Hypoxia-inducible Factor 1 Alpha (HIF-1 alpha) as a Prognostic Indicator in Patients with Gastric Tumors: A Meta-analysis

Background and Objective: Though researched for years, the prognostic role of hypoxia-inducible factor 1 alpha (HIF-1 alpha) in gastric cancer is still controversial. We thus undertook a systematic review to assess the relationship. Method: A systematically literature search of Pubmed, Embase, Web of Science, China Biological Medicine Disc and Cochrane Library was undertaken in February 2013, and the reference lists of articles were retrieved. Results: 12 trials (1,555 participants) were included to assess the association between HIF-1 alpha expression and survival. Summary hazard ratios (HRs) were calculated. HIF-1 alpha expression was significantly correlated with poor overall survival of gastric cancer patients (HR=1.34, 95% CI: 1.13-1.58; P=0.0009), but not with poor disease free survival of gastric cancer patients (HR=1.67, 95% CI: 0.99-2.82; P=0.06). Conclusion: HIF-1 alpha was associated with poor OS, but not DFS, especially for Asian patients. But studies evaluating relationships of HIF-1 alpha with OS and DFS in non-Asian gastric cancer patients appear needed.