Article
Cell Biology
Minjeong Yeon, Youngmi Kim, Deepak Pathak, Eunju Kwon, Dong Young Kim, Myeong Seon Jeong, Hyun Suk Jung, Dooil Jeoung
Summary: The cancer-associated gene CAGE plays a crucial role in promoting anticancer drug resistance and autophagic flux, while also influencing invasion potential. MiR-181b-5p and S1PR1 may act as negative regulators in controlling the expression of CAGE and autophagic flux.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xin Xie, Fu-Kang Sun, Xin Huang, Cheng-He Wang, Jun Dai, Ju-Ping Zhao, Chen Fang, Wei He
Summary: This study found that circSMARCA5 is downregulated in prostate cancer, and it suppresses the growth and metastasis of prostate cancer cells by affecting the miR-181b-5p-TIMP3 and miR-17-3p-TIMP3 axis. Targeting circSMARCA5-miR-181b-5p-TIMP3 and circSMARCA5-miR17-3p-TIMP3 axis could be a novel therapeutic strategy for prostate cancer.
Article
Biology
Yuhua Zou, Lei Zhang, Xin Zhong
Summary: Aberrant expression of miR-181b is closely associated with the development and progression of renal cell carcinoma, promoting proliferation and migration through targeting TIMP3 expression.
Article
Cell Biology
Wen Li, Yang-Yi-Yan Song, Ting Rao, Wei-Min Yu, Yuan Ruan, Jin-Zhuo Ning, Xiao-Bing Yao, Song-Yi-Sha Yang, Fan Cheng
Summary: This study identified the oncogenic role of circCSNK1G3 in RCC progression, demonstrating its regulation of miR-181b and TIMP3-mediated EMT process to promote tumor growth and metastasis in RCC. The potential of circCSNK1G3 as a diagnostic and prognostic biomarker in the clinic is highlighted, warranting further investigation in cancer research.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Qinqin Tian, Fung Ping Leung, Francis M. Chen, Xiao Yu Tian, Zhenyu Chen, Gary Tse, Shuangtao Ma, Wing Tak Wong
Summary: Butyrate prevents endothelial dysfunction in atherosclerosis by reducing endothelial NOX2 expression and ROS production via the PPAR delta/miR-181b pathway.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Shaorong Zhao, Teng Pan, Jinhai Deng, Lixia Cao, Jose M. Vicencio, Jingjing Liu, Guanglin Zhou, Tony Ng, Jin Zhang
Summary: This study reveals the important role of exosomal miR-181b-5p in doxorubicin resistance in breast cancer, and suggests its potential as a prognostic biomarker and therapeutic target for doxorubicin-resistant BC patients.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Article
Cell Biology
Weiyu Ni, Chao Jiang, Yizheng Wu, Haitao Zhang, Lili Wang, Jasper H. N. Yik, Dominik R. Haudenschild, Shunwu Fan, Shuying Shen, Ziang Hu
Summary: This study found that circSLC7A2 was decreased in the OA model and its circularization was regulated by FUS. The decrease of circSLC7A2 reduced the sponge of miR-4498 and further inhibited the expression of TIMP3, resulting in an inflammatory response. Intra-articular injection of circSLC7A2 alleviated OA progression in a mouse model of ACLT.
CELL PROLIFERATION
(2021)
Article
Medicine, Research & Experimental
Yue Li, Siyuan Fan, Weichang Xia, Baoru Qiao, Kai Huang, Jingqun Zhou, Minglu Liang
Summary: miR-181b inhibits angiogenesis by targeting CCN1 to suppress the AMPK signaling pathway, providing new insights for the development of pro-angiogenic treatment strategies.
