Review
Cell Biology
Seung-Hwan Jeong, Ja Hyeon Ku
Summary: This paper reviewed urinary markers for bladder cancer and compared their efficacies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Roberto Gasparri, Giulia Sedda, Valentina Caminiti, Patrick Maisonneuve, Elena Prisciandaro, Lorenzo Spaggiari
Summary: Lung cancer is the leading cause of cancer deaths worldwide, and early detection is crucial for reducing the burden of the disease. Current diagnostic techniques have limitations, highlighting the need for reliable biomarkers for early identification. Urine could be a non-invasive alternative matrix, with potential for discovering diagnostic biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Ryan Tsz-Hei Tse, Hongda Zhao, Christine Yim-Ping Wong, Carol Ka-Lo Cheng, Angel Wing-Yan Kong, Qiang Peng, Peter Ka-Fung Chiu, Chi-Fai Ng, Jeremy Yuen-Chun Teoh
Summary: Urinary cell-free DNA (ucfDNA) is a promising tool for bladder cancer detection and molecular classification, as it can differentiate bladder cancer patients from healthy controls based on its molecular features and identify unique genetic features of bladder cancer. Additionally, ucfDNA exhibits significant differences in non-muscle-invasive and muscle-invasive bladder cancers, showing its potential for future applications in the field.
Article
Chemistry, Analytical
Krzysztof Ossolinski, Tomasz Ruman, Valerie Copie, Brian P. Tripet, Artur Kolodziej, Aneta Plaza-Altamer, Anna Ossolinska, Tadeusz Ossolinski, Anna Nieczaj, Joanna Niziol
Summary: This study investigated polar metabolite profiles in urine samples from BC patients and normal controls using NMR and LDI-MS and identified potential markers for bladder cancer. The metabolites were able to distinguish urine samples from BC and NCs individuals, and correlate with tumor stages and grades. The findings suggest that these metabolite markers may be useful for non-invasive detection and monitoring of bladder cancer.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Medicine, General & Internal
Zuhu Yu, Chong Lu, Yongqing Lai
Summary: In this study, the expression profiles of miRNAs in serum samples of bladder cancer patients and healthy controls were detected, and five differentially expressed miRNAs were identified. A three-miRNA signature consisting of miR-27b-3p, miR-381-3p, and miR-451a was constructed with a high diagnostic efficiency for bladder cancer. This three-miRNA signature may serve as a promising non-invasive biomarker for early diagnosis of bladder cancer.
ANNALS OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Anna Maria Grimaldi, Cristina Lapucci, Marco Salvatore, Mariarosaria Incoronato, Maurizio Ferrari
Summary: This systematic review analyzes the effectiveness of urine miRNAs as diagnostic markers for bladder cancer. Although there were high-quality studies, the results were quite heterogeneous and no consistent miRNA signature was found.
Article
Oncology
Rui Wang, Huaixing Kang, Xu Zhang, Qing Nie, Hongling Wang, Chaojun Wang, Shujun Zhou
Summary: In this study, urine metabolomics was used to analyze the metabolites in patients with bladder cancer, resulting in the discovery of 19 differently expressed biomarkers. This research suggests the potential of metabolomics for bladder cancer diagnosis.
Article
Medicine, General & Internal
Jiahua Gan, Xing Zeng, Xiong Wang, Ya Wu, Ping Lei, Zhihua Wang, Chunguang Yang, Zhiquan Hu
Summary: This study evaluated the diagnostic value of candidate genes (ERG, PCA3, ARV7, PSMA, CK19, and EpCAM) in urinary exosomes. The results showed that the expression of these genes in urinary exosomes was significantly increased in patients with prostate cancer and was closely correlated with the Gleason score. Receiver operating characteristic curves demonstrated that these genes in urinary exosomes could distinguish patients with prostate cancer from healthy individuals.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Jordaens, Eline Oeyen, Hanny Willems, Filip Ameye, Stefan De Wachter, Patrick Pauwels, Inge Mertens
Summary: Protein biomarkers for non-muscle-invasive bladder cancer (NMIBC) were discovered in small urinary extracellular vesicles (sEVs) through a study comparing healthy individuals with NMIBC patients and tumor-free patients with recurrent NMIBC. The sEVs were isolated using ultrafiltration (UF) and size-exclusion chromatography (SEC), and 69 differentially expressed proteins were identified in the sEV fractions of NMIBC patients compared to healthy controls based on mass spectrometry (MS) data. MASP2, C3, A2M, CHMP2A, and NHE-RF1 showed the most potential as biomarkers for distinguishing healthy individuals from first diagnosis NMIBC patients.
Article
Biochemistry & Molecular Biology
Jia-Fong Jhang, Yuan-Hong Jiang, Hann-Chorng Kuo
Summary: This study investigated the role of urinary biomarkers in discriminating different bladder and bladder outlet dysfunctions in women with frequency-urgency syndrome. The results showed that there were significant variations in the urinary levels of inflammatory, neurogenic, and oxidative stress biomarkers among patients with different urodynamic subtypes. These findings suggest that the presence of varying bladder inflammation and oxidative stress conditions may have an impact on treatment outcomes in women with frequency-urgency syndrome.
Article
Medicine, General & Internal
Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan
Summary: This study identified potential biomarkers for bladder cancer diagnosis and disease progression using aptamer screening and systems biology analysis. Urine d-dimer showed high sensitivity (97%) for bladder cancer diagnosis, while urine IL-8 and IgA were associated with disease progression. These biomarkers could be used for initial triage and patient follow-up, reducing the need for invasive cystoscopy-based diagnostic methods.
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Veterinary Sciences
Ana Mafalda Rasteiro, Eva Sa e Lemos, Paula A. Oliveira, Rui M. Gil da Costa
Summary: Bladder cancer in veterinary medicine, particularly in companion animals, is still poorly understood but recent advances in identifying tumor markers and introducing targeted therapies have shown promise. This review focuses on small animal oncology and provides an update on the field, drawing comparisons with bladder cancer in humans and experimental models of the disease.
VETERINARY SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
