Article
Microbiology
Fernanda Sales Coelho, Sandra Grossi Gava, Luiza Freire Andrade, Juliana Assis Geraldo, Naiara Clemente Tavares, Felipe Miguel Nery Lunkes, Renata Heisler Neves, Jose Roberto Machado-Silva, Raymond J. Pierce, Guilherme Oliveira, Marina Moraes Mourao
Summary: This study characterizes the function of the protein arginine methyltransferase SmCARM1 in Schistosoma mansoni and highlights its potential as a drug target.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Derek W. Stouth, Tiffany L. Vanlieshout, Andrew I. Mikhail, Sean Y. Ng, Rozhin Raziee, Brittany A. Edgett, Goutham Vasam, Erin K. Webb, Kevin S. Gilotra, Matthew Markou, Hannah C. Pineda, Brianna G. Bettencourt-Mora, Haleema Noor, Zachary Moll, Megan E. Bittner, Brendon J. Gurd, Keir J. Menzies, Vladimir Ljubicic
Summary: CARM1 is a crucial regulator of skeletal muscle biology, controlling muscle mass and autophagy process. Loss of carm1 leads to decreased muscle mass, reduced autophagy flux, and impaired mitochondrial turnover.
Article
Hematology
Ceren Eyileten, Aleksandra Gasecka, Anna Nowak, Joanna Jarosz-Popek, Marta Wolska, Al-Medina Dizdarevic, Irene M. Lang, Marek Postula, Marcin Ufnal, Jolanta M. Siller-Matula
Summary: This study found that higher SDMA concentration was associated with lower platelet reactivity and major/minor bleeding events in ACS patients receiving DAPT. Therefore, SDMA has the potential to serve as a biomarker for individualization of antiplatelet therapy in ACS patients at high risk of bleeding complications.
THROMBOSIS RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Jie Zhen, Wei Chen, Yang Liu, Xuefeng Zang
Summary: Baicalin exhibits therapeutic activity towards acute pancreatitis by increasing miR-15a levels and inhibiting CDC42/MAP3K1, affecting acute pancreatitis by targeting MAP2K4 and inhibiting the JNK signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Kai Fan, Wei Huang, Hanping Qi, Chao Song, Cong He, Yongsheng Liu, Qianlong Zhang, Lixin Wang, Hongli Sun
Summary: miR-15a-5p is up-regulated in acute myocardial infarction and promotes ferroptosis by targeting GPX4, exacerbating hypoxic injury in myocardial cells. Egr-1 regulates the miR-15a-5p/GPX4 signaling pathway to inhibit ferroptosis and alleviate myocardial injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhen-Zhen Mo, Zhen Yuan, Yuan-Yuan Peng, Wan-Lu Zhou, Wei Dai, Guo Wang, Jie Tang, Wei Zhang, Bi-Lian Chen
Summary: We investigated the mechanism affecting bleeding risk in Chinese patients with acute coronary syndrome during the first year of clopidogrel treatment and found that the miR-6076 rs1463411 G polymorphism is significantly associated with bleeding risk, with the GT + GG genotype increasing the risk of bleeding.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Emeline Bollaert, Melissa Claus, Virginie Vandewalle, Sandrine Lenglez, Ahmed Essaghir, Jean-Baptiste Demoulin, Violaine Havelange
Summary: The study found that miR-15a-5p induces chemoresistance in AML cells by inhibiting daunorubicin-induced autophagy, suggesting that this miRNA could be a promising therapeutic target for chemoresistant AML patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Noelia Che, Kai-Yu Ng, Tin-Lok Wong, Man Tong, Phillis W. F. Kau, Lok-Hei Chan, Terence K. Lee, Michael S. Y. Huen, Jing-Ping Yun, Stephanie Ma
Summary: Autophagy plays a critical role in cancer cells such as hepatocellular carcinoma (HCC), and deficiency of the post-translational modification enzyme PRMT6 promotes autophagy induction in HCC under stress conditions. PRMT6 interacts with and methylates BAG5 to regulate HSC70 stability, influencing autophagy in HCC cells. Targeting BAG5 may be a promising strategy in HCC treatment to suppress autophagy and enhance sensitivity to sorafenib.
