Review
Psychiatry
Lauro Estivalete Marchionatti, Thyago Antonelli-Salgado, Isadora Nunes Erthal, Savio Luiz Santos Lopes, Luiza Silveira Lucas, Diego Barreto Reboucas, Ives Cavalcante Passos
Summary: This systematic review on the impact of disease progression in the treatment of bipolar disorder patients found that efficacy decreases with clinical progression, supporting early intervention. However, tailored recommendations cannot be made based on disease stages currently, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Jason Ng, Joshua D. Rosenblat, Leanna M. W. Lui, Kayla M. Teopiz, Yena Lee, Orly Lipsitz, Rodrigo B. Mansur, Nelson B. Rodrigues, Flora Nasri, Hartej Gill, Danielle S. Cha, Mehala Subramaniapillai, Roger C. Ho, Bing Cao, Roger S. McIntyre
Summary: The review and synthesis of existing literature on functional outcomes with ketamine/esketamine treatment in adults with treatment-resistant depression suggest mixed results across different functional measures, with improvements in general psychosocial functioning apparent. Future research is needed to explore the association between symptomatic improvement and functional improvement in TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Zainab Nabi, Jacki Stansfeld, Martin Ploderl, Lisa Wood, Joanna Moncrieff
Summary: This study is a systematic review and meta-analysis that includes all eligible data and evaluates the effect of lithium on suicide, non-fatal suicidal behavior, and suicide attempts. The results suggest that evidence from randomized trials is inconclusive and does not support the idea that lithium prevents suicide or suicidal behavior.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Roger S. McIntyre, Joshua D. Rosenblat, Nelson B. Rodrigues, Orly Lipsitz, David Chen-Li, Jung Goo Lee, Flora Nasri, Mehala Subramaniapillai, Kevin Kratiuk, Andrew Wang, Hartej Gill, Rodrigo B. Mansur, Roger Ho, Kangguang Lin, Yena Lee
Summary: The study found that intravenous ketamine can significantly improve cognitive function in TRD patients, especially in tests like DSST and PDQ-5-D. This improvement is mainly mediated by reduced depressive symptoms, indicating that ketamine has independent and rapid effects in promoting cognition.
PSYCHIATRY RESEARCH
(2021)
Review
Psychology, Clinical
Samuel T. Wilkinson, Daniel Trujillo Diaz, Zachary W. Rupp, Anubhav Kidambi, Karina L. Ramirez, Jose M. Flores, Victor J. Avila-Quintero, T. Greg Rhee, Mark Olfson, Michael H. Bloch
Summary: This study found that lithium has a protective effect against suicide in bipolar disorder, as well as in mixed diagnostic samples. Clozapine was also shown to reduce the odds of suicide in psychotic disorders. However, other treatments such as electroconvulsive therapy and antipsychotics did not show significant associations with suicide risk.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Amir Garakani, Frank D. Buono, Kaitlyn Larkin, Maxim Polonsky, Joseph F. Goldberg
Summary: This study adapted a standardized measure of obsessive-compulsive thinking to assess chronic suicidal ideation in patients with mood disorder, finding that the tool is internally consistent and reliable.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Neurosciences
Muhammad Youshay Jawad, Saleha Qasim, Menglu Ni, Ziji Guo, Joshua D. Di Vincenzo, Giacomo d'Andrea, Aniqa Tabassum, Andrea Mckenzie, Sebastian Badulescu, Iria Grande, Roger S. McIntyre
Summary: The scoping review synthesized the current literature on the use of ketamine in bipolar depression. The preliminary evidence suggests that ketamine is a promising treatment with minimal risk and some effectiveness. Future studies should focus on ketamine's role in acute and maintenance treatment phases, as well as its effects on recurrence prevention and anti-suicidal measures.
Review
Psychiatry
Yazen Alnefeesi, David Chen-Li, Ella Krane, Muhammad Youshay Jawad, Nelson B. Rodrigues, Felicia Ceban, Joshua D. Di Vincenzo, Shakila Meshkat, Roger C. M. Ho, Hartej Gill, Kayla M. Teopiz, Bing Cao, Yena Lee, Roger S. McIntyre, Joshua D. Rosenblat
Summary: Ketamine shows promising clinical effectiveness in the treatment of treatment-resistant depression (TRD), as demonstrated by a systematic review and meta-analysis. The study findings indicate a substantial mean antidepressant effect, with potential benefits for even the most treatment-resistant patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Lumbini Azim, Paul Hindmarch, Georgiana Browne, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, John R. Geddes, Nicola Goudie, Sandy Harvey, Timea Helter, Eva-Maria Holstein, Garry Martin, Phil Mawson, Jenny McCaffery, Richard Morriss, Judit Simon, Daniel Smith, Paul R. A. Stokes, Jenn Walker, Chris Weetman, Faye Wolstenhulme, Allan H. Young, Stuart Watson, R. Hamish McAllister-Williams
Summary: Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Current treatment options are limited, leading to a need for additional interventions. The PAX-BD study aims to evaluate the efficacy, safety, and health economic impact of pramipexole for patients with TRBD.
