Article
Environmental Sciences
Sara Ibrahim Hemmo, Abdallah Y. Naser, Hassan Alwafi, Munthir M. Mansour, Abeer F. R. Alanazi, Zahraa Jalal, Zahra Khalil Alsairafi, Vibhu Paudyal, Esra'a Alomari, Hamzeh Al-Momani, Emad M. Salawati, Mohammed Samannodi, Mohammad S. Dairi, Abdel Qader Al Bawab, Moaath K. Mustafa Ali, Saqer Alkharabsheh
Summary: The study revealed a significant increase in cardiovascular disease medication prescriptions in England and Wales over the past 15 years, while there was a notable decrease in hospitalization rates due to ischemic heart disease. This increase in medication prescriptions was correlated with the decrease in hospitalization rates for ischemic heart disease, potentially attributed to better control of risk factors associated with the disease.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Richard Border, Georgios Athanasiadis, Alfonso Buil, Andrew J. Schork, Na Cai, Alexander I. Young, Thomas Werge, Jonathan Flint, Kenneth S. Kendler, Sriram Sankararaman, Andy W. Dahl, Noah A. Zaitlen
Summary: The study introduces cross-trait assortative mating (xAM) as an alternative explanation for genetic correlations between different human traits, showing that xAM affects various phenotypes and can plausibly account for a substantial portion of genetic correlation estimates. The results suggest that previous reports may have overestimated the true genetic similarity between many phenotypes.
Article
Cardiac & Cardiovascular Systems
Lin Zhang, Yue Li, Hongxiu Li, Roujia Wang, Chunyu Wang, Hongsheng Sun, Keyang Zheng, Yujuan Zhang
Summary: This study aimed to investigate the independent effect of admission heart rate (HR) on the risk of major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) patients with different left ventricular ejection fraction (LVEF) levels. The study found that patients with higher admission HR had a significantly higher risk for MACEs. There was a significant interaction between LVEF and HR, indicating that LVEF levels should be considered when evaluating the association between admission HR and the prognosis of AMI patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Daniele Cappellani, Giulia Marconcini, Luca Manetti, Luigi Bartalena, Fausto Bogazzi
Summary: The first-line medical therapy for patients with amiodarone-induced thyrotoxicosis (AIT) affects the outcome of AIT patients, with appropriate therapy reducing the risk of cardiovascular events and hospitalizations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Oncology
A. Palazzo, C. Ciccarese, R. Iacovelli, M. C. Cannizzaro, A. Stefani, L. Salvatore, E. Bria, G. Tortora
Summary: The use of PARP inhibitors in cancer treatment is associated with an increased risk of cardiovascular events, hypertension, and thromboembolic events. However, routine cardiovascular monitoring may not be necessary in asymptomatic patients due to the low incidence of high-grade adverse events.
Article
Cardiac & Cardiovascular Systems
Celestino Sardu, Maria Consiglia Trotta, Ferdinando Carlo Sasso, Cosimo Sacra, Gerardo Carpinella, Ciro Mauro, Fabio Minicucci, Paolo Calabro, Michele D' Amico, Fabrizio D' Ascenzo, Ovidio De Filippo, Mario Iannaccone, Carmine Pizzi, Giuseppe Paolisso, Raffaele Marfella
Summary: This study assessed the effects of SGLT2-I therapy on Mv-NOCS patients and found that it significantly reduces the risk of major adverse cardiovascular events by improving glucose homeostasis, reducing systemic inflammation, and affecting the inflammation, lipid accumulation, and fibrous cap thickness of atherosclerotic plaques.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Mathematical & Computational Biology
Xiaoxi Shen, Yalu Wen, Yuehua Cui, Qing Lu
Summary: Genetic studies and population genetics theory suggest that complex diseases are characterized by genetic heterogeneity, with rare mutations potentially playing an important role. A conditional autoregressive model is proposed to consider heterogeneous genetic effects among individuals. The proposed method outperforms others when rare variants have a major contribution to the disease or when genetic effects vary in different individuals or subgroups.