Article
Cardiac & Cardiovascular Systems
Concetta Schiano, Carolina Balbi, Jacopo Burrello, Antonio Ruocco, Teresa Infante, Carmela Fiorito, Stefano Panella, Lucio Barile, Ciro Mauro, Giuseppe Vassalli, Claudio Napoli
Summary: DNA methylation is associated with cardiovascular diseases (CVDs). This study found that circulating extracellular vesicles (EVs) from acute coronary syndrome (ACS) patients showed increased levels of DNA methyltransferases (DNMTs) and reduced Ten-eleven translocation (TET) genes. By treating lymphocytes from healthy individuals with EVs, it was discovered that DNMTs carried by EVs play an important role in DNA methylation. Furthermore, ACS-EVs were found to regulate signaling pathways and gene expression in target cells.
Article
Biochemistry & Molecular Biology
Lu Xue, Lingyu Bao, Julia Roediger, Yijun Su, Bingyin Shi, Yun-Bo Shi
Summary: Adult stem cells are crucial in organ physiology and tissue repair, yet the mechanisms of their development remain unclear. PRMT1, a coactivator of T3 receptor, is highly expressed during intestinal maturation. Knockout of PRMT1 in the intestine surprisingly leads to increased cell proliferation and changes in cell types in the crypt, indicating a potential regulation beyond T3-signaling in intestinal development.
CELL AND BIOSCIENCE
(2021)
Article
Medicine, Research & Experimental
Xiang-Rui Qiao, Tao Zheng, Yifei Xie, Xinyi Yao, Zuyi Yuan, Yue Wu, Dong Zhou, Tao Chen
Summary: Polymorphisms in miR-146a and miR-34b are associated with the development and prognosis of ACS. The rs2910164 variant of miR-146a is closely related to ACS risk and may activate the NF-kappa B inflammatory pathway through oxidized miR-146a mispairing with IKBA 3'UTR.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Wenke Jin, Jin Zhang, Xiya Chen, Siwen Yin, Haiyang Yu, Feng Gao, Dahong Yao
Summary: CARM1 is a type I protein arginine methyltransferase that catalyzes arginine methylation of histone and non-histone substrates, and is closely related to cancer occurrence and progression. This review summarizes the molecular structure of CARM1, its regulatory pathways, and discusses its oncogenic functions in tumor development. Furthermore, representative CARM1 inhibitors are demonstrated, focusing on their design strategies and potential therapeutic applications. These findings shed light on the understanding of CARM1 mechanisms and provide insights for the development of targeted cancer therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Medicine, Research & Experimental
Jihoon Tak, Yun Seok Kim, Tae Hyun Kim, Gil-Chun Park, Shin Hwang, Sang Geon Kim
Summary: This study demonstrates that ER stress-induced overexpression of G alpha(12) in hepatocytes promotes ferroptosis through dysregulation of ALOX12 mediated by ROCK1, as well as decreased miR-15a. Inhibition of G alpha(12) overexpression and/or the ROCK1 axis may be a promising therapeutic strategy for acute liver injury.
Article
Medical Laboratory Technology
Linlin Meng, Xin Yu, Haitao Han, Xu Jia, Boang Hu, Lei Zhang, Zhihao Wang, Wei Zhang, Ming Zhong, Hui Zhu
Summary: This study investigates the expression of plasma miR-143 and miR-145 in patients with ACS and their association with the severity of coronary artery stenosis. The results show that plasma levels of miR-143 and miR-145 are significantly decreased in ACS patients and negatively correlated with coronary stenosis. Thus, plasma levels of miR-143 and miR-145 can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
CLINICAL BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Harm, Alexander Bild, Kristina Dittrich, Andreas Goldschmied, Jeremy Nestele, Madhumita Chatterjee, Xiaoqing Fu, Kyra Kolb, Tatsiana Castor, Oliver Borst, Tobias Geisler, Dominik Rath, Michael LaeMmerhofer, Meinrad Gawaz
Summary: The study revealed significant changes in the platelet lipidome in ACS patients, with a particular up-regulation of glycerophospholipids. These lipid alterations may play a role in the pathophysiology of ACS.
