Article
Peripheral Vascular Disease
Valentina Nardi, John Benson, Melanie C. Bois, Luca Saba, Anthony S. Larson, Ilke Ozcan, Ali Ahmad, David W. Morse, Fredric B. Meyer, Waleed Brinjikji, Giuseppe Lanzino, Lilach O. Lerman, Luis E. Savastano, Amir Lerman
Summary: This study found that intraplaque hemorrhage (IPH) as a marker of plaque vulnerability is more prominent in patients with mild carotid artery stenosis compared to those with moderate and severe stenosis, and a lower degree of stenosis is associated with a higher extent of IPH. This suggests that IPH may play an important role in the mechanism of stroke in patients with nonobstructive carotid stenosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuai Zhang, Lin Gao, Bing Kang, Xinxin Yu, Ran Zhang, Ximing Wang
Summary: A CT-based radiomics nomogram was developed and validated for the detection of intraplaque hemorrhage in carotid arteries. The results showed that the radiomics nomogram had satisfactory performance in distinguishing carotid plaques with and without intraplaque hemorrhage.
INSIGHTS INTO IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Shuai Zhang, Hui Gu, Xinxin Yu, Bing Kang, Xianshun Yuan, Ximing Wang
Summary: The study revealed a strong association between perivascular adipose tissue and intraplaque hemorrhage in the carotid artery. PFD could serve as a novel marker for identifying carotid IPH and risk stratification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Raiyan Tripti Zaman, Hisanori Kosuge, Sanjiv Sam Gambhir, Lei Xing
Summary: Carotid artery stenosis is a major cause of stroke or mini-stroke in the United States, and carotid endarterectomy is used to treat it. Researchers have developed a sensing interferometer imaging system to noninvasively assess vulnerable carotid plaques.
Article
Immunology
Shifu Li, Qian Zhang, Zheng Huang, Wengui Tao, Chudai Zeng, Langchao Yan, Fenghua Chen
Summary: The purpose of this study was to identify key biomarkers associated with intraplaque hemorrhage (IPH). Through comprehensive analysis and validation, a gene set containing eight genes was found to be involved in IPH, and four of these genes were identified as potential important biomarkers for IPH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Min Jee Kim, Hyo Sung Kwak, Seung Bae Hwang, Gyung Ho Chung
Summary: This study investigated the one-step detection of intraplaque hemorrhage in the carotid artery and vertebrobasilar artery using SNAP technology. Results showed a high prevalence of IPH in patients, with significantly higher wall thickness in the carotid IPH group and a higher prevalence of high grade stenosis in that group as well.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabiana Baganha, Thijs J. Sluiter, Rob C. M. de Jong, Louise A. van Alst, Hendrika A. B. Peters, J. Wouter Jukema, Mirela Delibegovic, Knut Pettersson, Paul H. A. Quax, Margreet R. de Vries
Summary: Based on the study in mice VG, PC-mAb can effectively inhibit the formation of atherosclerotic lesions by reducing IPA and IPH, decreasing neovessel density and macrophages influx, and increasing neovessel maturation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaoshuo Lv, Feng Wang, Mingsheng Sun, Congrui Sun, Xueqiang Fan, Bo Ma, Yuguang Yang, Zhidong Ye, Peng Liu, Jianyan Wen
Summary: Intraplaque hemorrhage (IPH) is a significant feature of unstable plaques and a risk factor for cardiovascular events. Our study identified ITGB2 and ITGAM as key hub genes in IPH pathogenesis, providing insights into the underlying mechanisms and potential targets for IPH diagnosis and immunotherapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Ui Yun Lee, Hyo Sung Kwak
Summary: This study aimed to assess plaque vulnerability by analyzing the relationship between morphological and hemodynamic factors in IPH and non-IPH patients. Higher WSS was observed in the IPH group, and combined analysis of SNAP sequences and WSS showed potential for evaluating the risk of carotid IPH.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Anna Kopczak, Andreas Schindler, Dominik Sepp, Anna Bayer-Karpinska, Rainer Malik, Mia L. Koch, Julia Zeller, Christoph Strecker, Daniel Janowitz, Frank A. Wollenweber, Johann-Martin Hempel, Tobias Boeckh-Behrens, Clemens C. Cyran, Andreas Helck, Andreas Harloff, Ulf Ziemann, Sven Poli, Holger Poppert, Tobias Saam, Martin Dichgans
