Article
Infectious Diseases
Frieder Fuchs, Federico Becerra-Aparicio, Kyriaki Xanthopoulou, Harald Seifert, Paul G. Higgins
Summary: This study investigated the in vitro activity of nitroxoline against carbapenem-resistant Acinetobacter baumannii. The results showed that nitroxoline exhibited excellent activity against a collection of carbapenem-resistant Acinetobacter baumannii isolates. This suggests that nitroxoline could be a promising drug for the treatment of lower urinary tract infections caused by this bacterium.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Valeria Mateo-Estrada, Jose Luis Fernandez-Vazquez, Julia Moreno-Manjon, Ismael L. Hernandez-Gonzalez, Eduardo Rodriguez-Noriega, Rayo Morfin-Otero, Maria Dolores Alcantar-Curiel, Santiago Castillo-Ramirez
Summary: This study used whole-genome sequencing to uncover the transmission dynamics of extensive and multidrug-resistant A. baumannii in a tertiary hospital over a decade, showing that accessory genome variation can be a powerful tool for conducting genomic epidemiology.
Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
Article
Microbiology
Alina Iovleva, Mustapha M. Mustapha, Marissa P. Griffith, Lauren Komarow, Courtney Luterbach, Daniel R. Evans, Eric Cober, Sandra S. Richter, Kirsten Rydell, Cesar A. Arias, Jesse T. Jacob, Robert A. Salata, Michael J. Satlin, Darren Wong, Robert A. Bonomo, David van Duin, Vaughn S. Cooper, Daria Van Tyne, Yohei Doi
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAb) is a significant threat to public health, particularly for hospitalized patients. The Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP) conducted whole-genome sequencing (WGS) analysis of 120 CRAb patients from four U.S. centers, revealing the dominance of the ST2(Pas) lineage within clonal complex 2 (CC2), as well as the emergence of sublineages with different antibiotic resistance phenotypes. The study emphasizes the need for real-time surveillance and molecular epidemiology to understand CRAb dissemination and clinical impact.
Article
Immunology
Sandra Sanchez-Urtaza, Alain Ocampo-Sosa, Ainhoa Molins-Bengoetxea, Mohammed A. A. El-Kholy, Marta Hernandez, David Abad, Sherine M. M. Shawky, Itziar Alkorta, Lucia Gallego
Summary: This study investigated the genetic characteristics and antimicrobial susceptibility profile of multidrug resistant Acinetobacter baumannii clinical isolates obtained from hospitals in Alexandria, Egypt. The results showed resistance to multiple antibiotics and the presence of various antibiotic resistance genes and virulence factors. The study highlights the importance of investigating molecular epidemiology to control the spread of these multidrug resistant isolates.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Paul G. Higgins, Meret Kniel, Sandra Rojak, Carsten Balczun, Holger Rohde, Hagen Frickmann, Ralf Matthias Hagen
Summary: The study investigated the molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolated by the German military medical service in Afghanistan. It found that most of the acquired carbapenem resistance in Afghanistan was associated with bla(OXA-23) and identified a variety of different clones from Afghan patients.
Article
Biology
Hams M. A. Mohamed, Hanan H. Abd-Elhafeez, Omar A. Al-Jabr, Mona A. El-Zamkan
Summary: This study investigated the presence of A. baumannii, its antimicrobial resistance, and biofilm formation in raw milk samples from Qena, Egypt. The results showed a high detection rate of A. baumannii in the milk samples, with resistant isolates carrying various resistance genes. Additionally, the majority of A. baumannii isolates exhibited the ability to form biofilms.
Article
Infectious Diseases
Bin Liu, Lei Liu
Summary: CRAB isolates from the ICU showed higher resistance to tigecycline and cefoperazone/sulbactam compared to RD. PCR detection revealed different ratios of resistance-associated genes in ICU and RD, while PFGE and MLST results also indicated variations in molecular epidemiology and resistance mechanisms between the two departments.
INFECTION AND DRUG RESISTANCE
(2021)
Editorial Material
Microbiology
Santiago Castillo-Ramirez
Summary: A recent study published in mBio sequenced the genomes of 313 carbapenem-resistant A. baumannii isolates from over 100 hospitals in almost 50 countries, providing an updated view of the global distribution of major international clones and their carbapenemase genes. Future global genomic epidemiology studies can be enhanced by considering both human and non-human isolates and their antibiotic resistance profiles.
