Review
Materials Science, Multidisciplinary
Hanze Hu, Chao Yang, Mingqiang Li, Dan Shao, Hai-Quan Mao, Kam W. Leong
Summary: Advances in nanoformulation using flash-based technology have led to the development of nanoscale tools for biosensing, imaging, and drug delivery in biomedicine. This review discusses the theoretical and experimental principles, mixing device design, and applications of flash-based self-assembly in biomedicine, focusing particularly on flash nanocomplexation (FNC) and flash nanoprecipitation (FNP). Challenges and future directions for flash-based nanoformulation in biomedicine are also highlighted.
Article
Engineering, Biomedical
Ni-Yuan Zhang, Xing-Jie Hu, Hong-Wei An, Jian-Xiao Liang, Hao Wang
Summary: AIEgens in highly aggregated states exhibit enhanced fluorescence, making them promising modules for highly emissive fluorescence biomaterials. Peptide-AIEgens hybrid biomaterials combine the biocompatibility and biofunction-editing properties of peptides, offering functions such as targeting ability, specificity, and stimuli-responsiveness. The programmable design of peptide-AIEgens enables the construction of intelligent entities with defined biological functions.
Review
Chemistry, Multidisciplinary
Jasmin Omar, Daniel Ponsford, Cecile A. Dreiss, Tung-Chun Lee, Xian Jun Loh
Summary: This article provides a detailed overview of the dynamic chemistry and design strategies behind supramolecular hydrogel formation, as well as the potential applications in the field of medicine and the considerations for further development.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Aref Abbasi Moud, Aliyeh Abbasi Moud
Summary: Cellulosic sources can be degraded to produce cellulose nanocrystals (CNCs), which have various applications in biomedicine, photonics, and material engineering due to their biodegradability, renewability, sustainability, and mechanical qualities. The rheological behavior of CNC suspension or in combination with other chemicals is crucial for the processing and design of CNC-based products. This review article provides new research on the shear rheology of CNC dispersion and CNC-based hydrogels, as well as their applications in technology and material science.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Quinn Prasser, Daniel Steinbach, Alexander S. Muench, Richard Neubert, Christian Weber, Petra Uhlmann, Florian Mertens, Felix A. Plamper
Summary: Although amphiphiles are widely used to modify interfaces, the process of interfacial reorganization remains unclear in many cases. In this study, a block copolymer system with electrostatic interactions was used to investigate the reorganization kinetics of adsorbed micelles at the water/n-decane interface. The results showed that electrostatic interactions slowed down the reorganization process, allowing for the observation of micellar flattening and merging towards a physically interconnected monolayer. The study also demonstrated that the rheological properties of the interface can be manipulated through redox reactions, and the formation of Prussian blue can stiffen the interface.
Article
Biophysics
Chunqian Zhao, Hongyuan Chen, Fengshan Wang, Xinke Zhang
Summary: Amphiphilic self-assembling peptides are widely used in biomedical fields due to their good compatibility and potential for drug delivery. However, there are no defined rules for their design and development, and rational strategies are needed for research. These peptides have a variety of applications in drug delivery, including delivering hydrophobic drugs and vaccines.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Polymer Science
Mariana Chelu, Adina Magdalena Musuc
Summary: Polymer gels are a class of polymeric materials that possess exceptional properties, such as versatility, soft structure, flexibility, stimuli-responsiveness, biodegradability, and biocompatibility. They find applications in various fields, including the food industry, agriculture, biomedical, and biosensor technology. This review provides an overview of polymer gels, their classification, highlighting important features, and recent developments in biomedical applications. It also presents perspectives on the future advancement of polymer hydrogels.
Article
Biochemistry & Molecular Biology
Alessandra Scelsi, Brigida Bochicchio, Andrew M. Smith, Antonio Laezza, Alberto Saiani, Antonietta Pepe
Summary: The assembly of gelating peptides with elastin-inspired peptide or dipeptide was investigated, revealing different nanotopologies and mechanical properties that could be utilized for fabricating materials with desired properties.
Review
Chemistry, Medicinal
Yota Okuno, Yasuhiko Iwasaki
Summary: Peptoids, a type of polymer with biocompatibility and easily adjustable side chains, have shown great potential in biomedical applications. In the past decade, researchers have created well-defined self-assemblies such as vesicles, micelles, sheets, and tubes using peptoids, and have analyzed them at the atomic level. This review focuses on the recent advancements in peptoid synthesis strategies and the development of anisotropic self-assemblies, specifically nanotubes and nanosheets, which exhibit ordered molecular arrangements. The protease resistance of peptoids has also been leveraged for various biomedical applications, including phototherapy, enzymatic mimetics, bio-imaging, and biosensing.