Summary: Complicated nonstenosing carotid artery plaques (CAPs) are an underestimated cause of stroke. This study aimed to determine the association between complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) and recurrent ischemic stroke or transient ischemic attack (TIA). The study found that patients with icCAP had a higher frequency of recurrent events, and a ruptured fibrous cap and intraplaque hemorrhage were significantly associated with an increased risk of recurrence.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Engineering, Biomedical
Yan Cai, Jichao Pan, Zhiyong Li
Summary: The study presents a mathematical model to evaluate the influences of intraplaque neovascularization and hemorrhage on vulnerable plaque development. The simulation results showed that high microvessel density region and extravascular flow across the leaky wall of the neovasculature contribute to intraplaque hemorrhage in vulnerable plaques. The sensitivity analysis of model parameters indicated that reducing microvessel density and wall permeability of the neovasculature can significantly decrease the IPH area and extent.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Clinical Neurology
Xiaoyuan Fan, Xiaoqian Zhang, Zhichao Lai, Tianye Lin, Hui You, Changwei Liu, Feng Feng
Summary: In patients with carotid stenosis, carotid intraplaque hemorrhage (IPH) is associated with an elevated total burden of cerebral small vessel disease (CSVD). The total CSVD score might be a more effective imaging marker linked with clinical symptoms compared to the degree of stenosis and primary collaterals.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Daina Kashiwazaki, Shusuke Yamamoto, Naoki Akioka, Emiko Hori, Takashi Shibata, Naoya Kuwayama, Kyo Noguchi, Satoshi Kuroda
Summary: This study aimed to clarify the characteristics of endothelial cell (EC) proliferation in intraplaque microvessels in vulnerable plaques and their impact on clinical results, focusing on dilated microvessels. The findings suggest that dilated microvessels with proliferative ECs play a key role in intraplaque hemorrhage (IPH) pathogenesis and are likely related to clinical onset and the recurrence of ischemic events.
ACTA NEUROCHIRURGICA
(2021)
Article
Clinical Neurology
Keisuke Tokunaga, So Tokunaga, Kenta Hara, Masahiro Yasaka, Yasushi Okada, Takanari Kitazono, Tomoyuki Tsumoto
Summary: The presence of intraplaque high-intensity signal (HIS) on time-of-flight magnetic resonance angiography (TOF-MRA) is associated with an increased risk of restenosis after carotid artery stenting (CAS), indicating that intraplaque hemorrhage is a predictor of restenosis after CAS.
JOURNAL OF NEUROSURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Valentina Nardi, John C. Benson, Luca Saba, Melanie C. Bois, Fredric B. Meyer, Giuseppe Lanzino, Lilach O. Lerman, Amir Lerman
Summary: This study aimed to investigate the relationship between carotid intraplaque hemorrhage (IPH) and cerebral microbleeds (CMBs). The results showed that patients with IPH were more likely to have CMBs, and the extent of IPH was associated with the number of CMBs. Additionally, patients with CMBs had a lower degree of carotid stenosis.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Vasiliki Koliaraki, Charles K. Pallangyo, Florian R. Greten, George Kollias
Article
Multidisciplinary Sciences
Ana Henriques, Vasiliki Koliaraki, George Kollias
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Alejandro Prados, George Kollias, Vasiliki Koliaraki
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Vasiliki Koliaraki, Niki Chalkidi, Ana Henriques, Christos Tzaferis, Apostolos Polykratis, Ari Waisman, Werner Muller, David J. Hackam, Manolis Pasparakis, George Kollias
Article
Immunology
