Article
Hematology
Jing Liu, Baiba K. Gillard, Dedipya Yelamanchili, Antonio M. Gotto, Corina Rosales, Henry J. Pownall
Summary: Mice lacking the HDL receptor Scarb1 exhibit increased bioavailability of FC in HDL, leading to elevated FC content in multiple tissue sites associated with female infertility, impaired cell maturation, cardiac dysfunction, and atherosclerosis. Sex-dependent differences in tissue-lipid composition and plasma FC clearance rates were also observed. Higher HDL-FC bioavailability may serve as a potential biomarker mechanistically linked to various pathologies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mitch Raith, Sarah J. Kauffman, Monireh Asoudeh, Jennifer A. Buczek, Nam-Goo Kang, Jimmy W. Mays, Paul Dalhaimer
Summary: The study demonstrates that soft, flexible, elongated PEO-PBD filomicelles can interact directly with the major high-density lipoprotein receptor SR-BI and be engulfed by macrophages and cells expressing SR-BI. The results also suggest that the cooperativity among SR-BI receptors on cell surfaces plays a crucial role in binding of nanoparticles.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Medicinal
Nurul Adila Azemi, Ahmad Khusairi Azemi, Luqman Abu-Bakar, Vigneswari Sevakumaran, Tengku Sifzizul Tengku Muhammad, Noraznawati Ismail
Summary: The present study found that Fraction-7 of Xestospongia muta and linoleic acid can increase the expression level of SR-BI gene and HDL uptake. This suggests that Fraction-7 of Xestospongia muta and linoleic acid have the potential to be explored as adjuncts in the treatment of hypercholesterolemia.
Article
Hematology
Hao Xu, Michael J. Thomas, Sushma Kaul, Rachel Kallinger, Amber B. Ouweneel, Elisa Maruko, Sabrina M. Oussaada, Aldo Jongejan, Huib A. Cense, Max Nieuwdorp, Mireille J. Serlie, Ira J. Goldberg, Mete Civelek, Brian W. Parks, Aldons J. Lusis, Darcy Knaack, Rebecca L. Schill, Sarah C. May, John J. Reho, Justin L. Grobe, Benjamin Gantner, Daisy Sahoo, Mary G. Sorci-Thomas
Summary: The study investigates the role of Pcpe2 in SR-BI-mediated HDL-C uptake and adipose lipid storage, revealing a novel function for Pcpe2 in modulating SR-BI expression and function. Pcpe2 deficiency leads to abnormal lipid storage in adipose tissue and affects cholesterol balance, with the restoration of SR-BI-mediated HDL-C uptake by preincubation with exogenous Pcpe2.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Peripheral Vascular Disease
Annabelle Rodriguez
Summary: Recent studies have shown a U-shaped association between low HDL-C levels and increased risk for all-cause and cause-specific mortality, while high HDL-C levels do not provide cardioprotection. Genetic studies have identified specific genes associated with high HDL-C and increased risk for myocardial infarction. These findings suggest the need for revision of clinical CVD risk calculators.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Hematology
Siavash Ghaffari, Erika Jang, Farnoosh Naderinabi, Rajiv Sanwal, Negar Khosraviani, Changsen Wang, Benjamin E. Steinberg, Neil M. Goldenberg, Jiro Ikeda, Warren L. Lee
Summary: This study reveals that intracellular HMGB1 regulates LDL transcytosis by prolonging the half-life of SREBP2 and enhancing SR-BI expression, and the nuclear localization of HMGB1 in response to LDL requires SR-BI.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manuela Strahlhofer-Augsten, Carolin Schliefsteiner, Silvija Cvitic, Meekha George, Ingrid Lang-Olip, Birgit Hirschmugl, Gunther Marsche, Uwe Lang, Boris Novakovic, Richard Saffery, Gernot Desoye, Christian Wadsack
Summary: The study demonstrates differential expression of SR-BI in ECA and ECV in the feto-placental vasculature, leading to distinct regulation of local cholesterol homeostasis. The difference in SR-BI expression in the two types of endothelial cells mainly affects the uptake of fetal HDL cholesteryl esters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Binxing Li, Evan W. George, Preejith Vachali, Fu-Yen Chang, Aruna Gorusupudi, Ranganathan Arunkumar, Nathan A. Giauque, Zihe Wan, Jeanne M. Frederick, Paul S. Bernstein
Summary: The HDL cholesterol receptor scavenger receptor BI (SR-BI) in the cells of retinal pigment epithelium (RPE) is believed to play a key role in the selective uptake of macular carotenoids lutein and zeaxanthin. Through experiments and cell studies, the researchers found that SR-BI can selectively uptake lutein and zeaxanthin, and this effect can be blocked by a specific mutation. Additionally, the partners of SR-BI, HDL and LIPC, were found to promote the uptake of these carotenoids.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Plant Sciences
Hongju Liu, Huiyi Xie, Changqun Li, Lingling Wang, Qiling Chen, Xin Ouyang, Chong Yan
Summary: In this study, DPB was found to reduce lipid accumulation in THP-1 macrophage-derived foam cells by regulating lipid intake and efflux through modulating gene expression. Additionally, DPB promoted LDL transport in HepG2 cells and inhibited cholesterol and fatty acid synthesis.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Petri Kresanov, Juha Mykkanen, Markku Ahotupa, Mika Ala-Korpela, Markus Juonala, Jari Kaikkonen, Mika Kahonen, Terho Lehtimaki, Tommi Vasankari, Jorma Viikari, Olli T. Raitakari
Summary: The study found that oxidized HDL lipids were not significantly associated with lipoprotein subclass lipid concentrations and composition after adjusting for certain factors, while oxidized LDL lipids were associated with multiple markers of lipoprotein subclass lipid concentrations and composition. Additionally, HDL and LDL subclass measures, such as phospholipid and triglyceride composition, were directly associated with oxidized LDL lipids, while cholesterol ester and free cholesterol composition in HDL and LDL were inversely associated. These results suggest that LDL oxidation may play a role in atherogenesis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Microbiology
Camilo Larrazabal, Sara Lopez-Osorio, Zahady D. Velasquez, Carlos Hermosilla, Anja Taubert, Liliana M. R. Silva
Summary: The study shows that SR-BI receptor plays a key role in the replication process of different coccidian species, and its specific blocker BLT-1 can significantly inhibit the development of these parasites. Additionally, BLT-1 treatment reduces invasive capacities and increases cytoplasmic Ca++ levels in infective stages of coccidian parasites, while also affecting host cell lipid metabolism.
