Targeting VIP and PACAP Receptor Signalling: New Therapeutic Strategies in Multiple Sclerosis

Cutting Edge: Vasoactive Intestinal Peptide (VIP) Induces Differentiation of Th17 Cells with a Distinctive Cytokine Profile

(2014) M. Yadav et al.   JOURNAL OF IMMUNOLOGY

VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1) G protein-coupled receptor mediation of VIP enhancement of murine experimental colitis

(2011) Mahesh Yadav et al.   CELLULAR IMMUNOLOGY

VIP-induced Neuroprotection of the Developing Brain

(2011) Sandrine Passemard et al.   CURRENT PHARMACEUTICAL DESIGN

Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP

(2010) Agnieszka Dejda et al.   BIOCHIMIE

Current and Future Role of Interferon Beta in the Therapy of Multiple Sclerosis

(2010) Rachel A. Farrell et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Development of PACAP38 Analogue with Improved Stability: Physicochemical and In Vitro/In Vivo Pharmacological Characterization

(2010) Satomi Onoue et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Emerging disease-modifying oral therapies for multiple sclerosis

(2010) Jacek Losy et al.   JOURNAL OF NEUROIMMUNOLOGY

Dendritic Cells Transduced With Lentiviral Vectors Expressing VIP Differentiate Into VIP-secreting Tolerogenic-like DCs

(2010) Miguel G Toscano et al.   MOLECULAR THERAPY

A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis

(2010) Gavin Giovannoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis

(2010) C. Abad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Consensus Statement Addressing Mesenchymal Stem Cell Transplantation for Multiple Sclerosis: It’s Time!

(2010) Christopher Siatskas et al.   Stem Cell Reviews and Reports

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Mesenchymal Stem Cell Homing: The Devil Is in the Details

(2009) Jeffrey M. Karp et al.   Cell Stem Cell

Pituitary Adenylate Cyclase-Activating Polypeptide: Focus on Structure- Activity Relationships of a Neuroprotective Peptide

(2009) S. Bourgault et al.   CURRENT MEDICINAL CHEMISTRY

Stem Cell and Gene Therapeutic Strategies for the Treatment of Multiple Sclerosis

(2009) Christopher Siatskas et al.   CURRENT MOLECULAR MEDICINE

Modulating receptor function through RAMPs: can they represent drug targets in themselves?

(2009) Patrick M. Sexton et al.   DRUG DISCOVERY TODAY

Synaptic Scaffolding Molecule Binds to and Regulates Vasoactive Intestinal Polypeptide Type-1 Receptor in Epithelial Cells

(2009) Heon Yung Gee et al.   GASTROENTEROLOGY

Molecular and Conformational Determinants of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) for Activation of the PAC1 Receptor

(2009) Steve Bourgault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial

(2009) Andrew D Goodman et al.   LANCET

Chemical synthesis and characterization of silver-protected vasoactive intestinal peptide nanoparticles

(2009) Rafael Fernandez-Montesinos et al.   Nanomedicine

VPAC1 receptor binding site: Contribution of photoaffinity labeling approach

(2009) A. Couvineau et al.   NEUROPEPTIDES

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

(2009) D. Vaudry et al.   PHARMACOLOGICAL REVIEWS

Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis

(2009) Yossan-Var Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trafficking Mesenchymal Stem Cell Engraftment and Differentiation in Tumor-Bearing Mice by Bioluminescence Imaging

(2009) Hui Wang et al.   STEM CELLS

Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R)

(2008) Xenia Beebe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

TCR signaling and environment affect vasoactive intestinal peptide receptor-1 (VPAC-1) expression in primary mouse CD4 T cells

(2008) Emilie E. Vomhof-DeKrey et al.   BRAIN BEHAVIOR AND IMMUNITY

Stimulatory and suppressive signal transduction regulates vasoactive intestinal peptide receptor-1 (VPAC-1) in primary mouse CD4 T cells

(2008) Emilie E. Vomhof-DeKrey et al.   BRAIN BEHAVIOR AND IMMUNITY

VIP-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: A novel targeted nanomedicine for breast cancer

(2008) H ONYUKSEL et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The N-Terminal Parts of VIP and Antagonist PG97–269 Physically Interact with Different Regions of the Human VPAC1 Receptor

(2008) Emilie Ceraudo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Biological and Structural Analysis of Truncated Analogs of PACAP27

(2008) Steve Bourgault et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Novel stable PACAP analogs with potent activity towards the PAC1 receptor

(2008) Steve Bourgault et al.   PEPTIDES

VPAC and PAC receptors: From ligands to function

(2008) Louise Dickson et al.   PHARMACOLOGY & THERAPEUTICS

Class-B GPCR activation: is ligand helix-capping the key?

(2008) Jean-Michel Neumann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitoxantrone as induction treatment in aggressive relapsing remitting multiple sclerosis: treatment response factors in a 5 year follow-up observational study of 100 consecutive patients

(2007) E. Le Page et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Vasoactive Intestinal Peptide (VIP) α-Helix Up to C Terminus Interacts with the N-Terminal Ectodomain of the Human VIP/Pituitary Adenylate Cyclase-Activating Peptide 1 Receptor: Photoaffinity, Molecular Modeling, and Dynamics

(2007) Emilie Ceraudo et al.   MOLECULAR ENDOCRINOLOGY

Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide

(2007) B.D. Armstrong et al.   NEUROSCIENCE

Complete Sequence of a Novel Protein Containing a Femtomolar-Activity-Dependent Neuroprotective Peptide

(2003) Merav Bassan et al.   JOURNAL OF NEUROCHEMISTRY