Article
Psychiatry
Vivien Kin Yi Chan, Hao Luo, Sandra Sau Man Chan, Chak Sing Lau, Winnie Wan Yin Yeung, Kuan Peng, Xinning Tong, May Pui San Lam, Ian Chi Kei Wong, Xue Li
Summary: Recent literature has shown that patients with depression have increased immune activation. This study aimed to explore the relationship between treatment-resistant depression (TRD) and subsequent autoimmune diseases. A cohort study and nested case-control study were conducted using electronic medical records in Hong Kong. The results indicated a significant association between TRD and autoimmune diseases, particularly in organ-specific diseases. The findings suggest that controlling chronic inflammation in hard-to-treat depression may help prevent autoimmunity.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Immunology
Michael Drozd, Mar Pujades-Rodriguez, Ann W. Morgan, Patrick J. Lillie, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon
Summary: Systemic inflammation assessed using C-reactive protein is common in many chronic diseases and is associated with increased long-term risk of fatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Neha A. John-Henderson, Taylor D. Kampf, Giovanni Alvarado, Cory J. Counts, Jade M. Larsen, Cara A. Palmer
Summary: This study investigated whether childhood adversity exacerbates the relationship between sleep restriction and inflammation. The results indicate that childhood adversity may amplify the effect of sleep loss on markers of inflammation.
Article
Immunology
Naoise Mac Giollabhui, Lauren B. Alloy, Lizanne J. S. Schweren, Catharina A. Hartman
Summary: Many depressed individuals experience difficulties in executive functioning, especially those with chronic inflammation. This study found that depression and higher CRP levels are associated with worse executive functioning, with this association being more pronounced in older adults.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Geriatrics & Gerontology
Paulina Zabielska, Sylwia Wieder-Huszla, Beata Karakiewicz, Karolina Skonieczna-Zydecka, Anna Lubkowska, Anna Jurczak
Summary: This study analyzed the balance between proinflammatory and antiinflammatory markers in longevous individuals aged >90 years old, finding a link between abnormal CRP levels and abnormal fibrinogen and IL-6 levels in this age group.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Medicine, General & Internal
Juan Carlos Ayus, Armando Luis Negri, Michael L. Moritz, Kyung Min Lee, Daniel Caputo, Maria Elena Borda, Alan S. Go, Carlos Eghi
Summary: Mild hyponatremia at admission is common in COVID-19 patients, associated with systemic inflammation, and an independent risk factor for hospital mortality.
FRONTIERS IN MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Setor K. Kunutsor, Sae Young Jae, Sudhir Kurl, Jussi Kauhanen, Jari A. Laukkanen
Summary: Inflammation and sauna bathing are independently associated with all-cause mortality risk in Caucasian men. Frequent sauna baths may offset the increased all-cause mortality risk associated with high sensitivity C-reactive protein levels.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arik Sheinenzon, Mona Shehadeh, Regina Michelis, Ety Shaoul, Ohad Ronen
Summary: This study examined the correlation between albumin levels and inflammatory indices in hospitalized patients, showing negative correlations between albumin and CRP/white blood cell levels and positive correlations with platelets/hemoglobin levels. The strongest negative correlation between albumin and CRP was found in the Internal Medicine departments. Linear regression analysis revealed a minor effect of CRP on albumin levels, particularly at very high CRP levels. Further exploration of the mechanisms underlying this negative correlation is needed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Psychiatry
Golam M. Khandaker, Jan Stochl, Stanley Zammit, Glyn Lewis, Robert Dantzer, Peter B. Jones
Summary: The study found that inflammation is associated with sub-clinical psychotic symptoms in young people in the general population, including symptoms like auditory hallucinations and anhedonia. This association may explain the apparent trans-diagnostic effect of inflammation.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Immunology
Douglas Teixeira Leffa, Arthur Caye, Ina Santos, Alicia Matijasevich, Ana Menezes, Fernando C. Wehrmeister, Isabel Oliveira, Eduardo Vitola, Claiton Henrique Dotto Bau, Eugenio Horacio Grevet, Luciana Tovo-Rodrigues, Luis Augusto Rohde
