Article
Biochemistry & Molecular Biology
Albena Momchilova, Roumen Pankov, Galya Staneva, Stefan Pankov, Plamen Krastev, Evgenia Vassileva, Rusina Hazarosova, Nikolai Krastev, Bozhil Robev, Biliana Nikolova, Adriana Pinkas
Summary: Resveratrol regulates sphingolipid metabolism in lung cancer cells, leading to changes in CER and S1P levels, and showing anti-cancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexey Surov, Andreas Wienke
Summary: This meta-analysis systematically reviewed the associations between SUVmax from FDG PET and the expression of VEGF and MVD. The results indicated a weak correlation between SUVmax and VEGF/MVD, suggesting that FDG PET may not be able to predict neoangiogenesis in malignant tumors.
ACADEMIC RADIOLOGY
(2021)
Article
Cell Biology
Karin Schelch, Lisa Vogel, Anja Schneller, Jelena Brankovic, Thomas Mohr, Rupert L. Mayer, Astrid Slany, Christopher Gerner, Michael Grusch
Summary: TGF beta and EGF can partly compensate for each other for stimulation of cell migration, but abrogation of TGF beta signaling may be more suitable to suppress cell invasion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ekaterina Patrakova, Mikhail Biryukov, Olga Troitskaya, Pavel Gugin, Elena Milakhina, Dmitriy Semenov, Julia Poletaeva, Elena Ryabchikova, Diana Novak, Nadezhda Kryachkova, Alina Polyakova, Maria Zhilnikova, Dmitriy Zakrevsky, Irina Schweigert, Olga Koval
Summary: Cold atmospheric plasma (CAP) is a widely studied approach for treating malignant neoplasms. This study determined the optimal discharge regime for direct CAP treatment of cancer cells and found that CAP weakly activated pro-survival autophagy in irradiated cells. The addition of the autophagy inhibitor chloroquine (CQ) promoted CAP-dependent cell death.
Article
Engineering, Biomedical
Wei-Dong Lu, Yi-Zhi Liu, Yan-Qi Yang, Zhi-Gang Liu, Kun Zhao, Jian-Rong Lu, Guang-Yan Lei, Yi-Yu Wang, Lin Cai, Rui-Fang Sun
Summary: The effects of hemostatic materials on tumor growth and recurrence are unclear. In this study, three commonly used naturally derived hemostatic materials, gelatin sponge, Surgicel, and biopaper, were evaluated for their impact on A549 lung adenocarcinoma cells. The results showed that gelatin sponge promoted tumor growth, while Surgicel and biopaper inhibited it.
MATERIALS TODAY BIO
(2022)
Article
Oncology
Saifei He, Xiaokun Ma, Ni Zheng, Guoyu Wang, Menghan Wang, Wei Xia, Donghai Yu
Summary: PRDM14 expression is associated with therapeutic sensitivity in lung adenocarcinoma, where overexpression reduces sensitivity to cisplatin, while silencing PRDM14 enhances sensitivity. Additionally, PRDM14 may promote glycolysis in human LUAD cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biology
Griselda Awanis, Salonee Banerjee, Robert Johnson, Sathuwarman Raveenthiraraj, Aya Elmeligy, Derek Warren, Jelena Gavrilovic, Anastasia Sobolewski
Summary: Tunneling nanotubes (TNTs) play a crucial role in intercellular communication and tumor progression. This study investigates the molecular mechanisms underlying TNT formation and identifies potential targets for inhibiting TNT formation as a novel approach for cancer treatment.
LIFE SCIENCE ALLIANCE
(2023)
Article
Pathology
Nathalie Guedj, Lorraine Blaise, Francois Cauchy, Miguel Albuquerque, Olivier Soubrane, Valerie Paradis
Summary: In this study, the prognostic value of stromal compartment in iCC was evaluated using multiparametric morphological analysis. It was found that high proportionated stromal area was associated with better disease-free survival (DFS), while low activated stroma index was linked to a better DFS. On the other hand, high collagen reticulation index was associated with poorer overall survival, suggesting potential clinical relevance in evaluating collagen reticulation in patients with iCC.
