Article
Multidisciplinary Sciences
Kai Zheng, Wentao Yang, Shengxing Wang, Mingsheng Sun, Zhenyi Jin, Wangde Zhang, Hualiang Ren, Chunmin Li
Summary: This study identified immune infiltration-related biomarkers in carotid atherosclerotic plaques (CAPs) through data analysis. The results showed that there were 11 different types of immune cell infiltration between the CAPs and control groups. Seven genes (BTK, LYN, PTPN11, CD163, CD4, ITGAL, and ITGB7) were identified as the hub genes of CAPs, which may serve as estimable drug targets for patients with CAPs.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Wei Li, Tao Wang, Xiao Zhang, Junge Zhu, Xu-Ying Li, Fangda Peng, Jing Dai, Jiyue Wang, Liyong Zhang, Yabing Wang, Xianyang Chen, Teng Xue, Chunguang Ding, Chaodong Wang, Liqun Jiao
Summary: The study utilized a lipidomics strategy to identify lipids present in radiation-induced carotid plaques and atherosclerotic carotid plaques, identifying 31 metabolites significantly higher in RICPs than ASCPs, 24 of which were triglycerides. Machine learning models identified 6 triglycerides as potential markers for distinguishing RICPs and ASCPs.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaotian Wu, Amy Daniel Ulumben, Steven Long, Wataru Katagiri, Moses Q. Wilks, Hushan Yuan, Brian Cortese, Chengeng Yang, Satoshi Kashiwagi, Hak Soo Choi, Marc D. Normandin, Georges El Fakhri, Raiyan T. Zaman
Summary: The evaluation of two macrophage-targeting fluorescent tracers for NIRF imaging in an atherosclerotic murine cohort showed high uptake in diseased vessels, indicating potential clinical applications. These tracers, such as TLR4-ZW800-1C and Feraheme-Alexa Fluor 750, have renal clearance ability and FDA approval, positioning them alongside other NIRF tracers like ICG. Further investigation with intravascular NIRF imaging and larger animal models is necessary for clinical translation.
Review
Biochemistry & Molecular Biology
Hiroshi Kobayashi, Sho Matsubara, Chiharu Yoshimoto, Hiroshi Shigetomi, Shogo Imanaka
Summary: This review summarizes the biological functions of TFPI1 and TFPI2 in preeclamptic patients and discusses future directions in preeclampsia research. TFPI1 is an important physiological inhibitor of the TF-initiated extrinsic coagulation pathway, while TFPI2 inhibits fibrinolysis and exerts antifibrinolytic activity. TFPI1 and TFPI2 may play important roles in regulating the coagulation and fibrinolytic system and trophoblast invasion. Concentrations of TF, TFPI1, and TFPI2 are significantly altered in preeclamptic women compared to normal pregnancies. The TFPI protein family may serve as predictive biomarkers for preeclampsia and guide precision therapy.
Article
Multidisciplinary Sciences
Xue Yan Cui, Geir Erland Tjonnfjord, Sandip M. Kanse, Anders Erik Astrup Dahm, Nina Iversen, Christiane Filion Myklebust, Ling Sun, Zhong Xing Jiang, Thor Ueland, James J. Campbell, Mitchell Ho, Per Morten Sandset
Summary: Plasma TFPI levels are higher in CLL patients compared to healthy controls, especially in those with advanced disease. TFPI enhances CXCL12-mediated migration of CLL cells through increased expression of the CXCR7 receptor. TFPI, which co-localizes with GPC3, plays a crucial role in regulating CXCR7 expression and TEM.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Mei-hua Bao, Ruo-qi Zhang, Xiao-shan Huang, Ji Zhou, Zhen Guo, Bao-feng Xu, Rui Liu
Summary: Atherosclerosis is a chronic inflammatory disease with high prevalence and mortality, where plaque rupture is the main cause of clinical events. Analyzing the transcriptomic and proteomic profiles of stable and unstable plaques helps to prevent clinical manifestations. The study identified differentially expressed RNAs and proteins related to stress response, gene transcription, immune response, nervous system functions, hematologic activities, and the endocrine system, providing insights into regulating plaque stability.
