Article
Environmental Sciences
Bin Wang, Heng Wan, Jing Cheng, Yingchao Chen, Yuying Wang, Yi Chen, Chi Chen, Wen Zhang, Fangzhen Xia, Ningjian Wang, Li Wang, Yingli Lu
Summary: Higher blood lead levels were associated with increased urinary albumin excretion in diabetic patients with vitamin D deficiency. However, this association was attenuated or non-significant in patients with sufficient vitamin D levels. The combination of high blood lead and low vitamin D levels corresponded to significantly higher urinary albumin-to-creatinine ratio. It was also found that the impact of blood lead levels on urinary albumin excretion was more pronounced in patients with reduced estimated glomerular filtration rate in the group with vitamin D deficiency.
ENVIRONMENTAL POLLUTION
(2021)
Review
Nutrition & Dietetics
Zaleha Md Isa, Norizzati Amsah, Norfazilah Ahmad
Summary: Vitamin D deficiency and insufficiency have negative effects on the outcome of Type 2 Diabetes Mellitus patients, including glycaemic control and the development of complications. Thus, screening for vitamin D levels in T2DM patients may be beneficial.
Article
Nutrition & Dietetics
Qunyan Xiang, Hui Xu, Junkun Zhan, Shuzhen Lu, Shuang Li, Yanjiao Wang, Yi Wang, Jieyu He, Yuqing Ni, Linsen Li, Yiyang Liu, Youshuo Liu
Summary: This study aimed to explore the association between insulin resistance (IR) and vitamin D deficiency (VDD). A negative correlation between the triglyceride-glucose (TyG) index and vitamin D level was found in patients with type 2 diabetes mellitus (T2DM). After adjusting for clinical and laboratory parameters, it was revealed that patients with higher TyG index had an increased risk of VDD in the T2DM population.
Article
Nutrition & Dietetics
Lulu Wang, Xue Liu, Jian Hou, Dandan Wei, Pengling Liu, Keliang Fan, Li Zhang, Luting Nie, Xing Li, Wenqian Huo, Tao Jing, Wenjie Li, Chongjian Wang, Zhenxing Mao
Summary: This study found a negative correlation between serum vitamin D and impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), as well as a negative correlation between serum 25(OH)D-2 and total 25(OH)D levels. The lipid profile, specifically total cholesterol (TC) and triglyceride (TG), partially mediated the relationship between vitamin D and IFG or T2DM. Additionally, there were interactive effects of serum 25(OH)D-2, total 25(OH)D, and testosterone on T2DM in females.
Article
Multidisciplinary Sciences
Jamil Said, David Lagat, Allan Kimaina, Chrispine Oduor
Summary: The study examined the relationship between serum vitamin D, insulin resistance, and beta cell function in a subpopulation of black Kenyan T2DM patients, and found that 74.1% of patients had vitamin D deficiency, which was positively correlated with beta cell function. The results indicate that beta cell dysfunction is more prominent than insulin resistance in this population.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Tahra Al Ali, Alizeh Ashfaq, Narjes Saheb Sharif-Askari, Salah Abusnana, Bashair M. Mussa
Summary: This study aims to investigate the association between vitamin D deficiency and diabetic neuropathy in Emirati patients with type 2 diabetes mellitus (T2DM). The results showed that among the 600 patients, 50% had diabetic neuropathy and these patients had lower vitamin D levels compared to those without neuropathy. The study suggests a high prevalence of vitamin D deficiency in Emirati patients with T2DM and highlights the importance of addressing this issue.
Article
Health Care Sciences & Services
Hang Zhao, Yong Tang, Chong Zheng, Luping Ren, Guangyao Song
Summary: This study found an independent association between vitamin D levels and insulin resistance in patients with type 2 diabetes mellitus.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Medicine, General & Internal
Wei-Jing Zhao, Xin-Yi Xia, Jun Yin
Summary: The study found that vitamin D deficiency is independently associated with a higher risk of DPN and DN in T2DM patients, but not DR. Additionally, vitamin D deficiency may serve as a potential predictor for both the occurrence and severity of DPN and DN.
CHINESE MEDICAL JOURNAL
(2021)
Review
Medicine, Research & Experimental
Qiaoli Zeng, Dehua Zou, Yue Wei, Yingguang Ouyang, Zhaohang Lao, Runmin Guo
Summary: This study evaluated the association between the VDR gene rs739837 and the risk of T2DM and GDM through a comprehensive meta-analysis and subgroup analysis. The results showed a significant association between VDR rs739837 polymorphism and T2DM susceptibility, while no association was found with GDM.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biology
Sushant Pokhrel, Nisha Giri, Rakesh Pokhrel, Bashu Dev Pardhe, Anit Lamichhane, Abhisek Chaudhary, Mahendra Prasad Bhatt
Summary: This study found that T2DM patients with poor glycemic control are more likely to develop dyslipidemia and cardiovascular disease risk due to vitamin D deficiency. There was a negative correlation between vitamin D levels and lipid markers, suggesting an important role of vitamin D in cardiovascular health of diabetes patients.
