Article
Biology
Sukanta Bhadra, Siyu Chen, Chang Liu
Summary: Depression is a major global health burden affecting millions of people worldwide. Studies have found complex associations between depression and metabolic disorders, identifying common differentially expressed genes.
Article
Immunology
Hongtu Cui, Ruilin Ma, Tao Hu, Gary Guishan Xiao, Chengjun Wu
Summary: In this study, a set of aberrantly expressed key genes was identified from the TCGA database, which accurately predicted the survival rate of patients with cervical squamous cell carcinoma (CESC). These genes were related to biological activities previously associated with cervical cancer and HPV infection. Furthermore, 5 key genes were highlighted as robust prognostic markers for patient's survival rate, providing novel options for cervical cancer prognosis and drug targets.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Leiming Fang, Qi Liu, Hongtu Cui, Yunji Zheng, Chengjun Wu
Summary: Breast cancer is a common malignant tumor in women globally, and early diagnosis and treatment are important global challenges. This study identified 2032 differentially expressed genes in breast cancer, and further analysis revealed 13 hub genes, including CCNB1 and PLK1, which may serve as potential therapeutic targets and prognostic markers.
Article
Genetics & Heredity
Fatemeh Abdolahi, Ali Shahraki, Roghayeh Sheervalilou, Sedigheh Sadat Mortazavi
Summary: This study identified ten genes associated with GC, which may help discover novel prognostic and diagnostic biomarkers as well as therapeutic targets for GC. Our results may advance the understanding of GC occurrence and progression.
BMC MEDICAL GENOMICS
(2023)
Article
Biotechnology & Applied Microbiology
Lei Luo, Jian-Hua Huang, Dong-Liang Liu, Shi-Gui Jiang, Fa-Lin Zhou, Song Jiang, Qi-Bin Yang, Yun-Dong Li, Tao Li, Li-Qi Tan, Li-Shi Yang
Summary: By analyzing the hepatopancreas transcriptome of Procambarus clarkii under 10°C and 30°C temperature stresses, the study revealed the stress pathways, response pathways, and the impact of high and low temperatures on hemocyte apoptosis and molecular mechanisms of P. clarkii.
Article
Plant Sciences
Xinzhuan Yao, Hufang Chen, Baohui Zhang, Litang Lu
Summary: It was found that there were significant differences in the content of aluminum, copper, and cadmium between polyploid tea varieties and other tea varieties. In addition, through the analysis of transcriptome data, it was found that changes in the expression of metal transporter genes affect the accumulation of metal elements in tea plants. These findings provide candidate genes for enhancing multi-metal tolerance in tea plants through genetic engineering technology.
Article
Horticulture
Quan-Hui Li, Shi-Peng Yang, Ya-Nan Yu, Abid Khan, Peng-Long Feng, Muhammad Ali, Deng-kui Shao, Ya-Yi Wang, Rui-Xing Zhang, Wen-Xian Gai, Rui Han, Xiao Ma, Quan-Gang Hou, Zhen-Hui Gong
Summary: The color formation of red and orange pepper fruits is closely related to the composition and content of carotenoids, with significantly higher levels of zeaxanthin, beta-cryptoxanthin, beta-carotene, and capsanthin found in red peppers compared to orange peppers, and higher levels of lutein in orange peppers compared to red peppers. Differentially expressed genes (DEGs) were identified to be involved in the biosynthesis of carotenoids, phenylpropanoids, flavonoids, and phenylalanine metabolism. Key genes such as CHYB1 and CCS were found to play significant roles in carotenoid biosynthesis during fruit development. Additionally, transcription factors such as F-box protein SKIP23, GATA transcription factor 26, and others may be involved in the regulation of carotenoid metabolism pathway in pepper fruit color formation.
SCIENTIA HORTICULTURAE
(2021)
Article
Neurosciences
Qingqing Ye, Zhensheng Huang, Weicheng Lu, Fang Yan, Weian Zeng, Jingdun Xie, Weiqiang Zhong
Summary: This study identified the common differentially expressed genes (co-DEGs) between neuropathic pain and aging and explored the underlying molecular mechanisms. It also predicted potential transcription factors, miRNAs regulation networks, and new drug targets. These findings provide novel insights for further research in neuropathic pain and aging.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Zhihua Qiu, Shaojun Li, Ming Luo, Shuanggen Zhu, Zhijian Wang, Yongjun Jiang
Summary: Spatial transcriptomics is a method that allows simultaneous detection of gene expression location and quantity within tissue sections. A new method called saSpatial was developed, which effectively identified differentially expressed genes (DEGs) in STs data. Compared to the classical method FindMarkers, saSpatial was able to discover more valuable genes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Plant Sciences
Norah Alyahya, Tahar Taybi
Summary: High salinity is a threat to agricultural output globally. RNA-Sequencing analysis showed that the number of differentially expressed genes in the roots of salt-treated bread wheat was higher than in the shoots. Key pathways involved in salt tolerance, such as glutathione metabolism and biosynthesis of secondary metabolites, were identified.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Xiaoxiao Xue, Jiayu Yu, Cheng Li, Fang Wang, Yatao Guo, Yongwen Li, Huijuan Shi
Summary: This study aimed to explore the genes and pathways involved in the therapeutic effects of oxymatrine on psoriasis. The results showed that oxymatrine can alter the abnormal expression of certain genes and pathways in psoriasis patients, and multi-pathway and multi-target therapy can effectively treat psoriasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Shenqiang Qiu, Anum Munir, Shaukat Iqbal Malik, Sajid Khan, Amjad Hassan
Summary: Osteoarthritis and rheumatoid arthritis are two common types of arthritis, with unclear etiology and prognosis. This study identified 250 differentially expressed genes in rheumatoid arthritis, with 32 found to play significant roles in RA pathogenesis. Analysis of these genes revealed associations with innate immune response, protein phosphorylation, transcription initiation, and other molecular ontologies.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Shaokang Zhao, Tingting Chen, Xinmao Luo, Shiyi Chen, Jie Wang, Songjia Lai, Xianbo Jia
Summary: Cattle-yak is an excellent hybrid of cattle and yak, characterized by better meat quality and stronger adaptability to harsh environments. However, male sterility of cattle-yak restricts the transmission of heterosis. By analyzing the mRNA and lncRNA expression profiles of cattle, yak, and cattle-yak, this study identified differentially expressed genes related to male sterility, providing a theoretical basis for breeding work.
Article
Oncology
Nana Li, Lingxiao Qiu, Cheng Zeng, Zeming Fang, Shanshan Chen, Xiangjin Song, Heng Song, Guojun Zhang
Summary: This study used bioinformatic methods to analyze DEGs in human IPF, revealing potential biomarkers and targets such as MPP1. The MAPK signaling pathway was found to be related to the occurrence and development of IPF. Additionally, the development of IPF lung cancer complications may be associated with the activation of genes enriched in PD-L1 expression and PD-1 checkpoint pathway, providing insights into the pathogenesis of IPF combined with lung cancer.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Piyush More, Sweta Talyan, Jean-Fred Fontaine, Enrique M. Muro, Miguel A. Andrade-Navarro
Summary: LincRNAs are long non-coding RNAs that lack functional evidence and their biogenesis is not well-understood. They are thought to originate from genomic duplication of coding material, resulting in pseudogenes, some of which may retain similarity to the parental gene for potential functional reasons.