Review
Medicine, General & Internal
Piotr K. Zakrzewski
Summary: Endometrial cancer is a major gynecological cancer among women in their menopausal and postmenopausal age, and the canonical TGF beta pathway plays a crucial role in its development and progression. The TGF beta cascade can act as both a tumor suppressor and tumor promoter, with its effects on endometrial cancer cells depending on the cancer disease stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Qian Huang, Rui Xiao, Jing Lu, Yao Zhang, Liang Xu, Jie Gao, Jing Sun, Haiping Wang
Summary: This study revealed that endoglin exacerbated PF by regulating the activation of TGF-beta/ALK/Smads signaling, while its knockdown could alleviate peritoneal injury, providing a novel potential therapeutic target in PF.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Isabel Burghardt, Elisa Ventura, Tobias Weiss, Judith Johanna Schroeder, Katharina Seystahl, Christian Zielasek, Dorothee Gramatzki, Michael Weller
Summary: Microvascular proliferation is a key feature of glioblastoma, and alternative angiogenic pathways may need to be explored as drug targets as anti-VEGF therapy does not prolong overall survival. Endoglin, a marker of proliferating endothelium, was found to have similar protein levels in tumor stroma and endothelium, correlated with proteins of TGF-beta superfamily signaling, but did not show a prognostic role in glioblastoma. Silencing the endoglin gene in glioma cells and human cerebral microvascular endothelial cells did not significantly affect TGF-beta superfamily ligand-dependent signaling, challenging the notion of endoglin as a promising therapeutic target in glioblastoma.
CELL AND TISSUE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tessa Gerrits, Isabella J. Brouwer, Kyra L. Dijkstra, Ron Wolterbeek, Jan A. Bruijn, Marion Scharpfenecker, Hans J. Baelde
Summary: Chronic kidney disease (CKD) involves progressive deterioration of renal function, characterized by glomerular sclerosis, tubular atrophy, and interstitial fibrosis. Endoglin, expressed in endothelial cells and fibroblasts, may function as a co-receptor of TGF signaling and potentially play a role in the progression of CKD. The study found that endoglin was upregulated in patients with CKD, particularly those with chronic allograft dysfunction and diabetic nephropathy. The overexpression of endoglin in human kidney fibroblasts also resulted in increased mRNA and protein upregulation of ECM components, suggesting its significance as a therapeutic target for the prevention of end-stage renal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zahira Deza, Giselle Romero Caimi, Miret Noelia, Lucia Coli, Ezequiel Ridruejo, Laura Alvarez
Summary: This study evaluated the antiproliferative and antiangiogenic effects of atorvastatin (AT) in the development of hepatocellular carcinoma (HCC). The results showed that AT inhibits the growth of liver tumors and cell proliferation, as well as the formation of blood vessels. These antitumor effects may be mediated by disrupting multiple hepatocarcinogenic pathways.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Mitsuharu Okutsu, Mami Yamada, Ken Tokizawa, Shuri Marui, Katsuhiko Suzuki, Vitor A. Lira, Kei Nagashima
Summary: Regular exercise helps protect arterial endothelial cells and reduce atherosclerotic plaque formation in mice, potentially through increasing autophagy levels in endothelial cells.
Article
Biochemistry & Molecular Biology
Lidia Ruiz-Llorente, M. Cristina Vega, Francisco J. Fernandez, Carmen Langa, Nicholas W. Morrell, Paul D. Upton, Carmelo Bernabeu
Summary: sEng is the soluble form of endoglin, expressed at high levels in various diseases. It serves as a marker of cardiovascular damage and tumor development, plays a pathogenic role in conditions like preeclampsia, and inhibits angiogenesis and tumor proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mahendra Jadhao, Chun-Lin Chen, Wangta Liu, Dhanashri Deshmukh, Wei-Ting Liao, Jeff Yi-Fu Chen, Ritesh Urade, Eing-Mei Tsai, Sheng-Kai Hsu, Li-Fang Wang, Chien-Chih Chiu
Summary: This study investigated the impact of phthalate exposure on angiogenesis in triple-negative breast cancer cells. The findings revealed that exposure to phthalates induced angiogenesis in breast cancer cells. Additionally, the overexpression of the glycoprotein endoglin (ENG) was found to be associated with tumor development and growth, and knocking down ENG inhibited phthalate-induced angiogenesis. Targeting ENG could potentially serve as an alternative treatment for controlling angiogenesis, limiting metastasis, and inhibiting cancer progression.