Article
Nutrition & Dietetics
Alyann Otrante, Amal Trigui, Roua Walha, Hicham Berrougui, Tamas Fulop, Abdelouahed Khalil
Summary: EVOO intake improves cholesterol efflux capacity of HDL in elderly subjects by modulating the distribution of HDL subclasses, leading to enhanced anti-atherogenic activity of HDL.
Article
Multidisciplinary Sciences
Ishtiaque Ahammad, Tabassum Binte Jamal, Arittra Bhattacharjee, Zeshan Mahmud Chowdhury, Suparna Rahman, Md Rakibul Hassan, Mohammad Uzzal Hossain, Keshob Chandra Das, Chaman Ara Keya, Md Salimullah
Summary: GRIN2A is a gene encoding NMDA receptors in the central nervous system, playing a crucial role in synaptic transmission, plasticity, and excitotoxicity. Variants in this gene, particularly the I463S variant, are predicted to have deleterious effects on protein structure and function. Bioinformatics tools were used to assess the impact of these variants, providing valuable insights for future research on GRIN2A-related diseases.
Review
Geriatrics & Gerontology
Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang, Yanyan Xu, Zhen Qin, Gangqiong Liu, Qiguang Wang, Kang Tian, Khoon S. Lim, Chris J. Charles, Jinying Zhang, Junnan Tang
Summary: Dyslipidemia increases the risk of atherosclerosis, and lipoproteins play a significant role in its development. Understanding lipoprotein function can help predict risk and provide novel treatment approaches for atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Anand Rohatgi, Marit Westerterp, Arnold von Eckardstein, Alan Remaley, Kerry-Anne Rye
Summary: Low high-density lipoprotein cholesterol (HDL-C) is associated with adverse lifestyle choices, cardiovascular diseases, inflammatory disorders, and other conditions. Therapeutic strategies targeting HDL-C levels have not been successful, and future focus should be on optimizing HDL function for better outcomes.
Review
Biochemistry & Molecular Biology
Megan E. Filbin, Jeffrey S. Kieft
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Adam Wallace, Megan E. Filbin, Bethany Veo, Craig McFarland, Janusz Stepinski, Marzena Jankowska-Anyszka, Edward Darzynkiewicz, Richard E. Davis
MOLECULAR AND CELLULAR BIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Megan E. Filbin, Breanna S. Vollmar, Dan Shi, Tamir Gonen, Jeffrey S. Kieft
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
John A. Hammond, Robert P. Rambo, Megan E. Filbin, Jeffrey S. Kieft
Article
Biochemistry & Molecular Biology
Megan E. Filbin, Jeffrey S. Kieft
Meeting Abstract
Biochemistry & Molecular Biology
Elizabeth Spear, Megan Filbin-Wong
Meeting Abstract
Biochemistry & Molecular Biology
Julie Y. Lee, Liheng Zhou, Laura D. Baquero-Galvis, Megan E. Filbin
Meeting Abstract
Biochemistry & Molecular Biology
Liheng Zhou, Julie Lee, Laura D. Baquero-Galvis, Megan E. Filbin
Meeting Abstract
Biochemistry & Molecular Biology
Nathan L. Nowling, Elizabeth A. Spear, Natasia Paukovich, John Manalastas, Beat Vogeli, Megan E. Filbin
Meeting Abstract
Biochemistry & Molecular Biology
John Manalastas, Elizabeth Spear, Megan Filbin
Meeting Abstract
Biochemistry & Molecular Biology
Megan E. Filbin-Wong, Tamir Gonen, Jeffrey S. Kieft
Meeting Abstract
Biochemistry & Molecular Biology
Laura D. Baquero Galvis, Elizabeth Shields, Evan J. Morrison, Megan E. Filbin-Wong
Meeting Abstract
Biochemistry & Molecular Biology
Megan E. Filbin-Wong, Tamir Gonen, Jeffrey S. Kieft
Meeting Abstract
Biochemistry & Molecular Biology
Scott-Wesley M. Bean, Laura D. Baquero Galvis, Evan J. Morrison, Megan E. Filbin-Wong