OPEN LIFE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Yujiao Jia, Tiantian Song, Zelin Li, Linling Zhou, Shuchun Chen
Summary: This study investigated the relationship between 25-hydroxyvitamin D and triglyceride glucose index levels in male and female patients with type 2 diabetes mellitus. The results showed a negative correlation between TyG levels and vitamin D levels in male patients, while no significant correlation was found in females. Additionally, the risk of vitamin D deficiency was significantly correlated with high TyG levels in the normal BMI group.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Medical Laboratory Technology
Yu Zhu, Ling Li, Ping Li
Summary: Vitamin D deficiency during pregnancy is common among women and can potentially affect the development and outcomes of gestational diabetes mellitus, but research results vary. Understanding the mechanisms of vitamin D deficiency on glucose metabolism and implementing vitamin D intervention are crucial for preventing and treating GDM.
CLINICA CHIMICA ACTA
(2022)
Article
Cardiac & Cardiovascular Systems
Bernadeta Chyrchel, Olga Kruszelnicka, Andrzej Surdacki
Summary: This study compared the effects of ticagrelor and clopidogrel on endothelial biomarkers and platelet reactivity in patients with acute coronary syndrome (ACS). The results showed that ticagrelor users had decreased platelet aggregation and soluble P-selectin levels compared to clopidogrel users. In addition, T2DM patients on ticagrelor had lower levels of soluble vascular cell adhesion molecule-1 compared to those on clopidogrel.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuxin Fan, Li Ding, Yalan Zhang, Hua Shu, Qing He, Jingqiu Cui, Gang Hu, Ming Liu
Summary: There is an association between vitamin D status and all-cause mortality among patients with type 2 diabetes. Very low or high concentrations of vitamin D may increase the risk of all-cause mortality in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zelin Li, Fei Wang, Yujiao Jia, Feiyue Guo, Shuchun Chen
Summary: This study found that the HGI levels were significantly higher in the vitamin D deficiency group compared to the group without deficiency, especially in female patients. The high HGI group had lower vitamin D levels compared to the low HGI group, and females had lower vitamin D levels but higher HGI levels compared to males. There was a negative correlation between 25(OH) D and HGI in all subjects, especially in the female subgroups.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Peripheral Vascular Disease
Ziying Lin, Hang Long Li, Man Fung Tsoi, Bernard Man Yung Cheung
Summary: This study evaluated the prevalence and factors associated with hypokalaemia in hydrochlorothiazide users. The study found a considerable prevalence of hypokalaemia among hydrochlorothiazide users, even among those who also took potassium supplements. Women, ethnic minorities, underweight individuals, monotherapy users, and participants with long-term therapy were more likely to have hypokalaemia.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Medicine, General & Internal
Mi Zhou, Duo Huang, Yangyang Cheng, Yee Man Lau, Wing Hon Lai, Yuk-Ming Lau, JoJo Hai, Chu Pak Lau, Esther W. Chan, Wen Sheng Yue, Ming-Liang Zuo, Li Xue Yin, Yingqing Feng, Ning Tan, Jiyan Chen, Xin Li Li, Hung Fat Tse, Chi Ho Lee, Wing-Sun Chow, Chung Wah Siu, Chun Ka Wong
Summary: This study implemented screening for left ventricular dysfunction in patients with type 2 diabetes mellitus and found a small percentage of patients at high risk for heart failure. Male gender, prior stroke, chronic kidney disease, and newly detected atrial fibrillation were significantly associated with elevated NT-proBNP levels. The study suggests that NT-proBNP and ECG screening can aid in early detection of cardiovascular complications and improve long-term outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hok Shing Tang, Chi Ting Kwan, Jianlong He, Pan Pan Ng, Siu Han Jojo Hai, Fung Yu James Kwok, Ho Fung Sze, Man Hon So, Hong Yip Lo, Ho Tung Ambrose Fong, Eric Yuk Fai Wan, Chi-Ho Lee, Esther Yee Tak Yu, Yee Tak Alta Lai, Chun Yin Jonan Lee, Siu Ting Leung, Hiu Lam Chan, Hung Fat Tse, Dudley J. Pennell, Raad H. Mohiaddin, Roxy Senior, Andrew T. Yan, Kai-Hang Yiu, Ming-Yen Ng
Summary: This study evaluated the prognostic utility of feature tracking (FT) parameters derived from cardiac magnetic resonance imaging (MRI) and found that left ventricular global longitudinal strain (LV GLS) is a significant independent predictor of adverse outcomes in patients with dilated cardiomyopathy (DCM). LV GLS can be used as a clinical indicator for predicting the prognosis of DCM patients and strengthens the clinical implementation of FT in cardiac MRI.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Endocrinology & Metabolism
Jia-Yi Huang, Yi-Kei Tse, Hang-Long Li, Cong Chen, Chun-Ting Zhao, Ming-Ya Liu, Mei-Zhen Wu, Qing-Wen Ren, Si-Yeung Yu, Denise Hung, Xin-Li Li, Hung-Fat Tse, Gregory Y. H. Lip, Kai-Hang Yiu
Summary: This study evaluated the association between prediabetes and heart failure, as well as the association of heart failure with changes in glycemic status. The results showed that prediabetes was associated with an increased risk of heart failure, while reverting to normoglycemia was associated with a decreased risk of heart failure.
