Article
Radiology, Nuclear Medicine & Medical Imaging
Kevin Liu, Patrik Goncalves Jorge, Ramesh Tailor, Raphael Moeckli, Emil Schuler
Summary: This study evaluated the performance of Gafchromic EBT3 film under various measurement conditions to simplify but enhance film dosimetry. The results showed that scanning the film within a certain time window and using a standard calibration curve introduced a maximum error of 2% over a dose range of 1-40 Gy. The film response was influenced by the film-read delay, film batch, scanner type, and beam energy.
Article
Nuclear Science & Technology
Wanook Ji, Jong-Bum Kim, Jin-Joo Kim
Summary: This study used peeled-off GafchromicTM EBT3 film to measure the activity distribution of the Ni-63 source and found that absorbed dose increased proportionally to source activity and exposure duration. Low energy beta particles could transport energy into the active layer, and two-dimensional dosimetric distribution was suitable for measuring activity distribution.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Nuclear Science & Technology
Maria A. Piliero, Francesco Pupillo, Stefano Presilla
Summary: In this study, the Konica Minolta CM-700d spectrophotometer was characterized as a portable device for radiation dosimetry using EBT3 GAFchromic films. The results showed high stability and reproducibility of colour measurements, with a dose measurement accuracy of 2% and faster readout speed.
RADIATION MEASUREMENTS
(2022)
Article
Oncology
Sun Young Moon, Yunhui Jo, Jaehyeon Seo, Dongho Shin, Myonggeun Yoon
Summary: This study describes a simple method of inter-fractional photon beam monitoring using Gafchromic EBT3 film. The methodology was found effective in quality assurance during radiotherapy treatments. Overall, the results showed good application of this method in both 3D-CRT and IMRT plans.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Instruments & Instrumentation
Liyun Chang, Shyh-An Yeh, Sheng-Yow Ho, Hueisch-Jy Ding, Pang-Yu Chen, Tsair-Fwu Lee
Summary: The EBT3 film is widely used for dosimetry quality assurance due to its high resolution and self-developing properties. A new adaptive calibration method has been proposed to recalibrate the film without the need for dose delivery. The results show that the adaptive calibration method is effective in reducing the difference between calculated film-dose and administered dose to less than 3%, making it a practical and cost-effective technique for clinical use.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daphnee Villoing, Charbel Koumeir, Arthur Bongrand, Arnaud Guertin, Ferid Haddad, Vincent Metivier, Freddy Poirier, Vincent Potiron, Noel Servagent, Stephane Supiot, Gregory Delpon, Sophie Chiavassa
Summary: This study evaluated the usability and dose rate dependency of several radiochromic films commonly used for dosimetry. The results show that EBT3 and EBT-XD films may overestimate the absolute dose in ultra-high dose rate proton beams, while OC-1 films do not have this issue.
Article
Nuclear Science & Technology
Megha Sharma, Ranjit Singh, N. Robert, G. Trivedi, P. Tomar, A. S. Oinam
Summary: The study evaluated the energy and dose rate dependence of Gafchromic EBT3 film irradiated with megavolt photon beams. The film sensitivity decreased with increasing dose, and differences among beam energies were more significant at low doses.
RADIATION MEASUREMENTS
(2021)
Article
Multidisciplinary Sciences
Misba Hamid Baba, Benoy Kumar Singh
Summary: This study compared the skin dose during head and neck radiation therapy between 2-dimensional radiotherapy (2DRT) and Intensity Modulated Radiotherapy (IMRT). The results showed that IMRT had lower skin dose and its measured dose was consistent with the treatment planning calculated dose. Therefore, IMRT is important for the radiation therapy of head and neck cancers.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2022)
Article
Dermatology
Rindala El Khoury, Marie Abboud, Rime Michael-Jubeli, Najet Yagoubi, Arlette Baillet-Guffroy, Toufic Rizk, Ali Tfayli, Roger Lteif
Summary: A new in vitro method using EBT3 Gafchromic (R) film as a substrate was developed for SPF testing of sunscreens. The study found a linear correlation between the absorbance of the film and the SPF value of the sunscreen covering it. This method proved to be reliable and closely related to real-life conditions.
