Journal
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
Volume 44, Issue 2, Pages 109-119Publisher
SAGE PUBLICATIONS LTD
DOI: 10.3109/00048670903270381
Keywords
heritability; neurocognitive factor structures; schizophrenia
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Funding
- Nature Science Foundation of China [30530300, 30125014]
- National Basic Research Program of China [2007CB512301]
- NARSAD Independent Investigator Award
- NARSAD Young Investigator Award
- Wellcome Trust
- State Scholarship Foundation of Greece
- Medical Research Council [G9817803B] Funding Source: researchfish
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Objectives: Schizophrenia patients have a wide range of cognitive deficits. To explore the structure of these deficits and index their psychometric properties in order to define the major separable factors, exploratory factor analysis (EFA) was performed on a series of neuropsychological test results in a sample of Han Chinese first-episode schizophrenia patients, their relatives and controls without mental illness. Methods: The factors derived from the composite sample were tested with confirmatory factor analysis (CFA) in each of the subsamples. The heritability of each factor was estimated by using the mixed linear model in order to determine whether the common factor scores describe the familiarity of the data. Results: A six-factor model of general mental activity, sort and shift, attention and anti-interference, logical memory, reasoning and problem-solving/executive function, and visual reproduction were extracted and confirmed on EFA and CFA. There was a hierarchy in cognitive performance deficits in relatives depending on their relatedness to probands. Patients performed more poorly than siblings/offspring in general mental activity, sort and shift, attention and anti-interference, logical memory, planning and problem-solving, but not in visual reproduction. The logical memory domain was found to be significantly heritable (h
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