Review
Cell Biology
Cadence F. Lee, Rachel E. Carley, Celia A. Butler, Alan R. Morrison
Summary: Coronary artery disease caused by atherosclerosis is a major global cause of morbidity and mortality, with inflammation mediated by immune signaling mechanisms playing a key role. Targeting hypercholesterolemia is a critical strategy in current treatments for atherosclerotic vascular disease, and future directions may involve regulating immune signaling pathways.
Review
Genetics & Heredity
Navneet Kumar, Chandi C. Mandal
Summary: Cholesterol accumulation in cancer cells is associated with tumor development, while cholesterol-lowering drugs have been found to play a role in the prevention and treatment of various cancers. Dysregulation of Akt in cancer is common and targeting Akt is considered an effective approach for cancer therapy. Cholesterol-lowering drugs affect Akt expression and activation in cancer cells, showing anticancer activity in different types of cancers.
FRONTIERS IN GENETICS
(2021)
Review
Cardiac & Cardiovascular Systems
Luis M. Beltran Romero, Antonio J. Vallejo-Vaz, Ovidio Muniz Grijalvo
Summary: High cholesterol is a causal factor for atherosclerotic cardiovascular disease, and statins play a central role in reducing the risk of cardiovascular events. Different types of stroke have different causes and pathophysiology, and survivors of stroke are at high risk for recurrence and death.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cell Biology
Maoduo Zhang, Ying Yi Zhang, Yongze Chen, Jia Wang, Qiang Wang, Hezhe Lu
Summary: The TGF-beta pathway in cancer has dual roles and is considered a potential new avenue for cancer therapy, but its functions and mechanisms of action require further investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Shaoyan Gao, Xiaohe Li, Qiuyan Jiang, Qing Liang, Fangxia Zhang, Shuangling Li, Ruiqin Zhang, Jiaoyan Luan, Jingyan Zhu, Xiaoting Gu, Ting Xiao, Hui Huang, Shanshan Chen, Wen Ning, Guang Yang, Cheng Yang, Honggang Zhou
Summary: Our study demonstrates that PKM2 promotes fibrosis progression by interacting with Smad7 and enhancing TGF-beta 1 signaling. Increased expression of PKM2 in the lungs of mice with pulmonary fibrosis contributes to fibrosis development. The PKM2 tetramer enhances TGF-beta 1 signaling by directly binding with Smad7, making it a key factor in fibrosis progression.
Review
Medicine, General & Internal
Silvia Grignaschi, Anna Sbalchiero, Giuseppe Spinozzi, Bianca Lucia Palermo, Claudia Cantarini, Chantal Nardiello, Lorenzo Cavagna, Carla Olivieri
Summary: This systematic review investigates the relationship between Endoglin (ENG) and Systemic Sclerosis (SSc) through the analysis of clinical and molecular studies. The results suggest that ENG expression is altered in SSc-affected cells and different disease phenotypes may be related to peculiar disregulations in soluble ENG concentrations.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Fei Lu, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu, Mulin Liu
Summary: The study found that CRC patients with high GPC1 expression had poor overall survival, and GPC1 may promote proliferation and migration of CRC cells by influencing the TGF-beta 1 signaling pathway. Additionally, silencing GPC1 inhibited TGF-beta 1 levels and increased SMAD2 expression.
