Article
Medicine, General & Internal
Dali Zhang, Danni Feng, Minjuan Ren, Ying Bai, Zhenwen Liu, Hongbo Wang
Summary: This study found that chronic hepatitis B infection is not a risk factor for HCC recurrence after liver transplantation, but tumor characteristics play a crucial role. Patients with detectable HBV DNA before transplantation often have more advanced tumor characteristics and a higher risk of HCC recurrence.
ANNALS OF MEDICINE
(2022)
Article
Oncology
I-Cheng Lee, Hao-Jan Lei, Gar-Yang Chau, Yi-Chen Yeh, Chi-Jung Wu, Chien-Wei Su, Teh-la Huo, Yee Chao, Han-Chieh Lin, Ming-Chih Hou, Yi-Hsiang Huang
Summary: The study found that in patients with HBV-related HCC undergoing surgical resection under NUCs therapy, factors such as HBsAg levels, cirrhosis, and other markers were associated with recurrence and mortality at different time intervals. The pre-operative HBsAg level was identified as an important predictor for long-term recurrence and survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Junyi Shen, Weili Qi, Junlong Dai, Shusheng Leng, Kangyi Jiang, Yu Zhang, Shun Ran, Chuan Li, Tianfu Wen
Summary: This study compared the effects of tenofovir (TDF) and entecavir (ETV) on the recurrence of hepatocellular carcinoma (HCC) beyond the Milan criteria. The results showed that TDF treatment significantly reduced the risk of HCC recurrence compared to ETV therapy.
CHINESE MEDICAL JOURNAL
(2022)
Article
Oncology
Wenpei Guo, Yuan Li, Liangbo Li, Jingjun Mu, Bo Wang, Zhiqiang Niu, Yijie Ning, Lixin Liu
Summary: This study investigated the predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation response index (SIRI), and systemic immune inflammation index (SII) for early recurrence after liver resection in hepatitis B-related hepatocellular carcinoma (HCC) patients. The joint index CIP, consisting of SIRI, PLR, NLR, SII, and pathological features, can better predict early recurrence and assist clinicians in making better clinical choices. The AUC of the joint prediction model was 0.804, which outperformed the single inflammatory index models.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Feng Xiao, Chuanli Liu, Junjie Wang, Yingnan Wei, Xinyu Wang, Yuemin Feng, Qiang Zhu
Summary: This study investigated the predictive value of preoperative serum GLDH levels in postoperative recurrence in patients with hepatitis B virus-related hepatocellular carcinoma. The results showed that high GLDH levels were associated with various malignant factors and were an independent predictor of disease-free survival.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Virology
Peng Lin, Dong-Yue Wen, Jin-Shu Pang, Wei Liao, Yu-Ji Chen, Yun He, Hong Yang
Summary: This study developed an overall survival prediction model based on protein expression profiles in HBV-infected nontumor liver tissues, demonstrating the feasibility of using protein expression profiles in nontumor liver tissues for survival prediction.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Surgery
Linye He, Zijing Xia, Xiaoyun Zhang, Zhihui Li, Tianfu Wen, Chuan Li
Summary: This study found that HBV-related HCC patients treated with consistent TDF therapy had a significantly lower risk of tumor recurrence than those treated with ETV after curative treatment.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Francesco Paolo Russo, Alberto Zanetto, Elisa Pinto, Sara Battistella, Barbara Penzo, Patrizia Burra, Fabio Farinati
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study investigated the relationship between the severity in the grading of microvascular invasion (MVI) and long-term oncological outcomes in patients with early-stage hepatocellular carcinoma (HCC). The results showed that the severity in MVI grading was independently associated with recurrence and survival after HCC resection. Patients with a more severe MVI grading (M2) require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Indah Jamtani, Kwang-Woong Lee, Yunhee Choi, YoungRok Choi, Jeong-Moo Lee, Eui-Soo Han, Kwangpyo Hong, Gyu-Seong Choi, Jong Man Kim, Nam-Joon Yi, Suk Kyun Hong, Jeik Byun, Su Young Hong, Sanggyeun Suh, Jae-Won Joh, Kyung-Suk Suh
Summary: This study aimed to develop a tailored prediction model of HCC-specific survival after transplantation, validated internally and externally. By combining multiple risk factors, the model showed good accuracy in predicting HCC-specific survival tailored for patients undergoing transplantation. The calculated SALT predictor provided accurate information on expected survival rates based on risk scores and specific characteristics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Ho Soo Chun, Sojeong Park, Minjong Lee, Yuri Cho, Ha Sung Kim, A. Reum Choe, Hwi Young Kim, Kwon Yoo, Tae Hun Kim
Summary: The study found a significant association between physical activity and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients treated with potent antiviral therapy, with increasing physical activity being beneficial in reducing the risk of HCC development.
