Article
Cell Biology
Karolina Kowalska, Dominika Ewa Habrowska-Gorczynska, Dominika Kurczewska, Kamila Dominska, Kinga Anna Urbanek, Agnieszka Wanda Piastowska-Ciesielska
Summary: Methylsulfonylmethane (MSM) may have a beneficial effect in endometrial cancer treatment, increasing cell sensitivity to chemotherapy drugs by regulating specific protein kinase pathways.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vladislav Chubinskiy-Nadezhdin, Svetlana Semenova, Valeria Vasileva, Alla Shatrova, Natalia Pugovkina, Yuri Negulyaev
Summary: Endometrial mesenchymal stem cells (eMSCs) have the ability to differentiate into different cell types and are influenced by mechanical forces in their microenvironment. This study identified Piezo1 proteins as mechanosensitive channels in the plasma membrane of eMSCs, which transduce mechanical stimuli into intracellular signaling pathways. The influx of Ca2+ triggered by Piezo1 activity is regulated by store-operated Ca2+ entry (SOCE) through the ORAI1 channel and STIM1/STIM2 Ca2+ sensors. Activation of Piezo1 or SOCE does not cause cytotoxicity in eMSCs but affects their migratory capacity and cell proliferation. This finding suggests that Piezo1 and SOCE play important roles in the regulation of intracellular calcium, which influences the migratory activity and regenerative potential of eMSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yani Yan, Cong Liu, Jian Zhang, Weiwei Li, Xiurong Yin, Lixia Dong, Shulan Pang, Xuefeng Li
Summary: SMC4 expression is increased in endometrial cancer and predicts poor overall survival. Silencing of SMC4 inhibits cell proliferation and promotes apoptosis, potentially through regulation of FoxO1 activity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Multidisciplinary Sciences
Ching-Yuan Wu, Yao-Hsu Yang, Yu-Shih Lin, Li-Hsin Shu, Hung-Te Liu, Yu-Huei Wu, Yu-Heng Wu
Summary: Danshen compound dihydroisotanshinone I (DT) inhibits viability of endometrial cancer cells by inducing apoptosis and ferroptosis, achieved by blocking GPX4 expression. In vivo experiments show that DT treatment significantly reduces tumor size without adverse effects.
Article
Biochemistry & Molecular Biology
Kongdong Li, Chuanzhi Guo, Jiacheng Ruan, Bo Ning, Chris Kong-Chu Wong, Haifeng Shi, Jie Gu
Summary: Cadmium (Cd2+) exposure-induced cytotoxicity and renal injury can be protected against by activating the calcium-sensing receptor (CaSR) to restore the intracellular Ca2+ homeostasis through the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) channel. SERCA2 degradation caused by Cd2+ can be inhibited by the proteasome inhibitor MG132, indicating the involvement of the proteasomal protein degradation pathway in maintaining SERCA2 stability. Targeting SERCA2 and the associated proteasome may provide a new therapeutic approach for preventing Cd2+-induced cytotoxicity and renal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Hantae Jo, Dongmin Jang, Sun Kyu Park, Mi-Gi Lee, Byungsun Cha, Chaewon Park, Yong Sub Shin, Hyein Park, Jin-myoung Baek, Hyojin Heo, Sofia Brito, Hyun Gyu Hwan, Sehyun Chae, Shao-wei Yan, Changho Lee, Churl K. Min, Bum-Ho Bin
Summary: 20(S)-protopanaxadiol (20(S)-PPD) inhibits human endometrial cancer cell proliferation by inducing cell death via a caspase-mediated apoptosis pathway, and it also shows tumor growth inhibition in xenograft mouse models.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Seung Bae Rho, Hyun Jung Byun, Boh-Ram Kim, Chang Hoon Lee
Summary: Metformin has anti-proliferative effects in cervical cancer cells, but not in endometrial cancer cells. This difference may be related to the expression of the LKB1 gene.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Food Science & Technology
Tong-Tong Tang, Li Jiang, Qian Zhong, Zhi-Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Zhao -Jun Wei
Summary: Saikosaponin D (SSD) shows cytotoxicity and induces apoptosis in human endometrial cancer Ishikawa cells, while being non-toxic to normal human cells. It also inhibits cell migration and invasion, potentially through the MAPK cascade pathway. These findings suggest that SSD could be a natural secondary metabolite with potential benefits in preventing and treating endometrial carcinoma.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Ranka Kanda, Yuko Miyagawa, Osamu Wada-Hiraike, Haruko Hiraike, Kazunori Nagasaka, Eiji Ryo, Tomoyuki Fujii, Yutaka Osuga, Takuya Ayabe
Summary: Ulipristal acetate (UPA) inhibits the growth, migration, and invasion of Ishikawa endometrial cancer cells via apoptosis induction while also activating proinflammatory cytokines. Combining UPA with an estrogen receptor antagonist may be useful in suppressing the secretion of proinflammatory cytokines induced by UPA alone.