STATISTICS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Kenneth Ekoru, Adebowale A. Adeyemo, Guanjie Chen, Ayo P. Doumatey, Jie Zhou, Amy R. Bentley, Daniel Shriner, Charles N. Rotimi
Summary: The study evaluated the predictive utility of genetic risk scores (GRS) for cardiometabolic traits in sub-Saharan Africans, African Americans, and European Americans. Results showed that GRS had significantly greater predictive utility in European Americans compared to African Americans and sub-Saharan Africans across all traits, especially for lipid traits. This highlights the need to improve diversity in genomic studies to ensure equitable clinical translation of GRS.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Endocrinology & Metabolism
Aleena Shujaat Ali, Cecilia Pham, Grant Morahan, Elif Ilhan Ekinci
Summary: This systematic review summarizes the existing evidence of genetic risk scores (GRSs) for predicting diabetic kidney disease (DKD) in people with type 1 or type 2 diabetes. Most studies of high methodological quality reported a statistically significant association between GRS and at least one measure of DKD. GRSs can be used to identify people with diabetes at high risk of developing DKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Geriatrics & Gerontology
Chi Yan, Zhimeng Xu, Weiqiang Huang
Summary: Ischemic heart disease leads to ischemic cardiomyopathy, which can be improved by angiogenesis, myogenesis, and targeting cellular senescence. Accumulation of senescent cells is a risk factor for cardiovascular diseases like atherosclerosis and myocardial infarction, highlighting the importance of understanding and addressing cellular senescence in heart health. Therapeutic strategies targeting senescent cells may hold promise for preventing cardiovascular diseases related to ischemic heart disease.
Article
Biochemistry & Molecular Biology
Jonathan L. Hess, Daniel S. Tylee, Manuel Mattheisen, Anders D. Borglum, Thomas D. Als, Jakob Grove, Thomas Werge, Preben Bo Mortensen, Ole Mors, Merete Nordentoft, David M. Hougaard, Jonas Byberg-Grauholm, Marie Baekvad-Hansen, Tiffany A. Greenwood, Ming T. Tsuang, David Curtis, Stacy Steinberg, Engilbert Sigurdsson, Hreinn Stefansson, Kari Stefansson, Howard J. Edenberg, Peter Holmans, Stephen Faraone, Stephen J. Glatt
Summary: This study proposed a theoretical framework based on genetic variations that promote resilience to highly heritable polygenic disorders, such as schizophrenia. By establishing a procedure to identify unaffected individuals with relatively high polygenic risk for the disease and generating the first known polygenic resilience score, this work laid a foundation for finding resilience variants for any complex, heritable disorder.
MOLECULAR PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Miaomiao Niu, Liying Zhang, Yikang Wang, Runqi Tu, Xiaotian Liu, Chongjian Wang, Ronghai Bie
Summary: This study explored the joint effects of genetic and lifestyle factors on blood pressure and hypertension in rural Chinese adults. The findings suggest that individuals with high genetic risk and unhealthful lifestyles are at a higher risk of hypertension, highlighting the importance of adhering to a healthful lifestyle in precision prevention of hypertension.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Atul Kumar, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson, Niklas Mattsson-Carlgren
Summary: This study investigated the associations between genetic risk factors for Alzheimer's disease (AD) and biomarkers in cerebrospinal fluid (CSF). The results showed that the genetic risk scores were associated with higher levels of soluble phosphorylated tau, and these associations were partly mediated by beta-amyloid pathology. The study identified Aβ-dependent and Aβ-independent subsets of the genetic risk scores. The findings have implications for the development of anti-tau drugs.
Article
Biochemistry & Molecular Biology
Ximei Huang, Youngmin Han, Kyunghye Jang, Minjoo Kim
Summary: In this study, a prediction model combining a genetic risk score and an oxidative stress score was found to have significant predictive ability for the incidence of prediabetes and type 2 diabetes in the Korean population. The genetic risk score and oxidative stress score showed significant associations with prediabetes and type 2 diabetes incidence.