EUROPEAN JOURNAL OF DERMATOLOGY
(2021)
Article
Environmental Sciences
Varsha R. Gedam, Anirudh Pradhan
Summary: Patient-specific intensity-modulated radiation therapy (IMRT) quality assurance is essential for complex radiotherapy treatment. The study shows that film dosimetry is a reliable verification system for patient-specific IMRT QA.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cesar Rodriguez, Diego Garcia-Pinto, Luis Carlos Martinez, Alfonso Lopez-Fernandez
Summary: The purpose of this study is to investigate a new analytical model for the dose-response curve of radiochromic EBT3 film in megavoltage photon beams. This model takes into account the different increase of two types of absorbents in the film with absorbed dose and can identify parameters dependent on the flatbed scanner and film model, as well as parameters exclusively dependent on the production lot. Compared with other commonly used models, the new model performs better in reducing systematic calibration uncertainties.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Engineering, Multidisciplinary
T. Medjadj, A. I. Ksenofontov, V. A. Klimanov, A. V. Dalechina, Y. S. Kirpichev
Summary: This study validates the penEasy Monte Carlo model for Leksell Gamma Knife Perfexion through experimental measurements, showing excellent agreement between penEasy and EBT3 results. The differences in output factors and dose profiles were found to be minimal, indicating the potential for clinical application in radiotherapy.
INSTRUMENTS AND EXPERIMENTAL TECHNIQUES
(2021)
Article
Chemistry, Physical
Megha Sharma, Ranjit Singh, Sunil Dutt, Parsee Tomar, Gaurav Trivedi, N. Robert
Summary: The study focused on the impact of dose delivered by a 15 MeV photon beam on the optical density/transmittance of EBT3 films, revealing varying trends in transmittance at different dose ranges and time points. The findings suggest that higher doses result in smaller changes in transmittance, with a dose-dependent phenomenon observed in optical density saturation. It is recommended to scan the films at specific time points post-irradiation based on the absorbed dose level.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Liyun Chang, Shyh-An Yeh, Sheng-Yow Ho, Hueisch-Jy Ding, Pang-Yu Chen, Tsair-Fwu Lee
Summary: In order to ensure treatment quality and reduce dose errors, scientists utilize intensity modulation with steep dose gradient in radiation treatment planning. They utilize the high-resolution EBT3 Gafchromic film to address aging effects and batch differences, and establish a new method for film calibration using artificial neural networks.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Daniel Sanchez-Parcerisa, Irene Sanz-Garcia, Paula Ibanez, Samuel Espana, Andrea Espinosa, Carolina Gutierrez-Neira, Alfonso Lopez, Juan Antonio Vera, Alejandro Mazal, Luis Mario Fraile, Jose Manuel Udias
Summary: Passive dosimetry with radiochromic films is widely used in proton radiotherapy, but film under-response for low-energy protons must be accounted and corrected for. A meta-analysis was performed on existing data to integrate different types of films, showing a linear decrease of relative efficiency with increasing LET, with no remarkable differences between the three types of films analyzed. Direct measurements with a 10 MeV proton beam further supported the findings.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Gabrielle Wishart, Priyanka Gupta, Giuseppe Schettino, Andrew Nisbet, Eirini Velliou
Summary: The efficacy of radiotherapy treatment varies based on tumor microenvironment (TME). Traditional 2D cell culture fails to replicate important TME features. Animal models have realistic in vivo architecture but are time-consuming and costly.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Majdi Alnowami, Fouad Abolaban, Hussam Hijazi, Andrew Nisbet
Summary: This study explores the use of artificial intelligence in adaptive radiation therapy treatment planning by predicting the tumor volume reduction rate. The results show that age, dose per fraction, and weight are the best predictors for tumor volume reduction rate.