Review
Chemistry, Multidisciplinary
Tengfei Wang, Cecilia Menard-Moyon, Alberto Bianco
Summary: Amino acid derivatives with amphiphilic properties have been extensively studied for their self-assembly into various nanostructures, making them suitable for biomedical applications due to their excellent biocompatibility and biodegradability.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Polymer Science
H. P. S. Abdul Khalil, Esam Bashir Yahya, Husnul Azan Tajarudin, Venugopal Balakrishnan, Halimatuddahliana Nasution
Summary: This article introduces the fabrication approach and properties of biopolymeric xerogels for the first time, and discusses their latest applications in drug delivery, wound healing and dressing, tissue scaffolding, and biosensing.
Review
Biochemistry & Molecular Biology
Ke Li, Yanfei Liu, Beibei Lou, Yifu Tan, Liwei Chen, Zhenbao Liu
Summary: In the past decades, DNA has been widely utilized in the field of nanostructures due to its programmable properties. This review presents different strategies for the functionalization of DNA on nanoparticle surfaces and discusses the roles of DNA in the assembly of nanostructures as well as the influencing factors. The biomedical applications of DNA-assembled nanostructures are also summarized. This review provides new insights into the application of DNA in nanostructure assembly.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Wanjun Xu, Zhixing Lin, Shuaijun Pan, Jingqu Chen, Tianzheng Wang, Christina Cortez-Jugo, Frank Caruso
Summary: This study demonstrates the direct assembly of metal-organic networks into nanoparticles using metal ions and polyphenols in aqueous solutions. The size and properties of the nanoparticles can be controlled by altering the assembly conditions and using buffers. Functional cargos can be readily loaded within the nanoparticles for various applications, thanks to the strong affinity of polyphenols to guest molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Pharmacology & Pharmacy
Xiaosong Le, Tianwen Gao, Li Wang, Feng Wei, Cuixia Chen, Yurong Zhao
Summary: A variety of functional biomaterials with different sizes and morphologies can be created through self-assembly, with a particular focus on amphiphilic peptide-based materials. These peptides can self-assemble into diverse nanostructures, and their formation is governed by a delicate balance of non-covalent interactions. This review highlights recent advances in the self-assembly of two types of peptides, surfactant-like peptides (SLPs) and peptide amphiphiles (PAs), and discusses their applications in various biomedical fields.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Dieu Phuong Nguyen Thi, Dieu Linh Tran, Phuong Le Thi, Ki Dong Park, Thai Thanh Hoang Thi
Summary: The study involved encapsulating bioactive compounds from Cordyline terminalis leaf extract in gelatin-polyethylene glycol-tyramine (GPT) / alpha-cyclodextrin (α-CD) gels to create materials for biomedical applications with antioxidant properties and high biocompatibility. The addition of the extract delayed gelation time, but sustained release of polyphenols was achieved by adjusting the aqCT amount and gel properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Romain Lambert, Emmanuel Ibarboure, Guillaume Fleury, Stephane Carlotti
Article
Chemistry, Applied
Ingrid Vikoren Mo, Yiming Feng, Marianne Oksnes Dalheim, Amalie Solberg, Finn L. Aachmann, Christophe Schatz, Bjorn E. Christensen
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Maxence Coudurier, Jimmy Faivre, Agnes Crepet, Catherine Ladaviere, Thierry Delair, Christophe Schatz, Stephane Trombotto
Article
Polymer Science
Victor Passos Gibson, Martin Fauquignon, Emmanuel Ibarboure, Jeanne Leblond Chain, Jean-Francois Le Meins
Article
Biochemistry & Molecular Biology
Ingrid Vikoren Mo, Marianne Oksnes Dalheim, Finn L. Aachmann, Christophe Schatz, Bjorn E. Christensen
Article
Chemistry, Applied
Ingrid Vikoren Mo, Christophe Schatz, Bjorn E. Christensen
Summary: By selectively oxidizing chitin oligomers, conjugation through both chain termini and formation of water-soluble chitin-based block polymers can be achieved. The oxidized A(n)M oligomers functionalized at both termini can also be used for preparing more complex block polysaccharides.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Applied
Amalie Solberg, Ingrid Mo, Line Aa Omtvedt, Berit L. Strand, Finn L. Aachmann, Christophe Schatz, Bjorn E. Christensen
Summary: This article discusses the chemistry and kinetics of engineered block polysaccharides, focusing on the application of oxyamine and hydrazide 'click' reactions, and provides useful protocols and methods for general use.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Dambarudhar Parida, Camille Bakkali-Hassani, Eric Lebraud, Christophe Schatz, Stephane Grelier, Daniel Taton, Joan Vignolle
Summary: This study demonstrates the use of ruthenium nanoparticles stabilized with simple polymerized ionic liquids as highly active and robust catalysts in hydrogenation reactions. The activity and selectivity of these catalysts can be manipulated through counter-anion exchange reactions, showing potential for reversible and selective control of catalyst activity in hydrogenation reactions.