Article
Nutrition & Dietetics
Jun Wang, Jianxin Li, Fangchao Liu, Keyong Huang, Xueli Yang, Xiaoqing Liu, Jie Cao, Shufeng Chen, Chong Shen, Ling Yu, Fanghong Lu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Dongfeng Gu, Xiangfeng Lu
Summary: This study evaluated the association between fruit intake and stroke risk, considering genetic predisposition. The findings suggest that increasing fruit intake can reduce stroke risk in individuals irrespective of their genetic risk, with greater absolute risk reductions observed in those with a high genetic risk.
Editorial Material
Cardiac & Cardiovascular Systems
Silvia Pulignani, Maria Grazia Andreassi
REVISTA ESPANOLA DE CARDIOLOGIA
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Alberto Aimo, Nicoletta Botto, Simona Vittorini, Michele Emdin
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2019)
Article
Biology
Maurizio Portaluri, Maria Fonte Petruzzelli, Francesco Tramacere, Maria Grazia Andreassi
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Environmental Sciences
Maria Grazia Andreassi, Andrea Borghini, Cecilia Vecoli, Emanuela Piccaluga, Giulio Guagliumi, Maurizio Del Greco, Fiorenzo Gaita, Eugenio Picano
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2020)
Article
Cardiac & Cardiovascular Systems
Giovanni Donato Aquaro, Antonio De Luca, Chiara Cappelletto, Francesca Raimondi, Francesco Bianco, Nicoletta Botto, Andrea Barison, Simona Romani, Pierluigi Lesizza, Enrico Fabris, Giancarlo Todiere, Crysanthos Grigoratos, Alessandro Pingitore, Davide Stolfo, Matteo Dal Ferro, Marco Merlo, Gianluca Di Bella, Gianfranco Sinagra
Article
Biotechnology & Applied Microbiology
Michael Fenech, Siegfried Knasmueller, Lisbeth E. Knudsen, Micheline Kirsch-Volders, Permal Deo, Bernhard Franzke, Helga Stopper, Maria-Grazia Andreassi, Claudia Bolognesi, Varinderpal S. Dhillon, Blanca Laffon, Karl-Heinz Wagner, Stefano Bonassi
Summary: The purpose of the Micronuclei and Disease special issue is to investigate the association of micronuclei with various diseases in humans, define mechanisms of this association, and identify gaps in knowledge for translating micronuclei assays into clinical practice. The issue includes 14 papers covering topics such as mechanisms of micronuclei formation, associations with different diseases, effects of interventions on micronuclei frequency, and a roadmap for clinical application. Most studies reviewed were case-control studies, with meta-analyses showing different mean ratios for micronuclei frequencies in non-cancer diseases and cancers, indicating the potential of micronuclei assays in identifying high-risk patients for preventive therapy.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Review
Medicine, General & Internal
Vincenzo Castiglione, Martina Modena, Alberto Aimo, Enrica Chiti, Nicoletta Botto, Simona Vittorini, Benedetta Guidi, Giuseppe Vergaro, Andrea Barison, Andrea Rossi, Claudio Passino, Alberto Giannoni, Marco Di Paolo, Michele Emdin
Summary: Molecular autopsy is the process of investigating sudden death through genetic analysis, particularly useful in cases where traditional autopsy does not provide conclusive answers. The adoption of next-generation sequencing technology has increased the detection rate of pathogenic variants and discovered new genotype-phenotype associations, but has also brought challenges in interpreting the large number of variants of unknown significance.
