Article
Nutrition & Dietetics
Wojciech Tanski, Natalia Swiatoniowska-Lonc, Mateusz Tabin, Beata Jankowska-Polanska
Summary: This systematic review analyzed 71 studies and found that increased consumption of omega-3 fatty acids may have a beneficial effect on reducing pain and disease activity in patients with rheumatoid arthritis (RA). The studies demonstrated the positive influence of unsaturated fatty acids on the clinical parameters of RA. The content of omega-3 fatty acids in the diet, mainly derived from fish, may contribute to a lower incidence of RA. The review suggests that a diet rich in long-chain unsaturated fatty acids should be the standard of care, along with pharmacotherapy, in the treatment of RA.
Article
Sport Sciences
Xiquan Weng, Chaoge Wang, Yu Yuan, Zhenhuan Wang, Jujiao Kuang, Xu Yan, Hao Chen
Summary: The study investigated the effects of exercise and cold exposure on insulin sensitivity and serum free fatty acid levels in diet-induced obese rats. The results showed that both exercise and cold exposure independently reduced insulin resistance. Exercise reduced serum free fatty acids, while cold exposure had no effect. There was a positive correlation between insulin resistance and serum free fatty acid levels. The combination of exercise and cold exposure reduced subcutaneous and visceral fat ratios. Additionally, exercise and cold exposure increased protein expression related to fatty acid uptake and oxidation in muscle.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Nutrition & Dietetics
Johanna Sigaux, Alice Bellicha, Camille Buscail, Chantal Julia, Rene-Marc Flipo, Alain Cantagrel, Francois Laporte, Caroline Beal, Marie-Christophe Boissier, Luca Semerano
Summary: This study aimed to investigate the relationship between serum lipid profiles and disease activity in patients with early rheumatoid arthritis (RA). The study found that a serum lipid profile rich in n-3 fatty acids was independently associated with persistently reduced disease activity, while a profile rich in n-6 fatty acids was associated with lower disease activity.
Article
Biochemistry & Molecular Biology
Ashraf Nahle, Yemisi Deborah Joseph, Sandra Pereira, Yusaku Mori, Frankie Poon, Hilda E. Ghadieh, Aleksandar Ivovic, Tejas Desai, Simona S. Ghanem, Suman Asalla, Harrison T. Muturi, Emelien M. Jentz, Jamie W. Joseph, Sonia M. Najjar, Adria Giacca
Summary: The study showed that NMN can improve glucose tolerance caused by a high-fat diet, but it may impair glucose tolerance under normal levels of free fatty acids. Therefore, caution should be exercised when considering the therapeutic use of NMN due to its dual effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ali Taylan, Baris Akinci, Burak Toprak, Merih Birlik, Fatma Demet Arslan, Hasan Ekerbicer, Baris Gundogdu, Ayfer Colak, Bahar Engin
Summary: This study investigated the relationship between disease activity and adipocytokine levels in early rheumatoid arthritis patients, finding that those with high disease activity had higher BMI and leptin levels, which decreased after treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Domenico Sergi, Juana Maria Sanz, Stefano Lazzer, Gloria Brombo, Giovanni Zuliani, Gianni Biolo, Bostjan Simunic, Rado Pisot, Edoardo Dalla Nora, Angelina Passaro
Summary: Dietary lipids play a crucial role in modulating metabolic inflammation, and interleukin 18 (IL-18) has been consistently linked to obesity and insulin resistance. This study aimed to assess if the quality of lipid intake affects IL-18 plasma levels and its implications on insulin resistance. The study confirmed that IL-18 is positively correlated with insulin resistance, and individuals with higher HOMA-IR levels displayed elevated IL-18 levels. The quality of dietary lipids, particularly the ratio between different fatty acids and the intake of omega-3, showed a negative correlation with IL-18 levels.
Article
Endocrinology & Metabolism
Chao Cao, Han-Chow E. Koh, Stephan Van Vliet, Bruce W. Patterson, Dominic N. Reeds, Richard Laforest, Robert J. Gropler, Bettina Mittendorfer
Summary: This study found that enhanced FFA clearance in people with obesity is negatively correlated with muscle insulin sensitivity, and the stimulatory effect of insulin on FFA clearance is more significant in obese individuals.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Multidisciplinary Sciences
Wenwen Huang, Yiping Zhang, Liping Zhong, Chunlong Sun, Zaiwang Zhang
Summary: A new method for determining the isomers of palmitoleic acid, cPOA and tPOA, has been developed and successfully applied in pharmacokinetic studies in rat serum. Fluctuating concentrations of cPOA and tPOA in rat serum were observed, suggesting reciprocal bio-conversion in the body.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Lin Liu, Chen-Xi Liang, Xiao-Wei Wang, Ke-Xin Pei, Xin-Di Ma, Chun-Xi Zhang, Jing-Hui Dong, Ming-Ming Gao, Jia-Wei Liao
Summary: This study found that surgical removal of adipose tissue before obesity onset did not effectively prevent hyperlipidemia, insulin resistance, fatty liver, or atherosclerosis in a mouse model.
