Review
Endocrinology & Metabolism
Kechong Zhou, Chao Li, Tao Chen, Xuejun Zhang, Baoluo Ma
Summary: In this meta-analysis of 16 studies, elevated levels of C-reactive protein (CRP) were found to be associated with worse overall survival, cancer-specific survival, and progression-free survival in patients with prostate cancer. Subgroup analysis based on disease staging yielded consistent results. However, further studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Minhong Wu, Yan Zhou, Qingsheng Chen, Zhiling Yu, Hongyong Gu, Pengxiu Lin, Yanling Li, Cailing Liu
Summary: This study suggests that C-reactive protein to albumin ratio (CAR) has a potential prognostic role in patients with urinary cancers. High pretreated CAR is associated with inferior overall survival and progression-free survival. CAR can act as a predictor in renal cell carcinoma, bladder cancer, and prostate cancer subgroups. The results of this study are reliable and robust.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Sheng Yang, Zongxin Zhang, Linglong Shen
Summary: The meta-analysis finds that increased C-reactive protein levels are significantly associated with poor overall survival and shortened progression-free survival in patients with cervical cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Xinglong He, Ade Su, Yongcheng Xu, Diaolong Ma, Guoyuan Yang, Yiyun Peng, Jin Guo, Ming Hu, Yuntao Ma
Summary: The lymphocyte-C-reactive protein ratio (LCR) is associated with the prognosis of colorectal cancer patients, with lower levels of LCR indicating poorer prognosis. More high-quality studies are needed to validate these findings.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Cheng-Long Han, Guang-Xiao Meng, Zi-Niu Ding, Zhao-Ru Dong, Zhi-Qiang Chen, Jian-Guo Hong, Lun-Jie Yan, Hui Liu, Bao-Wen Tian, Long-Shan Yang, Jun-Shuai Xue, Tao Li
Summary: This meta-analysis suggests that a high baseline C-reactive protein (CRP) level may indicate worse overall survival (OS) and progression-free survival (PFS) in cancer patients receiving immune checkpoint inhibitor (ICI) treatment. However, more high-quality prospective studies are needed to further evaluate the predictive value of CRP for ICI treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Samantha N. Neumann, Jun-Juan Li, Xiao-Dong Yuan, Shuo-Hua Chen, Chao-Ran Ma, Laura E. Murray-Kolb, Yun Shen, Shou-Ling Wu, Xiang Gao
Summary: The study demonstrated a significant association between anemia and insomnia in adults, even after adjusting for chronic inflammation. Meta-analysis results also confirmed a positive correlation between anemia and insomnia in adult populations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Oncology
Kong-Ying Lin, Qing-Jing Chen, Shi-Chuan Tang, Zhi-Wen Lin, Jian-Xi Zhang, Si-Ming Zheng, Yun-Tong Li, Xian-Ming Wang, Qiang Lu, Jun Fu, Luo-Bin Guo, Li-Fang Zheng, Peng-Hui You, Meng-Meng Wu, Ke-Can Lin, Wei-Ping Zhou, Tian Yang, Yong-Yi Zeng
Summary: The PACE risk score, incorporating AFP and CRP levels, is a valuable tool for stratifying postoperative risk in HCC patients and may complement the BCLC staging system.
Article
Immunology
Yiyang Zhang, Lianghe Lu, Zhangping He, Zhishen Xu, Zhicheng Xiang, Run-Cong Nie, Wenping Lin, Wenxu Chen, Jie Zhou, Yixin Yin, Juanjuan Xie, Youcheng Zhang, Xueyi Zheng, Tianchen Zhu, Xiaoxia Cai, Peng Li, Xue Chao, Mu-Yan Cai
Summary: The study supports the association between high serum CRP levels and response and PFS in HCC patients receiving PD-1 inhibitors. Pre-treatment levels of both CRP and AFP have great potential for determining the efficacy of PD-1 inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Liang Yue, Yi Lu, Yulin Li, Yilin Wang
Summary: This meta-analysis revealed that a high CRP/Alb ratio is associated with poorer overall survival (OS) and disease-free survival (DFS) in gastric cancer patients, making it an important prognostic factor regardless of sample size, nationality, or cutoff value source.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Clinical Neurology
Liuting Chen, Min Wang, Chanrui Yang, Yefei Wang, Bonan Hou
Summary: This study evaluated the prognostic value of high-sensitivity C-reactive protein (hs-CRP) levels in stroke patients and found that high hs-CRP levels were associated with increased mortality, risk of stroke recurrence, and poor prognosis in ischemic stroke patients. For hemorrhagic stroke patients, high hs-CRP levels were associated with all-cause mortality. Thus, hs-CRP levels may contribute to the prognosis prediction of stroke patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Qianqian Pan, Mingjing Wei, Mengyi Lu, Yaping Xu, Xing Xie, Xiao Li
Summary: This study found that elevated perioperative C-reactive protein levels were associated with poorer prognosis in patients with epithelial ovarian carcinoma, especially in advanced stage and serous patients.
CANCER MANAGEMENT AND RESEARCH
(2023)
Review
Medicine, General & Internal
Yan Pan, Yinmei Lou, Lin Wang
Summary: The C-reactive protein to albumin ratio (CAR) has been investigated in association with the prognosis of metastatic colorectal cancer (mCRC) in several studies, showing that higher CAR is significantly correlated with poorer overall survival and decreased progression-free survival/disease-free survival/recurrence-free survival. More large-sample clinical trials are needed to confirm the prognostic significance of CAR in mCRC.
Review
Oncology
Yongjuan Ye, Guozhi Wu, Hao Yuan, Ya Zheng, Yuping Wang, Qinghong Guo
Summary: The lymphocyte/C-reactive protein (LCR) level is associated with the clinical outcomes in patients with upper gastrointestinal cancers, with lower LCR levels indicating worse prognosis. More high-quality studies are needed to validate these findings.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Masashi Utsumi, Masaru Inagaki, Koji Kitada, Naoyuki Tokunaga, Midori Kondo, Kosuke Yunoki, Yuya Sakurai, Ryosuke Hamano, Hideaki Miyasou, Yousuke Tsunemitsu, Shinya Otsuka
Summary: This systematic review and meta-analysis found that an elevated preoperative C-reactive protein-to-albumin ratio is significantly associated with poor prognosis in patients with biliary tract cancer. The C-reactive protein-to-albumin ratio may serve as an independent prognostic biomarker for overall survival and recurrence-free survival in these patients.
Article
Cell Biology
Yaohua Yu, Weiwei Wu, Yanyan Dong, Jiliang Li
Summary: The study found that the C-reactive protein-to-albumin ratio (CAR) can predict sepsis and prognosis in severe burns, with higher CAR levels associated with lower 30-day postburn survival rates.
MEDIATORS OF INFLAMMATION
(2021)