Article
Polymer Science
Hongwei Li, Martin Fauquignon, Marie Haddou, Christophe Schatz, Jean-Paul Chapel
Summary: The study systematically investigated the surface activity of polyelectrolyte complex (PECs) suspensions as a function of the molar charge ratio Z. It was found that the surface tension of PECs decreases as the system approaches charge stoichiometry. The behavior of complex systems at stoichiometry is informative about the physical nature of the complexes.
Article
Chemistry, Organic
Axel Almansa, Damien Jardel, Stephane Massip, Thierry Tassaing, Christophe Schatz, Jeremy Domergue, Florian Molton, Carole Duboc, Jean-Marc Vincent
Summary: By photolysis, the structurally defined complex [Ni-2(II)(mu-OH2)(dtbbpy)(2)(BPCO2)(4)] can be reduced into a diamagnetic Ni-I dimer or Ni-0 metallic nanosheets, which can catalyze cross-coupling reactions under specific conditions.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Nouha Jemili, Martin Fauquignon, Etienne Grau, Nicolas Fatin-Rouge, Francois Dole, Jean-Paul Chapel, Wafa Essafi, Christophe Schatz
Summary: In this study, the electrostatic complexation between two strong polyelectrolytes, PDADMAC and P(St-co-SSNa), was investigated. The results showed that all the anionic charges of P(St-co-SSNa) were available for complexation with PDADMAC or a cationic dye. The strength of the electrostatic interaction was found to overcome the hydrophobic effect responsible for pearl formation, and the efficiency of complexation was not significantly influenced by differences in charge density between PDADMAC and P(St-co-SSNa). Additionally, the formation of colloidal PECs was observed to occur in two distinct steps: the pairing of opposite charges to form small primary complex particles, followed by their aggregation within finite-size clusters.
Article
Chemistry, Multidisciplinary
Tingting Zhang, Frederic Peruch, Amelie Weber, Katell Bathany, Martin Fauquignon, Angela Mutschler, Christophe Schatz, Bertrand Garbay
Summary: Developing new biomaterials for regenerative medicine, tissue engineering, and drug delivery is an active research area. Elastin-like polypeptides (ELPs) are promising candidates due to their biosourced, biocompatible, and biodegradable properties. In this study, we synthesized 15 acyl-ELP compounds by conjugating fatty acids to different ELPs and investigated their solution behavior and drug delivery potential. The acyl-ELP conjugates formed micelles at low temperatures and aggregated above the cloud point temperature, with critical micelle concentration and size depending on the nature and length of the fatty acid and ELP block length, respectively. Hydration analysis showed that ELPs were better hydrated in micelles compared to their individual state. The acyl-ELP micelles loaded with Nile red demonstrated efficient encapsulation and release, with the largest ELP conjugated to stearic acid showing the best loading conditions.
Article
Chemistry, Organic
Axel Almansa, Damien Jardel, Stephane Massip, Thierry Tassaing, Christophe Schatz, Jeremy Domergue, Florian Molton, Carole Duboc, Jean-Marc Vincent
Summary: In this study, a precatalytic system consisting of (NiX2)-X-II salts with a bipyridine-type ligand and aromatic carbonyl-based chromophores has been demonstrated to efficiently conduct cross-couplings mediated by light. Mechanistic studies revealed the reduction of a structurally defined complex into a Ni-I dimer in alcohols, while the formation of metallic ultrathin Ni nanosheets occurred in THF upon photolysis. The catalytic behavior of the system under UVA irradiation was also investigated, showing promising results in C(sp(3))-H arylation and O-arylation reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Tingting Zhang, Frederic Peruch, Anne-Laure Wirotius, Emmanuel Ibarboure, Frederic Rosu, Christophe Schatz, Bertrand Garbay
Summary: New biomaterials were developed by combining biocompatible blocks of polyisoprene and elastin-like polypeptide, which self-assemble into nanoparticles and can be used as drug delivery systems for various hydrophobic drugs.
Article
Polymer Science
Amalie Solberg, Ingrid V. Mo, Finn L. Aachmann, Christophe Schatz, Bjorn E. Christensen
Summary: Renewable resources can be utilized to prepare new types of stimuli-responsive polysaccharide-based block copolymers. Alginates, as natural polysaccharides, have unique properties, with G blocks playing a key role in binding calcium ions and hydrogel formation. By incorporating specific linkers, highly flexible polysaccharide-based block structures can be engineered for various applications.