CHINESE MEDICAL JOURNAL
(2021)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Article
Immunology
Kerstin Duerholz, Eva Schmid, Michael Frech, Vugar Azizov, Nadine Otterbein, Sebastien Lucas, Manfred Rauh, Georg Schett, Heiko Bruns, Mario M. Zaiss
Summary: The study found that autoimmune diseases are associated with an increased risk for cardiovascular events due to abnormal platelet clotting effects. It also identified a microbial-derived short chain fatty acid, propionate, that can affect platelet formation and function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Andre C. Carpentier
Summary: Insulin plays a significant role in regulating adipose tissue fatty acid metabolism by inhibiting NEFA flux. Insulin resistance in adipose tissue may lead to various metabolic abnormalities and complications of diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Rheumatology
George Athanasios Karpouzas, Bianca Papotti, Sarah Ormseth, Marcella Palumbo, Elizabeth Hernandez, Maria Pia Adorni, Francesca Zimetti, Matthew Budoff, Nicoletta Ronda
Summary: Cholesterol loading capacity (CLC) is associated with coronary atherosclerosis presence, burden, and cardiovascular risk in patients with rheumatoid arthritis (RA). It is particularly linked to high-risk low attenuation and obstructive plaques in non-users of biologic disease-modifying antirheumatic drugs (bDMARD).
Article
Food Science & Technology
Rui Wang, Cong-Lan Ji, Dan-Dan Feng, Yi-Jin Wu, Yan Li, Opeyemi Joshua Olatunji, Li-Jun Yu, Jian Zuo
Summary: This study investigates the effects of lard and related fatty acids intake on rheumatoid arthritis animal models. The results show that lard consumption can attenuate inflammation in rheumatic rodents by activating PPAR-gamma, regardless of intake amounts.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jin-Yue Yang, Lingyu Zhang, Tian-Tian Zhang, Cheng-Cheng Wang, Ying-Cai Zhao, Xiao-Yue Li, Yu-Ming Wang, Chang-Hu Xue
Summary: Previous studies have shown that EPA-PLs can improve glucose and lipid metabolism by increasing CD36 expression. However, the effects of EPA-PLs on glucose and lipid metabolism in CD36 mutation are still unclear. This study used SHR as a CD36 mutation model and found that dietary EPA-PLs could alleviate abnormal lipid levels and adipocyte hypertrophy in SHR. EPA-PLs also reduced triglyceride and cholesterol levels in the liver and improved glucose tolerance and insulin levels through the IRS/PI3K/AKT signaling pathway. These findings suggest that EPA-PLs provide a precise nutrition strategy for individuals with CD36 mutation.
Article
Cardiac & Cardiovascular Systems
Rodrigo Julio Cerci, Joao Vicente Vitola, Diana Paez, Alejandro Zuluaga, Marcio Sommer Bittencourt, Lilia M. Sierra-Galan, Patricia Carrascosa, Roxana Campisi, Claudia Gutierrez-Villamil, Amalia Peix, Duane Chambers, Mayra Sanches Velez, Carla M. G. Alvarado, Ana C. F. Ventura, Alejandro Maldonado, Alfredo P. Castanos, Teresa C. Diaz, Yariela Herrera, Manuel C. Vasquez, Ana A. Arrieta, Fernando Mut, Cole Hirschfeld, Eli Malkovskiy, Benjamin Goebel, Yosef Cohen, Michael Randazzo, Leslee J. Shaw, Michelle C. Williams, Todd C. Villines, Nathan Better, Sharmila Dorbala, Paolo Raggi, Thomas N. B. Pascual, Yaroslav Pynda, Maurizio Dondi, Andrew J. Einstein
Summary: The COVID-19 pandemic has significantly reduced cardiac diagnostic procedures in Latin America, with a decline in procedure volumes and a stronger association with social distancing measures compared to COVID-19 incidence. Proper balance and planning of social distancing measures are crucial to maintain access to medical care during a pandemic surge, especially in regions with high cardiovascular mortality.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Nikolaos Alexopoulos, Paolo Raggi
Article
Multidisciplinary Sciences
Viola Vaccarino, Amit J. J. Shah, Valeria Moncayo, Jonathon A. A. Nye, Marina Piccinelli, Yi-An Ko, Xin Ma, Nancy Murrah, Lucy Shallenberger, Emily Driggers, Nour Jajeh, Ammer Haffar, Omar Al-Abboud, Paolo Raggi, Martica H. H. Hall, Richard P. P. Sloan, Jack Goldberg, Nicholas L. L. Smith, Ernest V. V. Garcia, Arshed A. A. Quyyumi, J. Douglas Bremner, Donald L. L. Bliwise
Summary: This study found that twins with obstructive sleep apnea (OSA) had abnormal myocardial perfusion, suggesting subclinical myocardial scarring or infarction. The risk of abnormal myocardial perfusion was highest in twin pairs where both twins had OSA.
