Article
Neurosciences
Raquel Comaposada-Baro, Andrea Benito-Martinez, Juan Julian Escribano-Saiz, Maria Luisa Franco, Lorenzo Ceccarelli, Isabel Calatayud-Baselga, Helena Mira, Marcal Vilar
Summary: This study investigates the role of p75(NTR) in the basal forebrain during aging and its relationship with cholinergic neurodegeneration and dysregulated cholesterol metabolism. The findings suggest that the SAMP8-p75(exonIII-/-) mouse strain could serve as a good model for studying long-term cholinergic neurodegeneration in the central nervous system (CNS), and provide insights into the role of p75(NTR) in cholesterol biosynthesis regulation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Yanqiu Zhang, Yue Li, Yuhua Fan, Xiaoyuan Zhang, Zhihong Tang, Jing Qi, Baoshan Zhao, Fuyuan Li, Xiaofeng Chen, Huan Liang, Haiyan Xu, Dongliang Li
Summary: We found that SorCS3 is significantly downregulated in GBM, and low expression of SorCS3 predicts poor prognosis in patients. SorCS3 primarily suppresses cell invasion and proliferation via the NGF/p75(NTR) pathway, playing a critical role in inhibiting glioma progression.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Zhen Li, Yajing Duan, Wenhui Mao, Cheng Chen, Wensu Yuan, Xinghua Jin, Shuo Shi, Xun-Cheng Su, Carlos F. Ibanez, Zhi Lin
Summary: The p75 neurotrophin receptor contains a death domain (DD) that plays a crucial role in apoptotic and inflammatory signaling. Conflicting findings and controversy exist regarding the oligomeric states of the p75NTR-DD. However, new evidence from biophysical and biochemical studies demonstrates the coexistence of symmetric and asymmetric dimers of the p75NTR-DD, which can equilibrate with the monomeric form in solution. This reversible behavior may be important for the intracellular signaling function of the p75NTR-DD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Carlos Fernandez Moro, Natalie Geyer, Sara Harrizi, Yousra Hamidi, Sara Soderqvist, Danyil Kuznyecov, Evelina Tidholm Qvist, Media Salmonson Schaad, Laura Hermann, Amanda Lindberg, Rainer L. Heuchel, Alfonso Martin-Bernabe, Soniya Dhanjal, Anna C. Navis, Christina Villard, Andrea C. del Valle, Lorand Bozoky, Ernesto Sparrelid, Luc Dirix, Carina Strell, Arne Ostman, Bernhard Schmierer, Peter B. Vermeulen, Jennie Engstrand, Bela Bozoky, Marco Gerling
Summary: The perimetastatic capsule is a strong positive prognostic factor in liver metastases. This study reveals that survival is associated with the extent of encapsulation and tumor-hepatocyte contact. The capsule exhibits a gradual zonation, with different cellular composition in different regions. Capsule formation is correlated with decreased tumor viability and preoperative chemotherapy.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Carlos Fernandez Moro, Natalie Geyer, Sara Harrizi, Yousra Hamidi, Sara Soderqvist, Danyil Kuznyecov, Evelina Tidholm Qvist, Media Salmonson Schaad, Laura Hermann, Amanda Lindberg, Rainer L. Heuchel, Alfonso Martin-Bernabe, Soniya Dhanjal, Anna C. Navis, Christina Villard, Andrea C. del Valle, Lorand Bozoky, Ernesto Sparrelid, Luc Dirix, Carina Strell, Arne Ostman, Bernhard Schmierer, Peter B. Vermeulen, Jennie Engstrand, Bela Bozoky, Marco Gerling
Summary: The presence of a perimetastatic capsule is a positive prognostic factor in liver metastases, and its origin is linked to tumor invasion and reparative processes.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yanjun Liu, Peixu Cong, Tao Zhang, Rui Wang, Xiaoxu Wang, Junyi Liu, Xinceng Wang, Jie Xu, Yuming Wang, Jingfeng Wang, Changhu Xue
Summary: This study investigates the role of ethanolamine plasmalogen in Alzheimer's disease and metabolic diseases, providing insights into the mechanistic bases for these conditions. The findings suggest that ethanolamine plasmalogen deficiency may lead to the development of steatohepatitis and memory impairments, and restoring ethanolamine plasmalogen levels could prevent these diseases. The study reveals a potential therapeutic strategy for combating steatosis and memory impairments through modulation of plasmalogen levels.
