Article
Agriculture, Dairy & Animal Science
Taha M. Mohamed, Weizhong Sun, Gifty Z. Bumbie, Waleed M. Dosoky, Zebin Rao, Ping Hu, Liuting Wu, Zhiru Tang
Summary: This study investigated the effects of Bacillus subtilis supplementation on the growth performance, organ weight, and serum biochemical indices of broiler chickens. The results showed that Bacillus subtilis could be used as an alternative to antibiotics, as it improved body weight gain, organ weight, serum metabolite concentrations, and digestive enzyme activities in broilers.
Article
Food Science & Technology
Xandra Benthem de Grave, Janine Saltzmann, Julia Laurain, Maria A. Rodriguez, Francesc Molist, Sven Daenicke, Regiane R. Santos
Summary: Feeding sows diets with different levels of zearalenone (ZEN) affects the levels of ZEN, alpha-ZEL, and beta-ZEL in the serum of sows and piglets, as well as impacting backfat thickness and hormone levels in sows, and gut inflammation in piglets.
Article
Food Science & Technology
Jian Ji, Jian Yu, Wei Xu, Yi Zheng, Yinzhi Zhang, Xiulan Sun
Summary: Zearalenone and its derivatives pose a serious threat to food quality and animal health. The use of enzymes to degrade mycotoxins has become a popular method to counter this threat. In this study, a novel enzyme FSZ derived from Aspergillus niger was found to effectively degrade Zearalenone and its derivatives, providing potential application value.
Article
Food Science & Technology
Lulu Ma, Yanping Jiang, Fuguang Lu, Shujing Wang, Mei Liu, Faxiao Liu, Libo Huang, Yang Li, Ning Jiao, Shuzhen Jiang, Xuejun Yuan, Weiren Yang
Summary: This experiment investigated the changes in the proteomics of ZEN-induced intestinal damage in weaned piglets. The results showed that ZEN exposure caused intestinal damage and altered the expression of important proteins.
Article
Veterinary Sciences
Shunyi Qin, Yukai Peng, Fuze She, Jianbin Zhang, Liuan Li, Fu Chen
Summary: This study evaluated the positive effects of selenized-oligochitosan (SOC) on zearalenone-induced intestinal dysfunction in piglets. Sixty piglets were divided into four groups and assessed for various parameters related to intestinal structure and function. The results showed that SOC supplementation significantly improved intestinal health by increasing villus height, promoting enzyme activities, and enhancing tight junction protein expressions, while reducing plasma levels of metabolites associated with intestinal injury.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Shenggang Yin, Ting You, Jiayong Tang, Longqiong Wang, Gang Jia, Guangmang Liu, Gang Tian, Xiaoling Chen, Jingyi Cai, Bo Kang, Hua Zhao
Summary: This study investigated the effects of dietary licorice flavonoids powder (LFP) supplementation on antioxidant capacity and immunity in weaned piglets. The results showed that LFP supplementation improved the liver index and antioxidant capacity, reduced serum cholesterol levels, and alleviated inflammation in immune organs of piglets.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Li Cao, Jie Zhao, Jingru Xu, Lei Zhu, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wang
Summary: The study demonstrates that N-acetylcysteine (NAC) can alleviate the damage of Sertoli cells induced by Zearalenone (ZEA) and Deoxynivalenol (DON) by reducing oxidative damage and apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Food Science & Technology
Yulei Zhang, Binbin Ouyang, Wenli Zhang, Cuie Guang, Wei Xu, Wanmeng Mu
Summary: Mycotoxins, especially Zearalenone (ZEN), have become a global concern in recent years due to their widespread contamination in crops such as corn, wheat, and barley. ZEN, structurally similar to estrogen, poses a significant threat to both poultry growth and human health. While adsorption is the most commonly used physical method for ZEN removal, the biological degradation of ZEN, utilizing enzymes such as lactonase, peroxidase, and laccase, has shown superior potential compared to physical and chemical solutions. This comprehensive discussion and comparison of the advantages and disadvantages of these methods sheds light on the effective management of ZEN contamination.