Article
Medicine, General & Internal
Si-Yeung Yu, Hang-Long Li, Yi-Kei Tse, Xue Li, Qing-Wen Ren, Mei-Zhen Wu, Pui-Fai Wong, Hung-Fat Tse, Gregory. Y. H. Lip, Kai -Hang Yiu
Summary: The study aimed to investigate the potential protective effects of statin use among patients with infective endocarditis (IE), considering underlying diseases and bacterial culture variables. The effects of pre-admission and in-hospital statin use on mortality were estimated through propensity score analytics. The results showed that both pre-admission and in-hospital statin use were associated with a lower risk of 1-year mortality.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Cardiac & Cardiovascular Systems
Yi Kei Tse, Hang Long Li, Si Yeung Yu, Mei Zhen Wu, Qing Wen Ren, Jiayi Huang, Hung Fat Tse, Jeroen J. Bax, Kai Hang Yiu
Summary: This study examines the predictors, changes, and prognostic implications of right ventricular (RV) remodelling in patients undergoing double-valve surgery. The study found that RV remodelling is strongly related to adverse outcomes and should be considered in risk assessment and decision-making for double-valve surgery.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Medicine, General & Internal
Ziying Lin, Bernard Man Yung Cheung, Vicka Tang, Man Fung Tsoi
Summary: A retrospective study was conducted to evaluate the incidence of severe hypokalaemia requiring hospitalisation among hypertensive patients on indapamide. The study found that this condition is uncommon in patients on indapamide, especially in the initial weeks and months of treatment, and the use of sustained-release formulation reduces the risk.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Chun-Ka Wong, Tsun-Ho Lam, Song-Yan Liao, Yee-Man Lau, Hung-Fat Tse, Benjamin Y. F. So
Summary: Despite the success of immune checkpoint inhibitors (ICIs) in cancer treatment, the occurrence of immune-related adverse events (IRAEs) is a major concern. ICI-induced myocarditis is a severe form of IRAE, and understanding its pathogenesis and treatment is still limited. Mouse models have been developed to study ICI-induced myocarditis, but additional interventions are required to mimic the pathology in humans. This review focuses on the immunopathogenesis of ICI-induced myocarditis and its potential implications for treatment.
Article
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Marco Proietti, Tatjana Potpara, Moussa Mansour, Irina Savelieva, Hung Fat Tse, Andreas Goette, A. John Camm, Carina Blomstrom-Lundqvist, Dhiraj Gupta, Giuseppe Boriani
Summary: Stroke prevention in patients with atrial fibrillation has significantly improved with the introduction of non-vitamin K antagonist oral anticoagulants. Early rhythm control and cardiovascular risk factor management are also crucial in reducing the risk of stroke. Left atrial appendage occlusion or exclusion may be considered for patients who cannot undergo long-term oral anticoagulation. A holistic approach to atrial fibrillation management is recommended.
Editorial Material
Cardiac & Cardiovascular Systems
Yap-Hang Chan, Bernard M. Y. Cheung
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cell Biology
Eric Yuk Fai Wan, Anna Hoi Ying Mok, Vincent Ka Chun Yan, Cheyenne I. Ying Chan, Boyuan Wang, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Kai Hang Yiu, Hung Fat Tse, Chak Sing Lau, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: This study examines the risks of post-infection cardiovascular diseases (CVDs) among COVID-19 patients with different vaccination status. The findings indicate that vaccinated patients have a lower risk of CVD and all-cause mortality, with the lowest risk observed in those who completed three doses of vaccine. These results suggest a positive dose-response relationship between overall CVD risk reduction and the number of vaccine doses received.
CELL REPORTS MEDICINE
(2023)
Article
Primary Health Care
Juanying Zhen, Shuyun Liu, Guoru Zhao, Hao Peng, Aimin Xu, Chao Li, Jun Wu, Bernard Man Yung Cheung
Summary: This study investigates the relationship between lifestyle and hypertension in a Chinese population and finds that a healthy lifestyle score is inversely related to the risk of hypertension. This highlights the importance of addressing lifestyle to reduce the risk of hypertension.
Meeting Abstract
Cardiac & Cardiovascular Systems
X. Ye, E. S. Y. Chan, K. K. C. Man, C. K. Wong, H. F. Tse, E. W. Chan
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
N. M. C. Nga Man Carman Cheung, M. Z. Wu, Q. W. Ren, J. Y. Huang, Y. K. Tse, H. F. Tse, K. H. Yiu
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Ho-Ting Ngan, Kwong-Yue Chan, Chun-Ka Wong, Ka-Chun Un, Shu-Yue Sze, Puigi Shea, Cheung-Chi Lam, Yui-Ming Lam, Chor-Cheung Tam, Chu-Pak Lau, Hung-Fat Tse
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)