Review
Cell Biology
Lik-Wei Wong, Zijun Wang, Sheila Rui Xia Ang, Sreedharan Sajikumar
Summary: Aging and age-related neurodegenerative diseases can lead to cognitive decline, and the p75(NTR) receptor plays an important role in neuronal fate and synaptic plasticity. This review discusses the regulation of p75(NTR) in synaptic plasticity and its involvement in aging and neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2022)
Article
Agriculture, Dairy & Animal Science
Claudia Gatta, Valentina Schiano, Chiara Attanasio, Carla Lucini, Antonio Palladino
Summary: In this study, the presence of neurotrophic factors in the taste bud cells of zebrafish is demonstrated. These neurotrophins play an important role in taste bud function and share similarities with those found in mammals. This study further confirms the significance of the zebrafish model in translational research.
Article
Neurosciences
Zhihua Liu, Aijuan Yan, Jiahao Zhao, Shuyuan Yang, Lu Song, Zhenguo Liu
Summary: The study revealed the important role of p75NTR in patients with Parkinson's disease and suggested it as a new target for managing L-dopa-induced dyskinesia.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ozgun Ozalp, Ozge Cark, Yagmur Azbazdar, Betul Haykir, Gokhan Cucun, Ismail Kucukaylak, Gozde Alkan-Yesilyurt, Erdinc Sezgin, Gunes Ozhan
Summary: Nradd, a negative regulator of Wnt/beta-catenin signaling, suppresses Wnt-mediated patterning in zebrafish embryos and mammalian cells, highlighting its role in regulating cell growth and development through modulating Wnt signaling and apoptosis.
Article
Oncology
Annalisa Saltari, Andreas Dzung, Marika Quadri, Natascia Tiso, Nicola Facchinello, Alberto Hernandez-Barranco, Susana Garcia-Silva, Laura Nogues, Corinne Isabelle Stoffel, Phil F. Cheng, Patrick Turko, Ossia M. Eichhoff, Francesca Truzzi, Alessandra Marconi, Carlo Pincelli, Hector Peinado, Reinhard Dummer, Mitchell P. Levesque
Summary: CD271 has been extensively studied for its role in melanoma and its potential therapeutic implications. Activation of CD271 induces apoptosis in melanoma cells, reduces metastasis, and overcomes drug resistance, highlighting it as a promising target for melanoma therapy.
Article
Neurosciences
Austin B. Keeler, Amy L. Van Deusen, Irene Cheng, Corey M. Williams, Sarah M. Goggin, Ashley K. Hirt, Shayla A. Vradenburgh, Kristen Fread, Emily A. Puleo, Lucy Jin, Christopher D. Deppmann, Eli R. Zunder, Yipkin Calhan
Summary: This study presents a single-cell, protein-level atlas of mouse dorsal root ganglia and highlights the significance of protein-level measurements in identifying functional cell states during somatosensory development.
NATURE NEUROSCIENCE
(2022)
Article
Neurosciences
Victor Danelon, Sarah C. Garret-Thomson, Steven C. Almo, Francis S. Lee, Barbara L. Hempstead
Summary: Despite similarities with other TNFR superfamily members, p75 neurotrophin receptor (p75(NTR)) exhibits distinct characteristics in terms of expression, ligand interaction, and co-receptor utilization. Recent evolutionary adaptation allows B7-1 to engage with p75(NTR) in primates, triggering synaptic elimination in the brain. These findings suggest a shared response to immunoregulatory cues and highlight the immune-driven modulation of synaptic actions during injury or inflammation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biology
Anna Perri, Vittoria Rago, Rocco Malivindi, Lorenza Maltese, Danilo Lofaro, Emanuela Alessandra Greco, Luigi Tucci, Renzo Bonofiglio, Margherita Vergine, Sandro La Vignera, Eusebio Chiefari, Antonio Brunetti, Antonio Aversa
Summary: Studies have shown that p75(NTR) is overexpressed in several human cancer types, and in TGCTs, it may serve as a specific marker for seminoma and staging progression.
Article
Immunology
Dandan Zhang, Shengnan Zhao, Zhijie Zhang, Danfeng Xu, Di Lian, Jing Wu, Dake He, Kun Sun, Ling Li
Summary: The study revealed the crucial role of p75NTR signaling in the pathogenesis of Streptococcus pneumoniae meningitis. Treatment with a specific modulator alleviated clinical severity, tissue damage, and neuroinflammation. Additionally, long-term treatment showed positive effects on promoting neurogenesis.
JOURNAL OF NEUROINFLAMMATION
(2021)