Article
Medicine, General & Internal
Lukas Hermann Vogel, Iryna Dykun, Paolo Raggi, Axel Schmermund, Tienush Rassaf, Amir Abbas Mahabadi
Summary: There is no significant difference in the effect of high-intensity statin therapy (HIST) and low-to-intermediate intensity statin therapy (LIST) on coronary artery calcification (CAC) density.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Eliano P. Navarese, Alexandra J. Lansky, Michael E. Farkouh, Klaudyna Grzelakowska, Marc P. Bonaca, Diana A. Gorog, Paolo Raggi, Malte Kelm, Brandon Yeo, Julia Uminska, Nick Curzen, Jacek Kubica, William Wijns, Dean J. Kereiakes
Summary: This study conducted a large-scale meta-analysis to compare the effect of coronary revascularization plus medical therapy (MT) versus MT alone on noncardiac mortality in patients with chronic coronary syndrome (CCS). The results showed that there was no significant difference in noncardiac mortality between the two treatment groups in long-term follow-up.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Zakaria Almuwaqqat, Ernest V. Garcia, C. David Cooke, Mariana Garcia, Amit J. Shah, Lisa Elon, Yi-An Ko, Samaah Sullivan, Jonathon Nye, Marly Van Assen, Carlo De Cecco, Paolo Raggi, J. Douglas Bremner, Arshed A. Quyyumi, Viola Vaccarino
Summary: Microcirculatory dysfunction during psychological stress may result in diffuse myocardial ischemia. A novel quantification method for diffuse ischemia during mental stress (dMSI) was developed and its relationship with outcomes after a myocardial infarction (MI) was examined. The study found that higher levels of dMSI were associated with an increased risk of adverse events, particularly in women.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Hematology
Eliano P. Navarese, Donna Vine, Spencer Proctor, Klaudyna Grzelakowska, Sergio Berti, Jacek Kubica, Paolo Raggi
Summary: A large-scale Mendelian randomization study found a significant causal association between remnant cholesterol and cardiovascular outcomes, including coronary artery disease, myocardial infarction, and stroke. The study suggests that early screening for remnant cholesterol and long-term inhibition should be the focus of future therapeutic interventions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Maggie Wang, Chang Liu, Anish Shah, Yi-An Ko, Yan Sun, Rachel J. Lampert, Mariana Garcia, Kasra Moazzami, Zakaria Almuwaqqat, Laura Ward, Samaah Sullivan, Paolo Raggi, Doug Bremner, Arshed A. Quyyumi, Viola Vaccarino, Alanna A. Morris, Amit J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anish Shah, Viola Vaccarino, Yi-An Ko, Zakaria Almuwaqqat, Mariana Garcia, Kasra Moazzami, Maggie Wang, Oleksiy Levantsevych, an Young, Laura Ward, Jonathon Nye, Paolo Raggi, David S. Sheps, Rachel J. Lampert, Doug Bremner, Ernest V. Garcia, Arshed A. Quyyumi, Amit J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Brian Cheung, Zakaria Almuwaqqat, Jeong Hwan Kim, Muhammad Hammadah, Amit J. Shah, Yi-An Ko, Lisa Elon, Samaah Sullivan, Anish Shah, Ayman Alkhoder, Bruno B. Lima, Brad Pearce, Laura Ward, Michael Kutner, Yingtian Hu, Tene T. Lewis, Ernest V. Garcia, Jonathon A. Nye, David Sheps, Paolo Raggi, James Douglas Bremner, Viola Vaccarino, Arshed A. Quyyumi
Meeting Abstract
Cardiac & Cardiovascular Systems
E. Ferramosca, M. Napoli, V. Martella, S. Barbarini, M. L. Lefons, P. Ria, A. Zito, P. Raggi
Meeting Abstract
Cardiac & Cardiovascular Systems
P. Raggi, J. Milic, S. Renzetti, F. Motta, L. Gozzi, A. Cervo, G. Burastero, V. Iadisernia, G. Franceschi, M. Faltoni, C. Mussini, G. Sebastiani, S. Calza, G. Guaraldi
Meeting Abstract
Cardiac & Cardiovascular Systems
P. Raggi, S. Barbieri, J. Milic, L. Gozzi, A. Brigo, B. Beghe', A. Verduri, E. Clini, C. Mussini, G. Sebastiani, G. Guaraldi
Meeting Abstract
Cardiac & Cardiovascular Systems
D. F. Vine, P. Raggi, H. Becher, M. Ghosh, X. Wu
Meeting Abstract
Transplantation
Luis D'marco, Valmore Bermudez, Paolo Raggi
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)