshizawa, Masahiro Takeshima, Sayaka Ishino, Masaya Ogasawara, Dai Fujiwara, Yu Itoh, Aya Imanishi, Hidenobu Ohta, Kazuo Mishima
Summary: The severity of depressive symptoms is significantly associated with VTE, with a prevalence of 35% among patients receiving in-hospital electro-convulsive therapy for a major depressive episode.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Clinical Neurology
Xiuli Song, Xiaoran Liu, Yongjie Zhou, Xiangyang Zhang
Summary: This study aimed to investigate the incidence and potential relevant factors of suicide attempt among young Chinese patients with first-episode drug free (FEDN) major depressive disorder (MDD) to prevent suicidal behavior in this population. The study found that the prevalence of suicide attempt among FEDN MDD patients was 18.31%. Patients with suicide attempt had older age of onset, higher scores on measures of anxiety, depression, positive symptoms, and overall severity, as well as higher blood pressure, blood glucose levels, and thyroid function markers, but lower levels of HDL cholesterol. Logistic regression analysis revealed that duration of illness, hypertension, symptom severity, and certain metabolic indicators were associated with suicide attempts in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Shilin Liu, Keyi Lin, Yang Zhang, Yaotian Gao, Wei Wang, Mengcheng Du, Tao Jiang, Min Zhou, Xiangyang Zhang
Summary: This study aimed to evaluate the prevalence and risk factors of psychotic symptoms in middle-aged Chinese patients with first-episode drug naive (FEDN) major depressive disorder (MDD). The results showed that the prevalence of psychotic symptoms in middle-aged patients with FEDN MDD was 10.95%. Multivariate logistic regression analysis identified HAMA and HAMD scores, TSH, TC, and BMI levels as significant predictors of psychotic symptoms in MDD middle-aged patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Xiaohong Wang, Liying Yang, Jiacheng Liu, Chuanyi Kang, Yue Zheng, Siyu Qiu, Ying Zhao, Colin B. Goodman, Hanjing Emily Wu, Na Zhao, Xiangyang Zhang
Summary: This study found differences in depression severity, anxiety severity, and lipid levels between patients with psychotic major depressive disorder (PMD) and those with non-psychotic major depressive disorder (NPMD) in first-episode and drug-naive (FEDN) MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Eric Ettore, Philipp Mueller, Jonas Hinze, Michel Benoit, Bruno Giordana, Danilo Postin, Amandine Lecomte, Hali Lindsay, Philippe Robert, Alexandra Koenig
Summary: This article reviews the current application of digital tools for MDE diagnosis and highlights the shortcomings for further research. The study focuses on digital devices that are easy to use during clinical interviews and mental health issues where depression is common. The findings suggest that a digital phenotype of MDE can be identified based on modifications in speech features, nonverbal behavior, and physiological measurements. However, further longitudinal and prospective studies are needed to validate the potential of these markers.
JMIR MENTAL HEALTH
(2023)
Article
Psychiatry
Lijuan Yan, Chuanyi Kang, Xiaohong Wang, Liying Yang, Na Zhao, Xiangyang Zhang
Summary: This study compared serum lipid differences between young first-episode drug naive depressive disorder patients with and without psychotic symptoms. The results showed that patients with psychotic symptoms had higher levels of depression, anxiety, and serum lipid. Logistic regression analysis also found an association between total cholesterol and psychotic symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Health Care Sciences & Services
Oliver Miles, Robert West, Tom Nadarzynski
Summary: The study found that GP consultations were perceived as the most acceptable, while chatbots may be useful for sensitive health issues but less acceptable for severe health issues. There were no significant associations between participants’ characteristics and the acceptability of health consultation sources.
Article
Multidisciplinary Sciences
Britta Stapel, Daniela Fraccarollo, Mechthild Westhoff-Bleck, Johann Bauersachs, Ralf Lichtinghagen, Kirsten Jahn, Alexandra Burkert, Vanessa Buchholz, Stefan Bleich, Helge Frieling, Xiao-Qi Ding, Kai G. Kahl
Summary: Patients with Major Depressive Disorder (MDD) often have poor response to treatment. Disruptions in central energy metabolism and calorie restriction can improve neuroplasticity and affect mood and cognition. Fasting can improve cognitive-affective symptoms in MDD patients with moderate/severe symptoms that did not respond to prior therapy.
SCIENTIFIC REPORTS
(2022)
