Article
Medical Laboratory Technology
Dongdong Liu, Bangwei Che, Pan Chen, Jun He, Yi Mu, Kehang Chen, Wenjun Zhang, Shenghan Xu, Kaifa Tang
Summary: This study found that GSTs gene polymorphism may be a risk factor for PCa and can predict the susceptibility and malignancy of PCa. In Mets patients, GSTT1 null genotype significantly increased the risk of PCa, while GSTM1 null genotype and the effect of GSTP1 (AG + GG) on PCa were not significantly related to Mets.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Clinical Neurology
Hongzhou Liu, Ying Xu, Jie Peng
Summary: This study conducted a meta-analysis to investigate the association between GST gene deletions and susceptibility to mental disorder. The results suggested that GSTM1 null genotype may be a genetic risk factor for schizophrenia, while GSTT1 null genotype may have a protective effect. Additionally, the study proposed a new method for quality assessment, which could be valuable for future analyses.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Review
Medicine, General & Internal
Yi Zhu, Jian-Hua Yang, Jun-Ping Hu, Ming Qiao
Summary: This study revealed that the GSTM1 null, GSTT1 null and GSTP1-Val genotypes might be related to increased NAFLD susceptibility.
Article
Biochemistry & Molecular Biology
Baiming Jin, Siyuan Wan, Michael Boah, Jie Yang, Wenjing Ma, Man Lv, Haonan Li, Kewei Wang
Summary: This study found a significant negative correlation between the GSTM1 null genotype and susceptibility to arsenic poisoning, while the GSTT1 single null genotype and GSTM1-GSTT1 dual-null genotype were not associated with the risk of arsenic poisoning. Individuals with the GSTM1 null genotype may have lower susceptibility to arsenic poisoning.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Kazuya Maeda, Hajime Takikawa, Mitsuhiko Aiso, Kenji Tsuji, Tatehiro Kagawa, Masaaki Watanabe, Ken Sato, Shotaro Sakisaka, Yoichi Hiasa, Yoshiyuki Takei, Hiromasa Ohira, Etsuko Hashimoto, Minoru Ayada, Tadashi Ikegami, Noriaki Arakawa, Hiroyuki Kusuhara, Yoshiro Saito, Yuichi Sugiyama
Summary: The study aimed to investigate the role of GSTM1 and GSTT1 null genotypes in the occurrence of DILI in Japanese patients. The results revealed an association between the GSTM1 null genotype and an increased incidence of DILI in Japanese patients.
HEPATOLOGY RESEARCH
(2022)
Article
Environmental Sciences
Joanna Maria Drozdz-Afelt, Beata Barbara Koim-Puchowska, Piotr Kaminski
Summary: The study aimed to analyze antioxidant enzyme activity and malondialdehyde concentration in prostate cancer, finding a significant decrease in superoxide dismutase activity, which may be due to a deficiency in the antioxidant defense system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yeong-Chin Jou, Shou-Chieh Wang, Yuan-Chang Dia, Shou-Tsung Wang, Min-Hua Yu, Hsin-Yi Yang, Lei-Chin Chen, Cheng-Huang Shen, Yi-Wen Liu
Summary: The study demonstrated that GSTM5 acts as a tumor suppressor in bladder cancer cells without significantly affecting chemoresistance to cisplatin and mitomycin C, and the cellular levels of GSH are key mechanisms underlying the anticancer effect of GSTM5. Low gene expression and high DNA methylation levels of GSTM5 may serve as tumor markers for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Marius Stan, Vladimir Botnarciuc, Andra-Iulia Suceveanu, Laura Mazilu, Daniel Ovidiu Costea, Adrian-Paul Suceveanu, Dragos Serban, Corneliu Tudor, Anca Mitroi, Costel Brinzan, Felix Voinea
Summary: This study evaluated the diagnostic value of glutathione-S-transferase gene P1 (GST-P1) in patients with inconclusive prostate-specific antigen (PSA) values. The results showed that GST-P1 gene expression could improve the accuracy of diagnosing prostate cancer in patients with PSA values within the "grey area".
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Warin Rangubpit, Eukote Suwan, Danai Sangthong, Kannika Wongpanit, Roger W. Stich, Prapasiri Pongprayoon, Sathaporn Jittapalapong
Summary: In this study, molecular dynamics simulations were conducted to investigate the binding of GTX and GSH to RmGST. It was found that GSH binds tighter and sits rigidly inside the G-site, while GTX occupies both active sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Wenjun Zhang, Zheming Li, Miao Liu, Yi Mu, Jun He, Pan Chen, Dongdong Liu, Kehang Chen, Bangwei Che, Shenghan Xu, Hongyan Zhang, Kaifa Tang
Summary: The study demonstrated that gene polymorphism and metabolic syndrome may be potential risk factors for faster progression of benign prostatic enlargement and LUTS in BPH patients.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Endocrinology & Metabolism
Youn Kyung Chung, Jin Ju Kim, Min A. Hong, Kyu Ri Hwang, Soo Jin Chae, Sang Ho Yoon, Young Min Choi
Summary: The study found that the combination of AhRR CG or GG and GSTT1 null genotype, or the combination of GSTM1/GSTM1 null genotype, may be associated with an increased risk of PCOS, but there was no significant association between the combination of AhRR and GSTM1.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xingang Li, Yuanting Pang, Yiwang Zhong, Zhandong Cai, Qibin Ma, Ke Wen, Hai Nian
Summary: In this study, a tau-like glutathione transferase family gene named GmGSTU23 was identified in soybean, which showed a concentration-time-specific expression pattern in response to salt stress. Transgenic lines with GmGSTU23 displayed enhanced salt tolerance, root length, and fresh weight compared to the wild type. Changes in glutathione pools and associated enzyme activity were observed, indicating that GmGSTU23 enhances the activity of glutathione transferase to scavenge reactive oxygen species and glutathione, thereby conferring enhanced tolerance to salt stress in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Xin Dai, Dinh S. Bui, Caroline Lodge
Summary: Evidence on the association between GST genes and asthma remains weak or inconsistent. Failure to consider environmental exposures may explain the lack of consistency. There is a high likelihood that environmental exposures interact with GST genes in the antioxidant pathway. Carriers of specific GST genotypes are more susceptible to environmental oxidative exposures and have a higher risk of asthma. Further investigations are needed to explore the inconsistencies in results.
CURRENT ALLERGY AND ASTHMA REPORTS
(2021)
Article
Genetics & Heredity
Yu-Wen Zhao, Chu-Kun Wang, Xiao-Yu Huang, Da-Gang Hu
Summary: Anthocyanins play vital biological roles in plant growth and development, with GSTs being essential for their transportation. The study identified 38 GST genes in the apple genome and found 32 orthologous gene pairs between apple and Arabidopsis. MdGSTU12 was significantly correlated with anthocyanin variation in apple, indicating its importance in anthocyanin accumulation.
Article
Genetics & Heredity
Parnian Kheirkhah Rahimabad, A. Daniel Jones, Hongmei Zhang, Su Chen, Yu Jiang, Susan Ewart, John W. Holloway, Hasan Arshad, Shakiba Eslamimehr, Robert Bruce, Wilfried Karmaus
Summary: This study aimed to investigate whether polymorphisms in GST genes influence the effect of MSP on offspring DNAm. The results showed that in males, GST gene polymorphisms modified the associations between hydroxycotinine and DNAm, as well as between norcotinine and DNAm. In females, GST gene polymorphisms also modified the associations between hydroxycotinine and DNAm, as well as between norcotinine and DNAm. This study highlights the role of genetic polymorphism in GST genes in the susceptibility of DNAm to MSP.