Summary: A high comorbidity between ADHD and asthma has been identified, with inflammation potentially being the underlying mechanism. Data from the 1993 Pelotas birth cohort was used to evaluate the association between ADHD and asthma, revealing higher levels of inflammatory markers in individuals with both conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Public, Environmental & Occupational Health
Antonio Bernabe-Ortiz, Rodrigo M. Carrillo-Larco, Robert H. Gilman, Liam Smeeth, William Checkley, J. Jaime Miranda
Summary: This study assessed the association between hs-CRP and all-cause mortality using the cumulative burden approach. The results showed that high levels of hs-CRP were strongly associated with all-cause mortality. Additionally, two measurements of hs-CRP were better than one in predicting mortality, and the weighted cumulative approach had the best prognostic fit.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Obstetrics & Gynecology
Benjamin S. Harris, Anne Z. Steiner, Keturah R. Faurot, Anneliese Long, Anne Marie Jukic
Summary: The study suggests a potential association between systemic inflammation and menstrual cycle changes. Further research is needed to determine whether systemic inflammation alters the menstrual cycle or if long cycles are a marker for elevated systemic inflammation.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Immunology
I Verbiest, N. Michels, A. Tanghe, C. Braet
Summary: This study investigated the relationship between psychosocial stress and inflammation in obese children and adolescents, finding associations between emotional eating, external eating, attachment anxiety, and higher CRP values. The research also demonstrated that lifestyle intervention can reduce inflammation, with the decrease in inflammatory marker being influenced by psychosocial variables, particularly attachment avoidance.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Mengmeng Ji, Lingbin Du, Zhimin Ma, Junxing Xie, Yanqian Huang, Xiaoxia Wei, Xiangxiang Jiang, Jing Xu, Rong Yin, Yuzhuo Wang, Juncheng Dai, Guangfu Jin, Lin Xu, Chen Zhu, Zhibin Hu, Hongxia Ma, Meng Zhu, Hongbing Shen
Summary: Elevated CRP levels are associated with a 22% increased risk of lung cancer, with positive associations observed in small cell lung cancer, lung adenocarcinoma, and lung squamous cell carcinoma. However, no genetical association between circulating CRP levels and lung cancer risk was found. Adding CRP to the risk model of lung cancer can improve the model's performance in current smokers.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Clinical Neurology
Silvia Fraga, Sara Soares, Ana Cristina Santos, Henrique Barros
Summary: Children who experience physical abuse from their parents are more likely to have elevated levels of high sensitivity C-reactive protein (hs-CRP), with a positive correlation between the severity of violence and hs-CRP levels. This suggests that parental violence may have a negative impact on children's health, influencing inflammatory processes even at an early age.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Victoria E. Kettle, Mark Hamer, Fehmidah Munir, Jonathan Houdmont, Kelly Wilson, Robert Kerr, Ken Addley, Lauren B. Sherar, Stacy A. Clemes
Summary: This study found that long sitting time at work on workdays and prolonged TV viewing on workdays and non-workdays are associated with increased odds of engaging in multiple unhealthy behaviors.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
James W. White, Mark Hamer, G. David Batty
Summary: The study found that exposure to homelessness in early adulthood was essentially unrelated to biomarkers in middle age, with inconsistent links found for specific types of experience.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Editorial Material
Medicine, General & Internal
Mark Hamer, Joanna M. Blodgett
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Psychiatry
Andre O. Werneck, Brendon Stubbs, Aaron Kandola, Adewale L. Oyeyemi, Felipe B. Schuch, Mark Hamer, Davy Vancampfort, Danilo R. Silva
Summary: This study found associations between leisure-time physical activity and psychological distress and well-being, with higher frequency and intensity of leisure-time physical activity having greater effects. Body mass index partially mediated the relationship between leisure-time physical activity and psychological well-being.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Karl-Heinz Ladwig, Thomas C. Baghai, Frank Doyle, Mark Hamer, Christoph Herrmann-Lingen, Evelyn Kunschitz, Cedric Lemogne, Margarita Beresnevaite, Angelo Compare, Roland von Kaenel, Hendrik B. Sager, Willem Johan Kop
