Article
Chemistry, Medicinal
Pavel Barta, Petr Nachtigal, Jana Maixnerova, Lenka Zemankova, Frantisek Trejtnar
Summary: Freshly isolated rat renal cells have been found to be an effective tool for evaluating the cellular uptake of receptor-specific peptide analogs, especially those that are taken up by renal epithelial cells.
Article
Chemistry, Medicinal
Wenrui Sun, Binchuan Hu, Xiaoshan Zhang, Yuzhen Wang, Zheng Xiang, Guanyang Lin
Summary: This study investigated the nephrotoxicity of polymyxin B at different daily administration frequencies. The results showed that rats treated with twice-daily subcutaneous doses of polymyxin B exhibited higher renal toxicity compared to rats treated with once-daily doses.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Microbiology
Jack Chang, Gwendolyn M. Pais, Patti L. Engel, Patryk Klimek, Sylwia Marianski, Kimberly Valdez, Marc H. Scheetz
Summary: Vancomycin-induced kidney injury is common, and outcomes in humans are well predicted by animal models. This study employed our translational rat model to investigate temporal changes in the glomerular filtration rate (GFR) and correlations with kidney injury biomarkers related to various vancomycin dosing strategies.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Environmental Sciences
Tao Wei, Na Cao, Tiantian Han, Yi Chen, Xingtao Zhou, Liyang Niu, Wenting Liu, Chang Li
Summary: The present study investigated the nephrotoxicity and lipidomic mechanisms of 3-monochloropropane-1,2-diol (3-MCPD) in Sprague Dawley rats. The results showed that the ingestion of 3-MCPD caused dose-dependent renal impairment and altered oxidative stress indicators. Lipidomic analysis revealed that 3-MCPD interfered with glycerophospholipid metabolism and sphingolipid metabolism, leading to kidney injury. Additionally, 38 lipids were identified as potential biomarkers. This study provides new insights into the mechanism of 3-MCPD renal toxicity and offers a novel approach to its study using lipidomics.
Article
Agriculture, Multidisciplinary
Lu Li, Ziyue Wang, Yucai Li, Fuying Ma, Xinwei Wang, Haiyang Yan, Wenliang Li, Yong Pang, Yuan Yuan
Summary: The study found that allicin can protect the kidney from the harmful effects of acrylamide. Allicin restores mitochondrial function, inhibits p53 acetylation, prevents the translocation of cytochrome c, and reduces caspase expression, thereby relieving mitochondrial apoptosis caused by acrylamide.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Da-Bin Hwang, Min Ho Cha, Dong-Hoon Won, Yoo-Sub Shin, Shin-Young Kim, Changuk Kim, Eun-Ji Lee, Yoon Young Kim, Jun-Won Yun
Summary: Cisplatin, although an effective platinum-based anticancer drug, has limited availability due to its adverse side effects. This study found that male rats are more susceptible to cisplatin-induced nephrotoxicity, which is associated with renal dysfunction, testicular damage, and an imbalance in male hormone regulation. Additionally, genes related to gap junctions and mismatch repair were enriched in males following cisplatin treatment, shedding light on the potential mechanisms of sex differences in cisplatin-induced nephrotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Medha D. Joshi, Paulina Iacoban, Marc H. Scheetz
Summary: This study successfully encapsulated vancomycin in polyethylene glycol-coated liposomes (PEG-VANCO-lipo) and compared its effects with standard vancomycin. The results showed that PEG-VANCO-lipo resulted in lower levels of kidney injury, as indicated by decreased levels of KIM-1 in urine and reduced plasma vancomycin concentration. These findings suggest that PEG-VANCO-lipo has a high potential to decrease the nephrotoxicity of vancomycin clinically.
