Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model ofClostridium difficileinfection

Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U-Shaped Binding Mode

(2014) Jun Lu et al.   ACS Chemical Biology

Editorial Commentary: The Trials and Tribulations of Treating Clostridium difficile Infection--One Step Backward, One Step Forward, but Still Progress

(2014) M. H. Wilcox   CLINICAL INFECTIOUS DISEASES

Vancomycin, Metronidazole, or Tolevamer for Clostridium difficile Infection: Results From Two Multinational, Randomized, Controlled Trials

(2014) Stuart Johnson et al.   CLINICAL INFECTIOUS DISEASES

Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review

(2014) Lissa Tsutsumi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Action of nitroheterocyclic drugs against Clostridium difficile

(2014) Manish Kumar et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Chemical Modulation of the Biological Activity of Reutericyclin: a Membrane-Active Antibiotic from Lactobacillus reuteri

(2014) Philip T. Cherian et al.   Scientific Reports

Small animal models for the study ofClostridium difficiledisease pathogenesis

(2013) Melanie L. Hutton et al.   FEMS MICROBIOLOGY LETTERS

Prospects for flavonoid and related phytochemicals as nature-inspired treatments forClostridium difficileinfection

(2013) X. Wu et al.   JOURNAL OF APPLIED MICROBIOLOGY

Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity

(2013) Y. Miyamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vancomycin Treatment's Association with Delayed Intestinal Tissue Injury, Clostridial Overgrowth, and Recurrence of Clostridium difficile Infection in Mice

(2012) C. A. Warren et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Non-Systemic Drugs: A Critical Review

(2012) Dominique Charmot   CURRENT PHARMACEUTICAL DESIGN

The membrane as a target for controlling hypervirulent Clostridium difficile infections

(2012) X. Wu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antibacterial drug leads targeting isoprenoid biosynthesis

(2012) W. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics, microbiota, and immune defense

(2012) Carles Ubeda et al.   TRENDS IN IMMUNOLOGY

Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations

(2011) J. G. Hurdle et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synthesis of and Tautomerism in 3-Acyltetramic Acids

(2011) Yong-Chul Jeong et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemical Synthesis Enables Biochemical and Antibacterial Evaluation of Streptolydigin Antibiotics

(2011) Sergey V. Pronin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase

(2010) Lac V. Lee et al.   BIOCHEMISTRY

Metronidazole Is Still the Drug of Choice for Treatment of Anaerobic Infections

(2010) Sonja Löfmark et al.   CLINICAL INFECTIOUS DISEASES

Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)

(2010) Stuart H. Cohen et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Anti-Clostridium difficile Potential of Tetramic Acid Derivatives from Pseudomonas aeruginosa Quorum-Sensing Autoinducers

(2009) C. Ueda et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distinctive Profiles of Infection and Pathology in Hamsters Infected with Clostridium difficile Strains 630 and B1

(2009) D. Goulding et al.   INFECTION AND IMMUNITY

Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells

(2009) Shumei Zhai et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Convenient syntheses of 5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-oxadiazole-2(3H)thione and N-substituted 2-amino-5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-thiadiazoles

(2009) Javad Mirzaei et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis and Evaluation of N-Nicotinoyl-2-{2-(2-Methyl-5-Nitroimidazol-1-yl)Ethyloxy}-D,L-Glycine as a Colon-Specific Prodrug of Metronidazole

(2009) Duksoo Kim et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis of Novel Hybrid Molecules from Precursors With Known Antiparasitic Activity

(2009) Haythem Saadeh et al.   MOLECULES

Tetramic and tetronic acids: An update on new derivatives and biological aspects

(2008) Rainer Schobert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones

(2008) Stefan Peukert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Vancomycin for the Treatment ofClostridium difficileInfection: For Whom Is This Expensive Bullet Really Magic?

(2008) Jacques Pepin   CLINICAL INFECTIOUS DISEASES

Estimation of ADME Properties in Drug Discovery: Predicting Caco-2 Cell Permeability Using Atom-Based Stochastic and Non-stochastic Linear Indices

(2007) Juan A. Castillo-Garit et al.   JOURNAL OF PHARMACEUTICAL SCIENCES