Article
Oncology
Lin Wang, Hui Shi, Jia Wei, Wen-Xiu Chen, Yue-Xinzi Jin, Chun-Rong Gu, Yuan Mu, Jian Xu, Shi-Yang Pan
Summary: SP70 is highly expressed in hepatocellular carcinoma (HCC) and can be used as a predictor of early HCC recurrence.
FRONTIERS IN ONCOLOGY
(2023)
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Article
Virology
Song-Huy Nguyen-Dinh, Wei-Feng Li, Yueh-Wei Liu, Chih-Chi Wang, Yen-Hao Chen, Jing-Houng Wang, Chao-Hung Hung
Summary: Epidemiological data suggest that there are etiological variations of hepatocellular carcinoma (HCC) in different geographic areas, which may be associated with different outcomes. This study compared the viral etiology, clinicopathological characteristics, and surgical outcomes between Taiwanese and Vietnamese patients with HCC. The results showed that although the viral etiology and clinicopathological characteristics differed, the postoperative overall survival was comparable between patients in Taiwan and Vietnam.
Review
Immunology
Rukaiya Bashir Hamidu, Divya M. Chalikonda, Hie-Won Hann
Summary: Chronic HBV infection is a common cause of HCC, with males and postmenopausal females at higher risk for development. Evidence suggests females may have better outcomes, with gender disparities in various factors contributing to prognosis differences.
Article
Gastroenterology & Hepatology
Hannah S. J. Choi, Grishma Hirode, Chien-Hung Chen, Tung-Hung Su, Wai-Kay Seto, Stijn Van Hees, Margarita Papatheodoridi, Sabela Lens, Grace L. H. Wong, Sylvia M. Brakenhoff, Rong-Nan Chien, Jordan J. Feld, Milan J. Sonneveld, Henry L. Y. Chan, Xavier Forns, George Papatheodoridis, Thomas Vanwolleghem, Man-Fung Yuen, Yao-Chun Hsu, Jia-Horn Kao, Markus Cornberg, Bettina E. Hansen, Wen-Jue Jeng, Harry L. A. Janssen
Summary: This study compared the relapse rates and treatment outcomes after discontinuation of therapy in chronic hepatitis B patients using entecavir (ETV) and tenofovir disoproxil fumarate (TDF). It found that TDF was associated with a higher rate of HBsAg loss, earlier virological relapse, and higher clinical relapse compared to ETV. However, the rates of HBsAg loss and retreatment were similar between the two treatment groups. Finite therapy can be considered for CHB patients on either TDF or ETV therapy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Huapeng Lin, Terry Cheuk-Fung Yip, Xinrong Zhang, Guanlin Li, Yee-Kit Tse, Vicki Wing-Ki Hui, Lilian Yan Liang, Jimmy Che-To Lai, Stephen Lam Chan, Henry Lik-Yuen Chan, Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Summary: The relative importance of liver-related death increases with age in patients with NAFLD, especially among women.
Article
Gastroenterology & Hepatology
Harry L. A. Janssen, Jinlin Hou, Tarik Asselah, Henry L. Y. Chan, Fabien Zoulim, Yasuhito Tanaka, Ewa Janczewska, Ronald G. Nahass, Stefan Bourgeois, Maria Buti, Pietro Lampertico, Oliver Lenz, Thierry Verbinnen, Joris Vandenbossche, Willem Talloen, Ronald Kalmeijer, Maria Beumont, Michael Biermer, Umesh Shukla
Summary: The study evaluated the efficacy and safety of JNJ-56136379 in patients with chronic hepatitis B. The results showed that JNJ-56136379+NA significantly reduced HBV DNA and HBV RNA levels, but had limited effects on HBsAg or HBeAg declines in HBeAg-positive patients. Overall, JNJ-56136379 did not demonstrate clear superiority over NA in terms of efficacy.
Article
Gastroenterology & Hepatology
Terry Cheuk-Fung Yip, Vincent Wai-Sun Wong, Mandy Sze -Man Lai, Jimmy Che-To Lai, Vicki Wing-Ki Hui, Lilian Yan Liang, Yee-Kit Tse, Henry Lik-Yuen Chan, Grace Lai -Hung Wong
Summary: We investigated the long-term incidence of hepatocellular carcinoma (HCC) and hepatic decompensation among chronic hepatitis B patients who have achieved hepatitis B surface antigen (HBsAg) seroclearance. The study found that the proportion of patients who developed HCC after HBsAg clearance was 1.1%, while the proportion of patients who developed hepatic decompensation was 1.3%. HBsAg clearance for over 7 years was associated with a reduced risk of hepatic decompensation but not HCC.
