Article
Medicine, General & Internal
Ksawery Golawski, Wojciech Giermaziak, Michal Ciebiera, Cezary Wojtyla
Summary: Adequate weight gain during pregnancy is important for a healthy pregnancy, but excessive weight gain is associated with adverse pregnancy outcomes. Based on a Polish national survey of 10,319 women and 6930 children, excessive gestational weight gain is associated with higher birthweight, increased risk of birthweight over 4500 g, cesarean section/assisted delivery, pregnancy induced hypertension, hospitalization during pregnancy, and lower Apgar score in the first minute of neonate's life. However, there was no significant difference in premature rupture of membranes and labor inductions. Our study highlights the increased risk of adverse pregnancy outcomes with excessive gestational weight gain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Otilia Perichart-Perera, Jennifer Mier-Cabrera, Claudia Montserrat Flores-Robles, Nayeli Martinez-Cruz, Lidia Arce-Sanchez, Itzel Nallely Alvarado-Maldonado, Araceli Montoya-Estrada, Jose Romo-Yanez, Ameyalli Mariana Rodriguez-Cano, Guadalupe Estrada-Gutierrez, Salvador Sosa, Mario Guzman-Huerta, Rodrigo Ayala-Yanez, Enrique Reyes-Munoz
Summary: The addition of metformin to intensive medical nutrition therapy does not provide any benefit in preventing gestational diabetes mellitus among high-risk Mexican women.
Article
Medicine, General & Internal
Teresa A. Hillier, Kathryn L. Pedula, Keith K. Ogasawara, Kimberly K. Vesco, Caryn E. S. Oshiro, Suzanne L. Lubarsky, Jan Van Marter
Summary: In this study comparing one-step screening with two-step screening for gestational diabetes mellitus, the one-step approach resulted in more diagnoses of gestational diabetes mellitus but did not have a significant impact on the incidence of adverse perinatal and maternal outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Obstetrics & Gynecology
Xiao-guang Yin, Peng Wang, Mei-ting Zhou, De-qin Li, Rui-xue Tao, Fang-biao Tao, Yang Wang, Peng Zhu
Summary: The timing of gestational diabetes mellitus (GDM) diagnosis and gestational weight gains (GWG) during pregnancy are associated with the growth trajectory of children from perinatal to early childhood. GDM diagnosed before 26 weeks increases the risk of fetal overgrowth and higher birth weight, as well as higher BMI peak within 48 months. Maternal early GDM diagnosis and excessive gestational weight gains have additive impacts on offspring overgrowth, with higher levels of hsCRP observed in the early EGWG group.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Endocrinology & Metabolism
Caro Minschart, Astrid Lammertyn, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: The level of gestational weight gain (GWG) during pregnancy is associated with adverse pregnancy outcomes in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT). Low GWG below recommended levels frequently occurs in GDM women without increased risk for adverse outcomes. Excessive GWG is associated with increased risk for neonatal hypoglycemia and worse metabolic profile postpartum in GDM women, and with higher rates of instrumental delivery and larger infants in NGT women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Aiqi Yin, Fuying Tian, Xiaoxia Wu, Yixuan Chen, Kan Liu, Jianing Tong, Xiaonian Guan, Huafan Zhang, Linlin Wu, Jianmin Niu
Summary: This study evaluated the effect of weight gain in different trimesters on the risk of gestational diabetes mellitus (GDM). The results showed that insufficient weight gain in early pregnancy and excessive weight gain in middle pregnancy were associated with an increased risk of GDM. Strict control of weight gain in early pregnancy and sufficient nutrition in middle pregnancy are necessary.
CHINESE MEDICAL JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Sanna Mustaniemi, Hilkka Nikkinen, Aini Bloigu, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Eero Kajantie, Marja Vaarasmaki
Summary: The study showed that normal gestational weight gain is associated with a lower risk of large-for-gestational-age infants and lower birth weight standard deviation scores in the presence of gestational diabetes and maternal obesity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Nutrition & Dietetics
Shan Wu, Jiani Jin, Kai-Lun Hu, Yiqing Wu, Dan Zhang
Summary: This study aimed to evaluate the optimal intervention strategy to prevent gestational diabetes mellitus (GDM) and restrict gestational weight gain (GWG) among overweight/obese pregnant women. The results showed that PA and diet + PA interventions had a trend of preventing GDM, and interventions of diet, PA, and diet + PA were significant factors to restrict GWG. Overall, a combination of diet and physical activity intervention seemed to be the superior choice for both GDM prevention and excessive GWG.