Review
Clinical Neurology
Silvana Zito, Guido Nosari, Alessandro Pigoni, Chiara Moltrasio, Giuseppe Delvecchio
Summary: This review examines the relationship between testosterone levels and mood disorders, specifically major depressive disorder and bipolar disorder. The results from the reviewed studies were conflicting, with some showing low levels of testosterone in both disorders, while others showed a mixed picture of reduced, increased or no difference in testosterone levels. Overall, testosterone may serve as a useful biomarker in mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Neurosciences
Lauren Kuhns, Emese Kroon, Karis Colyer-Patel, Janna Cousijn
Summary: Current evidence suggests a bidirectional relationship between cannabis use, CUD, and the onset of depression, with cannabis use more consistently preceding the onset of bipolar disorder. Shared neurocognitive mechanisms and underlying genetic and environmental risk factors may explain part of the association, while further studies are needed to understand causal pathways and potential mechanisms for optimizing harm reduction and treatment strategies for individuals with comorbid cannabis use and mood disorders.
PSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Health Care Sciences & Services
Antonio Del Casale, Leda Marina Pomes, Luca Bonanni, Federica Fiasche, Clarissa Zocchi, Alessio Padovano, Ottavia De Luca, Gloria Angeletti, Roberto Brugnoli, Paolo Girardi, Robert Preissner, Marina Borro, Giovanna Gentile, Maurizio Pompili, Maurizio Simmaco
Summary: Pharmacogenomics-guided treatment may be effective in the cure of treatment-resistant depression. This study evaluated the clinical changes after PGT in patients with TRD and found that the PGT group showed significant improvements in efficacy index and clinical global impression compared to the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
J. P. Nakamura, A. Schroeder, A. Gibbons, S. Sundram, R. A. Hill
Summary: The study shows that maternal immune activation during pregnancy impacts schizophrenia-related cognitive constructs, but this is highly dependent on the timing of infection and the offspring's sex. Early MIA exposure causes female-specific cognitive disruptions, while late exposure affects male cognition, influencing neurodevelopmental processes.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, General & Internal
Michael Braude, Timothy Phan, Danny Con, Ian Woolley, Suresh Sundram, David Clarke, Anouk Dev, William Sievert
Summary: People with serious mental illness are not receiving adequate screening and treatment for hepatitis C virus. The study found that intensified community-based support can partially improve treatment outcomes, but investment in innovative screening and management strategies is needed to achieve healthcare parity.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Medicine, Research & Experimental
Winston Lee, Jana Zernant, Pei-Yin Su, Takayuki Nagasaki, Stephen H. Tsang, Rando Allikmets
Summary: This study provides a structured understanding of the genetic and clinical landscape of ABCA4 disease through genotype-phenotype correlation analysis, and adds a tool to quantitatively assess individual genotype-specific prognoses in patients.
Editorial Material
Psychiatry
Izaak Lim, Vesna Newman-Morris, Rebecca Hill, Elisabeth Hoehn, Nicholas Kowalenko, Rochelle Matacz, Campbell Paul, Rosalind Powrie, Lynn Priddis, Vibhay Raykar, Tanya Wright, Louise Newman, Suresh Sundram
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Andrew Gumley, Simon Bradstreet, John Ainsworth, Stephanie Allan, Mario Alvarez-Jimenez, Maximillian Birchwood, Andrew Briggs, Sandra Bucci, Sue Cotton, Lidia Engel, Paul French, Reeva Lederman, Shon Lewis, Matthew Machin, Graeme MacLennan, Hamish McLeod, Nicola McMeekin, Cathy Mihalopoulos, Emma Morton, John Norrie, Frank Reilly, Matthias Schwannauer, Swaran P. Singh, Suresh Sundram, Andrew Thompson, Chris Williams, Alison Yung, Lorna Aucott, John Farhall, John Gleeson
Summary: The study investigates the feasibility of a digital intervention in recognizing and managing early warning signs of relapse in schizophrenia to prevent relapse.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Article
Public, Environmental & Occupational Health
Katrina M. Long, Terry P. Haines, Sharon Clifford, Suresh Sundram, Velandai Srikanth, Rob Macindoe, Wing-Yin Leung, Jim Hlavac, Joanne Enticott
Summary: Residents of Residential Age Care Facilities have high rates of Emergency Department visits, with up to 55% being potentially avoidable. Limited English proficiency has negative impacts on healthcare outcomes for older people. This study did not find differences in hospital admission rates via the Emergency Department between residents with limited English proficiency and non-limited English proficiency controls.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Psychology, Clinical
Sandra Passardi, Debbie C. Hocking, Naser Morina, Suresh Sundram, Eva Alisic
Summary: This study explores the moral injury appraisals and associated mental health outcomes related to immigration detention on Nauru. The findings suggest that mandatory immigration detention can cause harm through moral injury. Collective efforts are needed to prevent the deterioration of refugee mental health.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Review
Psychiatry
Zhao Feng Liu, Amy Sylivris, Michael Gordon, Suresh Sundram
Summary: More than 50% of women experience mood disturbance in the postpartum period, with postpartum depression being a significant concern. Testing tryptophan levels may help identify those at risk for postpartum depression. The analysis shows that low total tryptophan levels in the first five days postpartum are significantly associated with postpartum depression, while free tryptophan levels do not show a significant association.