Article
Biochemistry & Molecular Biology
Ivana Barravecchia, Chiara De Cesari, Mattia Forcato, Francesca Scebba, Olga Pyankova, Joanna M. Bridger, Helen A. Foster, Giovanni Signore, Andrea Borghini, Mariagrazia Andreassi, Massimiliano Andreazzoli, Silvio Bicciato, Mario Enrico Pe, Debora Angeloni
Summary: Microgravity and space radiation have distinct effects on human endothelial cells in space flight, triggering different molecular pathways and leading to specific changes in cell structure and function. Tailored countermeasures should be developed separately for microgravity and space radiation to protect astronauts' health effectively.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Biancamaria Pierri, Carlo Buonerba, Andrea Pierri, Antonio Pizzolante, Amedeo Ferro, Anna Crispo, Valentina Bollati, Tiffany R. Sanchez, Maria Grazia Andreassi, Mauro Esposito, Pellegrino Cerino
Summary: This study proposes a new biomonitoring model based on a whole systemic analytical evaluation of environmental context, aiming to evaluate the risk of exposure to environmental pollutants, predict potential correlated clinical outcomes, and support public health interventions. It combines healthy human subjects in the cohort to identify potential risks of exposure and predict possible correlated clinical outcomes, particularly focusing on areas with high levels of pollution like the Campania region.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Andrea Rossi, Alberto Giannoni, Martina Nesti, Pasquale Notarstefano, Vincenzo Castiglione, Gianluca Solarino, Lucio Teresi, Gianluca Mirizzi, Vincenzo Russo, Luca Panchetti, Umberto Startari, Andrea Ripoli, Francesco Gentile, Amato Santoro, Nicoletta Botto, Giancarlo Casolo, Juan Sieira, Maurizio Pieroni, Pasquale Santangeli, Michele Emdin, Marcello Piacenti
Summary: Heterogeneity of refractory periods in the right ventricular outflow tract (RVOT) and right ventricular (RV) apex is a strong independent predictor of life-threatening arrhythmias in patients with Brugada syndrome (BrS), beyond traditional predictors and inducibility of ventricular tachycardia/ventricular fibrillation at electrophysiological study (EPS).
Article
Biochemistry & Molecular Biology
Maria Grazia Andreassi, Nadia Haddy, Mats Harms-Ringdahl, Jonica Campolo, Andrea Borghini, Francois Chevalier, Jochen M. Schwenk, Brice Fresneau, Stephanie Bolle, Manuel Fuentes, Siamak Haghdoost
Summary: The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission with the aim of improving understanding of long-term ionizing radiation risks for pediatric patients. This paper provides a detailed overview of the project's rationale, design, and methods for the biological aspect, with objectives to understand the molecular pathways and identify potential biomarkers involved in long-term health risks. Biological samples will be collected at three time points, and state-of-the-art analytical methods will be used to assess biomarker levels and explore proteomics and miRNA transcriptomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maria Grazia Andreassi
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Borghini, Antonella Mercuri, Jonica Campolo, Marina Parolini, Rudina Ndreu, Stefano Turchi, Maria Grazia Andreassi
Summary: A strong relationship between Chr9p21 rs1333049 variant and LTL was identified, and they interactively affect the risk of poor prognosis in CAD patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jonica Campolo, Andrea Borghini, Marina Parolini, Antonella Mercuri, Stefano Turchi, Maria Grazia Andreassi
Summary: Clinical and epidemiological evidence suggests a link between coronary artery disease (CAD) and cancer. This study aimed to identify risk factors and biomarkers that could predict cancer incidence and death in CAD patients. The study found that age, smoking, obesity, and systemic inflammatory indexes were associated with cancer incidence, while age was a predictor of cancer death. Lung and gastrointestinal cancer patients had higher levels of a specific biomarker. The study suggests that reducing risk factors and suppressing chronic inflammation may help prevent cancer in CAD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Donato Aquaro, Antonio De Luca, Chiara Cappelletto, Francesca Raimondi, Francesco Bianco, Nicoletta Botto, Pierluigi Lesizza, Crysanthos Grigoratos, Monia Minati, Matteo Dell'Omodarme, Alessandro Pingitore, Davide Stolfo, Matteo Dal Ferro, Marco Merlo, Gianluca Di Bella, Gianfranco Sinagra
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)