Article
Food Science & Technology
Iulian Alexandru Grosu, Cristina Valeria Bulgaru, Gina Cecilia Pistol, Ana Cismileanu, Daniela Eliza Marin, Ionelia Taranu
Summary: Pigs are highly sensitive to zearalenone (ZEN) contamination, especially after weaning, and it can have adverse effects on their health. There are no clear regulations regarding the maximum limit of ZEN in piglet feed, so further investigations are needed. This study examines the effects of different concentrations of ZEN on the microbiota, SCFA synthesis, and various markers in the colon of young pigs.
Article
Food Science & Technology
Johan S. Saenz, Alina Kurz, Ursula Ruczizka, Moritz Buenger, Maximiliane Dippel, Veronika Nagl, Bertrand Grenier, Andrea Ladinig, Jana Seifert, Evelyne Selberherr
Summary: Feeding animals with high concentrations of mycotoxins altered the gut microbiome composition, with an increase in Actinobacteria peptides and a decrease in Firmicutes peptides, as well as an increase in proteins associated with ribosomes and pentose-phosphate pathways, and a decrease in glycolysis and other carbohydrate metabolism pathways. Additionally, high levels of mycotoxins increased the abundance of the antioxidant enzyme thioredoxin-dependent peroxiredoxin, leading to disruption in the gut microbiome structure.
Article
Food Science & Technology
Pengfei Zhang, Changwei Jing, Ming Liang, Shuzhen Jiang, Libo Huang, Ning Jiao, Yang Li, Weiren Yang
Summary: This study found that high doses of ZEA exposure impaired cecal physical barrier functions by inhibiting the TGF-beta 1/Smads signaling pathway, while low doses of ZEA had no significant effect on cecum morphology and integrity by inhibiting the expression of smad7.
Article
Multidisciplinary Sciences
Jiregna Gari, Rahma Abdella
Summary: Mycotoxins produced by fungi, such as zearalenone, can be harmful to humans and animals. the use of microbial strains and enzymes for zearalenone degradation needs careful evaluation due to variability in effectiveness and potential safety concerns. Besides microbial and enzyme-based methods, physical or chemical treatments should also be explored for zearalenone detoxification.
Article
Agronomy
Valeria Cristina Bulgaru, Ana Maria Pertea, Iulian Alexandru Grosu, Andrei Cristian Anghel, Gina Cecilia Pistol, Daniela Eliza Marin, Anca Dinischiotu, Ionelia Taranu
Summary: Zearalenone (ZEN), a mycotoxin produced by Fusarium fungi, contaminates food and feed, causing health issues for humans and animals. Pigs, as major consumers of grains, are particularly sensitive to mycotoxins. This study observed the effects of ZEN at concentrations below and above the EU recommendation on oxidative and inflammatory responses in the colon of weaned piglets. Exposure to the lower concentration of ZEN (75 ppb) did not result in changes in stress and inflammation markers or associated signaling pathways.
Article
Food Science & Technology
Xue Liu, Na Wu, Mingyu Zhang, Feng Xue, Qing Xu
Summary: This study investigated the ability of the novel strain B73, isolated from petroleum-contaminated soil, to detoxify the mycotoxin Zearalenone (ZEN). The strain was identified as Bacillus spizizenii and showed a remarkable ability to degrade ZEN both in a minimal medium and in ZEN-contaminated agricultural products. The degradation rates reached high percentages, and the analysis of degradation products revealed a specific compound.
Article
Food Science & Technology
Yi Zhang, Xiaomeng Liu, Yunpeng Zhang, Xiaolin Zhang, He Huang
Summary: This study identified three new enzymes, CLA, EXO, and TRI, with high ability to degrade ZEN. These enzymes showed promising potential for practical application in ZEN detoxification.