Article
Obstetrics & Gynecology
Jiang-Feng Ke, Sheng Liu, Ri-Le Ge, Li Ma, Mei-Fang Li
Summary: In women with gestational diabetes mellitus (GDM), maternal pre-pregnancy body mass index (ppBMI) and gestational weight gain (GWG) are associated with adverse pregnancy outcomes (APOs). The study found that obese mothers and excessive GWG increase the risk of APOs, while inadequate GWG increases the risk of preterm birth.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Endocrinology & Metabolism
Marie Parfaite Uwimana Muhuza, Lixia Zhang, Qi Wu, Lu Qi, Danqing Chen, Zhaoxia Liang
Summary: This study investigated the association between HbA1c levels and adverse outcomes in women with gestational diabetes mellitus (GDM), considering maternal age, pre-pregnancy BMI, and gestational weight gain (GWG). The results showed that HbA1c was significantly associated with macrosomia, pregnancy-induced hypertension (PIH), preterm birth, and primary Cesarean section. The associations varied with maternal age, pre-pregnancy BMI, and GWG.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Angelo Sirico, Esther Diana Rossi, Valentina Anna Degennaro, Vincenzo Arena, Alessandro Rizzi, Linda Tartaglione, Mauro Di Leo, Dario Pitocco, Antonio Lanzone
Summary: The study investigated the placental expression of VEGF and CD31 in pregnancies complicated by gestational diabetes (GDM) and the influence of pregestational BMI and gestational weight gain (GWG) on this expression. The results showed that GDM pregnancies are characterized by increased placental expression of VEGF and CD31, and the expression of these markers is associated with maternal increased pregestational BMI and GWG.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Li-hua Lin, Juan Lin, Jian-ying Yan
Summary: In women with gestational diabetes mellitus, pre-pregnancy overweight or obesity, excessive gestational weight gain, and abnormal items of oral glucose tolerance test parameters independently contribute to adverse pregnancy outcomes, and the combined effect between these three factors appears to be multiplicative.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin Dai, Nansi S. Boghossian, Mark A. Sarzynski, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu, Liwei Chen
Summary: In this metabolome-wide association study, metabolomic markers associated with excessive gestational weight gain (GWG) were identified. Novel metabolites in the first and third trimesters were found to be associated with GWG, shedding light on the pathophysiology of GWG.
Article
Environmental Sciences
Andrea L. Deierlein, Haotian Wu, Allan C. Just, Allison J. Kupsco, Joseph M. Braun, Emily Oken, Diana C. Soria-Contreras, Alejandra Cantoral, Ma Luisa Pizano, Nia McRae, Martha M. Tellez-Rojo, Robert O. Wright, Andrea A. Baccarelli
Summary: The study found that prenatal exposure to phthalates was negatively associated with gestational weight gain and positively associated with long-term changes in maternal weight. Further investigation is needed to understand how phthalates influence body composition and whether they contribute to the development of obesity and other cardiometabolic diseases in women.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ning Wang, Yanqi Peng, Lu Wang, Lin Song, Bo Sun, Junxiang Wei, Ting Wang, Yang Mi, Wei Cui
Summary: The study aimed to analyze the risk factors for gestational diabetes mellitus (GDM) heterogeneity and its correlation with obesity. Results showed that GDM patients exhibit different glycemic physiology types, with specific obesity-related risk factors for the GDM-resistance subtype mediated by pre-pregnancy overweight/obesity and increased gestational weight gain in the first trimester.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Obstetrics & Gynecology
Renee J. Burger, Sofieke Temmink, Dagmar Wertaschnigg, Wessel Ganzevoort, Maya Reddy, Mary-Ann Davey, Euan Morrison Wallace, Ben-Willem Mol
Summary: The preterm birth rate is increasing in twin pregnancies in Victoria, Australia, primarily due to an increase in iatrogenic preterm birth. This rise is seen in both complicated and non-complicated pregnancies, and has not led to a reduction in perinatal mortality rates after 28 weeks of gestation.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2021)
Article
Nursing
Daniel L. Rolnik, Tony M. Korman, Andrea Rindt, Rhonda L. Stuart, Michelle L. Giles, Janine Rawlins, Kirsten R. Palmer, Andrew Stripp, Euan M. Wallace, Ryan J. Hodges
Summary: During a two-week period in May 2020, a study in Melbourne, Australia found a negligible rate of asymptomatic coronavirus infection among pregnant women, with all 350 tests returning negative results. This reflects low levels of community transmission during the study period.
Article
Obstetrics & Gynecology
Renee J. Burger, Josephina D. Temmink, Dagmar Wertaschnigg, Wessel Ganzevoort, Maya Reddy, Mary-Ann Davey, Euan M. Wallace, Ben-Willem Mol
Summary: The singleton preterm birth rate in Victoria is increasing, mainly driven by an increase in iatrogenic preterm birth both in pregnancies complicated by fetal growth problems and hypertension, as well as in pregnancies not complicated by these conditions. While there is a decrease in perinatal mortality in pregnancies with complications, there is no significant reduction in perinatal mortality from 28 weeks onwards or in the preterm weekly prospective stillbirth risk in pregnancies without complications.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Dermatology
Seungmin Ham, Craig Harrison, David de Kretser, Euan M. Wallace, Graeme Southwick, Peter Temple-Smith
Summary: The study found that activin A and connective tissue growth factor were significantly upregulated in keloid fibroblasts, and a single treatment of follistatin over 5 days significantly inhibited activin and various matrix-related genes in keloid fibroblasts. This suggests a potential therapeutic role of follistatin in managing keloids.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Obstetrics & Gynecology
A. G. Langston-Cox, D. Anderson, D. J. Creek, K. R. Palmer, S. A. Marshall, E. M. Wallace
Summary: Sulforaphane, an isothiocyanate found in cruciferous vegetables like broccoli, may serve as an adjuvant therapy for preeclampsia. The bioavailability of sulforaphane differs between non-pregnant women and women with preeclampsia, with higher doses required for pregnant women. Activation of broccoli extract results in better bioavailability of sulforaphane and may improve endothelial function and blood pressure in women with pregnancy hypertension.