FRONTIERS IN GENETICS
(2021)
Article
Computer Science, Interdisciplinary Applications
Rui Shen, Xinyu Tong, Dongye Li, Zihan Ning, Hualu Han, Yongjun Han, Dandan Yang, Chenlin Du, Tao Wang, Jingli Cao, Yilan Xu, Ran Huo, Huiyu Qiao, Xihai Zhao
Summary: This study investigated the association between slice-based and time-specific hemodynamic measurements and carotid vulnerable plaque using magnetic resonance (MR) vessel wall imaging and histology. The results showed that hemodynamic measurements were significantly associated with carotid intra-plaque hemorrhage (IPH). Combining hemodynamic measurements with carotid plaque burden may be a stronger indicator for carotid vulnerable plaque features than individual measurements alone.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Immunology
Lena Lavie, Erez Si-on, Aaron Hoffman
Summary: A subpopulation of CD66b+ neutrophils, resembling macrophage-foam cells, was found in carotid atherosclerotic plaques. These cells have altered morphology and functions, transforming into giant phagocytes with a massive lipid content. They may represent a new neutrophil-macrophage hybrid population with unknown significance and functions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pedro Landete, Carlos Ernesto Fernandez-Garcia, Jose M. Munoz, Alfonsi Friera, Julio Ancochea, Agueda Gonzalez-Rodriguez, Carmelo Garcia-Monzon
Summary: It is unclear whether the overlap syndrome (OS) of chronic obstructive pulmonary disease (COPD) and sleep apnea-hypopnea syndrome increases the risk of stroke associated with COPD itself. This study found that OS was associated with larger atherosclerotic plaques in the left carotid artery in COPD patients. Therefore, screening for OS in all COPD patients is recommended to identify those at higher risk of stroke.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
You Jee Jang, Hee Kyung Kim, Bum Chae Choi, Sang Jin Song, Jae Il Park, Sang Young Chun, Moon Kyoung Cho
Summary: The study found that tissue factor and Tfpi-2 expression are stimulated during ovulation in rats, while tissue factor levels are decreased in OHSS-induced rats. Interestingly, tissue factor concentrations in follicular fluids of women undergoing in vitro fertilization are correlated with pregnancy but not with OHSS.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Pieter J. Steinkamp, Jasper Vonk, Lydian A. Huisman, Gert-Jan Meersma, Gilles F. H. Diercks, Jan-Luuk Hillebrands, Wouter B. Nagengast, Clark J. Zeebregts, Riemer H. J. A. Slart, Hendrikus H. Boersma, Gooitzen M. van Dam
Summary: This study investigated the safety and feasibility of using bevacizumab-800CW, a near-infrared tracer targeting VEGF-A, for molecular assessment of atherosclerotic carotid plaques with MSOT. Results showed that the administration of 4.5 mg bevacizumab-800CW appeared to be safe in patients, but further studies are needed to evaluate tracer safety and optimize imaging outcomes.
Article
Hematology
Stephanie E. Reitsma, Lori A. Holle, Emma G. Bouck, Dougald M. Monroe, Alan E. Mast, John Burthem, Paula H. B. Bolton-Maggs, Gillian N. Gidley, Alisa S. Wolberg
Summary: This study suggests that tissue factor pathway inhibitor (TFPI) may play a role in modifying the bleeding risk in individuals with factor XI (FXI) deficiency. In vitro experiments showed that inhibition of TFPI enhanced clot formation and reduced fibrinolysis in FXI-deficient plasma, while increased TFPI had the opposite effects. Higher TFPI concentrations were observed in FXI-deficient individuals with bleeding compared to controls, and total plasma TFPI correlated with clotting and fibrinolysis parameters associated with bleeding risk. These findings indicate that TFPI may be a potential modifier of bleeding risk in FXI-deficient individuals.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Immunology
Shifu Li, Qian Zhang, Zheng Huang, Wengui Tao, Chudai Zeng, Langchao Yan, Fenghua Chen
Summary: The purpose of this study was to identify key biomarkers associated with intraplaque hemorrhage (IPH). Through comprehensive analysis and validation, a gene set containing eight genes was found to be involved in IPH, and four of these genes were identified as potential important biomarkers for IPH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Maria J. Forteza, Daniel F. J. Ketelhuth
Summary: In the past decade, there has been a growing interest in understanding the link between metabolism and immune response, leading to the emergence of a new field of research called immunometabolism. This interdisciplinary field explores the paradigms of immunology and metabolism to gain insights into disease pathogenesis and discover potential therapeutic targets. Recent studies have shown that metabolites not only serve as fuels in metabolic pathways, but also modulate vascular inflammation and atherosclerosis. This review article summarizes the common immunometabolic pathways in innate and adaptive immune cells and discusses the potential of targeting immunometabolism to prevent and treat cardiovascular diseases.
Article
Cardiac & Cardiovascular Systems
Curtis Williams, Donghee Han, Hidenobu Takagi, Christopher B. Fordyce, Stephanie Sellers, Philipp Blanke, Fay Y. Lin, Leslee J. Shaw, Sang-Eun Lee, Daniele Andreini, Mouaz H. Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araujo Gonsalves, Ilan Gottlieb, Martin Hadamitzky, Erica Maffei, Gianluca Pontone, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Renu Virmani, Habib Samady, Peter H. Stone, Daniel S. Berman, Jagat Narula, Jeroen J. Bax, Jonathon A. Leipsic, Hyuk-Jae Chang
Summary: The study aimed to investigate the effects of RAAS inhibitor on plaque progression and composition assessed by CCTA. Results showed that over nearly 4 years, RAAS inhibitor use did not significantly impact total atherosclerotic plaque progression, but there was a significant decrease in progression of non-calcified plaque in patients with a higher burden of baseline atherosclerosis.