Article
Pharmacology & Pharmacy
Osama Y. Althunibat, Mohammad H. Abukhalil, Saleem H. Aladaileh, Haitham Qaralleh, Wesam Al-Amarat, Manal A. Alfwuaires, Abdulmohsen I. Algefare, Nader Ibrahim Namazi, Sahar J. Melebary, Ahmad O. Babalghith, Carlos Adam Conte-Junior
Summary: Formononetin protects against gentamicin-induced renal damage in rats by exhibiting antioxidant, anti-inflammatory, and antiapoptotic activities and augmenting Nrf2 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Indra Dev, Saurabh Pal, Onila Lugun, Neha Singh, Kausar Mahmood Ansari
Summary: This study investigated the role of exosomes in OTA-mediated nephrotoxicity. The results showed that OTA treatment caused histopathological changes in kidney tissue and an increase in exosome secretion in rat's urine. Additionally, exposure of NRK57E cells to exosomes from OTA-treated rats resulted in increased cell proliferation, cell growth, and activation of the TGF-beta(1)/smad2/3 pathway. These findings are significant for a deeper understanding of OTA-induced nephrotoxicity.
Article
Biochemistry & Molecular Biology
Yasmen F. Mahran, Layla A. Al-Kharashi, Reem T. Atawia, Rawan Turki Alanazi, Amal M. Bin Dhahi, Rawd Alsubaie, Amira M. Badr
Summary: Carvacrol and thymol can protect the kidneys from radiation-induced damage by exerting antioxidative, anti-inflammatory, and antiapoptotic activities. They can also restore the downregulation of CGPR-TNF-a loop in acute radiation nephropathy, suggesting their involvement in the pathomechanisms of acute radiation nephropathy.
Review
Oncology
Raquel Davila Fajardo, Paulien Raymakers-Janssen, Martine van Grotel, Roelie M. van Wosten-van Asperen, Christianus H. Terhaard, Marc R. Lilien, Marry M. van den Heuvel-Eibrink, Geert O. Janssens
Summary: Nephrotoxicity may occur as a side effect after childhood kidney tumor treatment, and radiotherapy (RT) may have an additional effect. A systematic literature search in EMBASE found no significant difference in estimated glomerular filtration rate between patients who received RT and those who did not, suggesting that RT does not have a significant impact on kidney function decline as an independent factor.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Toxicology
Rao Fu, Soichiro Tajima, Tomohiro Shigematsu, Mengyu Zhang, Akihiro Tsuchimoto, Nobuaki Egashira, Ichiro Ieiri, Satohiro Masuda
Summary: A new nephrotoxicity with interstitial fibrosis rat model induced by tacrolimus administration has been successfully developed, showing renal dysfunction, histological injury, and increased expression of alpha-SMA, TGF-beta, and KIM-1 in the renal cortex within 2 weeks.
TOXICOLOGY LETTERS
(2021)
Article
Chemistry, Medicinal
Ji Hwan Lee, Musun Park, Kiwon Jung, Gyeongmin Hong, Hye Lim Lee, Dong-Wook Kim, Chang-Eop Kim, Ki Sung Kang
Summary: Gallic acid was found to increase cell survival and protect against nephrotoxicity induced by FK506. Its protective effect was strongest among the compounds tested and was further confirmed in a rat model. Molecular docking and bioavailability investigations provided supporting evidence for the nephroprotective function of gallic acid.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Rodica Ana Ungur, Ileana Monica Borda, Razvan Andrei Codea, Viorela Mihaela Ciortea, Bogdana Adriana Nasui, Sevastita Muste, Orsolya Sarpataky, Miuta Filip, Laszlo Irsay, Elena Cristina Craciun, Simona Cainap, Delia Bunea Jivanescu, Anca Lucia Pop, Victoria Emilia Singurean, Maria Crisan, Oana Bianca Groza, Georgiana Smaranda Martis (Petrut)
Summary: The flavonoid-rich extract of Sambucus nigra L. elderflower showed potential in inhibiting lipid peroxidation in gentamicin-induced nephrotoxicity, but did not significantly improve the activity of antioxidant enzymes.