Article
Agriculture, Dairy & Animal Science
Sandra Villagomez-Estrada, Jose Francisco Perez, Sandra van Kuijk, Diego Melo-Duran, Razzagh Karimirad, David Sola-Oriol
Summary: This study evaluated the effects of two different zinc and copper sources and supplementation levels on growing-finishing pigs, finding that low levels of zinc supplementation did not affect growth performance and carcass characteristics, but reducing dietary mineral content resulted in lower fecal mineral excretion. Pigs fed sulphate minerals had improved performance during the grower period, while those fed hydroxychloride minerals showed improved performance during the finishing period and greater carcass yield and mineral digestibility.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Food Science & Technology
Diego Melo-Duran, Jose Francisco Perez, Gemma Gonzalez-Ortiz, Sandra Villagomez-Estrada, Michael R. Bedford, Hadden Graham, David Sola-Oriol
Summary: Maize genotype and grain position on the cob significantly influence chemical composition and oligosaccharide content, particularly when treated with xylanase. The addition of xylanase increases the concentration of soluble compounds and xylotriose in the aqueous phase.
JOURNAL OF CEREAL SCIENCE
(2021)
Review
Agriculture, Dairy & Animal Science
Laia Blavi, David Sola-Oriol, Pol Llonch, Sergi Lopez-Verge, Susana Maria Martin-Orue, Jose Francisco Perez
Summary: The weaning period in swine industry is crucial, and a range of dietary and management strategies are needed to optimize health, maturity, and weight at weaning. Various strategies have been explored to enhance fetal growth, reduce oxidative and inflammatory status of sows, modulate sow microbiota, improve colostrum and milk production, and ensure care of neonatal piglets.
Article
Veterinary Sciences
David Reyes-Camacho, Jose Francisco Perez, Ester Vinyeta, Tobias Aumiller, Lourdes Criado-Mesas, Josep Maria Folch, Jan Dirk Van der Klis, David Sola-Oriol
Summary: The study found that supplementing gestating hyperprolific sow diets with a specific blend of phytogenic compounds (BPC) can influence neonatal gut morphology and gene expression related to intestinal health. This led to increased villus height and goblet cell volume density in the jejunum, as well as changes in gene expression associated with nutrient transport and immune response.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
M. Saladrigas-Garcia, M. D'Angelo, H. L. Ko, P. Nolis, Y. Ramayo-Caldas, J. M. Folch, P. Llonch, D. Sola-Oriol, J. F. Perez, S. M. Martin-Orue
Summary: This study investigated the impact of commercial early weaning on the gut microbiota, gene expression, and serum metabolomic response in piglets using an integrated-omic approach. The findings revealed significant changes in the gut microbiota and gene expression of the piglets after weaning, as well as notable alterations in metabolites. The results highlighted the complex interplay between gut microbiota, gene activity, and metabolic response in response to weaning stress.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Nedra Abdelli, Alison Ramser, Elizabeth S. Greene, Lesleigh Beer, Travis W. Tabler, Sara K. Orlowski, Jose Francisco Perez, David Sola-Oriol, Nicholas B. Anthony, Sami Dridi
Summary: The study revealed that heat stress affects body weight and the gene expression of nutrient transporters in the jejunum of different broiler populations, showing diverse impacts among populations.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Nedra Abdelli, David Sola-Oriol, Jose Francisco Perez
Summary: Plant phytogenic feed additives have been widely tested in poultry production to improve feed efficiency, digestion, and reduce pathogenic load, but their mechanisms of action still need further research. More efforts are needed to determine the proper inclusion levels and fully elucidate their mode of actions.