CARDIOVASCULAR RESEARCH
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Yuan Lin, Qiong Liu, Fangchao Liu, Keyong Huang, Jianxin Li, Xueli Yang, Xinyan Wang, Jichun Chen, Xiaoqing Liu, Jie Cao, Chong Shen, Ling Yu, Fanghong Lu, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Xiangfeng Lu, Jianfeng Huang, Dongfeng Gu
Summary: The study found that sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults, especially for those with >= 10 h/day of sedentary time. Additionally, failure to achieve the recommended level of moderate-to-vigorous physical activity (MVPA) may further exacerbate the adverse associations, with the highest cancer and mortality risks observed among participants with both >= 10 h/day of sedentary time and <= 150 min/week of MVPA.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2021)
Article
Environmental Sciences
Xiaolong Xing, Fangchao Liu, Xueli Yang, Qiong Liu, Xinyan Wang, Zhennan Lin, Keyong Huang, Jie Cao, Jianxin Li, Meng Fan, Xiaotian Chen, Cuizhen Zhang, Shufeng Chen, Xiangfeng Lu, Dongfeng Gu, Jianfeng Huang
Summary: Exposure to PM2.5 was found to decrease HRV, but this effect can be mitigated in patients with controlled blood pressure or receiving ARB treatment. These findings suggest that better BP control and ARB treatment could help alleviate the adverse impacts of PM2.5 exposure on HRV.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Sihan Huang, Xinyu Zhang, Zhongying Liu, Fengchao Liang, Jianxin Li, Keyong Huang, Xueli Yang, Jichun Chen, Xiaoqing Liu, Jie Cao, Shufeng Chen, Chong Shen, Ling Yu, Yingxin Zhao, Ying Deng, Dongsheng Hu, Jianfeng Huang, Yang Liu, Xiangfeng Lu, Fangchao Liu, Dongfeng Gu
Summary: This study used data from the China-PAR project to assess the long-term impacts of PM2.5 on body mass index (BMI) and the risk of overweight/obesity in China. The results showed a significant association between increasing PM2.5 levels and higher BMI as well as an increased risk of overweight/obesity. The exposure-response curve indicated a non-linear relationship between PM2.5 exposure and overweight/obesity, with the association being modified by factors such as age, diabetes mellitus, hypertension, and dyslipidemia.
ENVIRONMENTAL RESEARCH
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Qiong Liu, Keyong Huang, Fengchao Liang, Xueli Yang, Jianxin Li, Jichun Chen, Xiaoqing Liu, Jie Cao, Chong Shen, Ling Yu, Yingxin Zhao, Ying Deng, Ying Li, Dongsheng Hu, Xiangfeng Lu, Yang Liu, Dongfeng Gu, Fangchao Liu, Jianfeng Huang
Summary: This study found an interaction between the benefits of regular physical activity and exposure to air pollution in highly polluted regions on hypertension risk. Regular physical activity was associated with a reduced risk of hypertension only among participants with low PM2.5 exposure.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2022)
Article
Nutrition & Dietetics
Shuying Li, Xiubiao Tian, Yiyun Wang, Xumei Zhang, Liwen Zhang, Chen Li, Jing Li, Chunhua Wang, Huihuan Liu, Juan Liu, Hongjuan Liu, Xueli Yang, Weiqin Li, Junhong Leng, Xilin Yang, Naijun Tang, Qiang Zhang
Summary: This study found that higher folate concentrations were associated with increased risk of GDM, while higher B-12 concentrations were associated with reduced risk. Pregnancies with the MTHFR rs1801131 TT genotype were more susceptible to OCM nutrient-related GDM.
Article
Ophthalmology
Yuanyuan Liu, Baoqun Yao, Xi Chen, Xueli Yang, Yong Liu, Zhenggao Xie, Xiaofeng Chen, Zhigang Yuan, Xingrong Wang, Dan Hu, Xiang Ma, Weiqi Gao, Ruifeng Wang, Yuzhong Yang, Song Chen, Jingkai Zhang, Zuoqing Song, Junsu Wang, Jing Wang, Jinyun Pei, Weijuan Wang, Meiyan Wang, Jun Gao, Hongwen Zhang, Lian Tan, Wei Du, Xuehui Pan, Gang Liu, Xiujuan Du, Xu Hou, Xin Gao, Zhen Zhang, Zhansheng Shen, Changfu Wu, Xiaochang Yan, Shaoye Bo, Xinghuai Sun, Nai-jun Tang, Chun Zhang, Hua Yan
Summary: This study investigated the prevalence of glaucoma and associated factors in rural populations in 10 provinces in China. The results showed a high prevalence of glaucoma in rural areas, with primary angle-closure glaucoma being the most common type. Increasing age, smoking, cerebral stroke, type 2 diabetes, higher education, and higher personal income were identified as significant risk factors for glaucoma. A family history of glaucoma was also associated with the prevalence of glaucoma and blindness.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Heyue Du, Qingyang Shi, Peige Song, Xiong-Fei Pan, Xueli Yang, Lingmin Chen, Yazhou He, Geng Zong, Ye Zhu, Baihai Su, Sheyu Li