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Do Young Kim, Bao Nguyen Toan, Chee-Kiat Tan, Irsan Hasan, Lyana Setiawan, Ming -Lung Yu, Namiki Izumi, Nguyen Nguyen Huyen, Pierce Kah-Hoe Chow, Rosmawati Mohamed, Stephen Lam Chan, Tawesak Tanwandee, Teng-Yu Lee, Thi Thanh Nguyen Hai, Tian Yang, Woo -Chang Lee, Henry Lik Yuen Chan
Summary: PIVKA-II is valuable for detecting AFP-negative hepatocellular carcinoma (HCC), and could be used in combination with AFP for early HCC detection. It is clinically useful for monitoring HCC treatment, predicting recurrence and microvascular invasion risk, and facilitating patient selection for liver transplant. However, more evidence is needed for its role in surveillance, including small HCC.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ada S. F. Chan, Henry L. Y. Chan, Bruno K. L. Yan, Mooris K. C. Lai
Summary: A study conducted in a private hospital in Hong Kong found that the use of ATP bioluminescence assay is a rapid and cost-effective method for evaluating the presence of microbial residue on endoscopes and monitoring their cleanliness.
Article
Gastroenterology & Hepatology
Xinrong Zhang, Terry Cheuk-Fung Yip, Yee-Kit Tse, Vicki Wing-Ki Hui, Guanlin Li, Huapeng Lin, Lilian Yan Liang, Jimmy Che-To Lai, Mandy Sze-Man Lai, Johnny T. K. Cheung, Henry Lik-Yuen Chan, Stephen Lam Chan, Alice Pik-Shan Kong, Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Summary: This study found that risk factor control and treatment improved significantly in patients with NAFLD and T2D from 2000 to 2020, with improved glycemic and lipid control but no significant change in blood pressure control.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Kit Fai Lee, Eugene Yee Juen Lo, Sunny Yue Sun Cheung
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kenneth W. W. Lin, Rajneesh Kumar, Feng Shen, Henry L. -Y. Chan, Grace L. -H. Wong, Rahul Kumar, Wan Cheng Chow, Su Lin, Vincent W. -S. Wong, Jian-Gao Fan, George B. -B. Goh
Summary: The prevalence of concomitant chronic hepatitis B (CHB) and hepatic steatosis (HS) is increasing in Asia. Non-invasive tests (NITs) have good accuracy in predicting fibrosis degree in patients with concomitant CHB and HS.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Claudia Wing-Kwan Wu, Rashid Nok-Shun Lui, Vincent Wai-Sun Wong, Tsz-Fai Yam, Terry Cheuk-Fung Yip, Ken Liu, Jimmy Che-To Lai, Yee-Kit Tse, Tony Shu-Kam Mok, Henry Lik-Yuen Chan, Kelvin Kwok-Chai Ng, Grace Lai-Hung Wong, Stephen Lam Chan
Summary: The study successfully validated the efficacy of the Baveno VII criteria in predicting high-risk varices in patients with hepatocellular carcinoma, providing a non-invasive method for assessing the risk of variceal bleeding and hepatic decompensation.
Meeting Abstract
Gastroenterology & Hepatology
Che-To Lai, Vincent Wai-Sun Wong, Angel Mei-Ling Chim, Vicki Wing-Ki Hui, Yee-Kit Tse, Terry Cheuk-Fung Yip, Henry Lik-Yuen Chan, Grace Lai-Hung Wong
Meeting Abstract
Gastroenterology & Hepatology
Che-To Lai, Vincent Wai-Sun Wong, Vicki Wing-Ki Hui, Yee-Kit Tse, Terry Cheuk-Fung Yip, Henry Lik-Yuen Chan, Grace Lai-Hung Wong
Meeting Abstract
Gastroenterology & Hepatology
Yan Liang, Terry Cheuk-Fung Yip, Jimmy Che-To Lai, Amy Shuk-Man Lam, Yee-Kit Tse, Vicki Wing-Ki Hui, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
Meeting Abstract
Gastroenterology & Hepatology
Terry Cheuk-Fung Yip, Wayne Yau-Wang Hui, Wilfred Wang-Fung Ho, Zackary Kwun-Lam Tsang, Tsz-Fai Yam, Mandy Sze-Man Lai, Yee-Kit Tse, Henry Lik-Yuen Chan, Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Article
Surgery
Kam Cheung Wong, Kit Fai Lee, Eugene Y. J. Lo, Andrew K. Y. Fung, Hon Ting Lok, Sunny Y. S. Cheung, Kelvin K. C. Ng, John Wong, Paul B. S. Lai, Charing C. N. Chong
Summary: This study compared the peri-operative and long-term survival outcomes of minimally invasive liver resection (MILR) (robotic or laparoscopic) with open liver resection (OLR) in patients with hepatocellular carcinoma (HCC). The results showed that MILR group had better outcomes in terms of postoperative bleeding, complications, and length of hospital stay, while the survival rates were comparable between the two groups.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