Article
Microbiology
Taylor A. Crooks, Joseph D. Madison, Dana M. Walsh, William G. Herbert, Patricio R. Jeraldo, Nicholas Chia, William A. Cliby, Scott H. Kaufmann, Marina R. S. Walther-Antonio
Summary: Recent evidence suggests a potential association between endometrial cancer and Porphyromonas somerae. The bacteria demonstrated increased growth in response to 17 beta-estradiol, a known risk factor for endometrial cancer, while no significant changes in metabolite levels were observed. In vitro invasion assays showed evidence of intracellular invasion of P. somerae in endometrial adenocarcinoma cells, raising new questions about its role in endometrial cancer progression.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Medicine, General & Internal
Emma J. Crosbie, Sarah J. Kitson, Jessica N. McAlpine, Asima Mukhopadhyay, Melanie E. Powell, Naveena Singh
Summary: Endometrial cancer is the most common gynaecological cancer in high income countries, with a global rise in incidence. Obesity is the major underlying cause, posing challenges for diagnosis and treatment. Early presentation with postmenopausal bleeding ensures cure, but advanced cases have poor prognosis. Minimally invasive surgical staging and targeted chemotherapeutic strategies are important advances.
Article
Biochemistry & Molecular Biology
Fan Zhang, Yuan-Yuan Zhang, Run-Hui Ma, Kiran Thakur, Jinzhi Han, Fei Hu, Jian-Guo Zhang, Zhao-Jun Wei
Summary: The study investigated the mechanisms of AA on endometrial cancer (EC) Ishikawa cells through the combined analysis of differentially expressed miRNAs (DEMs) and genes, revealing that AA induces apoptosis and triggers autophagy via ER stress and DNA damage-related pathways. Key hub miRNAs were identified as potential regulators essential for the anticancer activity of AA, suggesting its potential as a candidate for dietary supplementation in cancer treatment and prevention.
Review
Oncology
Xing Zhang, Jia-Jing Lu, Ayitila Abudukeyoumu, Ding-Yu Hou, Jing Dong, Jiang-Nan Wu, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: Glucose plays a crucial role in the metabolism of endometrial cancer cells (ECCs). Overexpressed glucose transporters (GLUTs) in ECCs not only provide abundant glucose uptake, but also participate in the activation of important signaling pathways involved in proliferation, angiogenesis, and metastasis. In addition, the overexpression of GLUTs may lead to hormone therapy resistance and resistance to radiotherapy and chemoradiotherapy in ECCs. GLUT inhibitors hold promise as sensitizers in precision-targeted therapies for endometrial cancer (EC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaoshan Hong, Bin Wen, Huaming Zhang, Yuhan Li, Hengying Wu, Wei Zhao, Xiping Luo
Summary: The study revealed that the expression levels of NODAL and ALK7 were significantly decreased in endometrial cancer (EC) cells, and overexpression of NODAL could inhibit EC cell proliferation, invasion, and migration, and promote EC cell apoptosis, which is mediated by activating ALK7.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Dingde Long, Yayu Chen, Liangchao Qu, Yang Dong
Summary: Lidocaine inhibited the proliferation and migration of endometrial cancer cells by inducing autophagy, and promoted apoptosis.