Article
Neurosciences
Maria H. Madeira, Ines P. Marques, Sonia Ferreira, Diana Tavares, Torcato Santos, Ana Rita Santos, Joao Figueira, Conceicao Lobo, Jose Cunha-Vaz
Summary: Diabetic retinopathy is not only a microvascular disease, but also involves neurodegeneration, with different phenotypes identified based on the characteristics of neurodegeneration. Understanding these phenotypes may offer insights for improved treatment and management of diabetic individuals with retinopathy.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
P. Joseph, P. Pais, P. Gao, K. Teo, D. Xavier, P. Lopez-Jaramillo, K. Yusoff, A. Santoso, H. Gamra, S. H. Talukder, C. Christou, G. Dagenais, J. Tyrwhitt, J. Bosch, A. Dans, S. Yusuf
Summary: This study examined the effects of high-dose vitamin D in a population predominantly from non-Western countries and found that it did not reduce adverse skeletal or non-skeletal outcomes. On the contrary, it was associated with higher mortality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Ting Hu, Lulu Ren, Han Li, Zhuoling An
Summary: Vitamin D plays important roles in calcium-phosphate homeostasis and bone health. Recent studies have shown its non-skeletal functions in regulating endogenous metabolism. This study examined the effects of vitamin D supplementation or deficiency on metabolic phenotypes in mice using targeted metabolomics analysis. The results showed that vitamin D deficiency caused fat deposition in the liver, while supplementation improved fat accumulation. Metabolic perturbations related to vitamin D regulation were observed in various metabolic pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Nutrition & Dietetics
Enrico Maggio, Valeria Proietti Bocchini, Roberto Carnevale, Pasquale Pignatelli, Francesco Violi, Lorenzo Loffredo
Summary: A previous study found that vitamin E is effective in reducing the incidence of myocardial infarction only when taken without other antioxidants. It is unclear if it has the same effect on stroke. This meta-analysis compares the effect of vitamin E supplementation alone or combined with other antioxidants on the incidence of stroke.
Article
Cardiac & Cardiovascular Systems
Michael Boehm, Helmut Schumacher, Christian Werner, Koon K. Teo, Eva M. Lonn, Felix Mahfoud, Thimoteus Speer, Giuseppe Mancia, Josep Redon, Roland E. Schmieder, Karen Sliwa, Nikolaus Marx, Michael A. Weber, Ulrich Laufs, Bryan Williams, Salim Yusuf, Johannes F. E. Mann
Summary: This study analyzed the association between physical activity and renal and cardiovascular outcomes in high-risk patients aged >= 55 years. The results showed that moderate physical activity was associated with improved kidney outcomes, with a threshold of at least two sessions per week. The association between physical activity and renal outcomes did not differ significantly between those with and without diabetes, but the absolute benefit of activity was greater in people with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shmuel Somer, Andrew P. Levy
Summary: Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality in individuals with diabetes mellitus, likely due to oxidative stress and hyperglycemia. Clinical trials involving high doses of vitamin E or strict glycemic control in DM patients have not shown significant reduction of CVD. Proper patient selection based on haptoglobin genotype may be crucial in achieving better outcomes in preventing complications in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Eva Dedeckova, Roman Vitak, Michal Jirasko, Marketa Kralova, Ondrej Topolcan, Ladislav Pecen, Tomas Furst, Pavel Broz, Radek Kucera
Summary: This study aimed to determine if doses of 1000 IU or 2000 IU of vitamin D-3 are sufficient to reach the reference values of [25(OH)D]. The results showed that a dose of 1000 IU taken daily for 60 days only slightly increased vitamin D levels, while taking 2000 IU daily led to a sharp increase and maintained desired levels even after 30 days of cessation. Therefore, a daily dose of 2000 IU can maintain vitamin D levels for a longer period.
Review
Nutrition & Dietetics
Stepan Feduniw, Lidia Korczynska, Konrad Gorski, Magdalena Zgliczynska, Monika Baczkowska, Maciej Byrczak, Jakub Kociuba, Mohamed Ali, Michal Ciebiera
Summary: Menopause is a physiological change in women, but its symptoms can be difficult to accept and hormone therapy may not always be desirable. Vitamin E, as a phytoestrogen, is believed to be useful in alleviating some menopausal symptoms. This review aimed to assess the effectiveness of vitamin E in alleviating menopausal symptoms and found that it influences hot flashes, vascular modulation, lipid profile, and vaginal changes. However, estrogen administration has better clinical effects. Additional high-quality data is needed for conclusive findings.
Review
Nutrition & Dietetics
Yi-Yan Pei, Yu Zhang, Xing-Chen Peng, Zhe-Ran Liu, Ping Xu, Fang Fang
Summary: This systematic review and meta-analysis found that vitamin D supplementation was not associated with a lower risk of cardiovascular events or mortality. These findings do not support the routine use of vitamin D supplementation.
Article
Biochemistry & Molecular Biology
Katalin Koczok, Laszlo Horvath, Zeljka Korade, Zoltan Andras Mezei, Gabriella P. Szabo, Ned A. Porter, Eszter Kovacs, Karoly Mirnics, Istvan Balogh
Summary: The study investigated the effects of vitamin E supplementation in SLOS patients, showing a reduction in certain behavioral issues and an increase in plasma vitamin E concentration. The clinical response to therapy was associated with the baseline 7-DHC and 8-DHC/cholesterol ratio in some patients.
Article
Hematology
Jing-Wei Gao, Si You, Zhao-Yu Liu, Qing-Yun Hao, Jing-Feng Wang, Dominique A. Vuitton, Shao-Ling Zhang, Pin-Ming Liu
Summary: The study found that metabolically healthy obesity (MHO) is associated with an increased risk of coronary artery calcium (CAC) progression and subsequent cardiovascular disease events. However, MHO individuals have a lower risk of cardiovascular disease compared to metabolically healthy individuals with normal weight.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Dermatology
Enzo Berardesca, Norma Cameli
Summary: Vitamin E is a powerful antioxidant that protects against oxidative damage and neurodegenerative diseases. Supplementation of vitamin E can be beneficial in certain cases and chronic diseases. While some studies suggest a positive role of vitamin E in atopic dermatitis and psoriasis, further research is needed to confirm its efficacy.
DERMATOLOGIC THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Martin Alcala, Victoria E. Bolado, Isabel Sanchez-Vera, Sonia Clapes, Francisco Dasi, Guillermo Saez, Esther Carrera, Fabiola Alvarez-Gallego, Mary R. Loeken, Marta Viana
Summary: Studies on rats and cell cultures have shown that obesity depletes maternal glutathione, reducing the antioxidant capacity in embryos, which can lead to malformations. Vitamin E supplementation can prevent this process and protect against birth defects.
Article
Biochemistry & Molecular Biology
Francesco Violi, Cristina Nocella, Lorenzo Loffredo, Roberto Carnevale, Pasquale Pignatelli
Summary: Vitamin E possesses antioxidant and anti-inflammatory properties that have an impact on atherosclerosis and thrombus formation, but intervention trials have yielded negative results.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Peng An, Sitong Wan, Yongting Luo, Junjie Luo, Xu Zhang, Shuaishuai Zhou, Teng Xu, Jingjing He, Jeffrey Mechanick, Wen-Chih Wu, Fazheng Ren, Simin Liu
Summary: This study provides a comprehensive and up-to-date evidence-based map on the impact of micronutrients on cardiovascular disease outcomes. It reveals that supplementation of certain micronutrients can benefit cardiometabolic health, highlighting the importance of micronutrient diversity and the balance of benefits and risks.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
