Article
Cardiac & Cardiovascular Systems
Luigi Di Serafino, Fabio Mangiacapra, Stylianos Pyxaras, Carmine Morisco, Jozef Bartunek, Bernard De Bruyne, Federica De Luise, William Wijns, Emanuele Barbato
Summary: The study showed that patients with coronary microvascular impairment had lower digital reactive hyperemia indexes, and both the Reactive Hyperemic Index and the Framingham reactive hyperemic index were independent predictors of an IMR > 25.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Clinical Neurology
Robert P. Schnall, Jacob (Koby) Sheffy, Thomas Penzel
Summary: PAT technology accurately records pulsatile volume changes in the arteries of fingers, using a uniform pressure field to eliminate confounding factors and providing a robust measurement platform for sleep-related clinical areas. This method is particularly suitable for home sleep testing due to its patient-friendly nature and extensive validation.
SLEEP MEDICINE REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski
Summary: Inflammation plays a crucial role in the development and progression of atherosclerosis. It negatively affects endothelial barrier properties, glycocalyx, and extracellular matrix composition, leading to vascular remodeling, aneurysm formation, and reduced tissue perfusion. This review discusses the molecular and clinical effects of inflammatory processes on micro- and macrovasculature, with a focus on peripheral artery disease.
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Review
Cardiac & Cardiovascular Systems
Saul Penin-Grandes, Juan Martin-Hernandez, Pedro L. Valenzuela, Susana Lopez-Ortiz, Jose Pinto-Fraga, Lourdes del Rio Sola, Enzo Emanuele, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: Peripheral arterial disease is a cardiovascular disease characterized by atherosclerosis and myopathy in the lower limbs. Physical exercise can positively impact the clinical manifestation of PAD, improving functional capacity and quality of life.
Article
Cardiac & Cardiovascular Systems
Song-Young Park, Elizabeth J. Pekas, Cody P. Anderson, Tyler N. Kambis, Paras K. Mishra, Molly N. Schieber, TeSean K. Wooden, Jonathan R. Thompson, Kyung Soo Kim, Iraklis I. Pipinos
Summary: This study found that patients with PAD have impaired skeletal muscle arteriole endothelial function and mitochondrial respiration. The oxygen delivery and utilization capacity in the skeletal muscle are compromised due to microcirculatory and mitochondrial dysfunction. Targeting skeletal muscle arteriole function may lead to improvements in mitochondrial respiration and oxygen delivery and utilization capacity in patients with PAD.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Sorin Barac, Roxana Ramona Onofrei, Codruta Lazureanu, Robert Barna, Adrian Tutelca, Andreea Luciana Rata
Summary: This study summarized the histopathological changes in the arterial wall, intraarterial thrombus, and adjacent skeletal muscles in patients with acute limb ischemia and SARS-CoV-2 infection. The findings revealed that SARS-CoV-2 infection leads to endothelial destruction and inflammation, contributing to ischemia.
Review
Medicine, General & Internal
Geoffrey Newcomb, Laszlo Farkas
Summary: Our understanding of the pathophysiology of pulmonary arterial hypertension (PAH) has evolved over recent years, highlighting the importance of endothelial cell dysfunction and inflammation. Pulmonary vascular endothelial cells play a unique role in maintaining vascular integrity and function, and their dysregulated response to injury contributes to the development of PAH. Recent research has shown the presence of multiple distinct subpopulations of endothelial cells and their involvement in aberrant endothelial injury repair. Factors such as clonal expansion, immune dysregulation, and genetic mutations also play a role in the pathogenesis of PAH.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jaylen Hudson, Laszlo Farkas
Summary: Pulmonary artery hypertension (PAH) is now recognized as a pulmonary vascular disease with severe endothelial dysfunction, with epigenetic modifications playing a key role in its pathogenesis. Understanding endothelial cell regulation mechanisms and investigating epigenetic changes may lead to future therapeutic advancements in treating PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jiao-Jiao Gu, Yun-Long Hou, Yi-Hui Yan, Jie Li, Ya-Ru Wei, Kun Ma, Xiao-Qi Wang, Jie-Han Zhang, Dan-Dong Wang, Cui-Ru Li, Dong-Qi Li, Ling-Ling Sun, Huai-Lin Gao
Summary: Tongxinluo (TXL) promotes the treatment of diabetic peripheral arterial disease (PAD) by inhibiting endothelial cell pyroptosis, restoring endothelial cell function, and enhancing endothelial cell-smooth muscle cell interactions.
WORLD JOURNAL OF DIABETES
(2023)
Article
Cardiac & Cardiovascular Systems
Peter Ivak, Ivan Netuka, Zuzana Tucanova, Peter Wohlfahrt, Miroslav Konarik, Ondrej Szarszoi, Sarka Novakova, Milos Kubanek, Vera Lanska, Jan Pitha
Summary: The study found that in patients implanted with HM3 left-ventricular assist systems, the artificial pulsatility provided by the device did not prevent deterioration of vascular function.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Biology
Alexander J. Ainscough, Timothy J. Smith, Maike Haensel, Christopher J. Rhodes, Adam Fellows, Harry J. Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S. Howard, John Wharton, Benjamin Dunmore, Paul D. Upton, Martin R. Wilkins, Joshua B. Edel, Beata Wojciak-Stothard
Summary: The paper presents a biomimetic inducible model of pulmonary arterial hypertension (PAH) that combines natural and induced bone morphogenetic protein receptor 2 (BMPR2) dysfunction with hypoxia to induce smooth muscle activation and proliferation. The model enables insights into disease pathways and mechanisms of drug response through specific gene expression changes. It offers an easily accessible approach for researchers to study pulmonary vascular remodelling and advance drug development in PAH.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Pasha Normahani, Joseph J. Boyle, Luke Cave, Paul Brookes, Kevin J. Woollard, Usman Jaffer
Summary: This study investigates the immune status and gene expression differences between patients with intermittent claudication (IC) who experience a rise in urinary N-acetyl-beta-D-Glucosaminidase (NAG)/Creatinine (Cr) ratio following exercise and those who do not. The results show that patients with a rise in NAG/Cr ratio have higher IL-10/IL-12 ratio and differential gene expression compared to those without. These findings suggest that some IC patients may have altered immune status and susceptibility to systemic inflammation and renal injury following exercise.
Article
Toxicology
Wenting Cheng, Huanhuan Pang, Matthew J. Campen, Jianzhong Zhang, Yanting Li, Jinling Gao, Dunqiang Ren, Xiaoya Ji, Nathaniel Rothman, Qing Lan, Yuxin Zheng, Shuguang Leng, Zeping Hu, Jinglong Tang
Summary: Chronic exposure to diesel exhaust causes dysfunction in arterial endothelial cells, possibly due to circulatory metabolites.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Review
Endocrinology & Metabolism
Alberto La Valle, Marco Crocco, Decimo Silvio Chiarenza, Mohamad Maghnie, Giuseppe d'Annunzio
Summary: Endothelial dysfunction (ED) plays a significant role in various endocrine diseases, and assessment through non-invasive techniques can help in early identification of patient risks and prevention of the progression of more serious illnesses.
WORLD JOURNAL OF DIABETES
(2021)