Article
Peripheral Vascular Disease
Lauren A. Biwer, Brigett V. Carvajal, Qing Lu, Joshua J. Man, Iris Z. Jaffe
Summary: The study showed that deletion of endothelial MR in obese female animals can improve vascular dilation, and endothelial ER alpha plays a positive role in increasing nitric oxide to rescue vasodilation. MR and ER alpha may compete for striatin binding within endothelial cells to regulate NO.
Article
Nutrition & Dietetics
Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yukiko Nakano, Masato Kajikawa, Kenichi Yoshimura, Chikara Goto, Aya Mizobuchi, Shunsuke Tanigawa, Farina Mohamad Yusoff, Shinji Kishimoto, Tatsuya Maruhashi, Ayumu Nakashima, Yukihito Higashi
Summary: This study investigated the relationship between daily coffee intake and vascular function in patients with hypertension. The findings suggest that moderate coffee consumption may have beneficial effects on endothelial function and vascular smooth muscle function in these patients.
Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Devahuti Chaliha, Mauro Vaccarezza, Virginie Lam, Ryusuke Takechi, John C. Mamo
Summary: A 74-year-old female patient with suboptimal management of episodic tension headaches was treated with l-arginine and aged garlic extract, which resulted in significant improvement of symptoms for 2 years. This may be due to the vasodilatory effects of these substances on blood vessels. A randomized controlled trial is recommended to further test this hypothesis in migraine patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Endocrinology & Metabolism
Kun Yu, Zheng-Yuan Huang, Xue-Ling Xu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This article discusses the role of estrogen in the female endometrium and its regulatory role through nuclear and membrane-associated receptors. The importance of ERs in maintaining endometrial function is emphasized, and references for treating endometrial diseases are provided.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Carolina M. Lazaro, Jamaira A. Victorio, Ana Paula Davel, Helena C. F. Oliveira
Summary: The expression of CETP protects the vascular function in female animals and can improve endothelial dysfunction and the proatherogenic effect of cholesteryl ester transfer on atherosclerosis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Plant Sciences
Min-yao Li, Mu-xia Li, Nan Xu, Ze-hao Li, Yao-min Zhang, Yu-xuan Gan, Hui-juan Luo, Chang-lin Zhou, Yu-hong Liu, Zi-ren Su, Xiao-qi Huang, Xue-bao Zheng
Summary: Huangqin Decoction may act on ulcerative colitis by regulating targets and pathways related to improving the intestinal mucosal barrier and ameliorating endothelial dysfunction. ERS1 may be a new target to explore the mechanisms of UC.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Aya Mizobuchi, Shunsuke Tanigawa, Farina Mohamad Yusoff, Yukiko Nakano, Kazuaki Chayama, Ayumu Nakashima, Chikara Goto, Yukihito Higashi
Summary: This study investigated the associations of vascular function with season and outdoor temperature. The results showed no significant correlation between vascular function and season or outdoor temperature.
HYPERTENSION RESEARCH
(2023)
Article
Genetics & Heredity
Yuyou Yang, Naibo Feng, Li Liang, Rong Jiang, Yiming Pan, Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo
Summary: This study confirmed the important role of PGRN in regulating the estrogen signal, maintaining bone homeostasis. Our findings may provide a new strategy for the treatment of osteoporosis and maintaining bone homeostasis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Electrochemistry
Mengli Wang, Lele Ma, Le Kang, Mingsan Miao, Huaixia Yang
Summary: In this study, an electrochemical biosensor was developed for the sensitive detection of estrogen receptor alpha (ERa) in breast cancer. The biosensor utilized AuNPs-SWCNT nanocomposites and hemin@HKUST-1 for signal amplification. The biosensor demonstrated a low detection limit of 27.8 fg.ml(-1) and a good linear relationship between current intensity and the logarithm of ERa concentration. It also exhibited excellent selectivity, stability, reproducibility, and interference immunity, making it highly applicable in practical detection.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Review
Endocrinology & Metabolism
Peng Chen, Bo Li, Ling Ou-Yang
Summary: Estrogen receptors play crucial roles in regulating various physiological processes in humans. Abnormal signaling of these receptors can lead to a wide range of disorders. This review provides an overview of ER alpha, ER beta, and GPER1, highlighting their functions in both health and disease. Additionally, it discusses the potential clinical applications and challenges associated with these receptors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Abigayle B. Simon, Cassandra C. Derella, Marsha Blackburn, Jeffrey Thomas, Lawrence C. Layman, Matthew S. Nicholson, Jennifer Waller, Ahmed Elmarakby, Karim M. Saad, Ryan A. Harris
Summary: The study found that women with type 1 diabetes have higher levels of estradiol in the late follicular phase, leading to increased oxidative stress and endothelial dysfunction. The use of oral contraceptive pills appears to benefit endothelial function in patients with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Food Science & Technology
Baocai Xie, Dengke Pan, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu
Summary: Diosmetin treatment can reduce body weight and fat mass, improve glucose tolerance and insulin resistance by increasing energy expenditure through enhancing thermogenesis and browning of adipose tissue. Mechanistically, diosmetin acts as an agonist for estrogen receptors (ERs) to elevate their expression in adipose tissue, and the presence of ERs is essential for the metabolic benefits of diosmetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Aylin Del Moral-Morales, Juan Carlos Gonzalez-Orozco, Ana Maria Hernandez-Vega, Karina Hernandez-Ortega, Karla Mariana Pena-Gutierrez, Ignacio Camacho-Arroyo
Summary: A study found that in human Glioblastomas (GBM), the pro-oncogenic actions of 17 beta-estradiol (E2) are mediated by EZH2, which promotes proliferation, migration, and invasion of GBM cells. Although E2 does not modify EZH2 expression, gene silencing and pharmacological inhibition of EZH2 can block these pro-oncogenic actions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Developmental Biology
Ren Tanimoto, Kiyono Sekii, Kanako Morohaku, Jianzhen Li, David Pepin, Yayoi Obata
Summary: This study reveals that estrogen receptor 1 activated by estrogen binds to the 5' region of the Amh gene in cultured mouse fetal ovaries, upregulating its transcription and causing ectopic expression of AMH protein, which inhibits normal follicle formation. Additionally, the addition of AFP to the culture medium inhibits ectopic AMH expression via estrogen, leading to successful follicle formation in vitro.