Article
Agriculture, Dairy & Animal Science
Darae Kang, Kwanseob Shim
Summary: The study showed that early heat conditioning can reduce the negative impacts of acute heat stress on broilers by regulating heat shock proteins and corticosterone levels.
Article
Biochemistry & Molecular Biology
Tong Xing, Xinglian Xu, Lin Zhang, Feng Gao
Summary: The study demonstrated that acute L-glutamine (Gln) supplementation in broilers exposed to pre-slaughter transport can enhance the expression of HSP70 in the pectoralis major (PM) muscles, leading to improvements in meat quality by increasing muscle pH and water-holding capacity, reducing muscle fiber shrinkage, increasing ATP content, decreasing glycolytic enzyme activities, regulating AMP-activated protein kinase phosphorylation levels, and enhancing total superoxide dismutase and total antioxidant capability while decreasing reactive oxygen species, malonaldehyde, and carbonyl levels in the PM of transported broilers.
Article
Entomology
Shou-Min Fang, Qian Zhang, Yu-Li Zhang, Gui-Zheng Zhang, Ze Zhang, Quan-You Yu
Summary: The heat shock protein 70 family was identified in the whole genome of the silkworm, showing important roles in protecting against environmental stresses. The stress-inducible forms were found to play more crucial roles in adaptation to various stresses compared to the heat shock cognates.
Article
Biochemistry & Molecular Biology
Tal Belity, Michal Horowitz, Jay R. Hoffman, Yoram Epstein, Yaron Bruchim, Doron Todder, Hagit Cohen
Summary: Exposure to high ambient temperature can have extensive effects on brain structure and function. This study found that preconditioning with heat stress can improve resilience to predator-scent stress and may involve the induction of heat shock protein-70. Targeting this protein could be an attractive strategy for treating stress-related psychopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jing Bai, Yu-Cheng Wang, Yun-Cai Liu, Ya-Wen Chang, Xiao-Na Liu, Wei-Rong Gong, Yu-Zhou Du
Summary: The heat shock protein 70 family (HSP70) is one of the most diverse HSP families in terms of structure and function. Two new HSP70 genes (Bthsp70-2 and Bthsp70-3) were isolated from the phloem-feeding insect Bemisia tabaci, and their expression patterns during thermal stress were found to differ, expanding the understanding of HSP roles in B. tabaci.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Chang-Ni Lin, Yi-Cheng Tsai, Ching-Cheng Hsu, Yu-Ling Liang, Yi-Ying Wu, Chieh-Yi Kang, Chun-Hong Lin, Pang-Hung Hsu, Gwo-Bin Lee, Keng-Fu Hsu
Summary: Tx-01, a novel aptamer, shows specificity in recognizing ovarian cancer cells and tissues, inhibiting migration and invasion, and suppressing tumor growth through disrupting HSP70/NICD interaction. It acts as a prognostic factor and potential inhibitor in ovarian cancer treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Agriculture, Dairy & Animal Science
Bolin Zhang, Huilei Sun, Zewei Sun, Ning Liu, Rujie Liu, Qingzhen Zhong
Summary: Glutamine (Gln) addition protects porcine epithelial cells (IPEC-J2) from apoptosis and damage to the mucosal barrier induced by heat stress (HS), potentially through the mitochondrial apoptosis pathway mediated by heat shock protein 70 (HSP70). These findings provide a possible theoretical basis for mitigating HS-induced damage to porcine intestinal epithelium and offer insights for developing nutritional strategies to alleviate the negative effects of HS on farmed animals.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Plant Sciences
Koji Mikami, Ho Viet Khoa
Summary: Heat shock protein 70 (HSP70) is a conserved protein involved in maintaining protein folding and refolding in both prokaryotic and eukaryotic organisms. In the red alga Neopyropia yezoensis, we identified genes encoding HSP70 proteins in different cellular compartments. We found that membrane fluidization plays a role in the heat-induced expression of HSP70 genes in this alga. Our results suggest a unique regulatory system for heat-induced expression of HSP70 genes in N. yezoensis.
Article
Biochemistry & Molecular Biology
Mingzu Guo, Wenxi Xu, Yoshinari Yamamoto, Takuya Suzuki
Summary: The study found that curcumin can increase the expression of HSP70 in intestinal Caco-2 cells through transcriptional activation, possibly enhancing cell integrity. The effects of curcumin are regulated by various signaling pathways. This discovery is expected to contribute to a deeper understanding of the regulation of intestinal HSP70 by dietary components.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Neurosciences
Zhongting Zhao, Zheng Li, Fangning Du, Yixin Wang, Yue Wu, Kah-leong Lim, Lin Li, Naidi Yang, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Misfolding, aggregation, and abnormal degradation of proteins are believed to be key factors in the pathogenesis of PD. Heat shock protein 70 (Hsp70) and Parkin, an E3 ubiquitin ligase, have been found to play important roles in PD pathogenesis. This review focuses on the dysregulation of Hsp70 and Parkin, their interaction, and their potential therapeutic applications in PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zifei Han, Shelli R. McAlpine, Robert Chapman
Summary: This study demonstrates the successful delivery of inhibitors to block the interaction between Hsp70 and HOP using polymer nanogels. The results show the effectiveness of these inhibitors in inhibiting Hsp70 and inducing cancer cell death.
BIOORGANIC CHEMISTRY
(2022)
Article
Agronomy
Chuanbei Tian, Yaying Li, Yixia Wu, Wenqiang Chu, Huai Liu
Summary: In fluctuating climatic environments, heat acclimation in predatory mites is a superior adaptation strategy for effective agricultural pest management. The sustained accumulation of HSP70 proteins results in predatory mites with thermotolerance advantage, promoting their biological control function to pests. The divergent constitutive regulation of HSP70 to a thermal environment allows predators to adapt flexibly to extreme stress.
PEST MANAGEMENT SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Rixin Gong, Lu Xing, Jingwen Yin, Yuqing Ding, Xiaotao Liu, Jun Bao, Jianhong Li
Summary: Intermittent mild cold stimulation improves energy metabolism and stress resistance in the livers of broilers, aiding in their adaptation to low-temperature environments. Appropriate cold stimulation enhances stress resistance and mitigates the negative impact of cold environments on broilers.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Article
Veterinary Sciences
Adakole Sylvanus Adah, Joseph Olusegun Ayo, Deborah Arimie Adah, Charles Obiora Nwonuma, Teslim Alabi Lawal
Summary: This study aimed to determine the effects of oxidative stress on heat shock protein-70 (HSP-70) in horses during endurance exercise. The results showed that ergothioneine supplementation can modulate the synthesis of HSP-70 and alleviate the impact of oxidative stress on horses.
BMC VETERINARY RESEARCH
(2023)