Andreas Patsalos, Petros Tzerpos, Laszlo Halasz, Gergely Nagy, Attila Pap, Nikolas Giannakis, Konstantina Lyroni, Vasiliki Koliaraki, Eva Pintye, Balazs Derso, George Kollias, Charalampos G. Spilianakis, Laszlo Nagy
JOURNAL OF IMMUNOLOGY
(2019)
Review
Immunology
Vasiliki Koliaraki, Ana Henriques, Alejandro Prados, George Kollias
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Immunology
Aikaterini Hatzioannou, Aggelos Banos, Theodore Sakelaropoulos, Constantinos Fedonidis, Maria-Sophia Vidali, Maren Koehne, Kristian Haendler, Louis Boon, Ana Henriques, Vasiliki Koliaraki, Panagiotis Georgiadis, Jerome Zoidakis, Aikaterini Termentzi, Marc Beyer, Triantafyllos Chavakis, Dimitrios Boumpas, Aristotelis Tsirigos, Panayotis Verginis
Article
Multidisciplinary Sciences
Manolis Roulis, Aimilios Kaklamanos, Marina Schernthanner, Piotr Bielecki, Jun Zhao, Eleanna Kaffe, Laura-Sophie Frommelt, Rihao Qu, Marlene S. Knapp, Ana Henriques, Niki Chalkidi, Vasiliki Koliaraki, Jing Jiao, J. Richard Brewer, Maren Bacher, Holly N. Blackburn, Xiaoyun Zhao, Richard M. Breyer, Vassilis Aidinis, Dhanpat Jain, Bing Su, Harvey R. Herschman, Yuval Kluger, George Kollias, Richard A. Flavell
Review
Immunology
Vasiliki Koliaraki, Alejandro Prados, Marietta Armaka, George Kollias
Review
Cell Biology
Maria-Theodora Melissari, Niki Chalkidi, Michalis E. Sarris, Vasiliki Koliaraki
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Immunology
Alejandro Prados, Lucas Onder, Hung-Wei Cheng, Urs Morbe, Mechthild Lutge, Cristina Gil-Cruz, Christian Perez-Shibayama, Vasiliki Koliaraki, Burkhard Ludewig, George Kollias
Summary: The study reveals that fibroblastic reticular cells (FRCs) in Peyer's patches develop from two separate mesenchymal cell lineages, which converge to support immune cell activation and maintain intestinal homeostasis. This mosaic microenvironment plays a crucial role in controlling intestinal immunity, revealing key stromal cell infrastructures for this process.
Article
Biochemistry & Molecular Biology
Maria-Theodora Melissari, Ana Henriques, Christos Tzaferis, Alejandro Prados, Michalis E. Sarris, Niki Chalkidi, Dimitra Mavroeidi, Panagiotis Chouvardas, Sofia Grammenoudi, George Kollias, Vasiliki Koliaraki
Summary: This study investigates the various subsets of intestinal mesenchymal cells and their roles in intestinal morphogenesis and pathophysiology. The results show that Col6a1(Cre) mouse targets fibroblast subsets and perivascular cells, as well as mesenchymal aggregates crucial for intestinal development. In adulthood, Col6a1(+)/CD201(+) mesenchymal cells regulate enteroendocrine cell differentiation and epithelial proliferation. During acute colitis, they exhibit an inflammatory and extracellular matrix remodelling gene signature. However, these cells are dispensable for normal organ architecture in both homeostasis and tissue regeneration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Editorial Material
Immunology
Vasiliki Koliaraki, Gian-Paolo Dotto, Christopher D. Buckley, George Kollias
Summary: The First International Aegean Conference on Mesenchymal Cells in Health & Disease, held in Chania, Crete from 3-8 June 2022, brought together clinicians and scientists who work on mesenchymal or stromal cell biology across different fields including immunity, inflammation and cancer.
Article
Surgery
Christos Lioupis, Luc Francoeur
Summary: The diagnosis of late type III endoleaks on non-invasive imaging studies can be challenging, often leading to misdiagnosis as type I endoleaks. This report presents a case of misdiagnosed type III endoleak treated as Type Ia endoleak, with complications of intraluminal graft dislodgement during embolization using a liquid embolic agent (Squid). This uncommon complication was successfully recognized and treated. Type IIIb endoleaks should be considered in patients with persistent aneurysm sac perfusion despite embolization with liquid embolic agents.
VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Kazuki Nagashima, Shinichiro Sawa, Takeshi Nitta, Alejandro Prados, Vasiliki Koliaraki, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)