Article
Pediatrics
Rachel A. Hill, Atul Malhotra, Vathana Sackett, Katrina Williams, Michael Fahey, Kirsten R. Palmer, Rod W. Hunt, Hayley Darke, Izaak Lim, Vesna Newman-Morris, Jeanie L. Y. Cheong, Clare Whitehead, Joanne Said, Paulo Bignardi, Evelin Muraguchi, Luiz Carlos C. Fernandes Jr, Carlos Oliveira, Suresh Sundram
Summary: This study aims to investigate the long-term impacts of SARS-CoV-2 exposure on children exposed in utero. Women infected with SARS-CoV-2 during pregnancy will be recruited and compared with non-exposed women. By conducting long-term observations and comparisons, we hope to reveal the potential effects of in utero exposure to SARS-CoV-2 on neurodevelopment.
Review
Psychiatry
Harvey Whiteford, Nasser Bagheri, Sandra Diminic, Joanne Enticott, Caroline X. Gao, Matthew Hamilton, Ian B. Hickie, Long Khanh-Dao Le, Yong Yi Lee, Katrina M. Long, Patrick McGorry, Graham Meadows, Cathrine Mihalopoulos, Jo-An Occhipinti, Daniel Rock, Sebastian Rosenberg, Luis Salvador-Carulla, Adam Skinner
Summary: Australia's Fifth National Mental Health Plan requires governments to report on the progress of mental health service delivery changes and plan for future service provision. Modelling uncertain demands on the system can help decision-makers understand future changes in mental health service demand and choose appropriate responses. Modelling can also enhance scrutiny, accountability, and transparency of these processes.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Amit Lotan, Sandra Luza, Carlos M. Opazo, Scott Ayton, Darius J. R. Lane, Serafino Mancuso, Avril Pereira, Suresh Sundram, Cynthia Shannon Weickert, Chad Bousman, Christos Pantelis, Ian P. Everall, Ashley I. Bush
Summary: Current treatments for schizophrenia do not target disruptions in late maturational reshaping of the prefrontal cortex. Analysis of cortical iron biology in schizophrenia reveals elevated tissue iron and decreased ferritin, suggesting a potential link between perturbed cortical iron biology and the disorder, and offering a new therapeutic target.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Rachel A. Hill, Andrew Gibbons, Uni Han, Wittaya Suwakulsiri, Angela Taseska, Fleur Hammet, Melissa Southey, Atul Malhotra, Michael Fahey, Kirsten R. Palmer, Rod W. Hunt, Izaak Lim, Vesna Newman-Morris, Suresh Sundram
Summary: Infection during pregnancy can increase the risk of neurodevelopmental disorders in offspring. The impact of maternal SARS-CoV-2 infection on infant neurodevelopment is poorly understood. This study aims to investigate the DNA methylation alterations in infants exposed to SARS-CoV-2 in utero and explore the genes and pathways involved in neurodevelopment.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Chitra Vinnakota, Matthew R. R. Hudson, Nigel C. C. Jones, Suresh Sundram, Rachel A. A. Hill
Summary: Glutamate N-methyl-D-aspartate receptor (NMDAR) hypofunction is believed to be responsible for schizophrenia symptoms. Among the NMDAR subunits, the GluN2D subunit is implicated in schizophrenia-related phenotypes, and further research into this subunit may lead to novel therapeutic targets for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Chitra Vinnakota, Anna Schroeder, Xin Du, Kazutaka Ikeda, Soichiro Ide, Masayoshi Mishina, Matthew Hudson, Nigel Charles Jones, Suresh Sundram, Rachel Anne Hill
Summary: This study investigated the role of the GluN2D subunit in mediating schizophrenia-relevant behaviors induced by a range of NMDAR antagonists. The results showed that GluN2D-KO mice exhibited abnormal locomotor activity, anxiety-related behavior, and memory, and the effects of NMDAR antagonists were dependent on sex and genotype.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Brian Dean
Summary: Schizophrenia is a syndrome that requires drugs targeting muscarinic M1 and M4 receptors, rather than dopamine D2 receptors, as antipsychotic drugs do. It would be ideal to identify individuals who respond to drugs activating the CHRM1 and 4 receptors, as non-response to treatment could be restricted to specific sub-groups within the syndrome.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)