Article
Chemistry, Inorganic & Nuclear
Mohammad Usman, Rais Ahmad Khan, Mohammad Rashid Khan, Mohammad Abul Farah, Ibtisam I. BinSharfan, Walaa Alharbi, Jilani. P. Shaik, Narasimha Reddy Parine, Ali Alsalme, Sartaj Tabassum
Summary: Copper compounds show potential as next-generation metal anticancer drugs, with a newly synthesized polymer displaying high DNA binding propensity and selective cytotoxicity against A549 cancer cells. In vitro studies also revealed the polymer's ability to cleave DNA and its impact on gene expression in various cell lines.
DALTON TRANSACTIONS
(2021)
Article
Engineering, Chemical
Gehad Subaiea, Ahmed Alafnan, Abdulwahab Alamri, Talib Hussain, Shimaa Mahmoud Hassoun, Amr Selim Abu Lila, El-Sayed Khafagy, Ahmed A. A. Katamesh
Summary: "Umo Ishi" is a novel written by Kenzaburo Oe, in which the author reflects on and pursues peace and justice through a review of history and reality. Set against the backdrop of the Chinese resistance during World War II, the novel portrays the devastation of war on ordinary people and the distortion of human nature through the lives and inner monologues of different characters. By depicting the brutality of war and the complexity of human nature, the novel explores the meaning and impact of war on humanity, and calls for the pursuit of peace.
Article
Medicine, Research & Experimental
Kaiming Ren, Yong Yu, Xiwen Wang, Haijun Liu, Jungang Zhao
Summary: The study found that miR-340-3p may act as a tumor suppressor in LUAD progression by inhibiting HUS1 expression, providing a potential therapeutic target for LUAD.
Article
Oncology
Wen-Jun Liu, Peng-yu Pan, Ye Sun, Jian-bo Wang, Huan Zhou, Xin Xie, Zhi-yuan Duan, Han-yu Dong, Wen-na Chen, Li-de Zhang, Chun Wang
Summary: This study reveals the adaptive responses of cisplatin-resistant NSCLC cells to glutamine starvation and suggests that the iron chelator DFO can suppress the growth of these resistant cells through autophagic cell death and apoptosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Ling-Ling Yu, Yuan Wang, Zu-Ke Xiao, Sheng-Song Chen
Summary: HSPB8 plays a significant role in the progression of LUAC and may serve as a novel target for treating LUAC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Xue Wang, Yuetong Wang, Zhaoyuan Fang, Hua Wang, Jian Zhang, Longfu Zhang, Hsinyi Huang, Zhonglin Jiang, Yujuan Jin, Xiangkun Han, Shenda Hou, Bin Zhou, Feilong Meng, Luonan Chen, Kwok-Kin Wong, Jinfeng Liu, Zhiqi Zhang, Xin Zhang, Haiquan Chen, Yihua Sun, Liang Hu, Hongbin Ji
Summary: Somatic mutations of the chromatin remodeling gene ARID2 are found in around 7% of human lung adenocarcinomas, and its decreased expression is associated with lung cancer malignant progression. Knockout of ARID2 significantly promotes lung cancer progression, while knockdown of Hspa1a specifically inhibits malignant progression of ARID2-deficient lung cancers. Treatment with an HSPA1A inhibitor could significantly inhibit the malignant progression of lung cancer with ARID2 deficiency.
NATIONAL SCIENCE REVIEW
(2021)
Article
Biochemistry & Molecular Biology
Eiji Kasumi, Miku Chiba, Yoshie Kuzumaki, Hiroyuki Kuzuoka, Norifumi Sato, Banyu Takahashi
Summary: This study developed a new rat model that mimics human cancer cachexia, shedding light on the mechanism underlying the onset and progression of this syndrome. The rats transplanted with SLC cells exhibited anorexia, weight loss, muscle atrophy, weakness, anemia, inflammation, and low serum albumin. The model provides a promising tool for studying the pathogenesis and treatment of cancer cachexia.