Article
Genetics & Heredity
J. Visek, M. Blaha, V Blaha, M. Lasticova, M. Lanska, C. Andrys, J. Duintjer Tebbens, Ivone Cristina Igreja e Sa, K. Tripska, M. Vicen, I Najmanova, P. Nachtigal
Summary: The study analyzed data from FH patients undergoing lipoprotein apheresis (LA) treatment over 15 years, showing that long-term LA treatment significantly reduced cholesterol levels, improved endothelial dysfunction, and decreased levels of inflammation biomarkers in FH patients.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Alaei Faradonbeh, Ivone Igreja Sa, Hana Lastuvkova, Jolana Cermanova, Milos Hroch, Hana Faistova, Jaroslav Mokry, Zuzana Nova, Martin Uher, Petr Nachtigal, Petr Pavek, Stanislav Micuda
Summary: Metformin was found to stimulate bile secretion in healthy mice by increasing liver bile acid synthesis and intestinal bile acid reabsorption. However, when used in combination with estrogen, metformin exacerbated bile secretion impairment and led to a significant increase in plasma bile acid concentrations.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Hana Lastuvkova, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Milos Hroch, Jaroslav Mokry, Hana Faistova, Zuzana Nova, Radomir Hyspler, Ivone Cristina Igreja Sa, Petr Nachtigal, Alzbeta Stefela, Petr Pavek, Stanislav Micuda
Summary: Atorvastatin modulates bile acid metabolomics significantly by altering their intestinal processing and liver synthesis in control and NASH mice, improving liver conditions and reducing steatosis and inflammation in NASH animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Adela Diepoltova, Klara Konecna, Ondrej Jand'ourek, Petr Nachtigal
Summary: The study found that under specific conditions, the supplementation of tryptic soy broth with HP and using the shaking mode significantly promoted biofilm formation on pegs for Staphylococcus aureus. However, Staphylococcus epidermidis did not form biofilms on pegs under the same conditions. Preconditioning peg surfaces with FBS and HP led to a significant increase in biofilm biomass production for Staphylococcus epidermidis.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Katarina Tripska, Ivone Cristina Igreja Sa, Martina Vasinova, Matej Vicen, Radim Havelek, Samira Eissazadeh, Zuzana Svobodova, Barbora Vitverova, Charles Theuer, Carmelo Bernabeu, Petr Nachtigal
Summary: This study found that blocking the endoglin receptor using TRC105 can counteract endothelial dysfunction induced by high cholesterol and high glucose, suggesting that endoglin may be a potential therapeutic target for disorders associated with elevated cholesterol and glucose levels.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ivone Cristina Igreja Sa, Katarina Tripska, Fatemeh Alaei Faradonbeh, Milos Hroch, Hana Lastuvkova, Jolana Schreiberova, Marian Kacerovsky, Miguel Pericacho, Petr Nachtigal, Stanislav Micuda
Summary: Labetalol exacerbates the accumulation of bile acids (BA) in estrogen-induced cholestasis and soluble endoglin (sEng) aggravates this retention. Increased sEng levels might explain the coincidence of intrahepatic cholestasis of pregnancy (ICP) with preeclampsia. Monitoring of BA in pregnant women with preeclampsia and labetalol therapy is recommended.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Pavel Barta, Petr Nachtigal, Jana Maixnerova, Lenka Zemankova, Frantisek Trejtnar
Summary: Freshly isolated rat renal cells have been found to be an effective tool for evaluating the cellular uptake of receptor-specific peptide analogs, especially those that are taken up by renal epithelial cells.
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Eissazadeh, F. Alaei Faradonbeh, I. A. Igreja Sa, I. Nemeckova, K. Tripska, M. Vasinova, B. Vitverova, J. Rathouska, P. Nachtigal
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Lasticova, J. Visek, V. Blaha, M. Blaha, V. Liptak, P. Nachtigal
Article
Cardiac & Cardiovascular Systems
Iveta Nejmanova, Barbora Vitverova, Samira Eissazadeh, Katarina Tripska, Ivone Cristina Igreja Sa, Radomir Hyspler, Ivana Nemeckova, Miguel Pericacho, Petr Nachtigal
Summary: The study demonstrated that long-term exposure to high levels of sEng during aging can aggravate vascular function, leading to alterations in vasoconstriction properties and Eng signaling pathway. sEng may be considered a potential risk factor for the development of vascular dysfunction during aging.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
I. C. Igreja Sa, K. Tripka, S. Micuda, P. Nachtigal
Meeting Abstract
Cardiac & Cardiovascular Systems
K. Tripka, M. Vicen, R. Havelek, I. C. Igreja Sa, S. Eissazadeh, B. Vitverova, P. Nachtigal
Meeting Abstract
Cardiac & Cardiovascular Systems
V. Blaha, M. Blaha, M. Lanska, C. Andrys, J. D. Tebbens, I. C. Igreja Sa, K. Tripska, M. Vicen, J. Visek, M. Lasticova, P. Nachtigal
Meeting Abstract
Cardiac & Cardiovascular Systems
I. C. Igreja Sa, K. Tripka, H. Lastuvkova, M. Hroch, R. Hyspler, E. Dolezelova, S. Eissazadeh, M. Vasinova, S. Micuda, P. Nachtigal