Summary: This position paper provides a comprehensive overview of the scientific evidence of psychosocial aspects of heart failure, highlighting the importance of long-term management and psychological support, and critically examining the current shortcomings of interventions.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Immunology
T. Norris, J. M. Blodgett, N. T. Rogers, M. Hamer, S. M. Pinto Pereira
Summary: The study found that early-adult obesity is associated with an increased risk of poor physical functioning in mid-life, with approximately 23% of this effect mediated by its impact on C-reactive protein.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Public, Environmental & Occupational Health
Alice Sullivan, Matt Brown, Mark Hamer, George B. Ploubidis
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Hugues Sampasa-Kanyinga, Jean-Philippe Chaput, Bo-Huei Huang, Mitch J. Duncan, Mark Hamer, Emmanuel Stamatakis
Summary: This study examined the bidirectional association between discretionary screen time (DST) and sleep patterns in adults. The findings suggest that high DST is associated with poor sleep, and poor sleep is associated with high DST.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Aiden J. Chauntry, Nicolette C. Bishop, Mark Hamer, Nicola J. Paine
Summary: Sitting for long periods without interruption and the way we respond to short-term stress are linked to heart disease risk. Breaking up sitting with light activity can lower heart disease risk.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Psychology, Clinical
Verity Hailey, Abi Fisher, Mark Hamer, Daisy Fancourt
Summary: This study analyzed data from the COVID-19 lockdown period and found that social support played an important role in maintaining physical activity during the lockdown, while loneliness and social isolation did not show a significant association with physical activity.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Clinical Neurology
J. M. Blodgett, J. J. Mitchell, E. Stamatakis, S. Chastin, M. Hamer
Summary: This study found that spending more time on moderate to vigorous physical activity (MVPA) relative to sedentary behavior (SB), sleep, or light-intensity physical activity (LIPA) is associated with a lower risk of depression. Replacing sleep, SB, or LIPA with MVPA time was strongly associated with lower depression risk. Reallocating time between SB, sleep, or LIPA had minimal to no effect on depression risk.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Sport Sciences
Le Wei, Matthew N. Ahmadi, Hsiu-Wen Chan, Sebastien Chastin, Mark Hamer, Gita D. Mishra, Emmanuel Stamatakis
Summary: This study aimed to examine the associations between different types and contexts of stepping behaviors and cardiometabolic risk. The results showed that all stepping behaviors were beneficial to cardiometabolic health, with higher stair steps and peak 30-min walking intensity associated with a steep decline of adiposity biomarkers. Purposeful steps showed more consistent associations with cardiometabolic biomarkers than incidental steps.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
J. J. Mitchell, M. Hamer, J. M. Blodgett, G. S. Wannamethee, B. J. Jefferis
Summary: Evidence suggests that engaging in sporting leisure time physical activity (sporting-LTPA) is associated with healthy cognition in adults. This relationship may be due to the physiological effects of physical activity or other psychosocial factors related to sports. This study examined the association between sporting-LTPA and cognition, while controlling for device-measured physical activity volume, in both midlife and later-life participants. The results showed that there were positive associations between sporting-LTPA and cognition, and sports with team/partner elements were particularly beneficial.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
S. M. Pinto Pereira, J. J. Mitchell, J. M. Blodgett, M. Hamer, T. Norris
Summary: The study found an association between non-exercise testing cardiorespiratory fitness and cognitive function in middle age. However, this association disappeared when confounding factors were considered.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Public, Environmental & Occupational Health
Nicholas Scicluna, Mark Hamer, Joanna M. Blodgett
Summary: This study investigated the association between adolescent participation in exercise and sport and device-assessed physical activity (PA) levels in midlife. The results showed that active adolescents had higher total daily PA levels in midlife, but there was no evidence of an association with moderate to vigorous PA (MVPA) levels. This highlights the potential of early PA interventions to improve PA levels in adulthood.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)