Article
Veterinary Sciences
Nedra Abdelli, Jose Francisco Perez, Ester Vilarrasa, Diego Melo-Duran, Irene Cabeza Luna, Razzagh Karimirad, David Sola-Oriol
Summary: The study demonstrated the beneficial effects of microencapsulation technique in protecting and slow releasing fumaric acid and thymol in the gastrointestinal tracts of broilers, which also improved the growth performance and gut health of fasted chickens.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Sandra Villagomez-Estrada, Jose F. Perez, Diego Melo-Duran, Francesc Gonzalez-Sole, Matilde D'Angelo, Francisco J. Perez-Cano, David Sola-Oriol
Summary: During birth and lactation, piglets born from hyperprolific sows with light body weight exhibit higher expression of stress and pro-inflammatory genes. The present study aimed to evaluate the physiological weaknesses of light piglets compared to their middle-weight littermates through gene expression analysis. Light piglets showed downregulation of genes related to immune response, antioxidant enzymes, digestive enzymes, and nutrient transporters at birth. However, at the end of the suckling period, these gene expression differences disappeared and genes involved in barrier function, inflammation, and stress responses were over-expressed in light piglets compared to their heavier littermates. This suggests that light piglets have compromised gene expression for nutrient absorption, immune and stress responses from birth to the end of lactation.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Mireia Saladrigas-Garcia, David Sola-Oriol, Sergi Lopez-Verge, Matilde D'Angelo, Maria Carmen Collado, Bea Nielsen, Martin Faldyna, Jose Francisco Perez, Susana M. Martin-Orue
Summary: The aim of this study was to determine the effects of probiotic supplementation during gestation and lactation on the performance of sows and piglets, as well as the intestinal health of piglets after separation from the mother. Results showed that probiotic supplementation improved the reproductive performance of sows and had an impact on the fecal microbiota composition of both mothers and piglets.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Asal Forouzandeh, Laia Blavi, Jose Francisco Perez, Matilde D'Angelo, Francesc Gonzalez-Sole, Alessandra Monteiro, Hans H. Stein, David Sola-Oriol
Summary: The study investigates the effects of adding copper sulfate or monovalent copper oxide to the diet of growing pigs on oxidative stress, inflammation, gene abundance, and microbial modulation. The results show that these additions can regulate gene abundance related to the immune system and growth, and promote changes in the intestinal microbiota. However, monovalent copper oxide induces less systemic oxidation and inflammation compared to copper sulfate.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Francesc Gonzalez-Sole, David Sola-Oriol, Yuliaxis Ramayo-Caldas, Maria Rodriguez-Prado, Gemma Gonzalez Ortiz, Michael R. Bedford, Jose Francisco Perez
Summary: Supplementing XOS to lactating piglets promotes fiber-degrading bacterial populations in their hindgut. The effects of XOS supplementation on the microbiota have long-term implications during the nursery period.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Francesc Gonzalez-Sole, David Sola-Oriol, Sandra Villagomez-Estrada, Diego Melo-Duran, Laura Victoria Lopez, Nathaly Villarroel Roman, Marina Lopez-Arjona, Jose Francisco Perez
Summary: This study aimed to investigate whether the growth differences during the lactation and nursery periods in pigs are associated with fecal microbiota composition and fermentation capacity. The study found that fast-growing pigs during the nursery period had higher cortisone concentrations in their hair and a tendency to have a lower cortisol-to-cortisone ratio. Both lactation and nursery growth influenced the fecal microbiota structure. Additionally, the fecal butyrate concentration was higher in pigs with fast growth during lactation and/or nursery. The study highlights the importance of early colonization on the establishment of the adult microbiota and suggests the potential implications of cortisol conversion to cortisone in animals with fast growth.
Article
Agriculture, Dairy & Animal Science
Montserrat Paniagua, Sandra Villagomez-Estrada, Francisco Javier Crespo, Jose Francisco Perez, Anna Aris, Maria Devant, David Sola-Oriol
Summary: Weaning is a challenging period for pigs, resulting in digestive disturbances and hindered growth. The traditional use of zinc oxide and antibiotics to prevent gastrointestinal problems during this phase has been restricted due to concerns about the environment and bacterial resistance. This study explores the potential alternative of supplementing citrus flavonoids and a single antibiotic (amoxicillin) to minimize the use of multiple antibiotics and zinc oxide in weaned pigs. The results show that citrus flavonoids plus amoxicillin significantly improve growth performance, gut health, and gastrointestinal barrier function without detrimental effects on performance.
Article
Microbiology
Mireia Saladrigas-Garcia, Mario Duran, Matilde D'Angelo, Jaume Coma, Jose Francisco Perez, Susana Maria Martin-Orue
Summary: This study investigated the development of piglet gut microbiota from birth to weaning in commercial conditions, highlighting the impact of age on microbial diversity and the influence of farm environment on microbiota composition. Results showed a succession of microbial groups towards a more homogeneous ecosystem with increasing age, and differences in microbial colonization patterns and specific taxa between farms.