Article
Food Science & Technology
Yun-Soo Seo, Na-Rea Shin, Hyeon Hwa Nam, Jun-Ho Song, Byeong Cheol Moon, Goya Choi, In-Sik Shin, Joong-Sun Kim
Summary: The study found that P. brevitarsis significantly inhibits prostate hyperplasia in BPH animals, reduces dihydrotestosterone levels, and effectively reduces testosterone-induced prostatic epithelial cell hyperplasia.
FOOD SCIENCE & NUTRITION
(2021)
Article
Andrology
Dohyun Choi, Jiyeon Kim, Jinho An, Seonhwa Hong, Youngcheon Song, Hyunseok Kong
Summary: This study characterized the effects of sesquiterpene lactones costunolide (CO) and dehydrocostus lactone (DCL) on benign prostate hyperplasia (BPH), showing that they can help suppress the development of BPH and alleviate prostate lesions caused by the disease.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Nutrition & Dietetics
You-Jee Jang, Hye-Yeon Jung, Ju-Yeong Myeong, Kwang Hoon Song, Joseph Kwon, Duwoon Kim, Jae-Il Park
Summary: Benign prostatic hyperplasia (BPH) is an age-related urinary disease in elderly men. Current BPH treatments have adverse effects, prompting the search for alternative agents. Alginate oligosaccharide (AOS), derived from brown algae, inhibits prostate cancer cell proliferation. The effects of AOS on BPH and its underlying mechanisms are unclear.
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Plant Sciences
Do-Hyun Choi, Ji-Yeon Kim, Jin-Ho An, Seung-Hyun Sung, Hyun-Seok Kong
Summary: Saussurea costus may prevent and treat benign prostatic hyperplasia by modulating inflammation and apoptosis imbalance. The study demonstrated its efficacy in treating BPH, which could be a new therapeutic option.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Abdulmohsin J. Alamoudi, Sami A. Alessi, Waleed Y. Rizg, Abdulmajeed M. Jali, Awaji Y. Safhi, Fahad Y. Sabei, Sameer Alshehri, Khaled M. Hosny, Ashraf B. Abdel-Naim
Summary: This study found that cordycepin has the ability to prevent testosterone-induced benign prostatic hyperplasia (BPH) in rats. It exerts its effects through its antiproliferative, antioxidant, anti-inflammatory, pro-apoptotic actions, and modulation of AMPK and AKT activation.
Article
Cell Biology
David Julian Arias-Chavez, Patrick Mailloux-Salinas, Jessica Ledesma Aparicio, Elihu Campos-Perez, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Guadalupe Bravo
Summary: This study aimed to evaluate the therapeutic effect of selenium in combination with a tomato extract in aged rats with benign prostatic hyperplasia (BPH). The results showed that the combination treatment significantly reduced prostate weight and inhibited cell proliferation, while also decreasing oxidative stress and inflammation levels.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yani Zhao, Yan Zhang, Yao Li, Min Yang, Jiani Yuan, Yu Cao, Lu Xu, Xuexinyu Ma, Sisong Lin, Junming An, Siwang Wang
Summary: The study found that different doses of yohimbine effectively inhibited the increase in prostate index in BPH rats, and reduced the levels of dihydrotestosterone, prostatic acid phosphatase, prostate-specific antigen, proliferating cell nuclear antigen, and steroid 5 alpha-reductase, indicating that it exerts beneficial effects against BPH by modulating the steroid 5 alpha-reductase pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Kwang Hoon Song, Chang-Seob Seo, Won-Kyung Yang, Hyun-O Gu, Ki-Joong Kim, Seung-Hyung Kim
Summary: The study found that bamboo leaves extract (PPE) inhibited the activity and mRNA expression of human SRD5A2, providing a protective effect in a testosterone-induced BPH rat model. PPE treatment reduced prostate weight, serum hormone levels, and expression of specific genes related to prostate growth and inflammation, indicating its potential as a therapeutic agent for BPH.
Article
Agriculture, Multidisciplinary
Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An
Summary: Purple corn extract (PCE) has ameliorative effects on benign prostatic hyperplasia (BPH) by reducing androgen receptor (AR) expression and inhibiting the PI3K/AKT signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Weronika Ratajczak, Michal Lubkowski, Anna Lubkowska
Summary: This review article discusses the role of heat shock proteins (HSPs) in prostate diseases and their potential as therapeutic targets. HSPs are overexpressed in benign prostatic hyperplasia (BPH) and prostate cancer (PCa), and play roles in maintaining cell homeostasis, protein folding and repair, as well as immune response and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Pengyu Wei, Dongxu Lin, Mengyang Zhang, Changcheng Luo, Xiaoliang Wu, Bolang Deng, Kai Cui, Zhong Chen
Summary: Cryptotanshinone (CTS) has therapeutic effects on BPH by suppressing AR and EGFR/STAT3 axis activity, and modulating proliferation, apoptosis, EMT, and stromal collagen deposition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biology
Che-Hsueh Yang, Yen-Chuan Ou, Chi-Chien Lin, Yi-Sheng Lin, Min-Che Tung, Chia-Cheng Yu, Jen-Tai Lin, Chen-Yueh Wen
Summary: Phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, shows promising effects in treating BPH and PCa, based on animal and in-vitro studies. Further research is needed regarding its safety and effective dosages in human clinical trials.
Article
Plant Sciences
Ja Yeon Park, Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Jun Hee Lee, Hyun Jeong Kwak, Jae-Young Um
Summary: This study found that a water extract of Glycyrrhiza uralensis Fischer has potential therapeutic effects on BPH by inhibiting AR-5AR2 signaling and activating apoptosis signaling to reduce BPH development. Unlike finasteride, GUWE does not impact sperm count, suggesting lower toxicity and a safer alternative option for BPH treatment.