LABORATORY INVESTIGATION
(2021)
Article
Cell Biology
Li-Xia Xue, Lin-Yuan Shu, Hong-Mei Wang, Kai-Li Lu, Li-Gang Huang, Jing-Yan Xiang, Zhi Geng, Yu-Wu Zhao, Hao Chen
Summary: Promoting new blood vessel formation is a new strategy for treating ischemic stroke, and non-coding miRNAs have been considered potential therapeutic targets for this condition. In this study, overexpression of miR-181b in brain microvascular endothelial cells restored cell proliferation and enhanced angiogenesis in vitro. In rat models of focal cerebral ischemia, overexpression of miR-181b reduced infarction volume, promoted angiogenesis, and improved neurological function. The molecular mechanism behind these effects involves miR-181b binding to PTEN mRNA to induce downregulation, leading to PTEN/Akt pathway activation, upregulated expression of vascular endothelial growth factors, downregulated expression of endostatin, and promoted angiogenesis.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yimei Jiang, Qingqing Qiu, Xiaoqian Jing, Zijia Song, Yaqi Zhang, Changgang Wang, Kun Liu, Feng Ye, Xiaopin Ji, Fangxiu Luo, Ren Zhao
Summary: The tumor microenvironment plays a crucial role in the development of colorectal cancer (CRC). This study demonstrates that tumor-associated fibroblasts (CAFs) release exosomes containing miR-181b-3p, which promote CRC progression by regulating SNX2 expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Daniel G. Henriques, Renan Lyra Miranda, Romulo Sperduto Dezonne, Luiz Eduardo Wildemberg, Aline Helen da Silva Camacho, Leila Chimelli, Leandro Kasuki, Elisa B. Lamback, Alexandro Guterres, Monica R. Gadelha
Summary: This study identified miRNAs associated with resistance to fg-SRLs treatment in acromegaly using miRNA sequencing and bioinformatic analysis. It was found that miR-181a-5p, miR-181b-5p, and miR-383-5p were differentially expressed, with miR-181a-5p and miR-181b-5p downregulated and miR-383-5p upregulated in the uncontrolled group. ROC curve analysis showed that miR-383-5p had an NPV of 84.3% and a PPV of 84.5%. Thus, these miRNAs can serve as biomarkers and tools to guide clinical decisions in response to fg-SRLs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Adnan Fojnica, Zehra Gromilic, Semir Vranic, Michael Murkovic
Summary: Peptides are abundant molecules with diverse functions and biological activities. Flaxseed oil, a natural substance, has been extensively studied for its biological effects. Cyclolinopeptides (CLPs), one of the components of flaxseed, have gained attention due to their cyclic nature and potential therapeutic applications. CLPs have shown anticancer effects and can inhibit cancer cell growth in various cancer types.
Article
Multidisciplinary Sciences
Chengxin Ma, Dasa He, Pu Tian, Yuan Wang, Yunfei He, Qiuyao Wu, Zhenchang Jia, Xue Zhang, Peiyuan Zhang, Hao Ying, Zi-Bing Jin, Guohong Hu
Summary: This study reveals the crucial role of the TGF beta/miR-182/TLR4 axis in the polarization of tumor-associated macrophages (TAMs) and provides a theoretical basis for RNA-based therapeutics targeting TAMs in cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Orthopedics
Dexin Wang, Yu Fang, Liang Lin, Wensuo Long, Lei Wang, Liwei Yu, Huaiming Deng, Dan Wang
Summary: This study investigated the correlation between the aberrant upregulation of miR-181b and ferroptosis in chondrocytes during the progression of osteoarthritis (OA). The findings showed that miR-181b exacerbates OA disease progression by inhibiting SLC7A11 gene expression and increasing ferroptosis.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qingsong Tao, Ting Zhu, Xiaoqin Ge, Shengping Gong, Jianxin Guo
Summary: The study examines the application value of spiral CT lung density measurement software in diagnosing radioactive lung injuries. By measuring the CT values of different parts of the lungs in patients with radiation lung injuries, the study found significant differences in lung density between normal and abnormal cases. Spiral CT lung density measurement software can accurately evaluate and correlate lung density values with different types of radiation lung injuries.
CONTRAST MEDIA & MOLECULAR IMAGING
(2021)