Article
Environmental Sciences
Zhonggui Gong, Wenjing Liu, Ruilong Song, Wenxuan Dong, Kanglei Zhang, Jiahui Li, Hui Zou, Jiaqiao Zhu, Yonggang Ma, Gang Liu, Zongping Liu
Summary: Cadmium (Cd) is a heavy metal pollutant that targets the kidney. Previous studies have shown that Cd-induced nephrotoxicity is caused by apoptosis and autophagy disorders. The regulatory mechanisms of NF-kappa B in Cd-induced kidney injury are still unclear. This study found that Cd promotes the activation of NF-kappa B, which mediates the survival of NRK-52E cells through promoting autophagy and inhibiting apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Orthopedics
Servet Kerimoglu, Atilgan Onay, Yilmaz Guvercin, Atilla Citlak, Engin Yenilmez, Gokcen Kerimoglu
INDIAN JOURNAL OF ORTHOPAEDICS
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
I. Dogan, O. Sezen, B. Sonmez, A. Y. Zengin, E. Yenilmez, E. Yulug, I. Abidin, Z. Bahat
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2010)
Article
Hematology
Aysenur Bahadir, Nilgun Kurucu, Mine Kadioglu, Engin Yenilmez
TURKISH JOURNAL OF HEMATOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
E. Yulug, S. Turedi, O. Yildirim, E. Yenilmez, Y. Aliyazicioglu, S. Demir, S. Ozer-Yaman, A. Mentese
BIOTECHNIC & HISTOCHEMISTRY
(2019)
Article
Plant Sciences
Sila Ozlem Sener, Ufuk Ozgen, Seyda Kanbolat, Nuriye Korkmaz, Merve Badem, Hatice Hanci, Tuncay Dirmenci, Turan Arabaci, Rezzan Aliyazicioglu, Engin Yenilmez, Gulcin Saltan Iscan
Summary: This study investigated the therapeutic potential of endemic Cirsium species for obesity treatment, highlighting their compounds such as syringin, cimidahurinin, astragalin, afzelin, lupeol, and psi-taraxasterol. The extracts and orlistat were found to effectively reduce body weight and improve lipid metabolism in obese rats, showing promising anti-obesity effects through various pathways.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Medicine, General & Internal
Sila Ozlem Sener, Merve Badem, Ufuk Ozgen, Nuriye Korkmaz, Seyda Kanbolat, Gokcen Kerimoglu, Rezzan Aliyazicioglu, Engin Yenilmez, Esen Sezen Karaoglan
Summary: This study evaluated the antidiabetic and antioxidant effects of Lysimachia verticillaris extract and its isolated compounds in rats with STZ-induced type 1 diabetes. The results showed that the extract and compounds reduced blood glucose levels and increased insulin and antioxidant enzyme levels. Quercetin 3-O-beta-glucopyranoside exhibited the strongest antidiabetic effect. These findings suggest that Lysimachia verticillaris and its compounds could be potential sources of herbal medicine for treating diabetes.
Meeting Abstract
Transplantation
Kubra Kaynar, Rezzan Aliyazicioglu, Engin Yenilmez, Nuriye Korkmaz, Oguzhan Keskin, Seyda Akkaya, Sila Ozlem Sener, Ufuk Ozgen, Gamze Can, Sait Al
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Meeting Abstract
Developmental Biology
M. Kadioglu, I. Erkoseoglu, T. Aran, D. Altintas-Aykan, E. Yaris, N. I. Kalyoncu, E. Yenilmez
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
(2014)
Meeting Abstract
Developmental Biology
M. Kadioglu, I. Erkoseoglu, T. Aran, D. Altintas-Aykan, E. Yaris, N. I. Kalyoncu, E. Yenilmez
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
(2014)
Meeting Abstract
Developmental Biology
I. Erkoseoglu, M. Kadioglu, T. Aran, D. Altintas-Aykan, S. K. Gunak, E. Yaris, N. I. Kalyoncu, E. Yenilmez
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
(2014)
Article
Obstetrics & Gynecology
M. A. Osmanagaoglu, S. C. Karahan, T. Aran, S. Guven, A. Cora, M. Kopuz, H. Bozkaya
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2013)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
I. Dogan, O. Sezen, B. Sonmez, A. Y. Zengin, E. Yenilmez, E. Yulug, I. Abidin, Z. Bahat
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2010)
Article
Cardiac & Cardiovascular Systems
Celal Tekinbas, Hulya Ulusoy, Esin Yulug, Mehmet Muharrem Erol, Ahmet Alver, Engin Yenilmez, Sukran Geze, Murat Topbas
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2007)
Article
Medicine, Research & Experimental
Esra Ercan, Celal Candirli, Cihan Uysal, Bilge Cansu Uzun, Engin Yenilmez
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2016)