APPLIED SCIENCES-BASEL
(2022)
Review
Chemistry, Physical
Ming Tsuey Chew, David A. Bradley, Bleddyn Jones, Andrew Nisbet, Mark Hill
Summary: This article provides an overview of the effects of reduced low-level radiation on organisms, presenting available evidence and discussing theoretical possibilities.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Chemistry, Physical
N. Abdullah, D. A. Bradley, A. Nisbet, Z. Kamarul Zaman, S. S. Deraman, N. Mohd Noor
Summary: The dosimetric characteristics of germanium (Ge) doped optical fibres have been investigated as a potential alternative for electron beam therapy postal audits. Results showed good performance of the Ge-doped optical fibres in terms of signal fading, linear dose-response, and beam energy- and dose rate dependence.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabrielle Wishart, Priyanka Gupta, Andrew Nisbet, Eirini Velliou, Giuseppe Schettino
Summary: This study investigates the impact of static magnetic field on the radiation response of pancreatic cancer cells in a polyurethane-based highly macro-porous scaffold in both hypoxic and normoxic conditions. The results suggest that the presence of SMF enhances the effect of radiation in both hypoxic and normoxic conditions, providing insights into the potential interaction phenomenon between SMF and radiation in a three-dimensional microenvironment.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Ileana Silvestre Patallo, Anna Subiel, Rebecca Carter, Samuel Flynn, Giuseppe Schettino, Andrew Nisbet
Summary: This study characterized a detection system based on inorganic scintillators and assessed its suitability for dosimetry in preclinical radiation research. The system showed good performance in dose quality control, dose response, and dose output factor measurements. Therefore, the inorganic scintillation system is a useful tool for dose verification in medium-energy X-rays delivered by Image-Guided Small Animal Radiotherapy Platforms.
Article
Chemistry, Multidisciplinary
Hannah Mary T. Thomas, Helen Y. C. Wang, Amal Joseph Varghese, Ellen M. Donovan, Chris P. South, Helen Saxby, Andrew Nisbet, Vineet Prakash, Balu Krishna Sasidharan, Simon Pradeep Pavamani, Devakumar Devadhas, Manu Mathew, Rajesh Gunasingam Isiah, Philip M. Evans
Summary: The featured application of this work is in radiomics for medical imaging analysis, aiming to address the issue of establishing the stability and reproducibility of radiomic features. The study compared two feature extraction implementations, MATLAB and Pyradiomics, in analyzing independent datasets of CT scans. Results showed that 29 out of 43 reported stable features were highly reproducible between the two implementations. Based on reproducibility, useful radiomics features should be selected, and the methodology for evaluating reproducibility between datasets was validated.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Biomedical
Antony L. Palmer, David Nash, Wojciech Polak, Sarah Wilby
Summary: This study evaluated the differences between the new Gafchromic EBT4 film and the current EBT3 film for radiotherapy dosimetry. The results showed that EBT4 had more favorable characteristics for radiation dosimetry compared to EBT3, with improved signal-to-noise ratio. EBT4 provided better agreement with the planned doses and showed equivalent or smaller difference in measured dose compared to EBT3.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Stefan Escaida Navarro, Sepaldeep Singh Dhaliwal, Mario Sanz Lopez, Sarah Wilby, Antony L. Palmer, Wojciech Polak, Rochdi Merzouki, Christian Duriez
Summary: This paper introduces a novel concept for a phantom of the prostate, which is essential for studying and improving automated, robotized medical interventions. The phantom, equipped with sensors and numerical simulation, can estimate deformations caused by external forces and simulate the growth of the prostate due to inflammation.
IEEE TRANSACTIONS ON MEDICAL ROBOTICS AND BIONICS
(2022)
Meeting Abstract
Cell & Tissue Engineering
Gabrielle Wishart, Priyanka Gupta, Giuseppe Schettino, Andrew Nisbet, Eirini Velliou
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Priyanka Gupta, Pedro Perez-Mancera, Hemant Kocher, Andrew Nisbet, Giuseppe Schettino, Eirini Velliou
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Oncology
I. Silvestre Patallo, F. Shi, R. Carter, A. Nisbet
RADIOTHERAPY AND ONCOLOGY
(2022)
Meeting Abstract
Oncology
P. Nikou, A. Nisbet, A. Thompson, S. Gulliford, J. McClelland
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kamalram Thippu Jayaprakash, Denis Mostafa, Mohammad Hussein, Richard Shaffer, Agnieszka Michael, Mazhar Ajaz, Andrew Nisbet
Summary: In this study, a multiwell tissue culture plate irradiation setup was designed and developed, and the consistency between planned and measured/imaged radiation dose profiles was demonstrated. Analysis of cell viability, clonogenic potential, and DNA damage showed no significant differences between intensity-modulated radiotherapy and open-field, homogeneous irradiations. This research provides a novel platform for radiobiology experiments within a clinical environment.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Applied
Fouad Abolaban, Andrew Nisbet
Summary: In this study, a digital phantom and Monte Carlo modeling were used to simulate the irradiation geometry of a typical tumor volume in the brain region, and investigate the dose enhancement effects of nanoparticles with different elemental composition and concentration in radiation therapy.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)