Journal
AUDIOLOGY AND NEURO-OTOLOGY
Volume 19, Issue 2, Pages 91-96Publisher
KARGER
DOI: 10.1159/000357028
Keywords
Vestibular; Velocity storage; Perception; Eye movement; Dizziness
Funding
- MRC [MC_U950770497]
- Meniere's Society, UK
- Academy of Medical Sciences (AMS) [AMS-CSF3-Seemungal] Funding Source: researchfish
- Medical Research Council [MR/J004685/1, G0600183, MC_U950770497] Funding Source: researchfish
- MRC [G0600183, MR/J004685/1] Funding Source: UKRI
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Background: The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo- perceptual function. Methods: We studied 12 healthy naive subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task investigating perceptual motion detection and nystagmic thresholds (acceleration steps of 0.5 degrees/s(2)) and (2) suprathreshold responses to velocity steps of 90 degrees/s in which vestibulo-ocular and vestibuloperceptual time constants of decay, as well as VOR gain, were measured. Results: Prochlorperazine had no effect upon any measure of nystagmic or perceptual vestibular function compared to placebo. This lack of effects on vestibular- mediated motion perception suggests that the drug is likely to act more as an anti-emetic than as an antivertiginous agent. (C) 2013 S. Karger AG, Basel
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