REPRODUCTIVE SCIENCES
(2021)
Article
Nursing
Rodion Sharlov, David Taniar, Thanh Phan, Richard Beare, Velandai Srikanth, Henry Ma, Tanya Farrell, Colleen White, Euan M. Wallace, Miranda Davies-Tuck
Summary: This study aimed to use geo-mapping to identify the number of eligible women for homebirth in Victoria, Australia and plan future maternity care options. The findings showed that less than 1% of Australian women currently give birth at home, but half of the low risk women live within 25 km of seven Victorian hospitals. The results can be used to inform the expansion of maternity service options.
Editorial Material
Obstetrics & Gynecology
Roshan J. Selvaratnam, Mary-Ann Davey, Robyn M. Hudson, Tanya Farrell, Euan M. Wallace
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
R. J. Selvaratnam, D. L. Rolnik, M-A Davey, E. M. Wallace
Summary: The changing stillbirth risk profile of women has influenced the interpretation of stillbirth rate, with a faster decline in population rates of stillbirth due to changing maternal characteristics than previously estimated.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Annie Langston-Cox, Sarah A. Marshall, Daisy Lu, Kirsten R. Palmer, Euan M. Wallace
Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension and organ dysfunction. Traditional treatment has focused on antihypertensive medications, but recent insights into the pathogenesis have introduced new options such as melatonin. Melatonin, as a safe antioxidant, shows promise in improving maternal condition and protecting the fetus.
Article
Obstetrics & Gynecology
Roshan J. Selvaratnam, Euan M. Wallace, Rodney W. Hunt, Mary-Ann Davey
Summary: This study aimed to design a balance measure to address the specificity of FGR detection. The results showed variations in hospital performance on existing indicator of FGR detection and the balance measures, suggesting that introducing a balance measure may help reduce unintended harm associated with increased FGR detection.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
John P. Newnham, Chris Schilling, Stavros Petrou, Jonathan M. Morris, Euan M. Wallace, Kiarna Brown, Lindsay Edwards, Monika M. Skubisz, Scott W. White, Brendan Rynne, Catherine A. Arrese, Dorota A. Doherty
Summary: Preterm birth poses a significant economic burden to the Australian government, with costs mainly attributed to healthcare services and educational needs. Economic evaluations of interventions for preterm birth prevention or treatment should take into account these costs.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Endocrinology & Metabolism
James DS. Aridas, Tamara Yawno, Amy E. Sutherland, Ilias Nitsos, Flora Y. Wong, Rod W. Hunt, Michael Ditchfield, Michael C. Fahey, Atul Malhotra, Euan M. Wallace, Alistair J. Gunn, Graham Jenkin, Suzanne L. Miller
Summary: This study found that combined use of TH and MLT for neonatal encephalopathy in newborn lambs provides significantly greater neuroprotection than either treatment alone.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Obstetrics & Gynecology
Michael S. Tanner, Deborah De Guingand, Maya Reddy, Saskia Rowson, Daniel L. Rolnik, Fabricio Da Silva Costa, Mary-Ann Davey, Ben W. Mol, Euan M. Wallace, Kirsten R. Palmer
Summary: Among women with preeclampsia, those with comorbidities tend to deliver earlier and experience fewer maternal complications but more neonatal complications compared to those without comorbidities.
HYPERTENSION IN PREGNANCY
(2021)
Article
Obstetrics & Gynecology
Daniel L. Rolnik, Roshan J. Selvaratnam, Dagmar Wertaschnigg, Simon Meagher, Euan Wallace, Jon Hyett, Fabricio da Silva Costa, Andrew McLennan
Summary: This study aimed to assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. Women who underwent combined screening were less likely to experience preeclampsia, preterm birth, and other pregnancy complications compared to those who received standard care. The screening identified a population at high risk of adverse pregnancy outcomes and low-risk women suitable for less intensive antenatal care.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Developmental Biology
Yann W. Yap, Natalie J. Hannan, Euan M. Wallace, Sarah A. Marshall
Summary: Nrf proteins have been found to play a crucial role in placental-derived oxidative stress-induced pregnancy disorders. Successful silencing of Nrf proteins in human cells has been achieved for further research.