Summary: This study reveals the global burden of high LDL-C and finds that while the overall burden of high LDL-C has been controlled in the past 30 years, it is still increasing in countries with moderate SDI and the decreasing trend is disappearing in high SDI countries.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Mengfan Yan, Han Ge, Liwen Zhang, Xi Chen, Xueli Yang, Fangchao Liu, Anqi Shan, Fengchao Liang, Xuejun Li, Zhao Ma, Guanghui Dong, Yamin Liu, Jie Chen, Tong Wang, Baoxin Zhao, Qiang Zeng, Xiangfeng Lu, Yang Liu, Nai-jun Tang
Summary: A retrospective cohort study in northern China found that long-term exposure to high levels of PM2.5 increases the risk of chronic respiratory diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Liqiong Guo, Yanhua Wang, Xueli Yang, Ting Wang, Jingjing Yin, Lei Zhao, Yang Lin, Yufei Dai, Shike Hou, Huawei Duan
Summary: This study found an association between occupational PM2.5 exposure and epigenetic changes in the mitochondrial genome, which subsequently led to adverse health outcomes. The study also revealed that platelet mitochondrial DNA methylation acted as an intermediary between PAH exposure and lung function decline.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ye Tong, Fangchao Liu, Keyong Huang, Jianxin Li, Xueli Yang, Jichun Chen, Xiaoqing Liu, Jie Cao, Shufeng Chen, Ling Yu, Yingxin Zhao, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Chong Shen, Dongfeng Gu
Summary: This study examines the association between changes in fasting blood glucose status and the risk of developing cardiovascular disease (CVD). The results suggest that individuals with long-standing impaired fasting glucose (IFG) and progression to diabetes mellitus (DM) have a higher risk of developing CVD.
JOURNAL OF DIABETES
(2023)
Article
Environmental Sciences
Xinyan Wang, Shuai Zhang, Huihui Yan, Zhao Ma, Yunshan Zhang, Haining Luo, Xueli Yang
Summary: This study investigated the association between ambient PM2.5, O3 pollution, and ovarian reserve in reproductive-aged Chinese women. The results showed that increased exposure to PM2.5 and O3 was associated with decreased AMH levels, indicating reduced ovarian reserve. Notably, the effects of O3 exposure on ovarian reserve were different from those of PM2.5 exposure.
ENVIRONMENTAL POLLUTION
(2024)
Article
Engineering, Environmental
Chenxi Yuan, Fangchao Liu, Keyong Huang, Chong Shen, Jianxin Li, Fengchao Liang, Xueli Yang, Jie Cao, Shufeng Chen, Dongsheng Hu, Jianfeng Huang, Yang Liu, Xiangfeng Lu, Dongfeng Gu
Summary: Previous studies have shown a significant link between PM2.5 exposure and ASCVD incidence. This study further demonstrates that the association between PM2.5 exposure and ASCVD risk is more pronounced in individuals with high ASCVD risk, highlighting the importance of reducing PM2.5 exposure in the Chinese population, especially those with high ASCVD risk.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Xue Xia, Yue Cai, Xiang Cui, Ruixian Wu, Fangchao Liu, Keyong Huang, Xueli Yang, Xiangfeng Lu, Shiyong Wu, Dongfeng Gu
Summary: The declining trend of cardiovascular disease mortality in China has significantly contributed to increased life expectancy. Improvement in mortality rates is more pronounced in females, however, attention is needed for insufficient improvements in young males. Emphasis should be placed on prevention and control of atherosclerotic cardiovascular disease and stroke sequelae.
CHINESE MEDICAL JOURNAL
(2022)
Letter
Medicine, General & Internal
Xinyu Zhang, Fangchao Liu, Jianxin Li, Sihan Huang, Xue Xia, Keyong Huang, Qiong Liu, Jichun Chen, Xueli Yang, Xiaoqing Liu, Jie Cao, Chong Shen, Ling Yu, Yingxin Zhao, Ying Deng, Ying Li, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
CHINESE MEDICAL JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Fangchao Liu, Zhennan Lin, Xinyan Wang, Xueli Yang, Qiong Liu, Xiaolong Xing, Jie Cao, Jianxin Li, Keyong Huang, Weli Yan, Tingting Liu, Wei Li, Shufeng Chen, Xiangfeng Lu, Dongfeng Gu, Jianfeng Huang
Summary: This study found that short-term PM2.5 exposure is associated with elevations and variability in blood pressure, and that the circadian rhythm of blood pressure and blood pressure load in hypertensive patients are influenced by different blood pressure statuses or medication.