Article
Immunology
Minggui Wang, Lizhao Ge, Liang Chen, Lauren Komarow, Blake Hanson, Jinnethe Reyes, Eric Cober, Thamer Alenazi, Zhiyong Zong, Qing Xie, Zhengyin Liu, Lanjuan Li, Yunsong Yu, Hainv Gao, Souha S. Kanj, Jairo Figueroa, Erica Herc, Ezequiel Cordova, Gregory Weston, Paul Ananth Tambyah, Julia Garcia-Diaz, Keith S. Kaye, Sorabh Dhar, Jose M. Munita, Robert A. Salata, Samuel Vilchez, Martin E. Stryjewski, Maria Virginia Villegas Botero, Alina Iovleva, Scott R. Evans, Keri Baum, Carol Hill, Barry N. Kreiswirth, Robin Patel, David L. Paterson, Cesar A. Arias, Robert A. Bonomo, Henry F. Chambers, Vance G. Fowler, Michael J. Satlin, David van Duin, Yohei Doi
Summary: In this international, prospective observational cohort of 842 hospitalized patients with carbapenem-resistant Acinetobacter baumannii, infection types and clinical outcomes differed significantly across regions. Although clonal group 2 (CG2) strains were predominant, non-CG2 strains were associated with higher mortality.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Jia Jie Woon, Azanna Ahmad Kamar, Cindy Shuan Ju Teh, Nuryana Idris, Rosliza Zhazali, Suzana Saaibon, Harvinderjit Kaur Basauhra Singh, Jasreena Kaur Gill Charanjeet Singh, Adeeba Kamarulzaman, Sasheela Ponnampalavanar
Summary: This study describes an epidemiological investigation into a carbapenem-resistant Acinetobacter baumannii (CRAB) outbreak in a neonatal intensive care unit (NICU) and the subsequent strengthening of infection control interventions. The investigation identified gaps in existing infection control measures and implementation of immediate actions successfully halted further CRAB transmission.
Article
Infectious Diseases
Andrey Shelenkov, Yulia Mikhaylova, Lyudmila Petrova, Irina Gaidukova, Mikhail Zamyatin, Vasiliy Akimkin
Summary: The COVID-19 pandemic has impacted bacterial antimicrobial resistance and population structures in healthcare facilities, requiring detailed epidemiological investigations for confirmation. A study in Moscow's COVID-19 ICU characterized multidrug-resistant A. baumannii isolates, revealing genomic similarity with previously identified clones in the same facility.
Article
Microbiology
Valeria Mateo-Estrada, Leila Vali, Ahmed Hamouda, Benjamin A. Evans, Santiago Castillo-Ramirez
Summary: This study compares the genomic identity of Scottish cattle and pig isolates with human clinical international clones of Acinetobacter baumannii. The results show that the animal isolates represent novel clones distinct from the major international clones, and they possess fewer antibiotic resistance and virulence genes compared to the human clinical isolates.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Suhaila A. Al-Sheboul, Salam Z. Al-Moghrabi, Yasemin Shboul, Farah Atawneh, Ahmed H. Sharie, Laila F. Nimri
Summary: This study aimed to determine the presence and distribution of bla(OXA) genes among multidrug-resistant A. baumannii isolated from ICU patients in Jordanian hospitals. The results showed a high prevalence of multidrug-resistant strains with ESBL phenotype. Identification of ESBL genes is crucial for monitoring their transmission in hospitals.
Article
Immunology
Congcong Liu, Kaichao Chen, Yuchen Wu, Ling Huang, Yinfei Fang, Jiayue Lu, Yu Zeng, Miaomiao Xie, Edward Wai Chi Chan, Sheng Chen, Rong Zhang
Summary: Acinetobacter baumannii is a significant Gram-negative pathogen causing nosocomial infections. In China, a large portion of clinical A. baumannii strains are multidrug resistant, particularly towards carbapenems. Nationwide surveillance revealed a prevalence of carbapenem-resistant A. baumannii (CRAB) strains in intensive care units (ICUs), with clonal spread observed in some ICUs. Carbapenem-hydrolysing class D beta-lactamases (CHDL) were primarily responsible for carbapenem resistance, and the ST2 global clone was the predominant type of CRAB in China. Notably, CRAB isolates exhibited low resistance to colistin and tigecycline, but high resistance to ceftazidime-avibactam.
EMERGING MICROBES & INFECTIONS
(2022)